Ethnicity-oriented genomic analysis of pathogenesis underlysing sudden cardiac death of unknown cause

• Project/Area Number: 18KK0245
• Research Category: Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 53:Organ-based internal medicine and related fields
• Research Institution: National Cardiovascular Center Research Institute (2019-2021); Nagasaki University (2018)
• Principal Investigator: Makita Naomasa 国立研究開発法人国立循環器病研究センター, 研究所, 副所長 (00312356)
• Co-Investigator(Kenkyū-buntansha): 吉浦 孝一郎 長崎大学, 原爆後障害医療研究所, 教授 (00304931) ; 石川 泰輔 国立研究開発法人国立循環器病研究センター, オープンイノベーションセンター, 客員研究員 (60708692) ; 島本 恵子 国立研究開発法人国立循環器病研究センター, 病院, 医師 (00792699)
• Project Period (FY): 2018-10-09 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000); Fiscal Year 2020: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2019: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2018: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
• Keywords: ブルガダ症候群 / 単一塩基多型 / ゲノムワイド関連解析 / COX回帰解析 / 致死性不整脈 / 個別化予防医療 / COX比例ハザード解析 / ポリジェニックリスクスコア / 一塩基多型 / 心臓突然死 / 生存曲線 / 多因子疾患 / 多遺伝子リスクスコア / ゲノム編集 / Kaplan-Meier解析

Outline of Final Research Achievements

Brugada syndrome (BrS) is an inherited lethal arrhythmia syndrome prevalent in East Asia. In order to determine the genetic risks for sudden death and genetic basis of ethnic heterogeneity of BrS, we performed genome-wide association study involving 940 Japanese BrS patients, and identified a novel single nucleotide polymorphism (SNP) in addition to 3 previously identified SNPs. By stratification analyses of lethal arrhythmic events, we identified 3 novel SNPs associated with sudden death in BrS for the first time, and one of them was validated in European BrS cohort. Further COX regression analyses using genetic and clinical parameters hopefully establish a risk score system that allow prediction and prediction of sudden death in BrS.

Academic Significance and Societal Importance of the Research Achievements

BrSにおける突然死のリスクとして確立しているのは「致死性不整脈の既往」のみであり、現時点では突然死のハイリスク患者を発症前に予知する手段はない。またBrSの遺伝学的研究は白人の研究が主体であり、日本人のデータはない。本研究で我々は世界で初めて突然死関連SNPとそれを利用した突然死のリスクスコアを解明した。これは、BrS患者個人の突然死リスクを発症前に評価するもので、将来的に突然死の予防を実現化する可能をもつ。

Research Products

• [Int'l Joint Research] INSERM/UNIV Nantes/Sorbonne University(フランス)
• [Int'l Joint Research] University of Amsterdam/University Medical Center Utrecht/Netherlands Heart Institute(オランダ)
• [Int'l Joint Research] Istituto Auxologico Italiano/University of Milano-Bicocca/University of Pavia(イタリア)
• [Int'l Joint Research] Massachusetts General Hospital/Vanderbilt University Medical Center(米国)
• [Int'l Joint Research] King's College Hospital/University of Sheffield(英国)
• [Int'l Joint Research] INSERM/Nantes University(フランス)
• [Int'l Joint Research] Academic Medical Center(オランダ)
• [Int'l Joint Research] Pacific Rim Electrophys Res Inst(タイ)
• [Int'l Joint Research] Taiwan Medical University(中国)
• [Journal Article] Rotors anchored by refractory islands drive torsades de pointes in an experimental model of electrical storm (2022)
  • Author(s): Yamazaki M, Makita N, Tsuji Y, et al.
  • Journal Title: Heart Rhythm Volume: 19 Issue: 2 Pages: 318-329
  • DOI: 10.1016/j.hrthm.2021.10.012
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Electrocardiographic Diagnosis of Hypertrophic Cardiomyopathy in the Pre- and Post-Diagnostic Phases in Children and Adolescents (2021)
  • Author(s): Yoshinaga M, Horigome H, Yasuda K, Kogaki S, Tateno S, Ohta K, Hirono K, Hosokawa S, Takechi F, Ishikawa Y, Hata T, Ichida F, Ohno S, Makita N, Horie M, Takahashi H, Nagashima M.
  • Journal Title: Circulation Journal Volume: 86 Issue: 1 Pages: 118-127
  • DOI: 10.1253/circj.CJ-21-0376
  • NAID: 130008132672
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2021-12-24
  • Peer Reviewed / Open Access
• [Journal Article] Novel electrocardiographic criteria for short QT syndrome in children and adolescents (2021)
  • Author(s): Suzuki H, Horie M, Ishikawa T, Makita N, Nagashima M, et al.
  • Journal Title: EP Europace Volume: 23 Issue: 12 Pages: 2029-2038
  • DOI: 10.1093/europace/euab097
  • Peer Reviewed
• [Journal Article] Estimating the Posttest Probability of Long QT Syndrome Diagnosis for Rare <i>KCNH2</i> Variants (2021)
  • Author(s): Kozek K, Wada Y, Makita N, Ishikawa T, Crotti L, Kroncke BM, et al.
  • Journal Title: Circulation: Genomic and Precision Medicine Volume: 14 Issue: 4
  • DOI: 10.1161/circgen.120.003289
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Functionally validated SCN5A variants allow interpretation of pathogenicity and prediction of lethal events in Brugada syndrome. (2021)
  • Author(s): Ishikawa T, Kimoto H, Mishima H, Yamagata K, Ogata S, Aizawa Y, Hayashi K, Morita H, Nakajima T, Nakano Y, Nagase S, Murakoshi N, Kowase S, Ohkubo K, Aiba T, Morimoto S, Ohno S, Kamakura S, Nogami A, Takagi M, Karakachoff M, Dina C, Schott JJ, Yoshiura KI, Horie M, Shimizu W, Nishimura K, Kusano K, Makita N.
