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Development of real-time radiation detector capable of measuring with quality discrimination in neutron capture therapy

Research Project

Project/Area Number 18K19916
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 90:Biomedical engineering and related fields
Research InstitutionKyoto University

Principal Investigator

Tanaka Hiroki  京都大学, 複合原子力科学研究所, 准教授 (70391274)

Co-Investigator(Kenkyū-buntansha) 川端 信司  大阪医科大学, 医学部, 准教授 (20340549)
Project Period (FY) 2018-06-29 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords中性子捕捉療法 / BNCT / リアルタイム / 放射線検出器 / 線質弁別 / リアルタイム放射線検出器
Outline of Final Research Achievements

In boron neutron capture therapy (BNCT), neutrons are also irradiated to the outside of irradiation field due to neutron scattering and transmission from affected areas and structures such as collimator. Therefore, it is important to evaluate the dose at the whole-body position by radiation with different biological effects.
In this study, we developed a real-time neutron detector that enables radiation quality discrimination by combining moderator and Li-containing small scintillator for the purpose of evaluating the dose at the whole-body position by BNCT. Irradiation tests were performed on the neck, chest, and abdomen of the water phantom to simulate clinical practice from the temporal region. This made it possible to evaluate the neutron energy spectrum and succeeded in evaluating the dose.

Academic Significance and Societal Importance of the Research Achievements

切除不能な局所進行又は局所再発の頭頸部癌に対してホウ素中性子捕捉療法(BNCT)の保険適応による治療が始まった。今後、BNCTの効果が期待される一方で、放射線治療や陽子線治療でも考慮されているように、2次がんに起因する全身位置における線量評価が望まれている。本研究においては、中性子の線質を弁別して測定可能な検出器を開発した。本研究の成果により、BNCTの全身位置における線量をリアルタイムで評価することができるようになった。これを今後臨床へ応用することにより、2次がんに起因する線量評価の基礎データを取得することが期待される。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (27 results)

All 2021 2020 2019 2018

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (24 results) (of which Int'l Joint Research: 11 results)

  • [Journal Article] Development of real-time neutron detectors with different sensitivities to thermal, epithermal, and fast neutrons in BNCT2021

    • Author(s)
      Nishiki. Matsubayashi, Hiroki. Tanaka, Takushi. Takata, Keita Okazaki, Yoshinori. Sakurai, Minoru. Suzuki
    • Journal Title

      Radiation Measurements

      Volume: 140 Pages: 106489-106489

    • DOI

      10.1016/j.radmeas.2020.106489

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of PHITS for microdosimetry in BNCT to support radiobiological research2020

    • Author(s)
      Hu N.、Tanaka H.、Takata T.、Endo S.、Masunaga S.、Suzuki M.、Sakurai Y.
    • Journal Title

      Applied Radiation and Isotopes

      Volume: 161 Pages: 109148-109148

    • DOI

      10.1016/j.apradiso.2020.109148

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of real-time thermal neutron monitor array for boron neutron capture therapy2018

    • Author(s)
      Tanaka Hiroki、Takata Takushi、Sakurai Yoshinori、Kawabata Shinji、Suzuki Minoru、Masunaga Shin-ichiro、Ono Koji
    • Journal Title

      Therapeutic Radiology and Oncology

      Volume: 2 Pages: 51-51

    • DOI

      10.21037/tro.2018.10.10

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] BNCTにおけるリアルタイム中性子検出器を用いた全身被ばく線量評価システムの開発2021

    • Author(s)
      松林錦、高田卓志、佐藤視智飛、塚本智隆、岡崎啓太、笹木彬礼、櫻井良憲、田中浩基
    • Organizer
      第68回応用物理学会春季学術講演
    • Related Report
      2020 Annual Research Report
  • [Presentation] Neutron dose evaluation with real-time detectors at whole body position in BNCT2021

    • Author(s)
      N. Matsubayashi, T. Takushi, M. Sato, T. Tsukamoto, K. Okazaki, A. Sasaki, Y. Sakurai, H. Tanaka
    • Organizer
      第121回日本医学物理学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Development of real-time neutron detectors at whole body position in BNCT2020

    • Author(s)
      Nishiki. Matsubayashi, Takushi. Takata, Michitaka. Sato, Yoshinori. Sakurai, Hiroki. Tanaka
    • Organizer
      Online conference of the particle therapy co-operative group
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of real-time detectors with the individual sensitivity for thermal, epithermal, and fast neutron in BNCT2020

    • Author(s)
      Nishiki. Matsubayashi, Takushi. Takata, Michitaka. Sato, Yoshinori. Sakurai, Hiroki. Tanaka
    • Organizer
      第119回日本医学物理学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] BNCTにおける熱、熱外、高速中性子に感度をもつリアルタイム検出器を用いた線量評価システムの開発2020

    • Author(s)
      松林錦、高田卓志、櫻井良憲、佐藤視智飛、岡崎啓太、田中浩基
    • Organizer
      応用物理学会放射線分科会放射線夏の学校次世代放射線シンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] Improvement of a prompt gamma-ray imaging detector using a slab of LaBr3(Ce) scintillator and an 8 x 8 array MPPC for Boron Neutron Capture Therapy2019

    • Author(s)
      Keita Okazaki, Kiyotaka Akabori, Takushi Takata, Yoshinori Sakurai and Hiroki Tanaka
    • Organizer
      第118回日本医学物理学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] LiCAFシンチレータ―光ファイバ検出器における中性子-ガンマ線の弁別能の評価2019

