| Outline of Final Research Achievements |
Every single idividual cells that make up life, there are orientations such as front and back, left and right, which is referred to as cell polarity. The subcellular structures, such as the nucleus and endoplasmic reticulum, are arranged according to this cell polarity, and this arrangement is closely related to the roles of cells, those in nerves and muscles. Little is known about the molecular basis of how the cell polarity of individual cells is organized. In this study, we developed a new optical microscope that reports molecular orientations in live cells, tissues, and even whole organisms. Through understanding the mechanisms of cell polarity by observing the orientation of molecules that compose the cells, we will explore the mechanisms behind the morphogenesis of the body plans in life.
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