| Budget Amount *help |
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2020: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The fluidity of the plasma membrane not only allows the diffusion of proteins and other biomolecules within the membrane but also affects the function of these molecules through the formation of membrane nanodomains. Techniques for artificially producing lipid membrane nanodomains would enable us to reconstitute biological phenomena take place on the cellular membranes. In this study, we aimed to develop a technique to design artificial membrane nanodomains using DNA origami nanothechnology. DNA origami nanostructures were self-assembled into two-dimensional lattices on a mica-supported lipid bilayer membranes, which resulted in the compartmentalization of the bilayer surface into nanoscale domains with predesigned shapes which designated by the shapes of DNA origami building blocks.
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