• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Identification of Parkinson disease-specific mitochondrial pathogenesis for disease-modifying therapy

Research Project

Project/Area Number 18KK0242
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 52:General internal medicine and related fields
Research InstitutionJuntendo University

Principal Investigator

Saiki Shinji  順天堂大学, 医学部, 先任准教授 (00339996)

Co-Investigator(Kenkyū-buntansha) 笹澤 有紀子  順天堂大学, 大学院医学研究科, 特任助教 (20594922)
井本 正哉  慶應義塾大学, 理工学部(矢上), 教授 (60213253)
赤松 和土  順天堂大学, 大学院医学研究科, 教授 (60338184)
石川 景一  順天堂大学, 大学院医学研究科, 准教授 (90733973)
Project Period (FY) 2018-10-09 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2020: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2019: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywordsパーキンソン病 / オートファジー / ミトコンドリア / 代謝 / iPS細胞 / ES細胞 / ポリアミン / ケミカルバイオロジー
Outline of Final Research Achievements

In terms of the pathogenesis of Parkinson's disease, dysfunction of lysosomal proteinases and mitochondria are identified as key molecular mechanisms. In this context, we explored potential therapeutic application of 7 candidate chemicals protecting mitochondria with ES cell-derived neurons (UK) and iPS cell-derived neurons (Japan). We identified nicotinamide to rescue NAD+ insufficiency due to autophagy insufficiency, resulting in protecting cell death via the mitochondria dependent mechanisms.

Academic Significance and Societal Importance of the Research Achievements

パーキンソン病病態の中核をなすミトコンドリア機能障害に対して、NAD+レベルを上昇させることでミトコンドリア機能障害を回復させ、引いては細胞死を抑制するという全く新しい分子機構を持つ化合物nicotinamideを見出した。この作用点は新たなパーキンソン病治療標的となる可能性を秘めている。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (3 results)

All 2021 2020 Other

All Int'l Joint Research (1 results) Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results)

  • [Int'l Joint Research] Newcastle大学(英国)

    • Related Report
      2019 Research-status Report
  • [Journal Article] Metabolomic analysis data of MPP+-exposed SH-SY5Y cells using CE-TOFMS2021

    • Author(s)
      Amo Taku、Oji Yutaka、Saiki Shinji、Hattori Nobutaka
    • Journal Title

      Data in Brief

      Volume: 34 Pages: 106707-106707

    • DOI

      10.1016/j.dib.2020.106707

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers2020

    • Author(s)
      Kataura Tetsushi、Tashiro Etsu、Nishikawa Shota、Shibahara Kensuke、Muraoka Yoshihito、Miura Masahiro、Sakai Shun、Katoh Naohiro、Totsuka Misato、Onodera Masafumi、Shin-Ya Kazuo、Miyamoto Kengo、Sasazawa Yukiko、Hattori Nobutaka、Saiki Shinji、Imoto Masaya
    • Journal Title

      Autophagy

      Volume: Aug 7 Issue: 8 Pages: 1-17

    • DOI

      10.1080/15548627.2020.1794590

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access

URL: 

Published: 2018-10-12   Modified: 2023-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi