| Project/Area Number |
18K19949
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 90:Biomedical engineering and related fields
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| Research Institution | National Institutes for Quantum and Radiological Science and Technology |
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Principal Investigator |
Yamaya Taiga 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 先進核医学基盤研究部, グループリーダー(定常) (40392245)
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| Co-Investigator(Kenkyū-buntansha) |
樋口 隆弘 岡山大学, 医歯薬学総合研究科, 教授 (30739850)
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| Project Period (FY) |
2018-06-29 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
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| Keywords | PET / SPECT / MRI / 核医学 / コンプトンカメラ |
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| Outline of Final Research Achievements |
In a field of molecular imaging research, progress has been made for each modality such as PET, SPECT and MRI, but a potential of combining these modalities has not been studied well. Therefore, this work aimed at realization of combined PET/SPECR/MRI for small animals. Challenges made in this work were the realization of a Compton-PET system and the development of a compact depth-of-interaction (DOI) type detector.
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| Academic Significance and Societal Importance of the Research Achievements |
PET、SPECTおよびMRIの同時撮像が出来れば、高精細MRI画像に、複数のトレーサーによる生体内分子動態情報（血流、エネルギー代謝、レセプター、伝達物質等）の完全同時評価が加わるようになる。例えば、脳血流変化と神経活動の関連付けや、再生治療細胞の生体内位置と治療効果の同時取得など、特異的な生体機能を多角的に評価することが可能になり、サル等を使った賦活実験で脳機能の解明や薬物動態イメージングによる創薬研究の推進が期待される。
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