| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2021: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
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| Outline of Final Research Achievements |
Using Prg4CreERt2 mice which were developed in the Harvard Medical school, Prg4-expressing cells in the period of joint formation are not involved in the cartilage matrix synthesis. However, Prg4 expressing cells can give rise to all adult articular cartilage chondrocytes. Also, Prg4 expressing cells may contribute to tendon/ligament homeostasis under pathogenic conditions. The results of osteoarthritis (OA) model from Prg4-CreERT2; βcatenin floxed mice suggested CREB1 is associated with Prg4 induction by Wnt/β-catenin signaling. Another OA model of Prg4-CreERT2; Runx3 floxed mice suggested Runx3 contributes to cartilage homeostasis through the induction of Prg4 and Aggrecan (Acan) which is one of the proteoglycans in the cartilage.
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