  • Journal Title: Eur Heart J. Volume: 42(29) Issue: 29 Pages: 2854-2863
  • DOI: 10.1093/eurheartj/ehab254
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Brothers with novel compound heterozygous mutations in COL27A1 causing dental and genital abnormalities (2021)
  • Author(s): Satoh Chisei、Kondoh Tatsuro、Shimizu Hitomi、Kinoshita Akira、Mishima Hiroyuki、Nishimura Gen、Miyazaki Mutsuko、Okano Kunihiko、Kumai Yoshihiko、Yoshiura Koh-ichiro
  • Journal Title: European Journal of Medical Genetics Volume: 64 Issue: 2 Pages: 104125-104125
  • DOI: 10.1016/j.ejmg.2020.104125
  • Peer Reviewed
• [Journal Article] A unique missense variant in the E1A-binding protein P400 gene is implicated in schizophrenia by whole-exome sequencing and mutant mouse models (2021)
  • Author(s): Yoshiro Morimoto, Shinji Ono, Shintaro Yoshida, Hiroyuki Mishima, Akira Kinoshita, Takeshi Tanaka, Yoshihiro Komohara, Naohiro Kurotaki, Tatsuya Kishino, Yuji Okazaki, Hiroki Ozawa, Koh-ichiro Yoshiura, Akira Imamura
  • Journal Title: Translational Psychiatry Volume: 11 Issue: 1 Pages: 132-132
  • DOI: 10.1038/s41398-021-01258-1
  • NAID: 120007000270
  • Peer Reviewed / Open Access
• [Journal Article] Enhancing rare variant interpretation in inherited arrhythmias through quantitative analysis of consortium disease cohorts and population controls (2020)
  • Author(s): 2.Walsh R, Lahrouchi N, Tadros R, Kyndt F, Glinge C, Postema PG, et al.
  • Journal Title: Genetics in Medicine Volume: 23 Issue: 1 Pages: 47-58
  • DOI: 10.1038/s41436-020-00946-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] SCN5A Mutation Type and a Genetic Risk Score Associate Variably With Brugada Syndrome Phenotype in SCN5A Families (2020)
  • Author(s): 3.Wijeyeratne YD, Tanck MW, Mizusawa Y, Batchvarov V, Barc J, Crotti L, et al.
  • Journal Title: Circulation: Genomic and Precision Medicine Volume: 13 Issue: 6
  • DOI: 10.1161/circgen.120.002911
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cardiac Emerinopathy (2020)
  • Author(s): Ishikawa Taisuke、Ichida Fukiko、Makita Naomasa et al
  • Journal Title: Circulation: Arrhythmia and Electrophysiology Volume: 13 Issue: 10 Pages: 1165-1174
  • DOI: 10.1161/circep.120.008712
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Transethnic Genome-Wide Association Study Provides Insights in the Genetic Architecture and Heritability of Long QT Syndrome (2020)
  • Author(s): Lahrouchi N, Tadros R, Crotti L, Makiyama T et al.
  • Journal Title: Circulation Volume: 142 Issue: 4 Pages: 324-338
  • DOI: 10.1161/circulationaha.120.045956
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Expression of unfolded protein response markers in the pheochromocytoma with Waardenburg syndrome: a case report (2020)
  • Author(s): Morita Shuhei、Takeshima Ken、Ariyasu Hiroyuki、Furukawa Yasushi、Kishimoto Shohei、Tsuji Tomoya、Uraki Shinsuke、Mishima Hiroyuki、Kinoshita Akira、Takahashi Yuichi、Inaba Hidefumi、Iwakura Hiroshi、Furuta Hiroto、Nishi Masahiro、Doi Asako、Murata Shin-ichi、Yoshiura Koh-ichiro、Akamizu Takashi
  • Journal Title: BMC Endocrine Disorders Volume: 20 Issue: 1 Pages: 90-90
  • DOI: 10.1186/s12902-020-00574-9
  • Peer Reviewed / Open Access
• [Journal Article] A case of ezetimibe-effective hypercholesterolemia with a novel heterozygous variant in ABCG5 (2020)
  • Author(s): Nakano Y, Komiya C, Shimizu H, Mishima H, Shiba K, Tsujimoto K, Ikeda K, Kashimada K, Dateki S, Yoshiura KI, Ogawa Y, Yamada T.
  • Journal Title: Endocrine Journal Volume: 67 Issue: 11 Pages: 1099-1105
  • DOI: 10.1507/endocrj.ej20-0044
  • NAID: 130007945810
  • Peer Reviewed / Open Access
• [Journal Article] Targeting Adaptive IRE1α Signaling and PLK2 in Multiple Myeloma: Possible Anti-Tumor Mechanisms of KIRA8 and Nilotinib. (2020)
  • Author(s): Yamashita Y, Morita S, Hosoi H, Kobata H, Kishimoto S, Ishibashi T, Mishima H, Kinoshita A, Backes BJ, Yoshiura KI, Papa FR, Sonoki T, Tamura S
  • Journal Title: Int J Mol Sci. Volume: Aug 31;21(17) Issue: 17 Pages: 6314-6314
  • DOI: 10.3390/ijms21176314
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] KN3014, a piperidine-containing small compound, inhibits auto-secretion of IL-1β from PBMCs in a patient with Muckle?Wells syndrome (2020)
  • Author(s): Kaneko Naoe、Kurata Mie、Yamamoto Toshihiro、Shigemura Tomonari、Agematsu Kazunaga、Yamazaki Takashi、Takeda Hiroyuki、Sawasaki Tatsuya、Koga Tomohiro、Kawakami Atsushi、Yachie Akihiro、Migita Kiyoshi、Yoshiura Koh-ichiro、Urano Takeshi、Masumoto Junya
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 13562-13562
  • DOI: 10.1038/s41598-020-70513-0
  • Peer Reviewed / Open Access
• [Journal Article] EEC-LM-ADULT syndrome caused by R319H mutation in TP63 with ectrodactyly, syndactyly, and teeth anomaly (2020)
  • Author(s): Otsuki Yuki、Ueda Koichi、Nuri Takashi、Satoh Chisei、Maekawa Ryuta、Yoshiura Koh-ichiro
  • Journal Title: Medicine Volume: 99 Issue: 44 Pages: e22816-e22816
  • DOI: 10.1097/md.0000000000022816
  • Peer Reviewed / Open Access
• [Journal Article] Sphenoethmoidal meningoencephalocele with variable hypopituitarism: A case report and review of literature (2020)
  • Author(s): Morishima S, Maeda M, Itonaga T, Sato-Kawano N, Yoshiura KI, Ihara K.
