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Development of beyond human-level AI for medical image diagnosis systems

Research Project

Project/Area Number 18K19892
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 90:Biomedical engineering and related fields
Research InstitutionTohoku University

Principal Investigator

HOMMA Noriyasu  東北大学, 医学系研究科, 教授 (30282023)

Project Period (FY) 2018-06-29 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords計算機支援診断システム / 人工知能支援診断 / 乳がん / 乳房X線撮影
Outline of Final Research Achievements

In this research, next generation medical image diagnosis systems have been developed by using a deep learning based artificial intelligence (AI) that is capable of super-performance beyond human experts. The AI-aided (AID) systems have been applied for breast cancer screening using mammography exmas, gastric cancer screening using fluoroscopic stomac exams, and drowning diagnosis using forensic imaging (autopsy imaging) of x-ray computed tomography. Experimental results showed that the AID systems were able to achieve the human experts' level performance for the tasks. Specifically, the AID system for mammographic diagnosis demonstrated superior performance beyond human experts and further more, the system made human experts' performance even better. These results clearly demonstrated the usefulness and effectiveness of the proposed AID systems in clinical use.

Academic Significance and Societal Importance of the Research Achievements

本研究で開発したAIDシステムは、臨床上十分有用な高性能を達成した。このような医師の診療業務を支援、さらには一部を代替可能な高性能AIの実用化により、医師の業務量低減や非専門領域に対する支援、さらには遠隔医療などを含めた効率化を実現することが可能になり、地方における医師不足に起因する医療提供の持続可能性や、都市部に比して専門医偏在に起因する医療の均てん化問題などの改善に繋がると期待される。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (36 results)

All 2022 2021 2020 2019 2018 Other

All Int'l Joint Research (7 results) Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (25 results) (of which Int'l Joint Research: 7 results,  Invited: 8 results) Book (1 results)

  • [Int'l Joint Research] Univerisity of Saskatchewan(カナダ)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] Chinese Academy of Sciences(中国)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] University of Saskatchewan(カナダ)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] Chinese Academy of Sciences(中国)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] University of Saskatchewan(カナダ)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] Chinese Academy of Sciences(中国)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] サスカチュワン大学(カナダ)

    • Related Report
      2018 Research-status Report
  • [Journal Article] Adaptive Gaussian Mixture Model-Based Statistical Feature Extraction for Computer-Adided Diagnosis of Micro-Calcification Clusters in Mammograms2020

    • Author(s)
      70.Z. Zhang, X. Zhang, K. Ichiji, Y. Takane, S. Yanagaki, Y. Kawasumi, T. Ishibashi, N. Homma
    • Journal Title

      SICE Journal of Control, Measurement, and System Integration

      Volume: -

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Learning Entropy as a Learning-Based Information Concept2019

    • Author(s)
      Bukovsky Ivo、Kinsner Witold、Homma Noriyasu
    • Journal Title

      Entropy

      Volume: 21 Issue: 2 Pages: 166-166

    • DOI

      10.3390/e21020166

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 乳がん病変検出のための深層学習を用いた計算機支援画像診断システム2018

    • Author(s)
      鈴木真太郎,張暁勇,本間経康,市地慶,高根侑美,柳垣聡,川住祐介,石橋忠司,吉澤誠
    • Journal Title

      計測自動制御学会論文集

      Volume: 54 Pages: 659-669

    • NAID

      130007437725

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] 3D Deep Learning-Based Computer-Aided Diagnosis for Drowning Diagnosis Using Post-Mortem Computed Tomography2022

    • Author(s)
      Yuwen Zeng, Xiaoyong Zhang, Yusuke Kawasumi, Akihito Usui, Kei Ichiji, Masato Funayama, Noriyasu Homma
    • Organizer
      AROB-ISBC-SWARM
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 深層学習による死後肺CT画像を用いた説明可能な溺死鑑別システムに関する研究2021

    • Author(s)
      坂本奨太、張暁勇、本間経康、川住祐介、臼井章人、小河原輝正、舟山眞人、市地慶、杉田典大、吉澤誠
    • Organizer
      第18回コンピューテーショナル・インテリジェンス研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] An Interpretable Deep Learning Method for Forensic Diagnosis of Drowning2021

    • Author(s)
      Yuwen Zeng, Xiaoyong Zhang, Yusuke Kawasumi, Masato Funayama, Akihito Usui, Kei Ichiji, Noriyasu Homma
    • Organizer
      電気関係学会東北 支部連合大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Deep Learning-Based Interpretable Computer-Aided Diagnosis of Drowning for Forensic Radiology2021

    • Author(s)
      Yuwen Zeng, Xiaoyong Zhang, Yusuke Kawasumi, Akihito Usui, Kei Ichiji, Masato Funayama, Noriyasu Homma
    • Organizer
      SICE Annual Conference 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 医療AI実装と教育2021

    • Author(s)
      本間経康、酒井正夫、張暁勇、市地慶
    • Organizer
      Clinical AI x AI-MAILs Joint Symposium
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Deep CNN-Based Computer-Aided Diagnosis for Drowning Detection using Post-mortem Lungs CT Images2021

    • Author(s)
      Amber Habib Qureshi, Xiaoyong Zhang, Kei Ichiji, Yusuke Kawasumi, Akihito Usui, Masato Funayama, Noriyasu Homma
    • Organizer
      IEEE BIBM 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 医用画像診断の深化2021

    • Author(s)
      本間 経康
    • Organizer
      東北大学Clinical AI Annual Symposium
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] A Deep Learning Aided Drowning Diagnosis for Forensic Investigations Using Post-Mortem Lung CT Images2020

