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Disinfection of sinks in wards reduces the rate of detection of carbapenem-resistant Pseudomonas aeruginosa from patients: development of innovative methodology and basic study

Research Project

Project/Area Number 18K19659
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 58:Society medicine, nursing, and related fields
Research InstitutionHokkaido University

Principal Investigator

Ishiguro Nobuhisa  北海道大学, 大学病院, 准教授 (40168216)

Project Period (FY) 2018-06-29 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords緑膿菌 / 手洗い / 除菌 / 耐性緑膿菌 / 手洗いシンク / カルバペネム耐性 / 水周り
Outline of Final Research Achievements

The sink drainage systems in wards are considered to be reservoirs for antibiotic-resistant bacteria such as multidrug-resistant Pseudomonas aeruginosa (MDRP). Disinfection of sinks in wards might prevent the transmission of MDRP to patients, and the rate of detection of MDRP from patients might therefore be reduced. Disinfection of sinks in three wards was started in 2007, and genotypes of MDRP were analyzed using PCR-based ORF typing and multi-locus sequence typing. After starting the disinfection in 2007, the rate of detection of MDRP from patients was markedly reduced and genetically homologous MDRP strains almost disappeared. Disinfection of sink drainage systems in wards is effective for preventing transmission of MDRP to patients.

Academic Significance and Societal Importance of the Research Achievements

薬剤耐性菌が世界的に増加しており、その対策が大きな課題となっています。病院の病棟の手洗いは、様々な耐性菌の温床となっていることが知られています。一部の耐性菌は、手洗いを介して患者に伝播している可能性があります。我々は、手洗いの除菌を行うことで、多剤耐性緑膿菌という耐性菌の患者への伝播を抑えることができることを世界に先駆けて見出しました。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (23 results)

All 2022 2021 2020 2019 2018

All Journal Article (17 results) (of which Peer Reviewed: 16 results,  Open Access: 5 results) Presentation (6 results) (of which Invited: 2 results)

  • [Journal Article] Risk factors of multidrug-resistant pyogenic spondylitis in thoraco-lumbar spine: A retrospective study of 122 cases2022

    • Author(s)
      Yamada Katsuhisa、Takahata Masahiko、Ito Manabu、Nagahama Ken、Iwata Akira、Endo Tsutomu、Sudo Hideki、Ishiguro Nobuhisa、Iwasaki Norimasa
    • Journal Title

      Journal of Orthopaedic Science

      Volume: 27 Issue: 1 Pages: 95-100

    • DOI

      10.1016/j.jos.2020.11.020

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Therapeutic drug monitoring-enabled long-term use of linezolid for the successful treatment of refractory pyogenic spondylodiscitis without development of thrombocytopenia: A case report2021

    • Author(s)
      Daisho Takayuki、Kagami Keisuke、Yamazaki Koujiro、Ishiguro Nobuhisa、Endo Tsutomu、Takahata Masahiko、Suzuki Hisataka、Sugawara Mitsuru、Takekuma Yoh
    • Journal Title

      Journal of Orthopaedic Science

      Volume: 23 December Issue: 6 Pages: 1587-1591

    • DOI

      10.1016/j.jos.2021.11.018

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of a Novel Immunochromatographic Assay Using Monoclonal Antibodies against the Matrix Protein of Human Metapneumovirus2021

    • Author(s)
      Ishiguro Nobuhisa、Akutsu Yasushi、Azuma Katsuki、Yonekawa Motoharu、et al.
    • Journal Title

      Clinical Laboratory

      Volume: 67 Issue: 10/2021

    • DOI

      10.7754/clin.lab.2021.210232

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Three-day regimen of oseltamivir for post-exposure prophylaxis of influenza in hospital wards: a study protocol for a prospective, multi-center, single-arm trial2021

    • Author(s)
      Ishiguro Nobuhisa、Ito Yoichi M.、Iwasaki Sumio、Nagao Miki、Kawamura Hideki et al.
    • Journal Title

