Development of Multi-Channels Sensor Array Towards Simultaneous Discrimination of Mixed Volatile Molecules

• Project/Area Number: 18KK0112
• Research Category: Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 21:Electrical and electronic engineering and related fields
• Research Institution: The University of Tokyo (2020); Kyushu University (2018-2019)
• Principal Investigator: Nagashima Kazuki 東京大学, 大学院工学系研究科(工学部), 准教授 (10585988)
• Co-Investigator(Kenkyū-buntansha): 高橋 綱己 東京大学, 大学院工学系研究科(工学部), 特任准教授 (60724838) ; 細見 拓郎 東京大学, 大学院工学系研究科(工学部), 助教 (40830360)
• Project Period (FY): 2018-10-09 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000); Fiscal Year 2020: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2018: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
• Keywords: 金属酸化物 / センサ / 分子識別 / 揮発性分子

Outline of Final Research Achievements

In this study, we synthesized the highly robust, integrated metal oxide nano-film sensor array, which has a gradient molecular sensing property along in-plane direction, by combining a multi-compositional gradient nano-film deposition technique and a nano-lithography technique. and a high-speed electronic circuit. The real-time molecular sensing in 1024 sensors was also successfully demonstrated by the integrated high-speed electronic circuit together with the proof of concept for the detection and discrimination of volatile molecule mixture. Furthermore, we successfully established the design concept of surface click reaction on sensor surface towards the modification of surface chemical property using the thermally robust organic molecules.

Academic Significance and Societal Importance of the Research Achievements

本研究により、従来複雑な作製プロセスのため生じていたセンサアレイ数の限界や、少数センサ素子の誤作動などにより引き起こされるデータの信頼性低下の問題を本質的に打破する方法論を提案・実証した。素子抵抗値の制御やセンサを構成する元素数の増加、センサ応答や分子識別機能の改善など未だ多くの課題が残されているが、本研究で得られた一連の成果は、多角的な化学情報の安定的な収集・蓄積・利活用を目指す次世代の分子認識センサエレクトロニクス実現へ向けて極めて重要な知見となる。

Research Products

• [Int'l Joint Research] タイ国立電子コンピューター技術研究センター(タイ)
• [Int'l Joint Research] タイ国立電子コンピューター技術研究センター(タイ)
• [Journal Article] The impact of surface Cu2+ of ZnO/(Cu1-xZnx)O heterostructured nanowires on the adsorption and chemical transformation of carbonyl compounds (2021)
  • Author(s): J. Liu, K. Nagashima, Y. Nagamatsu, T. Hosomi, H. Saito, C. Wang, W. Mizukami, G. Zhang, B. Samransuksamer, T. Takahashi, M. Kanai, T. Yasui, Y. Baba and T. Yanagida
  • Journal Title: Chemical Science Volume: 12 Issue: 14 Pages: 5073-5081
  • DOI: 10.1039/d1sc00729g
  • Peer Reviewed / Open Access
• [Journal Article] Unusual Sequential Annealing Effect in Achieving High Thermal Stability of Conductive Al-Doped ZnO Nanofilms (2020)
  • Author(s): R. Yan, T. Takahashi, M. Kanai, T. Hosomi, G. Zhang, K. Nagashima and T. Yanagida
