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Surveillance of viruses causing zoonotic infections across three continents

Research Project

Project/Area Number 18KK0225
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 49:Pathology, infection/immunology, and related fields
Research InstitutionThe University of Tokyo

Principal Investigator

Kawaoka Yoshihiro  東京大学, 医科学研究所, 特任教授 (70135838)

Co-Investigator(Kenkyū-buntansha) 渡辺 登喜子  大阪大学, 微生物病研究所, 教授 (60557479)
岩附 研子  東京大学, 医科学研究所, 特任助教 (20376619)
山田 晋弥  東京大学, 医科学研究所, 助教 (90466839)
植木 紘史  東京大学, 医科学研究所, 特任研究員 (70794907)
Project Period (FY) 2018-10-09 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2020: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2019: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2018: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Keywordsウイルス / 人獣共通感染症 / 野生動物 / アフリカ / 南米 / アジア
Outline of Final Research Achievements

To determine the prevalence of various zoonotic viral infections in humans and wildlife in in Sierra Leone, West Africa and Bolivia, South America, in this study, we conducted serological surveys in humans and surveillance of viruses carried by wildlife. The results showed that many people in Freetown, the capital city of Sierra Leone, had antibodies against chikungunya virus and other viruses, suggesting that these viruses are widely circulating in Freetown. A survey of bats in Sierra Leone also identified a novel alpha coronavirus gene.

Academic Significance and Societal Importance of the Research Achievements

人獣共通感染症の疫学調査があまり行われていないシエラレオネ共和国やボリビア等で、ヒトおよび野生動物から得られたサンプルを用いて、One Healthの概念に基づいた包括的な調査を行う点に意義がある。野生動物における各種ウイルスの保有率を明らかにすることは、現地における将来的な人獣共通感染症の流行発生のリスク評価につながる。さらに本研究から得られる知見は、日本へのウイルスの侵入の可能性の検証、感染症予防・対策法の策定などに役立つ情報となり、社会的波及効果も期待できる。

Report

(7 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (24 results)

All 2021 2020 2019 2018 Other

All Int'l Joint Research (14 results) Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results) Presentation (6 results) (of which Int'l Joint Research: 3 results,  Invited: 4 results) Remarks (2 results)

  • [Int'l Joint Research] ウイスコンシン大学(米国)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] シエラレオネ大学(シエラレオネ)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] シエラレオネ大学(シエラレオネ)

    • Related Report
      2022 Research-status Report
  • [Int'l Joint Research] ガブリエル・レネ・モレノ自治大学(ボリビア)

    • Related Report
      2022 Research-status Report
  • [Int'l Joint Research] シエラレオネ大学(シエラレオネ)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] ウイスコンシン大学(米国)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] ウイスコンシン大学(米国)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] シエラレオネ大学(シエラレオネ)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] University of Wisconsin-Madison(米国)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] University of Sierra leone(シエラレオネ)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] ガブリエル・レネ・モレノ自治大学(ボリビア)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] アイルランガ大学(インドネシア)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] シエラレオネ大学(シエラレオネ)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] ガブリエル・レネ・モレノ自治大学(ボリビア)

    • Related Report
      2018 Research-status Report
  • [Journal Article] Villains or heroes? The raison detre of viruses2020

    • Author(s)
      Watanabe Tokiko、Kawaoka Yoshihiro
    • Journal Title

      Clinical & Translational Immunology

      Volume: 9 Issue: 2

    • DOI

      10.1002/cti2.1114

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Serological analysis of Ebola virus survivors and close contacts in Sierra Leone: A cross-sectional study2019

    • Author(s)
      Halfmann Peter J.、Eisfeld Amie J.、Watanabe Tokiko、Maemura Tadashi、Yamashita Makoto、Fukuyama Satoshi、Armbrust Tammy、Rozich Isaiah、N’jai Alhaji、Neumann Gabriele、Kawaoka Yoshihiro、Sahr Foday
    • Journal Title

      PLOS Neglected Tropical Diseases

      Volume: 13 Issue: 8 Pages: e0007654-e0007654

    • DOI

      10.1371/journal.pntd.0007654

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 縮重プライマーを用いたRT-PCR法による、コロナウイルス遺伝子検出系の確立2021

    • Author(s)
      七戸新太郎、高田光輔、Pascal Hingamp、冨田有里子、前村忠、Alhaji U. N'jai、河岡義裕、 遠藤寿、緒方博之、渡辺登喜子
    • Organizer
      第68回日本ウイルス学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] Research of zoonotic diseases: Control of Ebola virus disease.2018

    • Author(s)
      Tokiko Watanabe
    • Organizer
      Workshop on Environmental Viruses
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Centenary of the 1918 Spanish Influenza, the Worst Pandemic in the Recent History of the World2018

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      Influenza Virus Virulence factors, International Symposium
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Human Ebola Virus Disease Pathogenesis Revealed by Multi`Platform Omics Analysis.2018

    • Author(s)
      Yoshihiro Kawaoka
    • Organizer
      Keystone Symposia in Hong Kong
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Animal Models for Influenza Research.2018

    • Author(s)
      Iwatsuki-Horimoto K.
    • Organizer
      Symposium 'Zoonosis Research' in Veterinary Science at University of Tokyo
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Understanding influenza A virus budding by direct visualization of viral ribonucleoproteins at the plasma membrane.2018

    • Author(s)
      I-Hsuan Wang, Jiro Usukura, and Yoshihiro Kawaoka
    • Organizer
      The 66th Annual Meeting of the Japanese Society for Virology
    • Related Report
      2018 Research-status Report
  • [Remarks] 東京大学医科学研究所 感染・免疫部門 ウイルス感染分野

    • URL

      http://www.ims.u-tokyo.ac.jp/virology/

    • Related Report
      2023 Annual Research Report 2022 Research-status Report 2020 Research-status Report 2019 Research-status Report 2018 Research-status Report
  • [Remarks] 東京大学医科学研究所 ウイルス感染部門

    • URL

      http://www.ims.u-tokyo.ac.jp/virology/

    • Related Report
      2021 Research-status Report

URL: 

Published: 2018-10-12   Modified: 2025-01-30  

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