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Evaluation of effects on age and tissue regeneration by exercise intervention on high-risk myocardial infarction

Research Project

Project/Area Number 18K19689
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 58:Society medicine, nursing, and related fields
Research InstitutionYokohama City University

Principal Investigator

CHIBA Yumi  横浜市立大学, 医学部, 教授 (10313256)

Co-Investigator(Kenkyū-buntansha) 石上 友章  横浜市立大学, 医学部, 准教授 (50264651)
峯岸 慎太郎  横浜市立大学, 附属病院, 助教 (80458398)
藤田 孝之  福岡大学, 医学部, 教授 (40468202)
Project Period (FY) 2018-06-29 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2018: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywords間葉系幹細胞 / 再生 / 評価 / 心筋梗塞 / 炎症 / 免疫 / 加齢 / 幹細胞 / 運動
Outline of Final Research Achievements

In recent years, regenerative medicine using stem cells for damaged myocardium after myocardial infarction has attracted much attention, and the perspective of how to prevent fibrosis is an important issue. Especially in Japan, where the population is aging rapidly, there is an urgent need to evaluate stem cells, discover the usefulness of introducing cells into the body, and elucidate the mechanisms that lead to treatment in order to realize effective medical care after myocardial infarction. Cortical bone-derived stem cells are a new type of stem cells that have shown some usefulness in myocardial regeneration in the United States. In Japan, these stem cells were isolated and analyzed for therapeutic application, and new findings were obtained.

Academic Significance and Societal Importance of the Research Achievements

心筋梗塞後の損傷心筋への幹細胞を用いた再生医療は非常に注目されており、心筋再生治療につながる幹細胞の特徴やメカニズムの解明は急務である。皮質骨由来幹細胞は米国にて先駆け心筋再生への有用性を示していた新種の幹細胞であるが、世界でもほとんど扱われておらず、体性幹細胞としての本来の役割についても明確でされてきていない。そこで、日本でも本幹細胞を単離し、分析を進めてきた。これら実験遂行作業の中で、付随的に得られた成果も示されてきた。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (23 results)

All 2021 2020 2019 2018 2016

All Journal Article (13 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 13 results,  Open Access: 5 results) Presentation (10 results)

  • [Journal Article] Cell Surface and Functional Features of Cortical Bone Stem Cells2021

    • Author(s)
      Sasaki Norihiko、Itakura Yoko、Mohsin Sadia、Ishigami Tomoaki、Kubo Hajime、Chiba Yumi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 21 Pages: 11849-11849

    • DOI

      10.3390/ijms222111849

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Successful screening of sleep-disordered breathing using a pacemaker-based algorithm in Japan.2019

    • Author(s)
      Taguchi Y, Matsushita K, Ishikawa T, Matsumoto K, Hosoda J, Iguchi K, Matsushita H, Kubota K, Sumita S, Ishigami T, Tamura K.
    • Journal Title

      J Cardiol

      Volume: 73(5) Pages: 394-400

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of ATRAP in Renal Proximal Tubules on Angiotensin-Dependent Hypertension.2019

    • Author(s)
      Kinguchi S, Wakui H, Azushima K, Haruhara K, Koguchi T, Ohki K, Uneda K,Matsuda M, Haku S, Yamaji T, Yamada T, Kobayashi R, Minegishi S, Ishigami T,Yamashita A, Fujikawa T, Tamura K.
    • Journal Title

      J Am Heart Assoc

      Volume: 8(8)

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of rikkunshito on renal fibrosis and inflammation in angiotensin II-infused mice.2019

    • Author(s)
      Azushima K, Uneda K, Wakui H, Ohki K, Haruhara K, Kobayashi R, Haku S,Kinguchi S, Yamaji T, Minegishi S, Ishigami T, Yamashita A, Tamura K.
    • Journal Title

      Sci Rep

      Volume: 9(1) Pages: 6201-6201

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Lubiprostone as a potential therapeutic agent to improve intestinal permeability and prevent the development of atherosclerosis in apolipoprotein E-deficient mice.2019

    • Author(s)
      Arakawa K, Ishigami T(correspond), Nakai-Sugiyama M, Chen L, Doi H, Kino T, Minegishi S,Saigoh-Teranaka S, Sasaki-Nakashima R, Hibi K, Kimura K, Tamura K.
    • Journal Title

      PLoS One

      Volume: 14(6)

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Microbiota-derived Trimethylamine N-oxide Predicts Cardiovascular Risk After STEMI.2019

    • Author(s)
      Matsuzawa Y, Nakahashi H, Konishi M, Sato R, Kawashima C, Kikuchi S, Akiyama E, Iwahashi N, Maejima N, Okada K, Ebina T, Hibi K, Kosuge M, Ishigami T, Tamura K, Kimura K.
    • Journal Title

      Sci Rep

      Volume: 9(1) Pages: 11647-11647

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Native T1 time and extracellular volume fraction in differentiation of normal myocardium from non-ischemic dilated and hypertrophic cardiomyopathy myocardium: A systematic review and meta-analysis2019

    • Author(s)
      Minegishi S, Kato S, Takase-Minegishi K, Horita N, Azushima K, Wakui H,Ishigami T, Kosuge M, Kimura K, Tamura K.
    • Journal Title

      Int J Cardiol Heart Vasc

      Volume: 25 Pages: 100422-100422

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Angiotensin II type 1 receptor-associated protein deficiency attenuates sirtuin1 expression in an immortalised human renal proximal tubule cell line.2019

