| Project/Area Number |
18K19913
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 90:Biomedical engineering and related fields
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2018-06-29 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2018: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | セルロースナノファイバー / アパタイト核 / 生体活性 / 擬似体液 / アパタイト形成能 / 人工骨 |
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| Outline of Final Research Achievements |
An aqueous solution with doubled concentration of simulated body fluid (SBF) was prepared. The pH was raised by dissolving Tris-buffer and subsequently held. By this treatment, apatite nuclei (AN) were precipitated in the solution. Thus-obtained AN were mixed with the CeNF slurry. Then the mixture was pressed and dried. The specimens were immersed in SBF at pH 7.4 at 36.5 degree Celsius to evaluate apatite-forming ability. Apatite formation was observed on the whole surface of the samples after immersion in SBF for 1 day. From these results, it was found that apatite formation was induced by AN incorporated in the CeNF matrix and high apatite-forming ability was performed.
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| Academic Significance and Societal Importance of the Research Achievements |
セルロースナノファイバーはそれ自身のみでは生体活性を持たない。しかし本研究で研究代表者は、セルロースナノファイバーにアパタイト核と複合化させると、高いアパタイト形成能をセルロースナノファイバーに付与することができることを実証した。セルロースナノファイバーの高次構造にアパタイト核を複合させた三次元構造を構築することでセルロースナノファイバーに高い生体活性を付与し、アパタイト核が骨結合性、セルロースナノファイバーが機械的強度を担い、最適化された両者の組成が人工骨としての理想的な弾性率を担う、従来にない画期的な機能を有する人工骨の実現が可能となる。
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