    • Author(s)
      Noriyasu Homma, Xiaoyong Zhang, Amber Habib Qureshi, Takuya Konno, Yusuke Kawasumi, Akihito Usui, Masato Funayama, Ivo Bukovsky, Kei Ichiji, Norihiro Sugita, Makoto Yoshizawa
    • Organizer
      42nd Annual International Conference of IEEE Engineering in Medicine and Biology Society
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Feature Fusion に基づく深層学習を用いた乳房X 線画像上の病変検出2020

    • Author(s)
      今 佑太朗,張 暁勇,本間 経康, 吉澤 誠
    • Organizer
      計測自動制御学会東北支部第329回研究集会
    • Related Report
      2020 Research-status Report
  • [Presentation] CIの医学応用とモデリング2020

    • Author(s)
      本間 経康
    • Organizer
      計測自動制御学会システム・情報部門学術講演会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 深層学習との共創が拓く医用画像診断の深化2020

    • Author(s)
      本間 経康
    • Organizer
      計測自動制御学会CIフォーラム2020
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Human ability enhancement for reading mammographic masses by a deep learning technique2020

    • Author(s)
      Noriyasu Homma, Kyohei Noro, Xiaoyong Zhang, Yutaro Kon, Kei Ichiji, Ivo Bukovsky, Akiko Sato, Naoko Mori
    • Organizer
      2020 IEEE International Conference on Bioinformatics and Biomedicine
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 深層学習による死後CT画像を用いた溺死鑑別2020

    • Author(s)
      本間経康、佐藤亮太、張暁勇、今野拓也、Amber Qureshi、市地慶、臼井彰人、川住祐介、舟山眞人
    • Organizer
      第47回知能システムシンポジウム
    • Related Report
      2019 Research-status Report
  • [Presentation] Mammography読影における腫瘤の良悪性鑑別性能向上のための深層学習CAD2020

    • Author(s)
      野呂恭平,張暁勇,柳垣聡,森菜緒子,市地慶,本間経康
    • Organizer
      東北・北陸地区国立大学放射線技術科学シンポジウム
    • Related Report
      2019 Research-status Report
  • [Presentation] A Comparison Study of Deep Learning Techniques for Mass Detection in Mammograms2019

    • Author(s)
      K. Noro, X. Zhang, H. Takano, K. Ichiji, N. Homma
    • Organizer
      American Association of Physisists in Medicine Annual Meeting
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] CIと医学は相性が良い?2019

    • Author(s)
      本間経康
    • Organizer
      第16回Computational Intelligence研究会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 深層学習とマルチモダリティの可能性2019

    • Author(s)
      本間経康
    • Organizer
      第9回東北放射線医療技術学術大会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 乳腺濃度の左右非対称性と乳癌との関係性の解析2019

    • Author(s)
      遠藤唯華, 陳家旗, 張暁勇, 市地慶, 高根侑美, 柳垣聡, 石橋忠司, 本間経康
    • Organizer
      第9回東北放射線医療技術学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Risk Analysis of Bilateral Mammographic Density Differences for Breast Cancer: A Case-Control Study2019

    • Author(s)
      Jiaqi Chen、Xiaoyong Zhang、Tadashi Ishibashi、Yumi Takane、Satoru Yanagaki、Daisuke Shibuya、Kei Ichiji、Makoto Osanai、Noriyasu Homma
    • Organizer
      The 27th Annual Meeting of the Japanese Breast Cancer Society
    • Related Report
      2019 Research-status Report
  • [Presentation] Classification of Masses in Mammogram: A Comparison Study of State-of-the-Art Deep Learning Technologies2018

    • Author(s)
      H. TAKANO, X. ZHANG, N. HOMMA, M. YOSHIZAWA
    • Organizer
      AAPM Annual Meeting 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 乳房X線画像における良悪性鑑別が難しい腫瘤に対する深層学習の性能評価2018

    • Author(s)
      野呂恭平, 張暁勇, 高野寛己, 市地慶, 柳垣聡, 高根侑美, 石橋忠司, 本間経康
    • Organizer
      第46回日本放射線技術学会秋季学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Computer-Aided Diagnosis of Micro-Calcication Clusters in Mammograms Using an Adaptive Gaussian Mixture Model2018

    • Author(s)
      Zhang ZHANG, Xiaoyong ZHANG, Kei ICHIJI, Makoto OSANAI, Noriyasu HOMMA
    • Organizer
      SICEシステム・情報部門学術講演会2018
    • Related Report
      2018 Research-status Report
  • [Presentation] 乳房X線画像における画像診断が難しい腫瘤に対する深層学習を用いた良悪性鑑別の試み2018

    • Author(s)
      野呂恭平, 張暁勇, 高野寛己, 市地慶, 柳垣聡, 高根侑美, 石橋忠司, 本間経康
    • Organizer
      第14回コンピューテーショナル・インテリジェンス研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] 医療と深層学習の共進化2018

    • Author(s)
      本間経康
    • Organizer
      第8回次世代医療開発セミナー
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 深層学習は乳癌画像をどう読むか2018

    • Author(s)
      本間経康
    • Organizer
      第28回日本乳癌画像研究会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Book] 放射線治療AIと外科治療AI、第7章2020

    • Author(s)
      藤田 広志、有村 秀孝、諸岡 健一編、本間経康
    • Total Pages
      250
    • Publisher
      オーム社
    • ISBN
      9784274225475
    • Related Report
      2020 Research-status Report

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Published: 2018-07-25   Modified: 2023-01-30  

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