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Collection and utilization of bioresources and natural products from Indonesia

Research Project

Project/Area Number 18KK0219
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 47:Pharmaceutical sciences and related fields
Research InstitutionKitasato University

Principal Investigator

Tomoda Hiroshi  北里大学, 薬学部, 特任教授 (70164043)

Co-Investigator(Kenkyū-buntansha) 大城 太一  北里大学, 薬学部, 教授 (30458765)
大手 聡  北里大学, 薬学部, 講師 (00547979)
小林 啓介  北里大学, 薬学部, 講師 (80794734)
Project Period (FY) 2018-10-09 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2018: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Keywords天然資源 / ライブラリ / シード探索 / 創薬 / ライブラリー / 探索
Outline of Final Research Achievements

Approximately 700 strains of fungi and actinomycetes were isolated from soil samples collected in various regions of Indonesia at Hasanuddin University. A joint research agreement was concluded between Hasanuddin University, the Indonesia Institute of Science, and Kitasato University, to establish the system of using Indonesian microbial samples in Japan to be used as a source of drug discovery seeds. In addition, we have been searching for lipid metabolism regulating molecules derived from microorganisms and isolated 23 compounds including 3 new compounds.

Academic Significance and Societal Importance of the Research Achievements

インドネシアの生物多様性は世界3位と言われており、微生物を含む様々な未開拓天然資源が存在すると考えられる。東インドネシアの主要大学であるハサヌディン大学において、土壌から微生物を分離・保管し、それらの分離株を日本へ持ち帰り利用できる体制を整えられたことは、今後の天然物化学の発展に大いに寄与することが期待される。また、新規化合物を含む新たな脂質代謝制御剤を発見できたことから、これらをシードとした新たな医薬品開発への発展が期待できる。

Report

(7 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (24 results)

All 2024 2023 2022 2020 2019 2018 Other

All Int'l Joint Research (5 results) Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (8 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results) Remarks (8 results)

  • [Int'l Joint Research] ハサヌディン大学/インドネシア科学院(インドネシア)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] ハサヌディン大学/インドネシア科学院(インドネシア)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] ハサヌディン大学(UNHAS)/インドネシア科学院(LIPI)(インドネシア)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] ハサヌディン大学(UNHAS)/インドネシア科学院(LIPI)(インドネシア)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] ハサヌディン大学 (UNHAS)/インドネシア科学院 (LIPI)(インドネシア)

    • Related Report
      2018 Research-status Report
  • [Journal Article] Screening for microbial potentiators of neutral lipid degradation in CHO-K1 cells2022

    • Author(s)
      Nur Elyza Aiman Azizah、Kobayashi Keisuke、Ohte Satoshi、Tomoda Hiroshi、Ohshiro Taichi
    • Journal Title

      Drug Discoveries & Therapeutics

      Volume: 16 Issue: 6 Pages: 273-279

    • DOI

      10.5582/ddt.2022.01087

    • ISSN
      1881-7831, 1881-784X
    • Year and Date
      2022-12-25
    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] New Terpendole Congeners, Inhibitors of Sterol O-Acyltransferase, Produced by Volutella citrinella BF-04402020

    • Author(s)
      Nur Elyza Aiman Azizah、Kobayashi Keisuke、Amagai Ai、Ohshiro Taichi、Tomoda Hiroshi
    • Journal Title

      Molecules

      Volume: 25 Issue: 13 Pages: 3079-3079

    • DOI

      10.3390/molecules25133079

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Inhibition of cholesteryl ester synthesis by polyacetylenes from Atractylodes rhizome.2020

    • Author(s)
      Nur EAA, Ohshiro T, Kobayashi K, Wu J, Wahyudin E, Zhang H, Hayashi F, Kawagishi H, Tomoda H.
    • Journal Title

      Bioorg Med Chem Lett

      Volume: 30 Issue: 7 Pages: 126997-126997

    • DOI

      10.1016/j.bmcl.2020.126997

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Fungal srimane sesquiterpenoids from BF-1613 strain as sterol O-acyltransferase (SOAT) inhibitors2024