  • Journal Title: Clinical Pediatric Endocrinology Volume: 29 Issue: 4 Pages: 183-187
  • DOI: 10.1297/cpe.29.183
  • NAID: 130007922122
  • ISSN: 0918-5739, 1347-7358
  • Peer Reviewed / Open Access
• [Journal Article] Next-generation sequencing of the whole MEFV gene in Japanese patients with familial Mediterranean fever: a case-control association study (2020)
  • Author(s): Koga T, Sato S, Mishima H, Migita K, Endo Y, Umeda M, Sumiyoshi R, Nonaka F, Fukui S, Kawashiri SY, Iwamoto N, Ichinose K, Tamai M, Nakamura H, Origuchi T, Ueki Y, Masumoto J, Agematsu K, Yachie A, Yoshiura KI, Eguchi K, Kawakami A.
  • Journal Title: Clin Exp Rheumatol Volume: 127 Pages: 35-41
  • Peer Reviewed / Open Access
• [Journal Article] Transethnic genome-wide association study provides insights in the genetic architecture and heritability of long QT syndrome (2020)
  • Author(s): Lahrouchi N., Ishikawa T., Makita N., Connie R. B., et al.
  • Journal Title: Circulation Volume: -
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] TBX5 R264K acts as a modifier to develop dilated cardiomyopathy in mice independently of T-box pathway (2020)
  • Author(s): Miyao N., Hata Y., Izumi H., Nagaoka R., Oku Y., Takasaki I., Ishikawa T., Takarada S., Okabe M., Nakaoka H., Ibuki K., Ozawa S., Yoshida T., Hasegawa H., Makita N., Nishida N., Mori H., Ichida F., Hirono K.
  • Journal Title: PLOS ONE Volume: 15 Issue: 4 Pages: 0227393-0227393
  • DOI: 10.1371/journal.pone.0227393
  • Peer Reviewed / Open Access
• [Journal Article] Desmin‐related myopathy characterized by non‐compaction cardiomyopathy, cardiac conduction defect, and coronary artery dissection (2020)
  • Author(s): Tamiya R., Saito Y., Fukamachi D., Nagashima K., Aizawa Y., Ohkubo K., Hatta T., Sezai A., Tanaka M, Ishikawa T., Makita N., Sumitomo N., Okumura Y.
  • Journal Title: ESC Heart Failure Volume: - Issue: 3 Pages: 1338-1343
  • DOI: 10.1002/ehf2.12667
  • Peer Reviewed / Open Access
• [Journal Article] Identification of transmembrane protein 168 mutation in familial Brugada syndrome. (2020)
  • Author(s): Shimizu A, Zankov DP, Sato A, Komeno M, Toyoda F, Yamazaki S, Makita T, Noda T, Ikawa M, Asano Y, Miyashita Y, Takashima S, Morita H, Ishikawa T, Makita N, Hitosugi M, Matsuura H, Ohno S, Horie M, Ogita H.
  • Journal Title: FASEB Journal Volume: 34 Issue: 5 Pages: 6399-6417
  • DOI: 10.1096/fj.201902991r
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pathological Features of Lamin Cardiomyopathy (2020)
  • Author(s): Kawano H., Ishimatsu T., Ishijima I., Hayashi T., Ishikawa T., Makita N., Maemura K.
  • Journal Title: Circulation Journal Volume: -
  • NAID: 130007864268
  • Peer Reviewed / Open Access
• [Journal Article] 遺伝性不整脈のPrecision medicine (2020)
  • Author(s): 石川泰輔, 蒔田直昌
  • Journal Title: 週間 医学のあゆみ Volume: 272 Pages: 1279-1283
• [Journal Article] Brugada症候群の遺伝的背景 (2020)
  • Author(s): 蒔田直昌
  • Journal Title: 別冊・医学のあゆみ 遺伝性心血管疾患のすべて Volume: - Pages: 87-90
• [Journal Article] Possible mitochondrial dysfunction in a patient with deafness, dystonia, and cerebral hypomyelination (DDCH) due to BCAP31 Mutation. (2020)
  • Author(s): Shimizu K, Oba D, Nambu R, Tanaka M, Oguma E, Murayama K, Ohtake A, Yoshiura KI, Ohashi H.
  • Journal Title: Molecular Genetics and Genomic Medicine Volume: 17 Issue: 3
  • DOI: 10.1002/mgg3.1129
  • Peer Reviewed / Open Access
• [Journal Article] Calmodulin mutations and life-threatening cardiac arrhythmias: insights from the International Calmodulinopathy Registry (2019)
  • Author(s): Crotti Lia、Spazzolini Carla、Tester David J、Ohno Seiko、Ackerman Michael J、Schwartz Peter J, et al.