  • Journal Title: ACS Applied Electronic Materials Volume: 2 Issue: 7 Pages: 2064-2070
  • DOI: 10.1021/acsaelm.0c00321
  • Peer Reviewed
• [Journal Article] Facile Synthesis of Zinc Titanate Nanotubes via Reaction-byproduct Etching (2020)
  • Author(s): J. Liu, K. Nagashima, H. Yoshida, T. Hosomi, T. Takahashi, G. Zhang, M. Kanai, Y. He and T. Yanagida
  • Journal Title: Chemistry Letters Volume: 49 Issue: 10 Pages: 1220-1223
  • DOI: 10.1246/cl.200480
  • NAID: 130007923200
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Face-selective tungstate ions drive zinc oxide nanowire growth direction and dopant incorporation (2020)
  • Author(s): Liu J., Nagashima K,, Yamashita H., Mizukami W,, Uzuhashi J,, Hosomi T., Kanai m., Zhao X,, Miura Yoshinori, Zhang Guozhu, Takahashi Tsunaki, Suzuki Masaru, Sakai Daiki, Samransuksamer Benjarong, He Yong, Ohkubo Tadakatsu, Yasui Takao, Aoki Yuriko, Ho Johnny C., Baba Yoshinobu, Yanagida Takeshi
  • Journal Title: Communications Materials Volume: 1 Issue: 1 Pages: 58-58
  • DOI: 10.1038/s43246-020-00063-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Phosphonic Acid Modified ZnO Nanowire Sensors: Directing Reaction Pathway of Volatile Carbonyl Compounds (2020)
  • Author(s): C. Wang, T. Hosomi, K. Nagashima, T. Takahashi, G. Zhang, M. Kanai, H. Yoshida and T. Yanagida
  • Journal Title: ACS Applied Materials & Interfaces Volume: 12 Issue: 39 Pages: 44265-44272
  • DOI: 10.1021/acsami.0c10332
  • Peer Reviewed
• [Journal Article] Face-Selecive Crystal Growth of Hydrothermal Tungsten Oxide Nanowires for Sensing Volatile Molecules (2020)
  • Author(s): S. Nekita, K. Nagashima, G. Zhang, Q. Wang, M. Kanai, T. Takahashi, T. Hosomi, K. Nakamura, T. Okuyama and T. Yanagida
  • Journal Title: ACS Applied Nano Materials Volume: 3 Issue: 10 Pages: 10252-10260
  • DOI: 10.1021/acsanm.0c02194
  • Peer Reviewed
• [Journal Article] Oxygen-Induced Reversible Sn-Dopant Deactivation between Indium Tin Oxide and Single-Crystalline Oxide Nanowire Leading to Interfacial Switching (2020)
  • Author(s): Zeng Hao、Takahashi Tsunaki、Seki Takehito、Kanai Masaki、Zhang Guozhu、Hosomi Takuro、Nagashima Kazuki、Shibata Naoya、Yanagida Takeshi
  • Journal Title: ACS Applied Materials & Interfaces Volume: 12 Issue: 47 Pages: 52929-52936
  • DOI: 10.1021/acsami.0c16108
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Enhancement of pH Tolerance in Conductive Al-Doped ZnO Nanofilms via Sequential Annealing (2020)
  • Author(s): R. Yan, T. Takahashi, H. Zeng, T. Hosomi, M. Kanai, G. Zhang, K. Nagashima and T. Yanagida
  • Journal Title: ACS Applied Electronic Materials Volume: 3 Issue: 2 Pages: 955-962
  • DOI: 10.1021/acsaelm.0c01052
