Development of iron nitride microspheres for hyperthermia with highly efficient heating, automatic temperature control, and arterial embolization
| Project/Area Number |
18K19895
|
|---|
| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
|
| Allocation Type | Multi-year Fund |
|---|
| Review Section |
Medium-sized Section 90:Biomedical engineering and related fields
|
|---|
| Research Institution | Tokyo Medical and Dental University (2019)
Tohoku University (2018) |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
金高 弘恭 東北大学, 歯学研究科, 准教授 (50292222)
小川 智之 東北大学, 工学研究科, 准教授 (50372305)
|
|---|
| Project Period (FY) |
2018-06-29 – 2020-03-31
|
| Project Status |
Completed (Fiscal Year 2019)
|
| Budget Amount *help |
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
|
|---|
| Keywords | 窒化鉄 / 微小球 / 温熱治療 |
|---|
| Outline of Final Research Achievements |
Fe16N2, which is one of the iron nitrides, was obtained by reducing and nitriding magnetite (Fe3O4). Thus obtained Fe16N2 was estimated to show higher heat-generating ability than Fe3O4, and its cytocompatibility was almost same as that of Fe3O4. Further, it was found that Fe and Fe8N -deposited silica glass microspheres were obtained when silica glass microspheres were immersed in hydrofluoric acid containing iron ions and subjected to reduction-nitriding treatment.
|
| Academic Significance and Societal Importance of the Research Achievements |
がんの低侵襲治療法の一つに、、マグネタイトなどの酸化鉄微粒子が交流磁場中で発熱することを利用した温熱療法がある。窒化鉄はマグネタイトよりも高い発熱特性を示す可能性がある。そこで本研究では、がんの温熱治療に適した窒化鉄微小球を合成することを目的とした。その結果、窒化鉄はマグネタイトと同等の細胞適合性を示し、より高い発熱能を示す可能性が明らかとなった。さらに、シリカガラスをコアとし、その表面に純鉄と窒化鉄が析出した微小球が得られることも明らかとなった。このようにして得られた微小球はがんの温熱治療に有用であると期待される。
|
Report
(3 results)
Research Products
(10 results)
