Xanthophyll controlling bone metabolism for functional enhancement both of tooth and the bone.
| Project/Area Number |
18K19730
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
INADA MASAKI 東京農工大学, 工学(系)研究科(研究院), 准教授 (80401454)
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| Co-Investigator(Kenkyū-buntansha) |
平田 美智子 東京農工大学, 工学(系)研究科(研究院), 講師 (40544060)
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| Project Period (FY) |
2018-06-29 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2018: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | キサントフィル / 骨粗鬆症 / 歯周病 / スポーツ健康科学 / 健康科学 / 骨・歯 / 代謝 / 骨、歯 |
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| Outline of Final Research Achievements |
In this research project, a function of the Xanthophyll protecting a bone and the tooth was elucidated. The result applied to the development of the functional food of the new concept. The common mechanism about osteoporosis and periodontal disease was elucidated, and it was revealed that Xanthophyll had a suppression effect for both inflammatory and metabolic bone resorption. As a result of enforcement of the appropriate food intake examination, the development base of the functional foods which were effective for "a bone and the dental health maintenance" that utilized bone protection of the Xanthophyll was established.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究課題の実施により、キサントフィルの骨保護作用を活用して、歯と骨の健康維持に有用な機能性食品の開発への基盤が構築された。適正摂取量検討の結果、将来のヒト介入試験を実施して機能性表示食品として開発する方針を確立した。キサントフィルを活用した機能性食品が開発されれば歯周病や骨粗鬆症の罹患より歯と骨の健康を守る、日々の習慣としての健康増進が期待できる。
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Report
(3 results)
Research Products
(48 results)
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[Journal Article] Hypergravity and microgravity exhibited reversal effects on the bone and muscle mass in mice.2019
Author(s)
Tominari T, Ichimaru R, Taniguchi K, Yumoto A, Shirakawa M, Matsumoto C, Watanabe K, Hirata M, Itoh Y, Shiba D, Miyaura C, Inada M
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Journal Title
Sci Rep
Volume: 9(1)
Issue: 1
Pages: 6614-6614
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Beta-cryptoxanthin inhibits lipopolysaccharide-induced osteoclast differentiation and bone resorption via the suppression of inhibitor of NF-κB kinase activity.2019
Author(s)
Hirata N , Ichimaru R , Tominari T , Matsumoto C, Watanabe K ,Taniguchi K , Hirata M , Ma S, Suzuki K , Grundler FM , Miyaura C, Inada M
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Journal Title
Nutrients
Volume: 11
Issue: 2
Pages: 368-368
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Structure-activity relationship of anthocyanidins as an inhibitory effect on osteoclast differentiation.2018
Author(s)
Hirata N, Tominari T, Ichimaru R, Taniguchi K, Matsumoto C, Watanabe K, Hirata M, Ma S, Suzuki K, Grundler FM,Miyaura C, Inada M
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Journal Title
BPB_Reports
Volume: 2
Pages: 1-6
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Raloxifene reduces the risk of local alveolar bone destruction in a mouse model of periodontitis combined with systemic postmenopausal osteoporosis.2018
Author(s)
Ichimaru R, Tominari T, Yoshinouchi S, Matsumoto C, Watanabe K, Hirata M, Numabe Y, Murphy G, Nagase H, Miyaura C, Inada M
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Journal Title
Arch. Oral Biol
Volume: 85
Pages: 98-103
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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