    • Author(s)
      秋田 和彦、赤堀 清崇、田中 浩基、呼 尚徳、小野 公二
    • Organizer
      第118回日本医学物理学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 小片シンチレータを用いたファイバー型検出器の放射線劣化の評価2019

    • Author(s)
      赤堀清崇、田中浩基、高宮幸一、奥村良
    • Organizer
      第16回日本中性子捕捉療法学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 中性子捕捉療法のための全身位置における線質弁別測定が可能なリアルタイム放射線検出器の開発2019

    • Author(s)
      松林錦、高田卓志、佐藤視智飛、櫻井良憲、田中浩基
    • Organizer
      第16回日本中性子捕捉療法学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] LaBr3(Ce)シンチレータと8 x 8アレイのMPPCを組み合わせた即発ガンマ線イメージング検出器の開発2019

    • Author(s)
      岡﨑 啓太、赤堀 清崇、高田 卓志、櫻井 良憲、田中 浩基
    • Organizer
      第16回日本中性子捕捉療法学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] サイクロトロンベース熱外中性子源を用いた細胞・マウス用照射場の開発2019

    • Author(s)
      田中浩基、髙田卓志、密本俊典、櫻井良憲、増永慎一郎、小野公二、鈴木実
    • Organizer
      第16回日本中性子捕捉療法学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Development of a real-time neutron detector for measurement at whole body position in BNCT2019

    • Author(s)
      H. Tanaka, T. Takata, M. Sato, K. Okazaki, N. Hu, S. Kawabata, Y. Sakurai, S. Masunaga, M. Suzuki
    • Organizer
      2019 IEEE Nuclear Science Symposium (NSS) and Medical Imaging Conference (MIC)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Investigation of a prompt gamma-ray imaging detector with an 8 x 8 array LaBr3(Ce) scintillator and MPPC for Boron Neutron Capture Therapy2019

    • Author(s)
      Keita Okazaki, Kiyotaka Akabori, Takushi Takata, Yoshinori Sakurai, Hiroki Tanaka
    • Organizer
      10th Young Researchers BNCT Meeting
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of neutron irradiation field for cells and small animals using cyclotron-based epithermal neutron source2019

    • Author(s)
      Hiroki Tanaka, Takushi Takata, Toshinori Mitsumoto, Yoshinori Sakurai, Shin-ichiro Masunaga, Koji Ono, Minoru Suzuki
    • Organizer
      10th Young Researchers BNCT Meeting
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Calibration of real-time neutron monitor for BNCT utilizing a national neutron standard field2019

    • Author(s)
      K. Akabori, T. Mukawa H. Harano H. Tanaka
    • Organizer
      10th Young Researchers BNCT Meeting
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] BNCT 治療場における LiCAF シンチレータと中性子減速材を用いた 線質弁別可能なリアルタイム中性子検出器の開発2018

    • Author(s)
      佐藤視智飛、高田卓志、櫻井良憲、田中浩基
    • Organizer
      第15回日本中性子捕捉療法学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 遠隔可変型ボナー球スペクトロメーターの開発2018

    • Author(s)
      白石禎晶、内田良平、田中浩基、高田卓志、櫻井良憲
    • Organizer
      第15回日本中性子捕捉療法学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 生物学的効果を予測するために必要な物理工学的基盤技術2018

    • Author(s)
      田中浩基、高田卓志、櫻井良憲、木梨友子、鈴木実、増永慎一郎、 小野公二
    • Organizer
      第15回日本中性子捕捉療法学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Measurement of microdosimetric quantaties of a neutron source using a tissue equivalent proportional counter2018

    • Author(s)
      N. Hu, T. Takata, S. Endo, Y. Sakurai, H. Tanaka
    • Organizer
      2018 IEEE Nuclear Science Symposium and Medical Imaging Conference
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Overview of Cyclotron-based Epithermal Neutron Source(C-BENS) for BNCT2018

    • Author(s)
      Hiroki Tanaka, Minoru Suzuki, Toshinori Mitsumoto, Koji Ono
    • Organizer
      25th Conference on Application of Accelerators in Research and Industry
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] A real-time neutron monitor for BNCT2018

    • Author(s)
      Kiyotaka Akabori, Hiroki Tanaka
    • Organizer
      18 th International congress on neutron capture therapy
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Neutron beam quality measurement of accelerator-based neutron source using microdosimetric technique2018

    • Author(s)
      Naonori Hu, Takushi Takata, Keita Okazaki, Ryohei Uchida, Yoshinori Sakurai, Hiroki Tanaka
    • Organizer
      18 th International congress on neutron capture therapy
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of remote-changeable Bonner sphere spectrometer2018

    • Author(s)
      Sadaaki Shirashi, Ryohei Uchida, Takushi Takata, Hiroki Tanaka, Yoshinori Sakurai
    • Organizer
      18 th International congress on neutron capture therapy
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of real-time neutron detector for beam quality discrimination measurement using LiCAF scintillator and neutron moderator2018

    • Author(s)
      Michtaka Sato, Takushi Takata, Yoshinori Sakurai, Hiroki Tanaka
    • Organizer
      18 th International congress on neutron capture therapy
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

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Published: 2018-07-25   Modified: 2022-01-27  

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