    • Author(s)
      Yamaji T, Yamashita A, Wakui H, Azushima K, Uneda K, Fujikawa Y, Haku S,Kobayashi R, Ohki K, Haruhara K, Kinguchi S, Ishii T, Yamada T, Urate S, SuzukiT, Abe E, Tanaka S, Kamimura D, Ishigami T, Toya Y, Takahashi H, Tamura K.
    • Journal Title

      Sci Rep

      Volume: 9(1) Pages: 16550-16550

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Translationally controlled tumor protein (TCTP) plays a pivotal role in cardiomyocyte survival through a Bnip3-dependent mechanism.2019

    • Author(s)
      Cai W, Fujita T, Hidaka Y, Jin H, Suita K, Shigeta M, Kiyonari H, Umemura M, Yokoyama U, Sadoshima J, Ishikawa Y.
    • Journal Title

      Cell Death Dis

      Volume: 10 Issue: 8 Pages: 549-549

    • DOI

      10.1038/s41419-019-1787-7

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Doxorubicin induces trans-differentiation and MMP1 expression in cardiac fibroblasts via cell death-independent pathways.2019

    • Author(s)
      Narikawa M, Umemura M, Tanaka R, Hikichi M, Nagasako A, Fujita T, Yokoyama U, Ishigami T, Kimura K, Tamura K, Ishikawa Y.
    • Journal Title

      PLoS One.

      Volume: 14 Issue: 9 Pages: e0221940-e0221940

    • DOI

      10.1371/journal.pone.0221940

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prostaglandin E2 receptor EP4 regulates cell migration through Orai1.2019

    • Author(s)
      Osawa K, Umemura M, Nakakaji R, Tanaka R, Islam RM, Nagasako A, Fujita T, Yokoyama U, Koizumi T, Mitsudo K, Ishikawa Y.
    • Journal Title

      Cancer Sci.

      Volume: 111 Issue: 1 Pages: 160-174

    • DOI

      10.1111/cas.14247

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 心筋梗塞モデルマウスを用いた超音波検査法の手技に関する評価2019

    • Author(s)
      荻野千菜美, 千葉由美, 峯岸慎太郎, 石上友章
    • Journal Title

      横浜看護学雑誌

      Volume: 12(1) Pages: 61-69

    • NAID

      120006595097

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Epac activation inhibits IL-6-induced cardiac myocyte dysfunction.2016

    • Author(s)
      Jin H,Fujita T,Jin M,Kurotani R,Hidaka Y,Cai W,Suita K,Prajapati R,Liang C,Ohnuki Y,Mototani Y,Umemura M,Yokoyama U,Sato M,Okumura S,Ishikawa Y.
    • Journal Title

      J Physiol Sci.

      Volume: 印刷中 Issue: 1 Pages: 77-87

    • DOI

      10.1007/s12576-016-0509-5

    • NAID

      40021443658

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Evaluation of three-dimensional in vitro cell culture of cortical bone stem cells.2020

    • Author(s)
      千葉由美、佐用かなえ、小島伸彦、石上友章、久保一
    • Organizer
      第19回日本再生医療学会
    • Related Report
      2019 Research-status Report
  • [Presentation] Characteristics of CD117(c-kit) on cortical bone stem cells.2020

    • Author(s)
      千葉由美、佐々木紀彦、世古卓也、石上友章、久保一
    • Organizer
      第19回日本再生医療学会
    • Related Report
      2019 Research-status Report
  • [Presentation] n-3/n-6系脂肪酸含有量の異なる食餌別に見た心筋梗塞後の心機能の経時的変化2019

    • Author(s)
      篠崎澪、千葉由美
    • Organizer
      第15回日本移植・再生医療看護学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 食事中のn-3/n-6系脂肪酸の含有量の違いによる癒着への影響-動物モデルマウスを用いた実験より-2019

    • Author(s)
      中村郁海、千葉由美
    • Organizer
      第15回日本移植・再生医療看護学会
    • Related Report
      2019 Research-status Report
  • [Presentation] Characteristics of physical change related to myocardial infarction in mice.2019

    • Author(s)
      Yumi Chiba
    • Organizer
      第39回日本看護科学学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 心筋梗塞モデルマウス作成時の癒着発生に関する検討2018

    • Author(s)
      千葉由美, 塩田悠実, 豊田雅士, 石田治, 木下学
    • Organizer
      第28回日本病態生理学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 心筋梗塞モデルマウスを用いた有経験者と初学者とのエコー評価の比較検討2018

    • Author(s)
      千葉由美
    • Organizer
      第14回日本移植・再生医療看護学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 8週齢・48週齢の心筋梗塞モデルマウスの心機能の経時的変化2018

    • Author(s)
      世古卓也, 千葉由美, 峯岸慎太郎, 石上友章
    • Organizer
      第5回日本血管血流学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Evaluation of Measurement by Echography using Myocardial Infarcted Mouse.2018

    • Author(s)
      Ogino C, Chiba Y.
    • Organizer
      第38回日本看護科学学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] マウス皮質骨由来幹細胞の膜表面蛋白と分化の特徴2018

    • Author(s)
      千葉由美, 世古卓也, 石原賢司, 加藤智美, 中島理恵, 杉山美智子, 村松さやか, 豊田雅士, 石上友章, Hajime Kubo
    • Organizer
      第18回日本再生医療学会総会
    • Related Report
      2018 Research-status Report

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Published: 2018-07-25   Modified: 2024-01-30  

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