Research on niche- and cellular-rehabilitation

• Project/Area Number: 18K19739
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
• Research Institution: Kyoto University
• Principal Investigator: Kuroki Hiroshi 京都大学, 医学研究科, 教授 (20170110)
• Co-Investigator(Kenkyū-buntansha): 伊藤 明良 京都大学, 医学研究科, 助教 (50762134)
• Project Period (FY): 2018-06-29 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000); Fiscal Year 2019: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2018: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: リハビリテーション / 理学療法学 / 再生医療 / 移植医療 / 関節軟骨 / 神経

Outline of Final Research Achievements

This study revealed the effect of unloading by tail suspension on knee articular cartilage in rats, that of three-dimensional motion analysis of gait on functional evaluation outcomes after nerve crush injury in rats, that of heat stimuli during cell pellet culture on extracellular matrix synthesis, and that of combined therapy of cell transplantation and locomotor training on functional recovery in rats.

Academic Significance and Societal Importance of the Research Achievements

リハビリテーションで用いられる物理的刺激である荷重・免荷、および温熱、ならびに細胞移植とリハビリテーションで用いられる運動療法の併用治療が及ぼす影響について、動物を用いて明らかにした点に学術的意義がある。

Research Products

• [Journal Article] 3D Kinematic Analysis for the Functional Evaluation in the Rat Model of Sciatic Nerve Crush Injury (2020)
  • Author(s): Wang T, Ito A, Tajino J, Kuroki H, Aoyama T
  • Journal Title: J. Vis. Exp Volume: 156 Issue: 156
  • DOI: 10.3791/60267
  • NAID: 120006870866
  • Peer Reviewed / Open Access
• [Journal Article] Taking the Next Steps in Regenerative Rehabilitation: Establishment of a New Interdisciplinary Field (2020)
  • Author(s): Willett NJ, Aoyama T, Ito A, Kuroki H, Tajino J, Ambrosio F, et al.
  • Journal Title: Arch Phys Med Rehabil Volume: 101 Issue: 5 Pages: 917-923
  • DOI: 10.1016/j.apmr.2020.01.007
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Therapeutic effects of combined cell transplantation and locomotor training in rats with brain injury. (2019)
  • Author(s): Shimogawa T, Sakaguchi H, Kikuchi T, Tsuchimochi R, Sano N, Torikoshi S, Ito A, Aoyama T, Iihara K, Takahashi J.
  • Journal Title: NPJ Regen Med. Volume: 4 Issue: 1 Pages: 13-13
  • DOI: 10.1038/s41536-019-0075-6
  • Peer Reviewed / Open Access
• [Journal Article] Three-dimensional motion analysis for evaluating motor function in rodents with peripheral nerve injury (2019)
  • Author(s): Ito Akira、Tianshu Wang、Tajino Junichi
  • Journal Title: Neural Regeneration Research Volume: 14 Issue: 12 Pages: 2077-2077
  • DOI: 10.4103/1673-5374.262581
  • NAID: 120006867157
  • Peer Reviewed / Open Access
• [Journal Article] Lower-body positive pressure diminishes surface blood flow reactivity during treadmill walking (2019)
  • Author(s): Tajino J, Ito A, Torii Y, Tsuchimoto K, Iijima H, Zhang X, Tanima M, Yamaguchi S, Ieki H, Kakinoki R, Kuroki H
  • Journal Title: BMC Res Notes Volume: 12 Issue: 1 Pages: 733-733
  • DOI: 10.1186/s13104-019-4766-2
  • Peer Reviewed / Open Access
• [Journal Article] Induction of osteoarthritis by injecting monosodium iodoacetate into the patellofemoral joint of an experimental rat model (2018)
  • Author(s): Takahashi I, Matsuzaki T, Kuroki H, Hoso M.
  • Journal Title: PLoS One Volume: 13 Issue: 4 Pages: e0196625-e0196625
  • DOI: 10.1371/journal.pone.0196625
  • Peer Reviewed