  • Journal Title: European Heart Journal Volume: 40 Issue: 35 Pages: 2964-2975
  • DOI: 10.1093/eurheartj/ehz311
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 遺伝性不整脈の遺伝子診断：有効性と限界 (2019)
  • Author(s): 石川泰輔, 蒔田 直昌
  • Journal Title: 循環器病研究の進歩 Volume: 40 Pages: 58-66
• [Journal Article] Nonsense mutation in CFAP43 causes normal-pressure hydrocephalus with ciliary abnormalities (2019)
  • Author(s): Morimoto Y, Yoshida S, Kinoshita A, Satoh C, Mishima H, Yamaguchi N, Matsuda K, Sakaguchi M, Tanaka T, Komohara Y, Imamura A, Ozawa H, Nakashima M, Kurotaki N, Kishino T, Yoshiura K, Ono S
  • Journal Title: Neurology Volume: 92 Issue: 20
  • DOI: 10.1212/wnl.0000000000007505
  • NAID: 120006987711
  • Peer Reviewed / Open Access
• [Journal Article] Identification of a novel CCDC22 mutation in a patient with severe Epstein?Barr virus-associated hemophagocytic lymphohistiocytosis and aggressive natural killer cell leukemia (2019)
  • Author(s): Yamashita Y, Nishikawa A, Iwahashi Y, Fujimoto M, Sasaki I, Mishima H, Kinoshita A, Hemmi H, Kanazawa N, Ohshima K, Imadome KI, Murata SI、Yoshiura KI, Kaisho T, Sonoki T, Tamura S
  • Journal Title: International Journal of Hematology Volume: 印刷中 Issue: 6 Pages: 744-750
  • DOI: 10.1007/s12185-019-02595-0
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of Face2Gene using facial images of patients with congenital dysmorphic syndromes recruited in Japan (2019)
  • Author(s): Mishima Hiroyuki、Suzuki Hisato、Doi Michiko、Miyazaki Mutsuko、Watanabe Satoshi、Matsumoto Tadashi、Morifuji Kanako、Moriuchi Hiroyuki、Yoshiura Koh-ichiro、Kondoh Tatsuro、Kosaki Kenjiro
  • Journal Title: Journal of Human Genetics Volume: 64 Issue: 8 Pages: 789-794
  • DOI: 10.1038/s10038-019-0619-z
  • Peer Reviewed / Open Access
• [Journal Article] Cystic biliary atresia with paucity of bile ducts and gene mutation in KDM6A: a case report. (2019)
  • Author(s): Masui D, Fukahori S, Mizuochi T, Watanabe Y, Fukui K, Ishii S, Saikusa N, Hashizume N, Higashidate N, Sakamoto S, Takato A, Yoshiura KI, Tanaka Y, Yagi M.
  • Journal Title: Surgical Case Reports Volume: 5(1) Issue: 1 Pages: 132-132
  • DOI: 10.1186/s40792-019-0688-4
  • Peer Reviewed / Open Access
• [Journal Article] TERT mRNA Expression as a Novel Prognostic Marker in Papillary Thyroid Carcinomas (2019)
  • Author(s): Tanaka Aya、Matsuse Michiko、Saenko Vladimir、Nakao Tomoe、Yamanouchi Kosho、Sakimura Chika、Yano Hiroshi、Nishihara Eijun、Hirokawa Mitsuyoshi、Suzuki Keiji、Miyauchi Akira、Eguchi Susumu、Yoshiura Ko-ichiro、Yamashita Shunichi、Nagayasu Takeshi、Mitsutake Norisato
  • Journal Title: Thyroid Volume: 29 Issue: 8 Pages: 1105-1114
  • DOI: 10.1089/thy.2018.0695
  • NAID: 120006988431
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Atypical phenotype without fever in a Japanese family with an autosomal dominant transmission of familial Mediterranean fever due to heterozygous MEFV Thr577Asn mutations (2019)
  • Author(s): Endo Y., Koga T., Nakashima M., Mishima H., Yoshiura K. I. , Kawakami A.
  • Journal Title: Clinical and Experimental Rheumatology Volume: 37 Suppl 121(6) Pages: 161-162
• [Journal Article] Target Capture/Next-Generation Sequencing for Nonsyndromic Cleft Lip and Palate in the Japanese Population (2019)
  • Author(s): Shibano Masayasu、Watanabe Akira、Takano Nobuo、Mishima Hiroyuki、Kinoshita Akira、Yoshiura Koh-ichiro、Shibahara Takahiko
  • Journal Title: The Cleft Palate-Craniofacial Journal Volume: 57 Issue: 1 Pages: 80-87
  • DOI: 10.1177/1055665619857650
  • Peer Reviewed
• [Journal Article] KAT6B-related disorder in a patient with a novel frameshift variant (c.3925dup) (2019)
  • Author(s): Hamaguchi Yo、Aoki Mikihiro、Watanabe Satoshi、Mishima Hiroyuki、Yoshiura Koh-ichiro、Moriuchi Hiroyuki、Dateki Sumito
  • Journal Title: Human Genome Variation Volume: 6 Issue: 1 Pages: 54-54
  • DOI: 10.1038/s41439-019-0085-3
  • NAID: 120006988337
  • Peer Reviewed / Open Access
• [Journal Article] Genome analysis of myelodysplastic syndromes among atomic bomb survivors in Nagasaki (2019)
  • Author(s): Taguchi M, Mishima H, Shiozawa Y, Hayashida C, Kinoshita A, Nannya Y, Makishima H, Horai M, Matsuo M, Sato S, Itonaga H, Kato T, Taniguchi H, Imanishi D, Imaizumi Y, Hata T, Takenaka M, Moriuchi Y, Shiraishi Y, Miyano S, Ogawa S, Yoshiura K-i, Miyazaki Y
  • Journal Title: Haematologica Volume: 105 Issue: 2 Pages: 358-365
  • DOI: 10.3324/haematol.2019.219386
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association of Genetic and Clinical Aspects of Congenital Long QT Syndrome With Life-Threatening Arrhythmias in Japanese Patients (2019)
  • Author(s): Shimizu Wataru、Makimoto Hisaki、Yamagata Kenichiro、Kamakura Tsukasa、Wada Mitsuru、Miyamoto Koji、Inoue-Yamada Yuko、Okamura Hideo、Ishibashi Kohei、Noda Takashi、Nagase Satoshi、Miyazaki Aya、Sakaguchi Heima、Shiraishi Isao、Makiyama Takeru、Ohno Seiko、Itoh Hideki、et al
  • Journal Title: JAMA Cardiology Volume: in press Issue: 3 Pages: 246-254
  • DOI: 10.1001/jamacardio.2018.4925
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical Manifestations and Long-Term Mortality in <i>Lamin A/C</i> Mutation Carriers From a Japanese Multicenter Registry (2018)
  • Author(s): 14.Nakajima K, Aiba T, Makiyama T, Nishiuchi S, Ohno S, Kato K, Yamamoto Y, Doi T, Shizuta S, Onoue K, Yagihara N, Ishikawa T, Watanabe I, Kawakami H, Oginosawa Y, Murakoshi N, Nogami A, Aonuma K, Saito Y, Kimura T, Yasuda S, Makita N, Shimizu W, Horie M, Kusano K.
