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The high-speed dose calculation technology for human geometry which allows performing the high precision Monte-Carlo treatment planning

Research Project

Project/Area Number 18K19899
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 90:Biomedical engineering and related fields
Research InstitutionUniversity of Tsukuba

Principal Investigator

Kumada Hiroaki  筑波大学, 医学医療系, 准教授 (30354913)

Co-Investigator(Kenkyū-buntansha) 高田 健太  群馬県立県民健康科学大学, 診療放射線学部, 准教授 (10640782)
佐藤 達彦  国立研究開発法人日本原子力研究開発機構, 原子力科学研究部門 原子力科学研究所 原子力基礎工学研究センター, 研究主席 (30354707)
古田 琢哉  国立研究開発法人日本原子力研究開発機構, 原子力科学研究部門 原子力科学研究所 原子力基礎工学研究センター, 研究主幹 (40604575)
Project Period (FY) 2018-06-29 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2020: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords治療計画 / モンテカルロ法 / BNCT / 線量計算 / 並列計算 / 四面体法 / ボクセル法 / 線量評価 / モンテカルロ計算 / 人体モデル / 放射線治療技術学 / ホウ素中性子捕捉療法 / 連続四面体法 / メニーコア / 連続四面体
Outline of Final Research Achievements

A calculation model for a patient's head created by Tsukuba-Plan that is a treatment planning system was converted into a model constructed by the tetrahedron method and then calculation performance for the model has been evaluated. The results demonstrated that the calculation time can be shortened by about 50% compared to the conventional voxel method by adopting the tetrahedral method. In addition, PHITS as a Monte Carlo-based calculation code has been improved so that Monte Carlo calculations can be performed using the tetrahedral method.
As an issue that became clear in this research, when defining a complicated calculation model like a human head by the tetrahedron method, the material undefined area of the space definition or the material overlapping area in the complicated curved surface part with the current Tsukuba-plan technology Will occur. We wish to improve the system so that a tetrahedron model can be created automatically.

Academic Significance and Societal Importance of the Research Achievements

難治がん、再発がんの治療法の確立は人類の大きな課題である。がん治療法の中で放射線治療分野において必須である治療計画/線量評価作業において、モンテカルロ法を用いることで線量評価精度が高くなり、より適切な治療が期待できるが、計算時間が長時間かかるため、実用的ではなかった。本研究により、モンテカルロ法による線量評価の高速化、短時間化の見通しを得ることができた。これにより、放射線治療によるがん治療の高精度化を図ることができ、ひいては治療成績の向上に寄与できることが期待できる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (28 results)

All 2021 2020 2019 2018

All Journal Article (11 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 11 results,  Open Access: 4 results) Presentation (14 results) (of which Int'l Joint Research: 9 results,  Invited: 5 results) Book (2 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Verification for dose estimation performance of a Monte-Carlo based treatment planning system in University of Tsukuba2020

    • Author(s)
      Kumada Hiroaki, Takada Kenta, Aihara Teruhito, Matsumura Akira, Sakurai Hideyuki, Sakae Takeji
    • Journal Title

      Applied Radiation and Isotopes

      Volume: 166 Pages: 109222-109222

    • DOI

      10.1016/j.apradiso.2020.109222

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Monitoring patient movement with boron neutron capture therapy and motion capture technology2020

    • Author(s)
      Kumada Hiroaki, Takada Kenta, Terunuma Toshiyuki, Aihara Teruhito, Matsumura Akira, Sakurai Hideyuki, Sakae Takeji
    • Journal Title

      Applied Radiation and Isotopes

      Volume: 163 Pages: 109208-109208

    • DOI

      10.1016/j.apradiso.2020.109208

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Evaluation of the characteristics of the neutron beam of a linac-based neutron source for boron neutron capture therapy2020

    • Author(s)
      Kumada Hiroaki, Takada Kenta, Tanaka Susumu, Matsumoto Yoshitaka, Naito Fujio, Kurihara Toshikazu, Sugimura Takashi, Sato Masaharu, Matsumura Akira, Sakurai Hideyuki, Sakae Takeji
    • Journal Title

      Applied Radiation and Isotopes

      Volume: 165 Pages: 109246-109246

    • DOI

      10.1016/j.apradiso.2020.109246

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Neutron beam performance of iBNCT as linac-based neutron source for boron neutron capture therapy2020

    • Author(s)
      Kumada H, Tanaka S, Naito F, Kurihara T, Sugimura T, Sakurai H, Matsumura A, Sakae T
    • Journal Title

      EPJ Web of Conference

      Volume: 231 Pages: 1-4

    • DOI

      10.1051/epjconf/202023101003

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Beam performance of the iBNCT as a compact linac-based BNCT neutron source developed by University of Tsukuba2019

    • Author(s)
      Kumada Hiroaki、Takada Kenta、Naito Fujio、Kurihara Toshikazu、Sugimura Takashi、Matsumoto Yoshitaka、Sakurai Hideyuki、Matsumura Akira、Sakae Takeji
    • Journal Title

      AIP Conference Proceedings

      Volume: 2160 Pages: 1-10

    • DOI

      10.1063/1.5127705

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 3D-pintable lung phantom for distal falloff verification of proton Bragg peak2019

    • Author(s)
      Koketsu J, Kumada H, Takada k, Takei H, Mori Y, Kamizawa S, Hu Yuchao, Sakurai H, Sakae T.
    • Journal Title

      J Appl Clin Med Phys.

