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Structure of behavior: comparative cognitive neurobiological approach

Research Project

Project/Area Number 18KK0070
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 10:Psychology and related fields
Research InstitutionKeio University (2019-2020)
Waseda University (2018)

Principal Investigator

Toda Koji  慶應義塾大学, 文学部(三田), 助教 (60794948)

Co-Investigator(Kenkyū-buntansha) 櫻井 勝康  筑波大学, 国際統合睡眠医科学研究機構, 助教 (70507920)
橘 吉寿  神戸大学, 医学研究科, 准教授 (50373197)
Project Period (FY) 2018-10-09 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2020: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2019: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2018: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Keywords行動 / 学習 / 記憶 / 社会 / 認知 / 時間 / オプトジェネティクス / マウス / 時間知覚 / 条件づけ / 運動 / リッキング / ケモジェネティクス / 時間認識 / 報酬 / 予測 / カルシウムイメージング / 古典的条件づけ / オペラント条件づけ / 目標志向的行動 / 運動制御
Outline of Final Research Achievements

In this project, we aimed to understand psychological and neurobiological mechanisms of the behavior. We established novel behavioral experiments including appetitive and aversive classical/operant conditioning tasks for head-fixed mice. Using these tasks, we measured and manipulated neuronal activities with genetical, histological, pharmacological, optogenetic, and chemogenetic approaches. We also applied computational approach to understand the mechanism of the behavior.

Academic Significance and Societal Importance of the Research Achievements

本研究によって、伝統的な学習心理学的手法を、現代の最先端の分子生物学的および画像解析などの技術と融合させることによって、いわゆる「こころ」を調べるための様々な行動課題をアップデートし、「時間」、「学習」、「社会性」、「情動」などといった様々な行動の構造について明らかにした。今後は、こうした行動課題を分子生物学、行動薬理学、神経生理学などの手法と組み合わせることによって、様々な精神疾患の背後に潜む要因の解明などへの応用にもつながることが大いに期待できる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (33 results)

All 2021 2020 2019 2018 Other

All Int'l Joint Research (5 results) Journal Article (14 results) (of which Int'l Joint Research: 13 results,  Peer Reviewed: 14 results,  Open Access: 13 results) Presentation (14 results) (of which Invited: 5 results)

  • [Int'l Joint Research] Duke University/University of Tennessee(米国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Koc University(トルコ)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] University of Manitoba(カナダ)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Duke University/University of Tennessee(米国)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] Duke University/The University of Tennessee(米国)

    • Related Report
      2018 Research-status Report
  • [Journal Article] Widespread corticopetal projections from the oval paracentral nucleus of the intralaminar thalamic nuclei conveying orofacial proprioception in rats2021

    • Author(s)
      Tsutsumi Yumi, Mizuno Yuka, Haque Tahsinul, Sato Fumihiko, Furuta Takahiro, Oka Ayaka, Moritani Masayuki, Bae Yong Chul, Yamashiro Takashi, Tachibana Yoshihisa, Yoshida Atsushi
    • Journal Title

      Brain Structure and Function

      Volume: 226 Issue: 4 Pages: 1115-1133

    • DOI

      10.1007/s00429-021-02228-5

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pain induces stable, active microcircuits in the somatosensory cortex that provide a new therapeutic target.2021

    • Author(s)
      Okada T, Kato D, Nomura Y, Obata N, Quan X, Morinaga A, Yano H, Guo Z, Aoyama Y, Tachibana Y, Moorhouse AJ, Matoba O, Takiguchi T, Mizobuchi S and Wake H
    • Journal Title

      Sci Adv

      Volume: 7 Issue: 12 Pages: 8261-8261

    • DOI

      10.1126/sciadv.abd8261

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Posterior subthalamic nucleus (PSTh) mediates innate fear-associated hypothermia in mice.2021

    • Author(s)
      Liu C, Lee CY, Asher G, Cao L, Terakoshi Y, Cao P, Kobayakawa R, Kobayakawa K, Sakurai K, Liu Q
    • Journal Title

      Nature Communications

      Volume: -

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dysregulation of the Synaptic Cytoskeleton in the PFC Drives Neural Circuit Pathology, Leading to Social Dysfunction2020

    • Author(s)
      Kim Il Hwan, Kim Namsoo, Kim Sunwhi, Toda Koji, Catavero Christina M., Courtland Jamie L., Yin Henry H., Soderling Scott H.
    • Journal Title