  • Journal Title: Circulation Journal Volume: 82 Issue: 11 Pages: 2707-2714
  • DOI: 10.1253/circj.CJ-18-0339
  • NAID: 40021697176
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2018-10-25
  • Peer Reviewed / Open Access
• [Journal Article] Identification of a variant associated with early-onset diabetes in the intron of the insulin gene with exome sequencing (2018)
  • Author(s): Matsuno, S., Furuta, H., Kosaka, K., Doi, A., Yorifuji, T., Fukuda, T., Senmaru, T., Uraki, S., Matsutani, N., Furuta, M., Mishima, H., Iwakura, H., Nishi, M., Yoshiura, K., Fukui, M. and Akamizu, T.
  • Journal Title: J Diabetes Investig Volume: Epub ahead of print Issue: 4 Pages: 947-950
  • DOI: 10.1111/jdi.12974
  • Peer Reviewed / Open Access
• [Journal Article] HCN4 Gene Polymorphisms Are Associated With Occurrence of Tachycardia-Induced Cardiomyopathy in Patients With Atrial Fibrillation (2018)
  • Author(s): Nakano Yukiko、Ochi Hidenori、Sairaku Akinori、Onohara Yuko、Tokuyama Takehito、Motoda Chikaaki、Matsumura Hiroya、Tomomori Shunsuke、Amioka Michitaka、Hironobe Naoya、Ohkubo Yousaku、Okamura Shou、Makita Naomasa、Yoshida Yukihiko、Chayama Kazuaki、Kihara Yasuki
  • Journal Title: Circulation: Genomic and Precision Medicine Volume: 11 Issue: 7 Pages: 1-7
  • DOI: 10.1161/circgen.117.001980
  • Peer Reviewed
• [Journal Article] HCN4 pacemaker channels attenuate the parasympathetic response and stabilize the spontaneous firing of the sinoatrial node (2018)
  • Author(s): Kozasa Yuko、Nakashima Noriyuki、Ito Masayuki、Ishikawa Taisuke、Kimoto Hiroki、Ushijima Kazuo、Makita Naomasa、Takano Makoto
  • Journal Title: The Journal of Physiology Volume: 596 Issue: 5 Pages: 809-825
  • DOI: 10.1113/jp275303
  • Peer Reviewed / Open Access
• [Journal Article] Lack of genotype-phenotype correlation in Brugada Syndrome and Sudden Arrhythmic Death Syndrome families with reported pathogenic SCN1B variants (2018)
  • Author(s): Gray B., Hasdemir C., Ingles J., Aiba T., Makita N., Probst V., Wilde A. A. M., Newbury-Ecob R., Sheppard M. N., Semsarian C., Sy R. W., Behr E. R.
  • Journal Title: Heart Rhythm Volume: 15 Issue: 7 Pages: 1051-1057
  • DOI: 10.1016/j.hrthm.2018.03.015
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Brugada症候群の遺伝的背景 (2018)
  • Author(s): 蒔田直昌
  • Journal Title: 医学のあゆみ Volume: 268 Pages: 771-774
• [Journal Article] 進行性心臓伝導障害の病態と遺伝的背景 (2018)
  • Author(s): 石川泰輔, 蒔田直昌
  • Journal Title: 循環器内科 Volume: 84 Pages: 721-728
  • NAID: 40021757390
• [Journal Article] 心臓突然死の病態解明における最新の遺伝学研究―ゲノムワイド関連解析と次世代シークエンス解析― (2018)
  • Author(s): 蒔田直昌
  • Journal Title: 循環器内科 Volume: 84 Pages: 699-704
  • NAID: 40021757349
• [Journal Article] 家族性心房細動の遺伝子基盤 (2018)
  • Author(s): 蒔田直昌
  • Journal Title: 心電図 Volume: 38 Pages: 286-290
  • NAID: 130007596013
• [Presentation] Brugada Syndrome Risk Prediction (2021)
  • Author(s): Makita N.
  • Organizer: Taiwan Heart Rhythm Society Autumn Forum
  • Int'l Joint Research / Invited
• [Presentation] 網羅的遺伝子解析と不整脈研究の進歩 (2021)
  • Author(s): 蒔田直昌
  • Organizer: 第57回日本小児循環器学会学術集会
  • Invited
• [Presentation] Brugada症候群の突然死リスクを遺伝的にどう評価するか (2021)
  • Author(s): 蒔田直昌
  • Organizer: 第67回日本不整脈心電学会学術大会
  • Invited
• [Presentation] Functionally Validated SCN5A Variants Allow Interpretation of Pathogenicity and Prediction of Lethal Events in Brugada Syndrome (2021)
  • Author(s): Makita N.
  • Organizer: 第67回日本不整脈心電学会学術大会
  • Invited
• [Presentation] ブルガダ症候群の突然死リスクを遺伝的にどう評価するか (2021)
  • Author(s): 蒔田直昌
  • Organizer: 第30回東京循環器小児科治療AGORA
  • Invited
• [Presentation] Genetic Risks of Sudden Death in Brugada Syndrome (2020)
  • Author(s): Makita N.
  • Organizer: 第84回日本循環器学会学術集会
  • Int'l Joint Research / Invited
• [Presentation] Cardiac Emerinopathy, Novel Non-syndromic X-linked Left Ventricular Noncompaction Associated with Progressive Atrial Conduction Disturbance (2020)
  • Author(s): Ishikawa T, Aiba T, Ohno S, Yoshiura K, Makita N et al.
  • Organizer: 第84回日本循環器学会学術集会
  • Int'l Joint Research
• [Presentation] 新しいゲノム解析技術－メチル化解析－ (2020)
  • Author(s): 吉浦 孝一郎
  • Organizer: 第44回日本遺伝カウンセリング学会学術集会
• [Presentation] 成人期に診断に至ったCOL4A1変異関連疾患の1例 (2020)
  • Author(s): 中尾理沙，里 龍晴，林田 拓也，西口奈菜子，渡辺 聡，吉浦孝一郎，森内浩幸
  • Organizer: 第62回 日本小児神経学会学術集会
• [Presentation] PatakaraPlus: The project for individuals with Down Syndrome to develop oral and physical training and evaluation (2020)
  • Author(s): Mishima H, Kitahara T, Yoshiura, KI, Komatsu T, Lee M, Kondoh T.
