Evaluation of effects on age and tissue regeneration by exercise intervention on high-risk myocardial infarction
Project/Area Number |
18K19689
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Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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Allocation Type | Multi-year Fund |
Review Section |
Medium-sized Section 58:Society medicine, nursing, and related fields
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Research Institution | Yokohama City University |
Principal Investigator |
CHIBA Yumi 横浜市立大学, 医学部, 教授 (10313256)
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Co-Investigator(Kenkyū-buntansha) |
石上 友章 横浜市立大学, 医学部, 准教授 (50264651)
峯岸 慎太郎 横浜市立大学, 附属病院, 助教 (80458398)
藤田 孝之 福岡大学, 医学部, 教授 (40468202)
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Project Period (FY) |
2018-06-29 – 2023-03-31
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Project Status |
Completed (Fiscal Year 2022)
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Budget Amount *help |
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2018: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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Keywords | 間葉系幹細胞 / 再生 / 評価 / 心筋梗塞 / 炎症 / 免疫 / 加齢 / 幹細胞 / 運動 |
Outline of Final Research Achievements |
In recent years, regenerative medicine using stem cells for damaged myocardium after myocardial infarction has attracted much attention, and the perspective of how to prevent fibrosis is an important issue. Especially in Japan, where the population is aging rapidly, there is an urgent need to evaluate stem cells, discover the usefulness of introducing cells into the body, and elucidate the mechanisms that lead to treatment in order to realize effective medical care after myocardial infarction. Cortical bone-derived stem cells are a new type of stem cells that have shown some usefulness in myocardial regeneration in the United States. In Japan, these stem cells were isolated and analyzed for therapeutic application, and new findings were obtained.
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Academic Significance and Societal Importance of the Research Achievements |
心筋梗塞後の損傷心筋への幹細胞を用いた再生医療は非常に注目されており、心筋再生治療につながる幹細胞の特徴やメカニズムの解明は急務である。皮質骨由来幹細胞は米国にて先駆け心筋再生への有用性を示していた新種の幹細胞であるが、世界でもほとんど扱われておらず、体性幹細胞としての本来の役割についても明確でされてきていない。そこで、日本でも本幹細胞を単離し、分析を進めてきた。これら実験遂行作業の中で、付随的に得られた成果も示されてきた。
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Report
(5 results)
Research Products
(23 results)
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[Journal Article] Successful screening of sleep-disordered breathing using a pacemaker-based algorithm in Japan.2019
Author(s)
Taguchi Y, Matsushita K, Ishikawa T, Matsumoto K, Hosoda J, Iguchi K, Matsushita H, Kubota K, Sumita S, Ishigami T, Tamura K.
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Journal Title
J Cardiol
Volume: 73(5)
Pages: 394-400
Related Report
Peer Reviewed
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[Journal Article] Effects of ATRAP in Renal Proximal Tubules on Angiotensin-Dependent Hypertension.2019
Author(s)
Kinguchi S, Wakui H, Azushima K, Haruhara K, Koguchi T, Ohki K, Uneda K,Matsuda M, Haku S, Yamaji T, Yamada T, Kobayashi R, Minegishi S, Ishigami T,Yamashita A, Fujikawa T, Tamura K.
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Journal Title
J Am Heart Assoc
Volume: 8(8)
Related Report
Peer Reviewed
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[Journal Article] Effects of rikkunshito on renal fibrosis and inflammation in angiotensin II-infused mice.2019
Author(s)
Azushima K, Uneda K, Wakui H, Ohki K, Haruhara K, Kobayashi R, Haku S,Kinguchi S, Yamaji T, Minegishi S, Ishigami T, Yamashita A, Tamura K.
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Journal Title
Sci Rep
Volume: 9(1)
Pages: 6201-6201
Related Report
Peer Reviewed
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[Journal Article] Lubiprostone as a potential therapeutic agent to improve intestinal permeability and prevent the development of atherosclerosis in apolipoprotein E-deficient mice.2019
Author(s)
Arakawa K, Ishigami T(correspond), Nakai-Sugiyama M, Chen L, Doi H, Kino T, Minegishi S,Saigoh-Teranaka S, Sasaki-Nakashima R, Hibi K, Kimura K, Tamura K.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Microbiota-derived Trimethylamine N-oxide Predicts Cardiovascular Risk After STEMI.2019
Author(s)
Matsuzawa Y, Nakahashi H, Konishi M, Sato R, Kawashima C, Kikuchi S, Akiyama E, Iwahashi N, Maejima N, Okada K, Ebina T, Hibi K, Kosuge M, Ishigami T, Tamura K, Kimura K.
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Journal Title
Sci Rep
Volume: 9(1)
Pages: 11647-11647
Related Report
Peer Reviewed
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[Journal Article] Angiotensin II type 1 receptor-associated protein deficiency attenuates sirtuin1 expression in an immortalised human renal proximal tubule cell line.2019
Author(s)
Yamaji T, Yamashita A, Wakui H, Azushima K, Uneda K, Fujikawa Y, Haku S,Kobayashi R, Ohki K, Haruhara K, Kinguchi S, Ishii T, Yamada T, Urate S, SuzukiT, Abe E, Tanaka S, Kamimura D, Ishigami T, Toya Y, Takahashi H, Tamura K.
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Journal Title
Sci Rep
Volume: 9(1)
Pages: 16550-16550
Related Report
Peer Reviewed
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[Journal Article] Translationally controlled tumor protein (TCTP) plays a pivotal role in cardiomyocyte survival through a Bnip3-dependent mechanism.2019
Author(s)
Cai W, Fujita T, Hidaka Y, Jin H, Suita K, Shigeta M, Kiyonari H, Umemura M, Yokoyama U, Sadoshima J, Ishikawa Y.
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Journal Title
Cell Death Dis
Volume: 10
Issue: 8
Pages: 549-549
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Doxorubicin induces trans-differentiation and MMP1 expression in cardiac fibroblasts via cell death-independent pathways.2019
Author(s)
Narikawa M, Umemura M, Tanaka R, Hikichi M, Nagasako A, Fujita T, Yokoyama U, Ishigami T, Kimura K, Tamura K, Ishikawa Y.
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Journal Title
PLoS One.
Volume: 14
Issue: 9
Pages: e0221940-e0221940
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Prostaglandin E2 receptor EP4 regulates cell migration through Orai1.2019
Author(s)
Osawa K, Umemura M, Nakakaji R, Tanaka R, Islam RM, Nagasako A, Fujita T, Yokoyama U, Koizumi T, Mitsudo K, Ishikawa Y.
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Journal Title
Cancer Sci.
Volume: 111
Issue: 1
Pages: 160-174
DOI
Related Report
Peer Reviewed / Open Access
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