Identification of specific cell surface antigens for separation of neural crest derived cells and its application to bone regenerative medicine
Project/Area Number |
18K19655
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Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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Allocation Type | Multi-year Fund |
Review Section |
Medium-sized Section 57:Oral science and related fields
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Research Institution | Showa University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
山田 篤 昭和大学, 歯学部, 講師 (50407558)
|
Project Period (FY) |
2018-06-29 – 2020-03-31
|
Project Status |
Completed (Fiscal Year 2019)
|
Budget Amount *help |
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2018: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
|
Keywords | 神経堤由来細胞 / 神経堤細胞 |
Outline of Final Research Achievements |
Neural crest-derived cells (NCDCs) are expected to be a new cell source for regenerative medicine. They have a self-renewal capability and give rise to a multitude of cell lineages. In this study, we revealed that NCDCs could be proliferated and purified in vitro. Furthermore, NCDCs transplantation exerted bone regeneration ability for the repair of bone defect.
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Academic Significance and Societal Importance of the Research Achievements |
成長後も体内各所に潜伏し、一部の細胞で幹細胞の性質を維持する神経堤由来細胞を効率良く増殖・純化させる方法論や、神経堤由来細胞を用いた骨組織誘導法の開発によって、硬組織再生医療の臨床応用に向けて、生命科学や再生医学の研究と検討が一層加速することと考える。
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Report
(3 results)
Research Products
(56 results)
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[Journal Article] Possible involvement of elastase in enhanced osteoclast differentiation by neutrophils through degradation of osteoprotegerin.2020
Author(s)
Sugisaki R, Miyamoto Y, Yoshimura K, Sasa K, Kaneko K, Tanaka M, Itose M, Inoue S, Baba K, Shirota T, Chikazu D, Kamijo R
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Journal Title
Bone
Volume: 132
Pages: 115216-115216
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Visualization of junctional epithelial cell replacement by oral gingival epithelial cells over a life time and after gingivectomy.2019
Author(s)
Kato M, Tanaka J, Aizawa R, Yajima-Himuro S, Seki T, Tanaka K, Yamada A, Ogawa M, Kamijo R, Tsuji T, Mishima K, Yamamoto M
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Journal Title
Sci Rep
Volume: 9
Issue: 1
Pages: 7640-7640
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Cdc42 regulates cranial suture morphogenesis and ossification2019
Author(s)
Aizawa Ryo、Yamada Atsushi、Seki Tatsuaki、Tanaka Junichi、Nagahama Ryo、Ikehata Mikiko、Kato Tadashi、Sakashita Akiko、Ogata Hiroaki、Chikazu Daichi、Maki Koutaro、Mishima Kenji、Yamamoto Matsuo、Kamijo Ryutaro
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Journal Title
Biochemical and Biophysical Research Communications
Volume: 512
Issue: 2
Pages: 145-149
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Production of 8-nitro-cGMP in osteocytic cells and its upregulation by parathyroid hormone and prostaglandin E2.2019
Author(s)
Nagayama K, Miyamoto Y, Kaneko K, Yoshimura K, Sasa K, Akaike T, Fujii S, Izumida E, Uyama R, Chikazu D, Maki K, Kamijo R.
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Journal Title
In Vitro Cell Dev Biol Anim
Volume: 55
Issue: 1
Pages: 45-51
DOI
Related Report
Peer Reviewed
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[Journal Article] Monocarboxylate transporter-1 promotes osteoblast differentiation via suppression of p53, a negative regulator of osteoblast differentiation.2018
Author(s)
Sasa K, Yoshimura K, Yamada A, Suzuki D, Miyamoto Y, Imai H, Nagayama K, Maki K, Yamamoto M, Kamijo R
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Journal Title
Sci. Rep.
Volume: 8(1)
Issue: 1
Pages: 10579-10579
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] A preliminary report on dental implant condition among dependent elderly based on the survey among Japanese dental practitioners2018
Author(s)
Sato Y, Koyama S, Ohkubo C, Ogura S, Kamijo R, Sato S, Aida J, Izumi Y, Atsumi M, Isobe A, Baba S, Ikumi N, Watanabe F
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Journal Title
Int J Implant Dent
Volume: 4(1)
Issue: 1
Pages: 14-14
DOI
Related Report
Peer Reviewed
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[Journal Article] Cooperation of Rho family proteins Rac1 and Cdc42 in cartilage development and calcified tissue formation2018
Author(s)
Ikehata M, Yamada A, Fujita K, Yoshida Y, Kato T, Sakashita A, Ogata H, Iijima T, Kuroda M, Chikazu D, Kamijo R.
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Journal Title
Biochem Biophys Res Commun
Volume: 印刷中
Issue: 3
Pages: 525-529
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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