  • Organizer: 日本人類遺伝学会第65回大会
• [Presentation] Single Cell Electrophysiological Analysis of iPS Cell-Derived Cardiomyocytes Generated from Long-QT Syndrome Patients Carrying a CALM2 Mutation Using a Membrane Potential Imaging System (2019)
  • Author(s): Yamamoto Y., Makiyama T., Wuriyanghai Y., Kohjitani H., Hirose S., Gao J., Kashiwa A., Huang H., Ishikawa T., Ohno S., Chonabayashi K., Suda K., Yoshida Y., Horie M., Makita N., Kimura T.
  • Organizer: 第66回日本不整脈心電学会
• [Presentation] Genetic of cardiac conduction disturbance (2019)
  • Author(s): Makita N.
  • Organizer: 12th Asia Pacific heart Rhythm Society Scientific Session
  • Int'l Joint Research
• [Presentation] A case report of juvenile onset familial atrial fibrillation due to genetic defect (2019)
  • Author(s): Kumanomidou J., Makita N.
  • Organizer: 12th Asia Pacific Heart Rhythm Society Scientific Session
  • Int'l Joint Research
• [Presentation] Modeling Overlap Syndrome of Long QT and Brugada Syndrome Associated with Induced Pluripotent Stem Cells (2019)
  • Author(s): Kashiwa A., Makiyama T., Kohjitani H., Wuriyanghai Y., Yamamoto Y., Jungshan G., Huang H., Ishikawa T., Ohno S., Toyoda F., Sato S., Horie M., Makita N., Kimura T.
  • Organizer: The 40th Heart Rhythm Society Scientific Sessions
  • Int'l Joint Research
• [Presentation] Modeling Overlapping Phenotypes of Long-QT and Brugada Syndrome with CACNA1C-E1115K that Alters Ion Selectivity of the Cardiac L-Type Calcium Channel Using Induced Pluripotent Stem Cells (2019)
  • Author(s): Kashiwa A., Makiyama T., Kohjitani H., Hirose S., Gao J., Kashiwa A., Huang H., Ishikawa T., Ohno S., Chonabayashi K., Suda K., Yoshida Y., Horie M., Makita N., Kimura T.
  • Organizer: 第66回日本不整脈心電学会
• [Presentation] Functional Reappraisal of SCN5A Mutations Reemphasize Their Predictive Value for Lethal Cardiac Events in Brugada Syndrome (2019)
  • Author(s): Ishikawa T., Makita N.
  • Organizer: 第66回日本不整脈心電学会
• [Presentation] Cardiac Emerinopathy, Novel Nonsyndromic Xlinked Left Ventricular Noncompaction Associated With Progressive Atrial Conduction Disturbance (2019)
  • Author(s): Ishikawa T., Barc J., Mishima H., Hirono K., Terada S., Kowase S., Sato T., Mukai Y., Yui Y., Ohkubo K., Kimoto H., Hata Y., Aiba T., Ohno S., Chishaki A., Shimizu W., Horie M., Ichida F., Nogami A., Yoshiura K., Schott JJ., Makita N.
  • Organizer: The 40th Heart Rhythm Society Scientific Sessions
  • Int'l Joint Research
• [Presentation] Novel common genetic predispositions to sudden death in Brugada syndrome distinct from those to diagnostic Brugada-ECG pattern (2019)
  • Author(s): Ishikawa T.
  • Organizer: 第3回日本循環器病学会基礎研究フォーラム
  • Invited
• [Presentation] 患者由来iPS 細胞モデルを用いたCav 1.2イオン選択性を障害するCACNA1C-E1115K変異がQT 延長症候群、Brugada 症候群を発症するメカニズムの解析 (2019)
  • Author(s): 柏麻美, 牧山武, 糀谷泰, マウリッセン トーマス, ウリヤンハイ イミン, 山本雄大, ガオ ジンシャン, ファン ハイ, 今村知彦, 相澤卓範, 石川泰輔, 大野聖子, 豊田太, 佐藤誠一, 高橋一浩, ウォルツェン クヌート, 堀江稔, 蒔田直昌, 木村剛
  • Organizer: 第97回日本生理学会大会
• [Presentation] 進行性心臓伝導障害患者の網羅的遺伝子解析とin vitro 機能解析系を用いて明らかになった心臓コネキシン病の分子病態 (2019)
  • Author(s): 石川泰輔, 関明子, 蒔田直昌
  • Organizer: 第97回日本生理学会大会
• [Presentation] Brugada症候群の予後予測に対する分子生理学的アプローチ (2019)
  • Author(s): 石川泰輔, 蒔田直昌
  • Organizer: 第67回日本心臓病学会学術集会
• [Presentation] 発症前診断を行ったQT延長症候群の姉妹 (2019)
  • Author(s): 松下悠紀, 永田弾尺, 小川昌宣, 鹿田佐和子, 石川泰輔, 蒔田直昌
  • Organizer: 日本人類遺伝学会第64回大会
• [Presentation] 次世代シーケンス解析による特発性心室細動の遺伝背景の解明 (2019)
  • Author(s): 謝颯琴, 高橋篤, 大野聖子, 鎌倉令, 石川泰輔, 植田初江, 斯波真理子, 南野直人, 林研至, 八木原伸江, 中野由紀子, 伊藤英樹, 宮本恵宏, 田中敏博, 蒔田直昌, 堀江稔, 清水渉, 草野研吾, 安田聡, 相庭武司
  • Organizer: 日本人類遺伝学会第64回大会
• [Presentation] 若年発症の家族性心房細動症例で遺伝子異常を認めた1例 (2019)
  • Author(s): 岩橋英明, 熊埜御堂淳, 高橋淳彌, 大渕綾, 本多亮博, 平方佐季, 大塚昌紀, 大江征嗣, 蒔田直昌, 福本義弘
  • Organizer: 日本内科学会 第326回九州地方会
• [Presentation] ヒト正常圧水頭症の原因遺伝子 (2019)
  • Author(s): 吉浦孝一郎, 森本芳郎, 吉田真太朗, 菰原義弘, 松田勝也, 中島正洋, 三嶋博之, 木下晃, 小野慎治
  • Organizer: 第4回 放射線災害・医科学研究拠点カンファランス
• [Presentation] Genome Sequence for diagnosis and successive research of genetic disorders (2019)
