Structure of behavior: comparative cognitive neurobiological approach

• Project/Area Number: 18KK0070
• Research Category: Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 10:Psychology and related fields
• Research Institution: Keio University (2019-2020); Waseda University (2018)
• Principal Investigator: Toda Koji 慶應義塾大学, 文学部(三田), 助教 (60794948)
• Co-Investigator(Kenkyū-buntansha): 櫻井 勝康 筑波大学, 国際統合睡眠医科学研究機構, 助教 (70507920) ; 橘 吉寿 神戸大学, 医学研究科, 准教授 (50373197)
• Project Period (FY): 2018-10-09 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000); Fiscal Year 2020: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2019: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000); Fiscal Year 2018: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
• Keywords: 行動 / 学習 / 記憶 / 社会 / 認知 / 時間 / オプトジェネティクス / マウス / 時間知覚 / 条件づけ / 運動 / リッキング / ケモジェネティクス / 時間認識 / 報酬 / 予測 / カルシウムイメージング / 古典的条件づけ / オペラント条件づけ / 目標志向的行動 / 運動制御

Outline of Final Research Achievements

In this project, we aimed to understand psychological and neurobiological mechanisms of the behavior. We established novel behavioral experiments including appetitive and aversive classical/operant conditioning tasks for head-fixed mice. Using these tasks, we measured and manipulated neuronal activities with genetical, histological, pharmacological, optogenetic, and chemogenetic approaches. We also applied computational approach to understand the mechanism of the behavior.

Academic Significance and Societal Importance of the Research Achievements

本研究によって、伝統的な学習心理学的手法を、現代の最先端の分子生物学的および画像解析などの技術と融合させることによって、いわゆる「こころ」を調べるための様々な行動課題をアップデートし、「時間」、「学習」、「社会性」、「情動」などといった様々な行動の構造について明らかにした。今後は、こうした行動課題を分子生物学、行動薬理学、神経生理学などの手法と組み合わせることによって、様々な精神疾患の背後に潜む要因の解明などへの応用にもつながることが大いに期待できる。