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] 分子認識エレクトロニクスへ向けたナノ界面エンジニアリング (2020)
  • Author(s): 長島 一樹, 高橋 綱己, 細見 拓郎, 柳田 剛
  • Journal Title: 化学工業 Volume: 71 Pages: 518-524
  • NAID: 40022316803
• [Journal Article] 「次世代のセンシング材料」ー堅牢な分子認識界面の創製ー (2020)
  • Author(s): 23.長島 一樹, 高橋 綱己, 細見 拓郎, 柳田 剛
  • Journal Title: 月刊MATERIAL STAGE Volume: 20 Pages: 78-83
• [Journal Article] Improvements of Electrical Characteristics of Single-Crystalline ZnO Nanowire Field-Effect Transistors via Self-Assembled Monolayer Modification (2020)
  • Author(s): H. Zeng, T. Takahashi, T. Hosomi, K. Nagashima, M. Kanai, G. Zhang and T. Yanagida
  • Journal Title: Engineering Sciences Reports Volume: 41 Pages: 12-16
  • NAID: 120007053167
  • Peer Reviewed
• [Journal Article] Water?Organic Cosolvent Effect on Nucleation of Solution-Synthesized ZnO Nanowires (2019)
  • Author(s): Akihiro Yuya、Nagashima Kazuki、Hosomi Takuro、Kanai Masaki、Anzai Hiroshi、Takahashi Tsunaki、Zhang Guozhu、Yasui Takao、Baba Yoshinobu、Yanagida Takeshi
  • Journal Title: ACS Omega Volume: 4 Issue: 5 Pages: 8299-8304
  • DOI: 10.1021/acsomega.9b00945
  • Peer Reviewed / Open Access
• [Journal Article] Substantial Narrowing on the Width of “Concentration Window” of Hydrothermal ZnO Nanowires via Ammonia Addition (2019)
  • Author(s): Sakai Daiki、Nagashima Kazuki、Yoshida Hideto、Kanai Masaki、He Yong、Zhang Guozhu、Zhao Xixi、Takahashi Tsunaki、Yasui Takao、Hosomi Takuro、Uchida Yuki、Takeda Seiji、Baba Yoshinobu、Yanagida Takeshi
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 14160-14160
  • DOI: 10.1038/s41598-019-50641-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Redox-Inactive CO2 Determines Atmospheric Stability of Electrical Properties of ZnO Nanowire Devices through a Room-Temperature Surface Reaction (2019)
  • Author(s): Nakamura Kentaro、Takahashi Tsunaki、Hosomi Takuro、Seki Takehito、Kanai Masaki、Zhang Guozhu、Nagashima Kazuki、Shibata Naoya、Yanagida Takeshi
  • Journal Title: ACS Applied Materials & Interfaces Volume: 11 Issue: 43 Pages: 40260-40266
  • DOI: 10.1021/acsami.9b13231
  • Peer Reviewed
• [Journal Article] Synthesis of Monodispersedly Sized ZnO Nanowires from Randomly Sized Seeds (2019)
  • Author(s): Zhao Xixi、Nagashima Kazuki、Zhang Guozhu、Hosomi Takuro、Yoshida Hideto、Akihiro Yuya、Kanai Masaki、Mizukami Wataru、Zhu Zetao、Takahashi Tsunaki、Suzuki Masaru、Samransuksamer Benjarong、Meng Gang、Yasui Takao、Aoki Yuriko、Baba Yoshinobu、Yanagida Takeshi
  • Journal Title: Nano Letters Volume: 20 Issue: 1 Pages: 599-605
  • DOI: 10.1021/acs.nanolett.9b04367
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] “堅い”金属酸化物無機ナノ構造を用いた“柔らかい”分子群の匂いを識別・記録するエレクトロニクス (2019)
  • Author(s): 細見 拓郎, 高橋 綱己, 長島 一樹, 柳田 剛