  • Author(s): 吉浦孝一郎
  • Organizer: 第59回 日本先天異常学会学術集会
  • Int'l Joint Research / Invited
• [Presentation] 当院のIRUD の実績と遺伝カウンセリングの実際 (2019)
  • Author(s): 高尾真未, 宮田海香子, 松本正, 三嶋博之, 三浦清徳, 吉浦孝一郎
  • Organizer: 第26回 出生前から小児期にわたるゲノム医療フォーラム
• [Presentation] IRUDによって原因遺伝子が確定した家族の出生前検査に対する思い (2019)
  • Author(s): 宮田海香子, 松本正, 高尾真未, 三嶋博之, 三浦清徳, 吉浦孝一郎
  • Organizer: 第26回 出生前から小児期にわたるゲノム医療フォーラム
• [Presentation] 周産期領域における遺伝カウンセリング (2019)
  • Author(s): 長谷川ゆり, 宮田海香子, 三浦生子, 吉浦孝一郎, 三浦清徳
  • Organizer: 第64回 日本人類遺伝学会
  • Invited
• [Presentation] 乳がん患者における血漿遊離DNA (cfDNA) 濃度と血漿循環腫瘍DNA (ctDNA) の解析 (2019)
  • Author(s): 及川将弘, 瀬戸口優美香, 榎本康子, 久松和史, 濱田哲夫, 大坪竜太, 松本恵, 矢野洋, 永安武, 三嶋博之, 木下晃, 吉浦孝一郎
  • Organizer: 第64回 日本人類遺伝学会
• [Presentation] 次世代シーケンサーを用いた日本全域の家族性地中海熱患者におけるMEFV遺伝子の包括的解析 (2019)
  • Author(s): 古賀智裕, 三嶋博之, 宮田海香子, 三浦清徳, 吉浦孝一郎, 川上純
  • Organizer: 第64回 日本人類遺伝学会
• [Presentation] LARP7遺伝子複合ヘテロ接合体変異によるAlazami症候群の2症例 (2019)
  • Author(s): 伊達木澄人, 里龍晴, 渡辺聡, 宮田海香子, 近藤達郎, 松本正, 吉浦孝一郎, 森内浩幸
  • Organizer: 第64回 日本人類遺伝学会
• [Presentation] 本邦における先天性形態以上症候群患者の顔貌画像を用い他診断補助システムFace2Geneの評価 (2019)
  • Author(s): 三嶋博之, 鈴木寿人, 近藤達郎, 吉浦孝一郎, 小崎健次郎
  • Organizer: 第64回 日本人類遺伝学会
• [Presentation] 不整脈症候群で心臓が構造的に正常な患者における心筋症の原因遺伝子変異の特定 (2018)
  • Author(s): 八木原伸江, 渡部裕, 蒔田直昌, 堀江稔, 清水渉, 大野聖子, 長谷川奏恵, 相庭武司, 田中敏博, 角田達彦, 重水大智, 南野徹
  • Organizer: 第82回日本循環器学会学術集会
• [Presentation] CaMKII as a target for novel therapy to treat lethal ventricular tachyarrhythmias. (2018)
  • Author(s): 辻幸臣, 蒔田直昌
  • Organizer: 第57回日本生体医工学学会大会
• [Presentation] CALM2関連性QT延長症候群iPSCモデルにおいて、l-cis-diltiazemは遅延したL型calciumチャネルの不活性化をさらに強める (2018)
  • Author(s): 横井文香, 牧山武, 山本雄大, 張田健志, Yimin Wuriyanghai, 早野護, 西内英, 糀谷泰彦, 廣瀬紗也子, 高景山, 大野聖子, 豊田太, 吉田善紀, 蒔田直昌, 堀江稔, 木村剛
  • Organizer: 第82回日本循環器学会学術集会
• [Presentation] Torsadogenic Action Of Late Na+ Current In Experimental Electrical Storm (2018)
  • Author(s): Yamazaki M., Tsuji Y. , Niwa R., Tomii N., Arafune T., Honjo H., Dobrev D., Nattel S., Kodama I., Sakuma I., Makita N.
  • Organizer: The 39th Heart Rhythm Society Scientific Sessions
  • Int'l Joint Research / Invited
• [Presentation] Single Cell Electrophysiological Analysis of Human iPS Cell-Derived Cardiomyocytes Generated from Long-QT Syndrome Patients Carrying a CALM2 Mutation Using a Membrane Voltage Imaging System (2018)
  • Author(s): Yamamoto Y., Makiyama T, Wuriyanghai Y., Kohjitani H., Hirose S., Gao J, Kashiwa A., Kimura T., Ishikawa T., Motomura H., Makita N, Ohno S., Chonabayashi K., Yoshida Y., Suda K., Horie M
  • Organizer: The 11th Asia Pacific Heart Rhythm Society Scientific Session
  • Int'l Joint Research / Invited
• [Presentation] The inactivation of L-type Ca2+ Channel was impaired in Human iPS Cell Model of Long-QT Syndrome with CALM2-D134H Mutation. (2018)
  • Author(s): Yamamoto Y., Makiyama T., Harita T., Hayano M., Nishiuchi S., Wuriyanghai Y., Kohjitani H., Hirose S., Yokoi F., Ishikawa T., Ohno S., Chonabayashi K., Suda K., Yoshida Y., Horie M., Makita N., Kimura T.
  • Organizer: 第82回日本循環器学会学術集会
• [Presentation] Duration Predicts Events In Caucasians With E1784K-SCN5A: The E1784K International Consortium (2018)
  • Author(s): Wijeyeratne Y. ,Makita Naomasa et al.
  • Organizer: The 39th Heart Rhythm Society Scientific Sessions
  • Int'l Joint Research / Invited
• [Presentation] Mechanisms of Electrical Storm Associated With QT Prolongation: Successful Mapping of Torsades de Pointes in Rabbits (2018)
  • Author(s): Tsuji Y., Yamazaki M., Niwa R., Tomii N., Arafune T., Honjo H., Dobrev D., Nattel S., Kodama I., Sakuma I., Makita N
  • Organizer: American Heart Association Annual Scientific Sessions 2018
  • Int'l Joint Research / Invited
• [Presentation] HCN4 Polymorphisms and Tachycardia Induced Cardiomyopathy (2018)
  • Author(s): Nakano Y., Ochi H., Onohara Y., Sairaku A., Tokuyama T., Motoda C., Matsumura H., Tomomori S., Amioka M., Hironobe N., Ohkubo Y., Okamura S., Makita N., Yoshida Y., Chayama K., Kihara Y.