      BMC Infectious Diseases

      Volume: 21 Issue: 1 Pages: 887-887

    • DOI

      10.1186/s12879-021-06602-w

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical and virological outcomes with baloxavir compared with oseltamivir in pediatric patients aged 6 to <12 years with influenza: an open-label, randomized, active-controlled trial protocol2021

    • Author(s)
      Ishiguro Nobuhisa、Morioka Ichiro、Nakano Takashi、Furukawa Masashi、Tanaka Shintaro、Kinoshita Masahiro、Manabe Atsushi
    • Journal Title

      BMC Infectious Diseases

      Volume: 21 Issue: 1 Pages: 777-777

    • DOI

      10.1186/s12879-021-06494-w

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] P1 gene of Mycoplasma pneumoniae isolated from 2016 to 2019 and relationship between genotyping and macrolide resistance in Hokkaido, Japan2021

    • Author(s)
      Ishiguro Nobuhisa、Sato Rikako、Kikuta Hideaki、Nakanishi Masanori、Aoyagi Hayato et al.
    • Journal Title

      Journal of Medical Microbiology

      Volume: 70 Issue: 6

    • DOI

      10.1099/jmm.0.001365

    • NAID

      120007168591

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Point-of-care molecular diagnosis of Mycoplasma pneumoniae including macrolide sensitivity using quenching probe polymerase chain reaction2021

    • Author(s)
      Ishiguro Nobuhisa、Sato Rikako、Mori Toshihiko、Tanaka Hiroshi、Narita Mitsuo、Nagano Takashi、Owaku Masato、Miyajima Kensuke、Manabe Atsushi
    • Journal Title

      PLOS ONE

      Volume: 16 Issue: 10 Pages: 0258694-0258694

    • DOI

      10.1371/journal.pone.0258694

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical outcomes of intervention for carbapenems and anti-methicillin-resistant Staphylococcus aureus antibiotics by an antimicrobial stewardship team2021

    • Author(s)
      Kagami Keisuke、Ishiguro Nobuhisa、Yamada Takehiro、Niinuma Yusuke、Iwasaki Sumio、Taki Keisuke、Fukumoto Tatsuya、Hayasaka Kasumi、Nishida Mutsumi、Sugita Junichi、Teshima Takanori、Sugawara Mitsuru、Takekuma Yoh
    • Journal Title

      American Journal of Infection Control

      Volume: 49 Issue: 12 Pages: 1493-1498

    • DOI

      10.1016/j.ajic.2021.08.011

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy and safety of colistin for the treatment of infections caused by multidrug-resistant gram-negative bacilli2021

    • Author(s)
      Kagami Keisuke、Ishiguro Nobuhisa、Yamada Takehiro、Niinuma Yusuke、Iwasaki Sumio、Taki Keisuke、Fukumoto Tatsuya、Hayasaka Kasumi、Oyamada Reiko、Watanabe Tsubasa、Nishida Mutsumi、Sugita Junichi、Teshima Takanori、Sugawara Mitsuru、Takekuma Yoh
    • Journal Title

      Journal of Infection and Chemotherapy

      Volume: 27 Issue: 3 Pages: 473-479

    • DOI

      10.1016/j.jiac.2020.10.024

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of a novel immunochromatographic assay using silver amplification technology for detection of Mycoplasma pneumoniae from throat swab samples in pediatric patients2021

    • Author(s)
      Nobuhisa Ishiguro, Hideaki Kikuta, Mutsuko Konno, Rikako Sato and Atsushi Manabe
    • Journal Title

      Journal of Laboratory Medicine

      Volume: - Issue: 3 Pages: 189-192

    • DOI

      10.1515/labmed-2020-0096

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of a Novel Immunochromatographic Assay Using Monoclonal Antibodies against the Matrix Protein of Human Metapneumovirus2021

    • Author(s)
      Nobuhisa Ishiguro, Yasushi Akutsu, Katsuki Azuma et al
    • Journal Title

      Clinical Laboratory

      Volume: -

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] P 1 gene of Mycoplasma pneumoniae isolated from 2016 to 2019 and relationship between genotyping and macrolide resistance in Hokkaido, Japan2021

    • Author(s)
      Nobuhisa Ishiguro, Rikako Sato, Hideaki Kikuta et al.
    • Journal Title

      Journal of Medical Microbiology.