Research Products

• [Int'l Joint Research] Duke University/University of Tennessee(米国)
• [Int'l Joint Research] Koc University(トルコ)
• [Int'l Joint Research] University of Manitoba(カナダ)
• [Int'l Joint Research] Duke University/University of Tennessee(米国)
• [Int'l Joint Research] Duke University/The University of Tennessee(米国)
• [Journal Article] Widespread corticopetal projections from the oval paracentral nucleus of the intralaminar thalamic nuclei conveying orofacial proprioception in rats (2021)
  • Author(s): Tsutsumi Yumi, Mizuno Yuka, Haque Tahsinul, Sato Fumihiko, Furuta Takahiro, Oka Ayaka, Moritani Masayuki, Bae Yong Chul, Yamashiro Takashi, Tachibana Yoshihisa, Yoshida Atsushi
  • Journal Title: Brain Structure and Function Volume: 226 Issue: 4 Pages: 1115-1133
  • DOI: 10.1007/s00429-021-02228-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pain induces stable, active microcircuits in the somatosensory cortex that provide a new therapeutic target. (2021)
  • Author(s): Okada T, Kato D, Nomura Y, Obata N, Quan X, Morinaga A, Yano H, Guo Z, Aoyama Y, Tachibana Y, Moorhouse AJ, Matoba O, Takiguchi T, Mizobuchi S and Wake H
  • Journal Title: Sci Adv Volume: 7 Issue: 12 Pages: 8261-8261
  • DOI: 10.1126/sciadv.abd8261
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Posterior subthalamic nucleus (PSTh) mediates innate fear-associated hypothermia in mice. (2021)
  • Author(s): Liu C, Lee CY, Asher G, Cao L, Terakoshi Y, Cao P, Kobayakawa R, Kobayakawa K, Sakurai K, Liu Q
  • Journal Title: Nature Communications Volume: -
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dysregulation of the Synaptic Cytoskeleton in the PFC Drives Neural Circuit Pathology, Leading to Social Dysfunction (2020)
  • Author(s): Kim Il Hwan, Kim Namsoo, Kim Sunwhi, Toda Koji, Catavero Christina M., Courtland Jamie L., Yin Henry H., Soderling Scott H.
  • Journal Title: Cell Reports Volume: 32 Issue: 4 Pages: 107965-107965
  • DOI: 10.1016/j.celrep.2020.107965
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Ascending projection of jaw-closing muscle-proprioception to the intralaminar thalamic nuclei in rats. (2020)
  • Author(s): Sato F, Kado S, Tsutsumi Y, Tachibana Y, Ikenoue E, Furuta T, Uchino K, Bae YC, Uzawa N, Yoshida A.
  • Journal Title: Brain Research Volume: - Pages: 146830-146830
  • DOI: 10.1016/j.brainres.2020.146830
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Proprioceptive thalamus receiving forelimb and neck muscle spindle inputs via the external cuneate nucleus in the rat (2020)
  • Author(s): Uemura Yume、Haque Tahsinul、Sato Fumihiko、Tsutsumi Yumi、Ohara Haruka、Oka Ayaka、Furuta Takahiro、Bae Yong Chul、Yamashiro Takashi、Tachibana Yoshihisa、Yoshida Atsushi
  • Journal Title: Brain Structure and Function Volume: 225 Issue: 7 Pages: 2177-2192
  • DOI: 10.1007/s00429-020-02118-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] General anesthetics activate a potent central pain-suppression circuit in the amygdala. (2020)
  • Author(s): Hua T, Chen B, Lu D, Sakurai K, Zhao S, Han BX, Kim J, Yin L, Chen Y, Lu J, Wang F.
  • Journal Title: Nature Neuroscience Volume: - Issue: 7 Pages: 854-868
  • DOI: 10.1038/s41593-020-0632-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A discrete neuronal circuit induces a hibernation-like state in rodents (2020)
  • Author(s): Takahashi TM, Sunagawa GA, Soya S, Abe M, Sakurai K, Ishikawa K, Yanagisawa M, Hama H, Hasegawa E, Miyawaki A, Sakimura K, Takahashi M, Sakurai T.
  • Journal Title: Nature Volume: - Issue: 7814 Pages: 109-114
  • DOI: 10.1038/s41586-020-2163-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hyper-Activation of mPFC Underlies Specific Traumatic Stress-Induced Sleep-Wake EEG Disturbances (2020)
  • Author(s): Tingting Lou, Jing Ma, Zhiqiang Wang, Yuka Terakoshi, Chia-Ying Lee, Greg Asher, Liqin Cao, Zhiyu Chen, Katsuyasu Sakurai, Qinghua Liu
  • Journal Title: Frontiers in Neuroscience Volume: 14 Pages: 883-883
  • DOI: 10.3389/fnins.2020.00883
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dysregulation of the synaptic cytoskeleton in the PFC drives neural circuit pathology leading to social dysfunction. (2020)
  • Author(s): Kim IH, Kim N, Kim S, Toda K, Catavero CM, Courtland JL, Yin HH, Soderling SH
  • Journal Title: Cell Reports Volume: -
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Motor learning requires myelination to reduce asynchrony and spontaneity in neural activity (2019)