  • Organizer: The 65th Annual Meeting of the Japan Heart Rhythm Society
• [Presentation] Clinical Manifestations and Long-term Mortality in Lamin A/C Mutation Carriers from the Japanese Multicenter Registry (2018)
  • Author(s): Nakajima K., Aiba T., Makiyama T., Nishiuchi S., Ohno S., Doi T., Shizuta S., Onoue K., Yagihara N., Ishikawa T., Watanabe I., Oginosawa Y., Nogami A., Aonuma K., Saitoh Y., Kimura T., Makita N., Shimizu W., Horie M., Kusano K.
  • Organizer: The 65th Annual Meeting of the Japan Heart Rhythm Society
• [Presentation] Genotype-Dependent Differences in Short QT Syndrome (2018)
  • Author(s): Makita N.
  • Organizer: The 11th Asia Pacific Heart Rhythm Society Scientific Session
  • Int'l Joint Research / Invited
• [Presentation] Atrial Conduction Defects Caused by a Connexin45 Mutation (2018)
  • Author(s): Makita N.
  • Organizer: The 11th Asia Pacific Heart Rhythm Society Scientific Session
  • Int'l Joint Research / Invited
• [Presentation] Novel Arrhythmia Syndrome Associated with Gap Junction Mutations (2018)
  • Author(s): Makita N.
  • Organizer: The 11th Asia Pacific Heart Rhythm Society Scientific Session
  • Int'l Joint Research / Invited
• [Presentation] Clinical and Genetic Basis of Calmodulinopathy (2018)
  • Author(s): Makita N.
  • Organizer: The 11th Asia Pacific Heart Rhythm Society Scientific Session
  • Int'l Joint Research / Invited
• [Presentation] Pathophysiology of Inherited Arrhythmias Associated with Ca Handling Abnormality (2018)
  • Author(s): Makita N.
  • Organizer: The 65th Annual Meeting of the Japan Heart Rhythm Society
• [Presentation] Mutation Hot-spot-based Risk Stratification In Long QT Syndrome Type 1: Data From A Nationwide Japanese LQT Registry (2018)
  • Author(s): Kashiwa A., Aiba T., Makimoto H., Yamagata K. , Keiko S. , Yagihara N., Watanabe H. , Ohno S., Hayashi K. , Sumitomo N., Yoshinaga M. , Morita H., Miyamoto Y. , Makita N. , Horie M., Yasuda S., Kusano K., Shimizu W. , The_Japanese_LQTS_registry_investigators.
  • Organizer: The 39th Heart Rhythm Society Scientific Sessions
  • Int'l Joint Research / Invited
• [Presentation] Cardiac Connexin Syndrome: A New Inherited Cardiac Conduction Disease Entity with Distinct Electrophysiological and Extracardiac Manifestations. (2018)
  • Author(s): Ishikawa T., Seki A., Hagiwara N., Makita N.
  • Organizer: 第82回日本循環器学会学術大会
• [Presentation] Rare Coding Variants in Genes Other Than SCN5A Are Minimal Genetic Burden on the Prognosis of Brugada Syndrome (2018)
  • Author(s): Ishikawa T., Mishima H., Ohno S., T. Aiba, Nakano Y., Aizawa Y., Nakajima T., Hayashi K., Murakoshi N., Yagihara N., Kimoto H., Makiyama T., Watanabe H., Morita H., Yoshiura K., Nogami A., Shimizu W., Horie M., Tanaka T., Makita N.
  • Organizer: The 65th Annual Meeting of the Japan Heart Rhythm Society
• [Presentation] Lack Of Genotype-phenotype Correlation In Brugada Syndrome And Sudden Arrhythmic Death Syndrome Families With Reported Pathogenic SCN1B Variants (2018)
  • Author(s): Gray B. , Hasdemir C. , Ingles J. , Aiba T., Makita N. , PROBST V. , Wilde A., Semsarian C. , Sy R., Behr E.
  • Organizer: The 39th Heart Rhythm Society Scientific Sessions
  • Int'l Joint Research / Invited
• [Book] ゼロから学ぶブルガダ症候群 (2020)
  • Author(s): 石川泰輔, 蒔田直昌
  • Total Pages: 133
  • Publisher: 大道学館出版部
  • ISBN: 9784924391840
• [Book] 遺伝医学への招待（改訂第6版） (2020)
  • Author(s): 新川詔夫, 太田亨, 吉浦孝一郎, 三宅紀子
  • Total Pages: 196
  • Publisher: 南江堂
  • ISBN: 9784524249312
• [Book] 標準生理学 第9版 (2019)
  • Author(s): 蒔田直昌 （本間 研一 編）
  • Total Pages: 1172
  • Publisher: 医学書院
  • ISBN: 9784260034296
• [Book] 循環器科の心電図: ECG for Cardiologists (2018)
  • Author(s): 石川泰輔、蒔田直昌 （村川裕二 編）
  • Total Pages: 215
  • Publisher: 南江堂
  • ISBN: 9784524237913
• [Book] 循環器内科専門医バイブル (2018)
  • Author(s): 辻幸臣・蒔田直昌(小室一成・ 平尾見三 編）
  • Total Pages: 376
  • Publisher: 中山書店
  • ISBN: 9784521745855
• [Remarks] 国立循環器病研究センター 創薬オミックス解析センター 研究ついて
  • URL: https://www.ncvc.go.jp/oic/divisions/omix/research/project02/
• [Remarks] 国立循環器病研究センター 創薬オミックス解析センター 研究プロジェクト
  • URL: http://www.ncvc.go.jp/omics/research/project02.html
• [Remarks] 国立循環器病研究センター 創薬オミックス解析センターホームぺージ
  • URL: http://www.ncvc.go.jp/omics/research/project02.html