  • Journal Title: 無機マテリアル Volume: 26 Pages: 346-353
• [Journal Article] Rational Method of Monitoring Molecular Transformations on Metal-Oxide Nanowire Surfaces (2019)
  • Author(s): C. Wang, T. Hosomi, K. Nagashima, T. Takahashi, G. Zhang, M. Kanai, H. Zeng, W. Mizukami, N. Shioya, T. Shimoaka, Y. Aoki, J. Terao, T. Hasegawa and T. Yanagida
  • Journal Title: Nano Lett. Volume: 19 Issue: 4 Pages: 2443-2449
  • DOI: 10.1021/acs.nanolett.8b05180
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Anomalous Reversible Sn-Dopant Deactivation between Indium Tin Oxide and Single-Crystalline Oxide Nanowire (2021)
  • Author(s): 11.Hao Zeng, Tsunaki Takahashi, Takehito Seki, Masaki Kanai, Guozhu Zhang, Takuro Hosomi, Kazuki Nagashima, Naoya Shibata and Takeshi Yanagida
  • Organizer: 第68回応用物理学会春季学術講演会
• [Presentation] ホスホン酸修飾を用いたナノワイヤセンサ上における標的化合物の反応経路制御 (2020)
  • Author(s): 1.細見 拓郎, Chen Wang, 長島 一樹, 高橋 綱己, 金井 真樹, Guozhu Zhang, 柳田 剛
  • Organizer: 第11回分子アーキテクトニクス研究会
• [Presentation] 堅牢なナノ界面と分子認識エレクトロニクス (2020)
  • Author(s): 長島一樹, 高橋綱己, 細見拓郎, 柳田 剛
  • Organizer: 第81回応用物理学会秋季学術講演会
  • Invited
• [Presentation] アンサンブル分子センシングによる堅牢な呼気診断法の開発 (2020)
  • Author(s): 3.長島 一樹, Chaiyanut Jirayupat, 細見 拓郎, 高橋 綱己, Guozhu Zhang, 金井 真樹, 柳田 剛
  • Organizer: 第81回応用物理学会秋季学術講演会
• [Presentation] ZnOナノワイヤによる官能基位置選択的な直鎖ケトンの自動酸化促進 (2019)
  • Author(s): 細見 拓郎, 井上 暉英, 長島 一樹, 高橋 綱己, 張 国柱, 金井 真樹, 柳田 剛
  • Organizer: 第80回応用物理学秋季学術講演会
• [Presentation] Water-Organic Cosolvent Effect on Nucleation of Solution-Synthesized ZnO Nanowires (2019)
  • Author(s): Kazuki Nagashima, Yuya Akihiro, Takuro Hosomi, Masaki Kanai, Tsunaki Takahashi, Guozhu Zhang, Takeshi Yanagida
  • Organizer: 第38回電子材料シンポジウム
• [Presentation] ZnOナノワイヤ上における官能基位置選択的なケトンの自動酸化メカニズムの解明 (2019)
  • Author(s): 細見 拓郎, 井上 暉英, 長島 一樹, 高橋 綱己, 張 国柱, 金井 真樹, 塩谷 暢貴, 下赤 卓史, 長谷川 健, 柳田 剛
  • Organizer: 分子アーキテクトニクス研究会第10回研究会
• [Presentation] クリックケミストリーを用いた金属酸化物表面に対するユニバーサルな分子修飾方法の開発 (2019)
  • Author(s): 山口 倫門, 細見 拓郎, 長島 一樹, 高橋 綱己, 金井 真樹, 張 国柱, 柳田 剛
  • Organizer: 分子アーキテクトニクス研究会第10回研究会
• [Presentation] 有機分子修飾による単結晶金属酸化物ナノワイヤ表面反応制御 (2019)
  • Author(s): 清水 將博, 高橋 綱己, 細見 拓郎, Guozhu Zhang, 金井 真樹, 長島 一樹, 柳田 剛
  • Organizer: 分子アーキテクトニクス研究会第10回研究会
• [Presentation] Metal Oxide Nanowire Surface for Molecular Recognition (2019)
  • Author(s): K. Nagashima, T. Hosomi, T. Takahashi and T. Yanagida
  • Organizer: The 2nd Material Research Society of Thailand International Conference (MRS-Thailand 2019)
  • Int'l Joint Research / Invited
• [Presentation] Metal Oxide Nanowire Based Robust Molecular Recognition Electronics (2019)
  • Author(s): K. Nagashima
  • Organizer: The 3rd International Conference on Frontier Technology Innovation (ICFTI-2019)
  • Int'l Joint Research / Invited