    • Author(s)
      Nur Elyza, Keisuke Kobayashi, Hiroshi Tomoda, Taichi Ohshiro
    • Organizer
      日本薬学会第144年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Searching for Lipid Metabolism Regulators in Mammalian Cells from Microorganism2023

    • Author(s)
      Elyza Aiman Azizah Nur, Keisuke Kobayashi, Satoshi Ohte, Hiroshi Tomoda, and Taichi Ohshiro
    • Organizer
      13th ISISM, 10th ISIBio, and 20th ACM meeting
    • Related Report
      2023 Annual Research Report
  • [Presentation] 真菌 Volutella citrinella BF-0440 株が生産する新規 voluhemin 類と terpendole 類に関する研究2022

    • Author(s)
      Nur Elyza、小林 啓介、供田 洋、大城 太一
    • Organizer
      第12回AKPS北里化学シンポジウム(優秀ポスター賞)
    • Related Report
      2022 Research-status Report
  • [Presentation] 真菌Volutella citrinella BF-0440株が生産する新規テルペンドール類に関する研究2022

    • Author(s)
      Elyza Nur、小林 啓介、大城 太一、供田 洋
    • Organizer
      日本薬学会第142年会
    • Related Report
      2021 Research-status Report
  • [Presentation] 真菌Volutella citrinella BF-0440株が生産する新規SOAT阻害剤に関する研究2020

    • Author(s)
      Elyza Aiman Azhiza Nur
    • Organizer
      日本薬学会第140回年会
    • Related Report
      2019 Research-status Report
  • [Presentation] Discovery of anti-mycobacterial compounds from microorganisms2019

    • Author(s)
      Hiroshi Tomoda
    • Organizer
      International Seminar on Bioscience and Drug Discovery
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Inhibition of cholesteryl ester accumulation by polyacetylenes isolated from Atractylodes rhizome2019

    • Author(s)
      Elyza Nur, Taichi Ohshiro, Jing Wu, Hirokazu Kawagishi, Hiroshi Tomoda
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Research-status Report
  • [Presentation] New Anti-Mycobacterial Compounds from Microorganisms.2018

    • Author(s)
      Hiroshi Tomoda
    • Organizer
      BIT's 7th Annual World Congress of Infectious Diseases 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Remarks] 北里大学薬学部微生物薬品製造学教室HP

    • URL

      https://www.kitasato-u.ac.jp/pharm/research/laboratory/laboratory-detail/?lab_pk=1669807811#content

    • Related Report
      2023 Annual Research Report
  • [Remarks] 北里大学薬学部微生物薬品製造学教室HP

    • URL

      https://www.kitasato-u.ac.jp/pharm/research/laboratory/laboratory-detail/?lab_pk=1669807811

    • Related Report
      2022 Research-status Report
  • [Remarks] 北里大学薬学部 低・中分子創薬講座

    • URL

      http://www.pharm.kitasato-u.ac.jp/discovery/index.html

    • Related Report
      2021 Research-status Report
  • [Remarks] 北里大学薬学部 微生物薬品製造学教室

    • URL

      https://www.pharm-kitasato-u-microbchem.com

    • Related Report
      2021 Research-status Report
  • [Remarks] 北里大学薬学部 低・中分子創薬講座

    • URL

      http://www.pharm.kitasato-u.ac.jp/discovery/index.html

    • Related Report
      2020 Research-status Report
  • [Remarks] 北里大学薬学部 微生物薬品製造学教室

    • URL

      https://www.pharm-kitasato-u-microbchem.com

    • Related Report
      2020 Research-status Report
  • [Remarks] 北里大学薬学部微生物薬品製造学教室

    • URL

      http://www.pharm.kitasato-u.ac.jp/microbchem/wei_sheng_wu_yao_pin_zhi_zao_xue/Welcome.html

    • Related Report
      2019 Research-status Report 2018 Research-status Report
  • [Remarks] 北里大学 海外国際交流協定校一覧

    • URL

      https://www.kitasato-u.ac.jp/jp/globalization/exchange/college.html

    • Related Report
      2019 Research-status Report 2018 Research-status Report

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Published: 2018-10-12   Modified: 2025-01-30  

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