Are differences in the capacity to oxidize fat associated with the risk of developing lifestyle-related diseases in middle-aged and older adults?
Project/Area Number |
18K19759
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Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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Allocation Type | Multi-year Fund |
Review Section |
Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
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Research Institution | Surugadai University (2021-2023) Waseda University (2018-2020) |
Principal Investigator |
坂本 静男 駿河台大学, スポーツ科学部, 特任教授 (00266032)
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Co-Investigator(Kenkyū-buntansha) |
谷澤 薫平 早稲田大学, スポーツ科学学術院, 准教授 (50771812)
田端 宏樹 順天堂大学, 大学院医学研究科, 博士研究員 (50876886)
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Project Period (FY) |
2018-06-29 – 2024-03-31
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Project Status |
Completed (Fiscal Year 2023)
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Budget Amount *help |
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 脂質代謝能力 / 耐糖能異常 / 高血圧症 / 脂質異常症 / 縦断調査 / 肥満 / 糖尿病 / 脂質代謝異常症 / ゲノムワイド関連解析 / 遺伝子多型 / 多遺伝子リスクスコア / 生活習慣病 / 最大脂質酸化量 / メタボリックシンドローム / コホート研究 |
Outline of Annual Research Achievements |
脂質をエネルギー基質として利用する能力である脂質代謝能力は生活習慣病のリスクとの関連が示されている。しかし、中高齢者における脂質代謝能力と生活習慣病との関連については十分に検討されていない。そこで、早稲田大学の40歳以上の卒業生および配偶者を対象とした前向き観察型コホート研究”WASEDA’S Health Study”の測定データを用いて脂質代謝能力と生活習慣病との関連を検討した。 2023年度はコロナ禍で中断していたWASEDA’S Health Studyの追跡測定が再開され、203名の追跡測定を実施した。そこで、脂質代謝能力の指標として用いられる運動負荷試験により測定した脂質酸化量の最大値(maximal fat oxidation:MFO)がベースライン測定と追跡測定の両方で揃っている男性126名、女性61名の計187名を対象に高血圧、高TG血症および低HDLコレステロールを含む脂質異常症、空腹時血糖値110mg/dL以上の耐糖能異常の新規発症率を検討した。ベースライン測定と追跡測定でMFOが向上した人に対し、低下した人の多変量調整オッズ比および95%信頼区間(CI)をロジスティック回帰分析を用いて年齢、性別、追跡年数を調整して算出した。 脂質異常症、耐糖能異常では有意な差は認められなかったが、高血圧の新規発症オッズ比がMFO向上群に対してMFO低下群で有意に高かった (OR:2.525,95%CI:1.043-6.098)。 よって、脂質代謝能力の低下は高血圧の新規発症と関連する可能性が示唆された。生活習慣病と関連し、肥満であっても脂質代謝能力が高い人では高血圧になりにくい可能性が示唆された。しかしながら、潜在的交絡因子の調整が十分ではないため、今後さらなる検討が求められる。
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Report
(6 results)
Research Products
(42 results)
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[Journal Article] Association Between Dietary Patterns and Different Metabolic Phenotypes in Japanese Adults: WASEDA'S Health Study2022
Author(s)
Tanisawa K, Ito T, Kawakami R, Usui C, Kawamura T, Suzuki K, Sakamoto S, Ishii K, Muraoka I, Oka K, Higuchi M
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Journal Title
Front Nutr
Volume: 9
Pages: 779967-779967
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Association Between Dietary Patterns and Different Metabolic Phenotypes in Japanese Adults: WASEDA'S Health Study2021
Author(s)
Tanisawa K, Ito T, Kawakami R, Usui C, Kawamura T, Suzuki K, Sakamoto S, Ishii K, Muraoka I, Oka K, Higuchi M
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Journal Title
Clin Nutr
Volume: 40(11)
Issue: 11
Pages: 5523-5530
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Female Athletes Genetically Susceptible to Fatigue Fracture Are Resistant to Muscle Injury2021
Author(s)
Miyamoto-Mikami E, Kumagai H, Tanisawa K, Taga Y, Hirata K, Kikuchi N, Kamiya N, Kawakami R, Midorikawa T, Kawamura T, Kakigi R, Natsume T, Zempo H, Suzuki K, Kohmura Y, Mizuno K, Torii S, Sakamoto S, Oka K, Higuchi M, Naito H, Miyamoto N, Fuku N
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Journal Title
Medicine & Science in Sports & Exercise
Volume: Publish Ahead of Print
Issue: 9
Pages: 0-0
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Association between alcohol dietary pattern and prevalence of dyslipidaemia: WASEDA'S Health Study2021
Author(s)
Tanisawa K, Ito T, Kawakami R, Usui C, Kawamura T, Suzuki K, Sakamoto S, Ishii K, Muraoka I, Oka K, Higuchi M
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Journal Title
Br J Nutr
Volume: -
Issue: 11
Pages: 1712-1722
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Determinants of Resting Oxidative Stress in Middle-Aged and Elderly Men and Women: WASEDA’S Health Study2021
Author(s)
2.Takuji Kawamura, Kumpei Tanisawa, Ryoko Kawakami, Chiyoko Usui, Tomoko Ito, Hiroki Tabata, Nobuhiro Nakamura, Sayaka Kurosawa, Wonjun Choi, Sihui Ma, Zsolt Radak, Susumu S. Sawada, Katsuhiko Suzuki, Kaori Ishii, Shizuo Sakamoto, Koichiro Oka, Mitsuru Higuchi, and Isao Muraoka.