  • Author(s): Kato Daisuke、Wake Hiroaki、Lee Philip R.、Tachibana Yoshihisa、Ono Riho、Sugio Shouta、Tsuji Yukio、Tanaka Yasuyo H.、Tanaka Yasuhiro R.、Masamizu Yoshito、Hira Riichiro、Moorhouse Andrew J.、Tamamaki Nobuaki、Ikenaka Kazuhiro、Matsukawa Noriyuki、Fields R. Douglas、Nabekura Junichi、Matsuzaki Masanori
  • Journal Title: Glia Volume: 68 Issue: 1 Pages: 193-210
  • DOI: 10.1002/glia.23713
  • NAID: 120006775953
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A specialized neural circuit gates social vocalizations in the mouse. (2019)
  • Author(s): Tschida K, Michael V, Takatoh J, Han BX, Zhao S, Sakurai K, Mooney R, Wang F.
  • Journal Title: Neuron Volume: 103 Issue: 3 Pages: 459-472
  • DOI: 10.1016/j.neuron.2019.05.025
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Dual microglia effects on blood brain barrier permeability induced by systemic inflammation (2019)
  • Author(s): Haruwaka Koichiro、Ikegami Ako、Tachibana Yoshihisa、Ohno Nobuhiko、Konishi Hiroyuki、Hashimoto Akari、Matsumoto Mami、Kato Daisuke、Ono Riho、Kiyama Hiroshi、Moorhouse Andrew J.、Nabekura Junichi、Wake Hiroaki
  • Journal Title: Nature Communications Volume: 10 Issue: 1 Pages: 5816-5816
  • DOI: 10.1038/s41467-019-13812-z
  • NAID: 120006786954
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Oral splint ameliorates tic symptoms in patients with tourette syndrome (2019)
  • Author(s): Murakami Jumpei、Tachibana Yoshihisa、Akiyama Shigehisa、Kato Takafumi、Taniguchi Aya、Nakajima Yoshiaki、Shimoda Mao、Wake Hiroaki、Kano Yukiko、Takada Masahiko、Nambu Atsushi、Yoshida Atsushi
  • Journal Title: Movement Disorders Volume: 34 Issue: 10 Pages: 1577-1578
  • DOI: 10.1002/mds.27819
  • NAID: 120006799316
  • Peer Reviewed / Open Access
• [Presentation] Effects of systemic oxytocin manipulations on social hierarchy in mice. (2020)
  • Author(s): Nasukawa, D., Ujihara, Y., Yamada, K., Yatagai, S. & Toda, K.
  • Organizer: 日本動物心理学会第80回大会
• [Presentation] Conditioned licking suppression in head-fixed mice. (2020)
  • Author(s): Niki, Y., Ujihara, Y., Yamada, K., Yatagai, S. & Toda, K.
  • Organizer: 日本動物心理学会第80回大会
• [Presentation] Reversal learning in head-fixed mice. (2020)
  • Author(s): Toda K., Yamamoto K., Yamada, K., Niki, Y., Nasukawa, D., Yatagai, S. & Ujihara, Y.
  • Organizer: 日本動物心理学会第80回大会
• [Presentation] Effects of pharmacological manipulations of dopamine receptors on learning and memory in head-fixed mice. (2020)
  • Author(s): Yamada, K., Ujihara, Y. & Toda, K.
  • Organizer: 日本動物心理学会第80回大会
• [Presentation] Effects of optogenetic manipulations of GABAergic neurons in the hippocampus on interval timing in head-fixed mice. (2020)
  • Author(s): Yatagai, S., Ujihara, Y., Niki, Y., Yamada, K., Sakurai, K. & Toda, K.
  • Organizer: 日本動物心理学会第80回大会
• [Presentation] Developing new auditory prosthesis: auditory perception evoked by trans-tympanic laser stimulation in Mongolian gerbil. (2020)
  • Author(s): Uenaka et al., Tamai, Y., Ito, Y., Toda, K., Hiryu, S. & Kobayasi, KI.
  • Organizer: 日本比較生理生化学会第42回大会
• [Presentation] Let there be sound: auditory perception evoked by trans-tympanic laser stimulation in Mongolian gerbils. (2020)
  • Author(s): Uenaka, M., Tamai, Y., Ito, Y., Toda, K., Hiryu, S. & Kobayasi, KI.
  • Organizer: 日本動物心理学会第80回大会
• [Presentation] Effects of pharmacological manipulations on interval timing in head-fixed mice. (2020)
  • Author(s): Ujihara, Y., Yatagai, S., Niki, Y., Yamada, K. & Toda, K.
  • Organizer: 日本動物心理学会第80回大会
• [Presentation] Does laser irradiation of auditory nerves create auditory perception? (2020)
  • Author(s): Tamai, Y., Uenaka, M., Ito, Y., Toda, K., Furuyama, T., Hiryu, S. & Kobayasi, KI.
  • Organizer: 日本神経科学学会第43回大会
• [Presentation] Neural mechanism of time perception. (2020)
  • Author(s): Toda, K., Yatagai, S., Yamada, K., Yamamoto, K., Sakurai, K., Meck, WH. & Yin, HH.
  • Organizer: 日本生理学会第97回大会
  • Invited
• [Presentation] Laser induced auditory perception in Mongolian gerbil (Meriones unguiculatus). (2019)
  • Author(s): Tamai, Y., Uenaka, M., Ito, Y., Furuyama, T., Horinouchi, K., Murashima, N., Mithimoto, I., Toda, K., Hiryu, S. & Kobayasi, KI.
  • Organizer: 日本比較生理生化学会第43回大会
  • Invited
• [Presentation] Neural correlates of time perception in head-fixed mice. (2019)
  • Author(s): Yatagai, S., Yamada, K., Yamamoto, K., Sakurai, K. & Toda, K.
  • Organizer: 日本動物心理学会第79回大会
  • Invited
• [Presentation] Understanding the properties of learning by extracting behavioral elements with machine learning in mice. (2019)
  • Author(s): Yamada, K. & Toda, K.
  • Organizer: 日本動物心理学会第79回大会
  • Invited
• [Presentation] 比較認知神経科学の挑戦 (2018)
  • Author(s): 兎田幸司
  • Organizer: 日本比較生理生化学会
  • Invited