| Project/Area Number |
18K19950
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 90:Biomedical engineering and related fields
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| Research Institution | Okayama University |
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Principal Investigator |
KAMIYA ATSUNORI 岡山大学, 医歯薬学総合研究科, 教授 (30324370)
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| Project Period (FY) |
2018-06-29 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 自律神経 / がん |
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| Outline of Final Research Achievements |
The autonomic nerves are cables, that connect the brain with organs. They transmit command signals to the organ and regulate its function. In the present study, we have developed a new method to record individual nerve fiber activities between organs that are difficult to be examined by existing methods, and also a new one to microscopic image the neural activities (seeing). In addition, by using these methods, we have recorded sympathetic nerve activity that innervates the breast cancer tissue.
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| Academic Significance and Societal Importance of the Research Achievements |
自律神経系は、全身の臓器に分布し、身体各所の生体情報を感知して脳に送り（求心路）、各臓器の機能を調節します（遠心路）。自律神経系は、健康時においては、生体恒常性や生命を維持する役割を担いますので、一方、病態とも深く関わっています。従って、本研究で開発した、自律神経線維の活動を解析する方法は、健康時における、各臓器に分布する自律神経の働きを理解したり、がんを含む様々な病気の仕組み（病態生理）を解明する上においても、役に立つように期待されます。
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