      Cell Reports

      Volume: 32 Issue: 4 Pages: 107965-107965

    • DOI

      10.1016/j.celrep.2020.107965

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ascending projection of jaw-closing muscle-proprioception to the intralaminar thalamic nuclei in rats.2020

    • Author(s)
      Sato F, Kado S, Tsutsumi Y, Tachibana Y, Ikenoue E, Furuta T, Uchino K, Bae YC, Uzawa N, Yoshida A.
    • Journal Title

      Brain Research

      Volume: - Pages: 146830-146830

    • DOI

      10.1016/j.brainres.2020.146830

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Proprioceptive thalamus receiving forelimb and neck muscle spindle inputs via the external cuneate nucleus in the rat2020

    • Author(s)
      Uemura Yume、Haque Tahsinul、Sato Fumihiko、Tsutsumi Yumi、Ohara Haruka、Oka Ayaka、Furuta Takahiro、Bae Yong Chul、Yamashiro Takashi、Tachibana Yoshihisa、Yoshida Atsushi
    • Journal Title

      Brain Structure and Function

      Volume: 225 Issue: 7 Pages: 2177-2192

    • DOI

      10.1007/s00429-020-02118-2

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] General anesthetics activate a potent central pain-suppression circuit in the amygdala.2020

    • Author(s)
      Hua T, Chen B, Lu D, Sakurai K, Zhao S, Han BX, Kim J, Yin L, Chen Y, Lu J, Wang F.
    • Journal Title

      Nature Neuroscience

      Volume: - Issue: 7 Pages: 854-868

    • DOI

      10.1038/s41593-020-0632-8

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A discrete neuronal circuit induces a hibernation-like state in rodents2020

    • Author(s)
      Takahashi TM, Sunagawa GA, Soya S, Abe M, Sakurai K, Ishikawa K, Yanagisawa M, Hama H, Hasegawa E, Miyawaki A, Sakimura K, Takahashi M, Sakurai T.
    • Journal Title

      Nature

      Volume: - Issue: 7814 Pages: 109-114

    • DOI

      10.1038/s41586-020-2163-6

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hyper-Activation of mPFC Underlies Specific Traumatic Stress-Induced Sleep-Wake EEG Disturbances2020

    • Author(s)
      Tingting Lou, Jing Ma, Zhiqiang Wang, Yuka Terakoshi, Chia-Ying Lee, Greg Asher, Liqin Cao, Zhiyu Chen, Katsuyasu Sakurai, Qinghua Liu
    • Journal Title

      Frontiers in Neuroscience

      Volume: 14 Pages: 883-883

    • DOI

      10.3389/fnins.2020.00883

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dysregulation of the synaptic cytoskeleton in the PFC drives neural circuit pathology leading to social dysfunction.2020

    • Author(s)
      Kim IH, Kim N, Kim S, Toda K, Catavero CM, Courtland JL, Yin HH, Soderling SH
    • Journal Title

      Cell Reports

      Volume: -

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Motor learning requires myelination to reduce asynchrony and spontaneity in neural activity2019

    • Author(s)
      Kato Daisuke、Wake Hiroaki、Lee Philip R.、Tachibana Yoshihisa、Ono Riho、Sugio Shouta、Tsuji Yukio、Tanaka Yasuyo H.、Tanaka Yasuhiro R.、Masamizu Yoshito、Hira Riichiro、Moorhouse Andrew J.、Tamamaki Nobuaki、Ikenaka Kazuhiro、Matsukawa Noriyuki、Fields R. Douglas、Nabekura Junichi、Matsuzaki Masanori
    • Journal Title

      Glia

      Volume: 68 Issue: 1 Pages: 193-210

    • DOI

      10.1002/glia.23713

    • NAID

      120006775953

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A specialized neural circuit gates social vocalizations in the mouse.2019

    • Author(s)
      Tschida K, Michael V, Takatoh J, Han BX, Zhao S, Sakurai K, Mooney R, Wang F.
    • Journal Title

      Neuron

      Volume: 103 Issue: 3 Pages: 459-472

    • DOI

      10.1016/j.neuron.2019.05.025

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Dual microglia effects on blood brain barrier permeability induced by systemic inflammation2019

    • Author(s)
      Haruwaka Koichiro、Ikegami Ako、Tachibana Yoshihisa、Ohno Nobuhiko、Konishi Hiroyuki、Hashimoto Akari、Matsumoto Mami、Kato Daisuke、Ono Riho、Kiyama Hiroshi、Moorhouse Andrew J.、Nabekura Junichi、Wake Hiroaki
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 5816-5816

