| Project/Area Number |
18K19759
|
|---|
| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
|
| Allocation Type | Multi-year Fund |
|---|
| Review Section |
Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
|
|---|
| Research Institution | Surugadai University (2021-2023)
Waseda University (2018-2020) |
|---|
Principal Investigator |
Sakamoto Shizuo 駿河台大学, スポーツ科学部, 特任教授 (00266032)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
谷澤 薫平 早稲田大学, スポーツ科学学術院, 准教授 (50771812)
田端 宏樹 順天堂大学, 大学院医学研究科, 博士研究員 (50876886)
|
|---|
| Project Period (FY) |
2018-06-29 – 2024-03-31
|
| Project Status |
Completed (Fiscal Year 2023)
|
| Budget Amount *help |
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 脂質代謝能力 / 生活習慣病 / 遺伝因子 / メタボリックシンドローム / 耐糖能異常 / 高血圧症 / 脂質異常症 / 縦断調査 / 肥満 / 糖尿病 / 脂質代謝異常症 / ゲノムワイド関連解析 / 遺伝子多型 / 多遺伝子リスクスコア / 最大脂質酸化量 / コホート研究 |
|---|
| Outline of Final Research Achievements |
The capacity to oxidize fat refers to the ability to utilize lipids as an energy substrate within the body. Although a decline in the capacity to oxidize fat has been reported to be associated with weight gain and insulin resistance, its direct relationship with lifestyle-related diseases remains unclear. Therefore, we examined the association between the capacity to oxidize fat and lifestyle-related diseases in a cohort of middle-aged and elderly Japanese men and women.
Our study results indicated that, particularly among men with visceral fat obesity, there is a potential association between the capacity to oxidize fat and lipid metabolism disorders. Furthermore, longitudinal research suggested that changes in the capacity to oxidize fat may be linked to the onset of hypertension. Moving forward, we plan to continue follow-up studies on the cohort to more precisely investigate the relationship between changes in the capacity to oxidize fat and the onset of lifestyle-related diseases.
|
| Academic Significance and Societal Importance of the Research Achievements |
脂質代謝能力の低下はインスリン抵抗性の増大やメタボリックシンドローム危険因子保有数と関連すると示されていたが、本研究で初めて、男性内臓脂肪型肥満者と限定的ではあるものの、生活習慣病と関連する可能性が示唆された。
内臓脂肪型肥満者で関連がみられた点より、脂質代謝能力はメタボリックシンドロームから生活習慣病発症までの過程でのリスク評価や予防介入指標として役立つ可能性があるかもしれない。
|