      Volume: 20(9) Issue: 9 Pages: 86-94

    • DOI

      10.1002/acm2.12706

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] A next generation radiotherapy using neutrons: Boron Neutron Capture Therapy (BNCT)2019

    • Author(s)
      櫻井良憲, 熊田博明, 鬼柳善明
    • Journal Title

      Journal of the Atomic Energy Society of Japan

      Volume: 61 Issue: 6 Pages: 469-473

    • DOI

      10.3327/jaesjb.61.6_469

    • NAID

      130007828086

    • ISSN
      1882-2606, 2433-7285
    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] DEPTH DISTRIBUTIONS OF RBE-WEIGHTED DOSE and PHOTON-ISOEFFECTIVE DOSE FOR BORON NEUTRON CAPTURE THERAPY2018

    • Author(s)
      3.T. Sato, S. Masunaga, H. Kumada, N. Hamada
    • Journal Title

      Radiation Protection Dosimetry

      Volume: 180 Issue: 1-2 Pages: 1-4

    • DOI

      10.1093/rpd/ncy235

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Treatment planning system and patient positioning for boron neutron capture therapy2018

    • Author(s)
      H. Kumada and T. Takada
    • Journal Title

      Therapeutic Radiology and Oncology

      Volume: Special Issue Pages: 1-11

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Investigation of the neutron spectrum measurement method for dose evaluation in boron neutron capture therapy2018

    • Author(s)
      T. Onishi H. Kumada, K. Takada F. Naito, T. Kurihara, T. Sakae
    • Journal Title

      Applied Radiation and Isotopes

      Volume: 140 Pages: 5-11

    • DOI

      10.1016/j.apradiso.2018.06.004

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 医療用加速器中性子源の開発と産業・工業分野への応用2018

    • Author(s)
      熊田博明
    • Journal Title

      Isotope News

      Volume: 757 Pages: 22-25

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] 次世代がん放射線治療:BNCTの研究開発最前線-世界をリードする医療用加速器中性子源技術2021

    • Author(s)
      熊田博明
    • Organizer
      中部原子力懇談会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Beam Design Considerations for BNCT device2020

    • Author(s)
      H. Kumada, Y. Sakurai, H. Tanaka, Y. Kiyanagi
    • Organizer
      IAEA Technical Meeting on Advances in Boron Neutron Capture Therapy
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Beam performance of the linac-based neutron source for BNCT in University of Tsukuba2020

    • Author(s)
      H. Kumada, Y. Li, S. Tanaka, F. Naito, T. Kurihara, T. Sugimura, M. Sato, H. Sakurai, T. Sakae
    • Organizer
      UCANS_Web-2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] BNCT治療装置の国際標準化について2020

    • Author(s)
      熊田博明
    • Organizer
      令和2年度京都大学複合原子力科学研究所専門研究会
    • Related Report
      2020 Annual Research Report
  • [Presentation] MULTIMODAL MONTE CARLO TREATMENT SYSTEM CAPABLE OF MICRODOSIMETRY WITH PHITS2020

    • Author(s)
      H Kumada, K. Takada, T. Sato, H. Sakurai1 T. Sakae
    • Organizer
      Mini-Micro-Nano Dosimetry (MMND) 2020
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] erification of performance for dose estimation for BNCT by the Monte Carlo based multi-modal treatment planning system2019

    • Author(s)
      Kumada H., Takada K., Tanaka S., Matsumura A., Sakurai H., Sakae T.,
    • Organizer
      PTCOG58
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of a core technologies for multi-modal treatment planning system with the high-speed and high-precision Monte Carlo dose calculation engine2019

    • Author(s)
      Kumada H., Takada K., Sato T.
    • Organizer
      11th CCS International Symposium 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of the Monte Carlo based treatment planning system by combination with the tetrahedral based human modeling method2019

    • Author(s)
      熊田博明
    • Organizer
      第117回日本医学物理学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Treatment planning and dose estimation for BNCT2019

    • Author(s)
      Kumada H
    • Organizer
      1st Ru BNCT Conference
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] BNCT用治療計画プログラムの現状と今後の課題2018

    • Author(s)
      熊田博明
    • Organizer
      日本中性子捕捉療法学会第15回学術大会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] BNCTの技術2018

    • Author(s)
      熊田博明
    • Organizer
      第65回放射線治療研究会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Verification for dose estimation performance of a Monte-Carlo based treatment planning system in University of Tsukuba2018

    • Author(s)
      H. Kumada, K. Takada, T. Aihara, T. Ohnishi, A. Matsumura, H. Sakurai, T. Sakae
    • Organizer
      18th International Congress on Neutron Capture Therapy (ICNCT-18)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Current status of development for accelerator-based neutron source and peripheral devices for BNCT2018

    • Author(s)
      H. Kumada
    • Organizer
      International Symposium of Accelerator based NCT technologies
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Three-dimenstional analysis using polygons in Particle and Heavy Ion Transport code System (PHITS)", 20th Topical Meeting of the Radiation Protection and Shielding Division of ANS2018

    • Author(s)
      T. Furuta
    • Organizer
      RPSD2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Book] Proton Beam Radiotherapy2020

    • Author(s)
      Kumada H.
    • Total Pages
      235
    • Publisher
      Springer
    • ISBN
      9789811374531
    • Related Report
      2019 Research-status Report
  • [Book] BNCT基礎から臨床応用まで2018

    • Author(s)
      中村浩之、他
    • Total Pages
      167
    • Publisher
      大阪公立大学共同出版社
    • Related Report
      2018 Research-status Report
  • [Patent(Industrial Property Rights)] ホウ素中性子捕捉療法(BNCT)用治療計画システム、BNCTシステム及びBNCT2019

    • Inventor(s)
      熊田博明
    • Industrial Property Rights Holder
      熊田博明
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2019 Research-status Report
    • Overseas

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Published: 2018-07-25   Modified: 2022-01-27  

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