| Budget Amount *help |
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2020: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
In this study, we analyzed the mRNA level of cancer immunity-related genes in tumors of various mouse models, and identified the immune status reflecting antitumor activity by using our algorithm. We also found that the defined immune status can be useful for evaluating the antitumor activity induced by an adjuvant-loaded lipid nanoparticle (nano-DDS). Furthermore, we designed a new strategy based on the analysis of tumor, and succeeded in inducing antitumor effect against a refractory tumor having a resistance to the current cancer immunotherapy.
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