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Development of iron nitride microspheres for hyperthermia with highly efficient heating, automatic temperature control, and arterial embolization

Research Project

Project/Area Number 18K19895
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 90:Biomedical engineering and related fields
Research InstitutionTokyo Medical and Dental University (2019)
Tohoku University (2018)

Principal Investigator

Kawashita Masakazu  東京医科歯科大学, 生体材料工学研究所, 教授 (70314234)

Co-Investigator(Kenkyū-buntansha) 金高 弘恭  東北大学, 歯学研究科, 准教授 (50292222)
小川 智之  東北大学, 工学研究科, 准教授 (50372305)
Project Period (FY) 2018-06-29 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords窒化鉄 / 微小球 / 温熱治療
Outline of Final Research Achievements

Fe16N2, which is one of the iron nitrides, was obtained by reducing and nitriding magnetite (Fe3O4). Thus obtained Fe16N2 was estimated to show higher heat-generating ability than Fe3O4, and its cytocompatibility was almost same as that of Fe3O4. Further, it was found that Fe and Fe8N -deposited silica glass microspheres were obtained when silica glass microspheres were immersed in hydrofluoric acid containing iron ions and subjected to reduction-nitriding treatment.

Academic Significance and Societal Importance of the Research Achievements

がんの低侵襲治療法の一つに、、マグネタイトなどの酸化鉄微粒子が交流磁場中で発熱することを利用した温熱療法がある。窒化鉄はマグネタイトよりも高い発熱特性を示す可能性がある。そこで本研究では、がんの温熱治療に適した窒化鉄微小球を合成することを目的とした。その結果、窒化鉄はマグネタイトと同等の細胞適合性を示し、より高い発熱能を示す可能性が明らかとなった。さらに、シリカガラスをコアとし、その表面に純鉄と窒化鉄が析出した微小球が得られることも明らかとなった。このようにして得られた微小球はがんの温熱治療に有用であると期待される。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (10 results)

All 2019 2018 Other

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (7 results) (of which Int'l Joint Research: 4 results,  Invited: 2 results) Remarks (1 results)

  • [Journal Article] Synthesis of iron nitride nanoparticles from magnetite nanoparticles of different sizes for application to magnetic hyperthermia2019

    • Author(s)
      M. Shibata, T. Ogawa and M. Kawashita
    • Journal Title

      Ceramics International

      Volume: 45 Issue: 17 Pages: 23707-23714

    • DOI

      10.1016/j.ceramint.2019.08.086

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 経カテーテル動脈塞栓治療用微小球の合成2018

    • Author(s)
      川下将一
    • Journal Title

      セラミックス

      Volume: 53 Pages: 814-818

    • Related Report
      2018 Research-status Report
  • [Presentation] Cytotoxicity of iron nitride nanoparticles for biomedical applications2019

    • Author(s)
      M. Shibata, H. Kanetaka, M. Furuya, K. Yokota, T. Ogawa, M. Kawashita
    • Organizer
      the 30th Annual Meeting of the European Society for Biomaterials
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of iron nitride as thermal seeds for hyperthermia2019

    • Author(s)
      M. Kawashita, M. Shibata, T. Ogawa, M. Furuya, K. Yokota, H. Kanetaka
    • Organizer
      19th Asian BioCeramics Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 深部がんの血管内治療に用いられる微小球2019

    • Author(s)
      川下将一
    • Organizer
      ニューガラスフォーラム若手懇談会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 窒化鉄を含む磁気温熱治療用材料の作製2019

    • Author(s)
      柴田美咲, 小川智之, 金高弘恭, 古谷真衣子, 横田琴音, 横井太史, 川下将一
    • Organizer
      第23回生体関連セラミックス討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 窒化鉄ナノ粒子のラット由来線維芽細胞に対する毒性2019

    • Author(s)
      柴田美咲、金高弘恭、古谷真衣子、横田琴音、小川智之、川下 将一
    • Organizer
      日本セラミックス協会2019年年会
    • Related Report
      2018 Research-status Report
  • [Presentation] Synthesis of iron nitride for magnetic hyperthermia of cancer2018

    • Author(s)
      M. Shibata, T. Ogawa and M. Kawashita
    • Organizer
      the 29th Annual Meeting of the European Society for Biomaterials
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Magnetic property and heat-generating ability of iron nitrides2018

    • Author(s)
      M. Shibata, T. Ogawa, H. Kanetaka, M. Furuya, K. Yokota and M. Kawashita
    • Organizer
      30th Symposium and Annual Meeting of the International Society for Ceramics in Medicine
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Remarks] 東京医科歯科大学 生体材料工学研究所 無機生体材料学分野 (川下研究室)

    • URL

      http://www.tmd.ac.jp/bcr/

    • Related Report
      2019 Annual Research Report 2018 Research-status Report

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Published: 2018-07-25   Modified: 2021-02-19  

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