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Molecular mechanisms of p75NTR modulation in the regeneration of pulp sensory function

Research Project

Project/Area Number 18K19632
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 57:Oral science and related fields
Research InstitutionTohoku University

Principal Investigator

Inuzuka Hiroyuki  東北大学, 歯学研究科, 准教授 (20335863)

Co-Investigator(Kenkyū-buntansha) 福本 敏  九州大学, 歯学研究院, 教授 (30264253)
齋藤 正寛  東北大学, 歯学研究科, 教授 (40215562)
清水 康平  大阪市立大学, 大学院医学研究科, 助教 (70727073)
Project Period (FY) 2018-06-29 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywordsp75NTR / タンパク質分解 / 蛋白質分解 / 歯髄幹細胞 / 神経成長因子
Outline of Final Research Achievements

Efficient regeneration of pulp sensory function requires neural and axon regeneration and proper axon guidance in the dental pulp. In this study, we focused on the regulatory mechanisms of p75 neurotrophin receptor (p75NTR), an essential factor for neural differentiation, survival, and axon elongation. We found that post-translational modifications play a role in the regulation of p75NTR and modulate its activity. The findings of this study will provide an insight into developing a potential approach for the efficient regeneration of pulp function.

Academic Significance and Societal Importance of the Research Achievements

間葉系幹細胞マーカーおよび神経成長因子受容体として機能するp75NTRの活性調節分子機序を解析し受容体活性化の任意制御を試みることは、効率的な神経分化誘導法の開発に向けた有力なアプローチとなり得る。移植医療分野で応用が進む間葉系幹細胞移植は特に脊髄損傷や脳梗塞など神経変性疾患の分野で顕著な成績を上げていることから、本研究で得られた知見は、神経組織・知覚機能再生法開発の分子機序解明の手がかりとなる可能性を有している。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (11 results)

All 2020 2019 2018 Other

All Int'l Joint Research (1 results) Journal Article (6 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 6 results,  Open Access: 1 results) Presentation (4 results) (of which Invited: 1 results)

  • [Int'l Joint Research] Beth Israel Deaconess Medical Center(米国)

    • Related Report
      2018 Research-status Report
  • [Journal Article] Lipin-2 degradation elicits a proinflammatory gene signature in macrophages2020

    • Author(s)
      Watahiki Asami、Shimizu Kouhei、Hoshikawa Seira、Chiba Mitsuki、Kitamura Hiroshi、Egusa Hiroshi、Fukumoto Satoshi、Inuzuka Hiroyuki
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 524 Issue: 2 Pages: 477-483

    • DOI

      10.1016/j.bbrc.2020.01.119

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SCFβ-TrCP ubiquitinates CHK1 in an AMPK-dependent manner in response to glucose deprivation2019

    • Author(s)
      Ma Ying、Cui Danrui、Xiong Xiufang、Inuzuka Hiroyuki、Wei Wenyi、Sun Yi、North Brian J.、Zhao Yongchao
    • Journal Title

      Molecular Oncology

      Volume: 13 Issue: 2 Pages: 307-321

    • DOI

      10.1002/1878-0261.12403

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Physiological functions of FBW7 in cancer and metabolism2018

    • Author(s)
      Shimizu Kouhei、Nihira Naoe Taira、Inuzuka Hiroyuki、Wei Wenyi
    • Journal Title

      Cellular Signalling

      Volume: 46 Pages: 15-22

    • DOI

      10.1016/j.cellsig.2018.02.009

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] SCFβ-TRCP E3 ubiquitin ligase targets the tumor suppressor ZNRF3 for ubiquitination and degradation2018

    • Author(s)
      Ci Yanpeng、Li Xiaoning、Chen Maorong、Zhong Jiateng、North Brian J.、Inuzuka Hiroyuki、He Xi、Li Yu、Guo Jianping、Dai Xiangpeng
    • Journal Title

      Protein & Cell

      Volume: 9 Issue: 10 Pages: 879-889

    • DOI

      10.1007/s13238-018-0510-2

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Skp2-dependent reactivation of AKT drives resistance to PI3K inhibitors2018

    • Author(s)
      Clement Emilie、Inuzuka Hiroyuki、Nihira Naoe T.、Wei Wenyi、Toker Alex
    • Journal Title

      Science Signaling

      Volume: 11 Issue: 521 Pages: 3810-3810

    • DOI

      10.1126/scisignal.aao3810

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] SCFFBW7-mediated degradation of Brg1 suppresses gastric cancer metastasis2018

    • Author(s)
      Huang Li-Yu、Zhao Junjie、Chen Hao、Wan Lixin、Inuzuka Hiroyuki、Guo Jianping、Fu Xuhong、Zhai Yangyang、Lu Zhaoning、Wang Xuefei、Han Ze-Guang、Sun Yihong、Wei Wenyi
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 3569-3569

    • DOI

      10.1038/s41467-018-06038-y

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Regulation of cell survival through post-translational modifications of MCL-1 in tumorigenesis2019

    • Author(s)
      Hiroyuki Inuzuka, Kouhei Shimizu, Mitsuki Chiba, Satoshi Fukumoto, Wenyi Wei
    • Organizer
      The Kick-off Symposium of Advanced Graduate Program for Future Medicine and Health Care
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] ユビキチン-プロテアソーム経路の破綻によるMCL1安定化機構とその制御方法の検討2018

    • Author(s)
      清水 康平、千葉 満生、犬塚 博之、福本 敏
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] プロテアソーム阻害剤を用いた効率的骨芽細胞分化誘導法の検討2018

    • Author(s)
      星川 聖良、千葉 満生、綿引 麻美、清水 康平、犬塚 博之、福本 敏
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Lipin 2タンパク質分解を介したマクロファージ活性化調節機構の解析2018

    • Author(s)
      綿引麻美、清水康平、瓜生英尚、星川聖良、福本敏、江草宏、犬塚博之
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Research-status Report

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Published: 2018-07-25   Modified: 2021-02-19  

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