      Volume: -

    • NAID

      120007168591

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Proposal of COVID-19 Clinical Risk Score for the management of suspected COVID-19 cases: a case control study2020

    • Author(s)
      Nakakubo Sho、Suzuki Masaru、Kamada Keisuke、Yamashita Yu、Nakamura Junichi、Horii Hiroshi、Sato Kazuki、Matsumoto Munehiro、Abe Yuki、Tsuji Kosuke、Ishiguro Nobuhisa、Nasuhara Yasuyuki、Konno Satoshi
    • Journal Title

      BMC Infectious Diseases

      Volume: 20 Issue: 1

    • DOI

      10.1186/s12879-020-05604-4

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of Daptomycin-Induced Cellular Membrane Injury in Skeletal Muscle2020

    • Author(s)
      Yamada Takehiro、Ishikawa Shuhei、Ishiguro Nobuhisa、Kobayashi Masaki、Iseki Ken
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 43 Issue: 9 Pages: 1338-1345

    • DOI

      10.1248/bpb.b20-00217

    • NAID

      130007894865

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] An adult case of severe life-threatening Mycoplasma pneumoniae pneumonia due to a macrolide-resistant strain, Japan: a case report2019

    • Author(s)
      Matsumoto Munehiro、Nagaoka Kentaro、Suzuki Masaru、Konno Satoshi、Takahashi Kei、Takashina Taichi、Ishiguro Nobuhisa、Nishimura Masaharu
    • Journal Title

      BMC Infectious Diseases

      Volume: 19 Issue: 1 Pages: 204-208

    • DOI

      10.1186/s12879-019-3846-1

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Construction of a flow chart?like risk prediction model of ganciclovir‐induced neutropaenia including severity grade: A data mining approach using decision tree2019

    • Author(s)
      Imai Shungo、Yamada Takehiro、Kasashi Kumiko、Ishiguro Nobuhisa、Kobayashi Masaki、Iseki Ken
    • Journal Title

      Journal of Clinical Pharmacy and Therapeutics

      Volume: 44 Issue: 5 Pages: 726-734

    • DOI

      10.1111/jcpt.12852

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical effectiveness of four neuraminidase inhibitors (oseltamivir, zanamivir, laninamivir, and peramivir) for children with influenza A and B in the 2014?2015 to 2016?2017 influenza seasons in Japan2018

    • Author(s)
      Ishiguro Nobuhisa、Koseki Naoko、Kaiho Miki、et.al.
    • Journal Title

      Journal of Infection and Chemotherapy

      Volume: 24 Issue: 6 Pages: 449-457

    • DOI

      10.1016/j.jiac.2018.01.013

    • NAID

      120006636165

    • Related Report
      2018 Research-status Report
  • [Presentation] シンポジウム 15「スポーツイベントに関するシンポジウム」 「サッカー」2021

    • Author(s)
      石黒信久
    • Organizer
      第95回日本感染症学会学術講演会/第69回日本化学療法学会総会 合同学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 教育講演「NICUにおける薬剤耐性菌の制御」2021

    • Author(s)
      石黒信久
    • Organizer
      第65回日本新生児成育医学会・学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] NICUにおける薬剤耐性菌の制御2021

    • Author(s)
      石黒信久
    • Organizer
      第65回日本新生児成育医学会・学術集会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 多剤耐性菌の感染対策及びその治療2019

    • Author(s)
      石黒信久
    • Organizer
      インフェクションコントロール
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] インフルエンザ対策における予防投与2019

    • Author(s)
      石黒信久、小山田玲子、渡邊翼、岩崎澄央、山田武宏
    • Organizer
      第34回日本環境感染学会総会・学術集会 シンポジウム9
    • Related Report
      2018 Research-status Report
  • [Presentation] 小児におけるインフルエンザの治療2018

    • Author(s)
      石黒信久
    • Organizer
      第6回北海道小児外科フォーラム
    • Related Report
      2018 Research-status Report

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Published: 2018-07-25   Modified: 2023-01-30  

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