    • DOI

      10.1038/s41467-019-13812-z

    • NAID

      120006786954

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Oral splint ameliorates tic symptoms in patients with tourette syndrome2019

    • Author(s)
      Murakami Jumpei、Tachibana Yoshihisa、Akiyama Shigehisa、Kato Takafumi、Taniguchi Aya、Nakajima Yoshiaki、Shimoda Mao、Wake Hiroaki、Kano Yukiko、Takada Masahiko、Nambu Atsushi、Yoshida Atsushi
    • Journal Title

      Movement Disorders

      Volume: 34 Issue: 10 Pages: 1577-1578

    • DOI

      10.1002/mds.27819

    • NAID

      120006799316

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Effects of systemic oxytocin manipulations on social hierarchy in mice.2020

    • Author(s)
      Nasukawa, D., Ujihara, Y., Yamada, K., Yatagai, S. & Toda, K.
    • Organizer
      日本動物心理学会第80回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Conditioned licking suppression in head-fixed mice.2020

    • Author(s)
      Niki, Y., Ujihara, Y., Yamada, K., Yatagai, S. & Toda, K.
    • Organizer
      日本動物心理学会第80回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Reversal learning in head-fixed mice.2020

    • Author(s)
      Toda K., Yamamoto K., Yamada, K., Niki, Y., Nasukawa, D., Yatagai, S. & Ujihara, Y.
    • Organizer
      日本動物心理学会第80回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Effects of pharmacological manipulations of dopamine receptors on learning and memory in head-fixed mice.2020

    • Author(s)
      Yamada, K., Ujihara, Y. & Toda, K.
    • Organizer
      日本動物心理学会第80回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Effects of optogenetic manipulations of GABAergic neurons in the hippocampus on interval timing in head-fixed mice.2020

    • Author(s)
      Yatagai, S., Ujihara, Y., Niki, Y., Yamada, K., Sakurai, K. & Toda, K.
    • Organizer
      日本動物心理学会第80回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Developing new auditory prosthesis: auditory perception evoked by trans-tympanic laser stimulation in Mongolian gerbil.2020

    • Author(s)
      Uenaka et al., Tamai, Y., Ito, Y., Toda, K., Hiryu, S. & Kobayasi, KI.
    • Organizer
      日本比較生理生化学会第42回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Let there be sound: auditory perception evoked by trans-tympanic laser stimulation in Mongolian gerbils.2020

    • Author(s)
      Uenaka, M., Tamai, Y., Ito, Y., Toda, K., Hiryu, S. & Kobayasi, KI.
    • Organizer
      日本動物心理学会第80回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Effects of pharmacological manipulations on interval timing in head-fixed mice.2020

    • Author(s)
      Ujihara, Y., Yatagai, S., Niki, Y., Yamada, K. & Toda, K.
    • Organizer
      日本動物心理学会第80回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Does laser irradiation of auditory nerves create auditory perception?2020

    • Author(s)
      Tamai, Y., Uenaka, M., Ito, Y., Toda, K., Furuyama, T., Hiryu, S. & Kobayasi, KI.
    • Organizer
      日本神経科学学会第43回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Neural mechanism of time perception.2020

    • Author(s)
      Toda, K., Yatagai, S., Yamada, K., Yamamoto, K., Sakurai, K., Meck, WH. & Yin, HH.
    • Organizer
      日本生理学会第97回大会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Laser induced auditory perception in Mongolian gerbil (Meriones unguiculatus).2019

    • Author(s)
      Tamai, Y., Uenaka, M., Ito, Y., Furuyama, T., Horinouchi, K., Murashima, N., Mithimoto, I., Toda, K., Hiryu, S. & Kobayasi, KI.
    • Organizer
      日本比較生理生化学会第43回大会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Neural correlates of time perception in head-fixed mice.2019

    • Author(s)
      Yatagai, S., Yamada, K., Yamamoto, K., Sakurai, K. & Toda, K.
    • Organizer
      日本動物心理学会第79回大会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Understanding the properties of learning by extracting behavioral elements with machine learning in mice.2019

    • Author(s)
      Yamada, K. & Toda, K.
    • Organizer
      日本動物心理学会第79回大会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 比較認知神経科学の挑戦2018

    • Author(s)
      兎田幸司
    • Organizer
      日本比較生理生化学会
    • Related Report
      2018 Research-status Report
    • Invited

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Published: 2018-10-12   Modified: 2022-01-27  

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