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Journal Title
Oxidative Medicine and Cellular Longevity
Volume: in press
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Effects of Chios mastic gum and exercise on physical characteristics, blood lipid markers, insulin resistance, and hepatic function in healthy Japanese men2018
Author(s)
Fukazawa T, Smyrnioudis I, Konishi M, Takahashi M, Kim H-K, Nishimaki M, Xiang M, and Sakamoto S
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Journal Title
Food Science and Biotechnology.
Volume: 27(3)
Pages: 773-780
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] Cardiorespiratory fitness and calf circumference with the prevalence of diabetes: WASEDA’S Health Study2020
Author(s)
Dong Wang, Susumu S. Sawada, Kotaro Sato, Sakura Koriyama, Hiroki Tabata, Kumpei Tanisawa, Ryoko Kawakami, Katsuhiko Suzuki, Mitsuru Higuchi, Kaori Ishii, Koichiro Oka, Shizuo Sakamoto
Organizer
International Society for Physical Activity and Health
Related Report
Int'l Joint Research
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[Presentation] Walking speed and prevalence of lifestyle-related diseases in adults: WASEDA'S Health Study2020
Author(s)
Kotaro Sato, Susumu S. Sawada, Dong Wang, Sakura Koriyama, Hiroki Tabata, Kumpei Tanisawa, Ryoko Kawakami, Tomoko Ito, Chiyoko Usui, Kaori Ishii, Katsuhiko Suzuki, Mitsuru Higuchi, Koichiro Oka, Shizuo Sakamoto
Organizer
25th Annual Congress of the European College of Sport Science
Related Report
Int'l Joint Research
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[Presentation] Cardiorespiratory fitness and calf circumference with the prevalence of diabetes: WASEDA’S Health Study2020
Author(s)
Dong Wang, Susumu S. Sawada, Kotaro Sato, Sakura Koriyama, Hiroki Tabata, Kumpei Tanisawa, Ryoko Kawakami, Katsuhiko Suzuki, Mitsuru Higuchi, Kaori Ishii, Koichiro Oka, Shizuo Sakamoto
Organizer
25th Annual Congress of the European College of Sport Science
Related Report
Int'l Joint Research
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[Presentation] Effects of acute endurance exercise performed in the morning or evening on 24-h interstitial fluid glucose levels.2019
Author(s)
Kim, H,K., Furuhashi, S., Fukazawa, M., Okubo, J., Ozaki, M., Chijiki, H., Nanba, T., Oneda, S., Shinto, T., Tabata, H., Takahashi, M., Sakamoto, S., Shibata, S.
Organizer
The 24th Annual Congress of the European College of Sport Science, Czech, Praha
Related Report
Int'l Joint Research
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[Presentation] Parasympathetic nervous regulation and prevalence of lifestyle-related diseases in Japanese: WASEDA'S Health Study.2019
Author(s)
Konishi M, Sawada S, Kawakami R, Tanisawa K, Tabata H, Nakamura N, Kim HK, Ito T, Higuchi M, Suzuki1 K, Torii S, Lee IM, Blair SN, Oka K, Sakamoto S.
Organizer
American College of Sports Medicine's 66th Annual Meeting, Orlando, Florida
Related Report
Int'l Joint Research
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