| Project/Area Number |
18K19655
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 57:Oral science and related fields
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| Research Institution | Showa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
山田 篤 昭和大学, 歯学部, 講師 (50407558)
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| Project Period (FY) |
2018-06-29 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2018: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 神経堤由来細胞 / 神経堤細胞 |
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| Outline of Final Research Achievements |
Neural crest-derived cells (NCDCs) are expected to be a new cell source for regenerative medicine. They have a self-renewal capability and give rise to a multitude of cell lineages. In this study, we revealed that NCDCs could be proliferated and purified in vitro. Furthermore, NCDCs transplantation exerted bone regeneration ability for the repair of bone defect.
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| Academic Significance and Societal Importance of the Research Achievements |
成長後も体内各所に潜伏し、一部の細胞で幹細胞の性質を維持する神経堤由来細胞を効率良く増殖・純化させる方法論や、神経堤由来細胞を用いた骨組織誘導法の開発によって、硬組織再生医療の臨床応用に向けて、生命科学や再生医学の研究と検討が一層加速することと考える。
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