• [Presentation] Post-Seed Engineering for Synthesizing Monodispersely Sized ZnO Nanowires (2019)
  • Author(s): X. Zhao, K. Nagashima, G. Zhang, T. Hosomi, Y. Akihiro, M. Kanai, T. Takahashi, M. Suzuki, B. Samransuksamer and T. Yanagida
  • Organizer: International School and Symposium on Nanoscale Transport and phoTonics 2019 (ISNTT2019)
  • Int'l Joint Research
• [Presentation] Sequential Compensation Effect of Anion/Cation Vacancies on Thermal Stability of Electrical Conductivity of Al-doped ZnO Nanofilms (2019)
  • Author(s): R. Yan, T. Takahashi, M. Kanai, T. Hosomi, G. Zhang, K. Nagashima and T. Yanagida
  • Organizer: Materials Research Meeting 2019
  • Int'l Joint Research
• [Presentation] Chemical Interaction of Volatile Aldehyde Molecules on ZnO Nanowire Surface (2018)
  • Author(s): Chen Wang, Kazuki Nagashima, Takuro Hosomi, Guozhu Zhang, Tsunaki Takahashi, Hideto Yoshida, Masaki Kanai, Seiji Takeda, Takeshi Yanagida
  • Organizer: 第37回電子材料シンポジウム
• [Presentation] Crucial Role of Tungstate Ions on Elemental Doping of Hydrothermal ZnO Nanowires (2018)
  • Author(s): Hiroki Yamashita, Kazuki Nagashima, Tsunaki Takahashi, Takuro Hosomi, Guozhu Zhang, Masaki Kanai, Takeshi Yanagida
  • Organizer: 第37回電子材料シンポジウム
• [Presentation] 単結晶ナノワイヤ表面に対する分光分析を用いた酸化物表面におけるアルデヒドの化学変換経路の解明 (2018)
  • Author(s): 細見 拓郎, Wang Chen, 長島 一樹, 高橋 綱己, 張 国柱, 金井 真樹, 水上 渉, 塩谷 暢貴, 下赤 卓史, 玉岡 武泰, 吉田 秀人, 竹田 精治, 安井 隆雄, 馬場嘉信, 青木 百合子, 寺尾 潤, 長谷川 健, 柳田 剛
  • Organizer: 統合物質創製化学研究推進機構第4回国内シンポジウム
• [Presentation] 単結晶酸化物ナノワイヤに対する分光的測定を用いたZnO上でのアルデヒドの分子変換メカニズムの解明 (2018)
  • Author(s): 細見 拓郎, Wang Chen, 長島 一樹, 高橋 綱己, 張 国柱, 金井 真樹, 水上 渉, 塩谷 暢貴, 下赤 卓史, 玉岡 武泰, 吉田 秀人, 竹田 精治, 安井 隆雄, 馬場嘉信, 青木 百合子, 寺尾 潤, 長谷川 健, 柳田 剛
  • Organizer: 9th 分子アーキテクトニクス研究会
• [Presentation] 原子相互拡散法によるW-Zn-O薄膜の組成制御及び電子輸送特性評価 (2018)
  • Author(s): 白石 悟, 長島 一樹, 細見 拓郎, 高橋 綱己, 張 国柱, 金井 真樹, 柳田 剛
  • Organizer: 第4回ナノ分析化学討論会
• [Presentation] Spectroscopic Analysis on Single Crystalline Nanowire Surface Reveals Chemical Transformation Pathways on An Aldehyde on ZnO (2018)
  • Author(s): C. Wang, T. Hosomi, K. Nagashima, T. Takahashi, G. Zhang, M. Kanai, H. Zeng and T. Yanagida
  • Organizer: The 20th Cross Straits Symposium on Energy and Environmental Science and Technology (CSS-EEST20)
  • Invited
• [Presentation] Systematic study on thermal stability of electrical characteristics of Al doped ZnO formed by pulsed laser deposition metho (2018)
  • Author(s): R. Yan, T. Takahashi, M. Kanai, G. Zhang, T. Hosomi, K. Nagashima and T. Yanagida
  • Organizer: The 3rd Asian Applied Physics Conference (Asian-APC)
  • Invited
• [Remarks]
  • URL: https://knagashima.weebly.com/
• [Remarks] Researchmap
  • URL: https://researchmap.jp/nagashima0402