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Construction of optically-controlled DNA nano-robot and its application to cell measurement

Research Project

Project/Area Number 18K19922
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 90:Biomedical engineering and related fields
Research InstitutionOsaka University

Principal Investigator

Ogura Yusuke  大阪大学, 情報科学研究科, 准教授 (20346191)

Co-Investigator(Kenkyū-buntansha) 山田 憲嗣  大阪大学, 医学系研究科, 招へい教授 (70364114)
西村 隆宏  大阪大学, 工学研究科, 助教 (10722829)
Project Period (FY) 2018-06-29 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywordsナノロボット / 光制御 / DNAゲル / 消光分子 / 生体計測
Outline of Final Research Achievements

We developed fundamental techniques to construct optically-controlled DNA nano-robots for measuring physical characteristics. A DNA nano-robot which can expand and contract was designed and fabricated. Repeated or local drives by light irradiation was confirmed. We also demonstrated the synthesis and decomposition of DNA hydrogels according to light signals. Experimental results suggest that some techniques, such as patterning of DNA hydrogels and control of object mobility in the hydrogels, are applicable to arrangement of DNA nano-robots.

Academic Significance and Societal Importance of the Research Achievements

ナノロボットは細胞などの生体解析・制御のツールとして期待されている.本研究の手法は,外部からの光信号に従った刺激を対象に与えながら,その応答を計測できる可能性があり,物理特性に基づく細胞スクリーニングの精度向上などに資すると考えられる.また,伝搬光のサイズはサブμmに制限されるが,自律性や分子選択性を持つナノロボットの介在によりナノ領域の計測・制御を行うアプローチは光の利用方法の新しい方向性を提示する.

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (10 results)

All 2019 2018

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (9 results) (of which Int'l Joint Research: 4 results,  Invited: 3 results)

  • [Journal Article] Optical decomposition of DNA gel and modication of object mobility on micrometre scale2019

    • Author(s)
      Suguru Shimomura, Takahiro Nishimura, Yusuke Ogura, Jun Tanida
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 19858-19858

    • DOI

      10.1038/s41598-019-56501-z

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Object movement change in optical decomposition of DNA gels2019

    • Author(s)
      Suguru Shimomura, Takahiro Nishimura Yusuke Ogura, Jun Tanida
    • Organizer
      The 9th Korea-Japan Workshop on Digital Holography and Information Photonics
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Superresolution bioimaging by subdiffraction-limit pattern illumination2019

    • Author(s)
      Yusuke Ogura, Riki Yamada, Takahiro Nishimura, Yosuke Tamada, Takashi Murata, Jun Tanida
    • Organizer
      The 9th Korea-JapanWorkshop on Digital Holography and Information Photonics
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Integration of DNA and Photonics for Computing, Sensing, and Fabrication2019

    • Author(s)
      Yusuke Ogura, Jinya Inoue, Suguru Shimomura, Takahiro Nishimura, Jun Tanida
    • Organizer
      15th International Conference on Polymers and Advanced Materials (ICFPAM2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] サブ回折限界光スポット走査に基づく超解像ライブイメージング2019

    • Author(s)
      山田理己,小倉裕介,西村隆宏,玉田洋介,村田隆,谷田純
    • Organizer
      Optics & Photonics Japan 2019 (OPJ2019)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 光熱駆動DNAナノマシンの空間光制御2019

    • Author(s)
      山田理己,西村隆宏,小倉裕介,谷田純
    • Organizer
      第80回応用物理学会秋季学術講演会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ホログラフィによるサブ回折限界スポット生成とバイオイメージング応用2019

    • Author(s)
      小倉裕介
    • Organizer
      第2回極みプロジェクトシンポジウム/第6回イメージング数理研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 無輻射失活過程に基づく光駆動型DNAナノマシン2019

    • Author(s)
      山田理己,西村隆宏,小倉裕介,谷田純
    • Organizer
      情報フォトニクス研究グループ第17回関西学生研究論文講演会
    • Related Report
      2018 Research-status Report
  • [Presentation] 光によるDNAゲルの形状制御とDNAマイクロマシンへの展開2018

    • Author(s)
      下村優,西村隆宏,小倉裕介,谷田純
    • Organizer
      第19回情報フォトニクス研究グループ研究会(秋合宿)
    • Related Report
      2018 Research-status Report
  • [Presentation] Patterning of DNA hydrogels by photodecomposition with visible light2018

    • Author(s)
      Suguru Shimomura, Takahiro Nishimura, Yusuke Ogura, Jun Tanida
    • Organizer
      Microfluidics, BioMEMS, and Medical Microsystems XVII, SPIE BIOS 2019
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

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Published: 2018-07-25   Modified: 2021-02-19  

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