Development of a novel analytical method for intracranial injuries and diseases Using NMR modal analysis of postmortem cerebrospinal fluid.
| Project/Area Number |
18K19705
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 58:Society medicine, nursing, and related fields
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| Research Institution | Nippon Medical School |
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Principal Investigator |
Hirakawa Keiko 日本医科大学, 医学部, 非常勤講師 (30165162)
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| Co-Investigator(Kenkyū-buntansha) |
金涌 佳雅 日本医科大学, 大学院医学研究科, 大学院教授 (80465343)
小池 薫 京都大学, 医学研究科, 名誉教授 (10267164)
足立 好司 日本医科大学, 医学部, 准教授 (00231928)
山崎 峰雄 日本医科大学, 医学部, 教授 (10277577)
早川 秀幸 日本医科大学, 大学院医学研究科, 研究生 (10373052)
柚木 知之 京都大学, 医学研究科, 准教授 (50639094)
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| Project Period (FY) |
2018-06-29 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2018: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 死体 / 髄液 / NMR / モード解析 / 死因 / 頭蓋内傷病変 / 死後髄液 / 死後 |
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| Outline of Final Research Achievements |
Postmortem cerebrospinal fluid (CSF), which can be collected during postmortem examination, is a useful sample for forensic diagnosis to determine the presence or absence of subarachnoid hemorrhage by whether it is bloody or clear. Since postmortem CSF is often routinely collected in forensic practice, it is expected to be utilized developmentally for diagnosis. In this research, postmortem CSF from postmortem examinations and forensic autopsies, in which the cause of death is known, was used to perform NMR modal analysis to verify its association with the cause of death. It was difficult to make a detailed association of cause of death in each case based solely on the results of NMR modal analysis of the postmortem CSF obtained in this study. However, NMR modal analysis of the postmortem CSF suggested the possibility of identifying sudden death, death due to inflammatory disease, and death from external causes as the cause of death, i.e., the pathological condition prior to death.
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| Academic Significance and Societal Importance of the Research Achievements |
異状死の死因究明は、法医学における重要な使命であるが、法医解剖や死後画像診断は必ずしも十分に普及しているとは言い難いのが現状である。死後髄液の採取自体は容易で特別な装置を要するものではないので、死後髄液のNMRモード特性から、頭蓋内病変の有無、死因との関連性の情報を抽出できれば、法医実務への貢献は大きいと考える。解剖検査による死因究明を凌駕する精度は困難ではあろうが、死体検案での信頼度の高い死因究明の方法として、社会的意義は高いだろう。また本研究を通じた、死後髄液の死因の病態生理学的分析は、法医病理学の基礎研究の新たな対象試料として髄液が期待できる可能性を示唆させる学術的意義を有すると認める。
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Report
(6 results)
Research Products
(2 results)
