| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2021: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2020: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2019: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Outline of Final Research Achievements |
Chronic alcohol consumption can lead to the development of hyperammonemia due to liver dysfunction. We identified that liver failure-associated hyperammonemia induces neuroinflammation which can be described by the increased number of reactive astrocytes in the brain. We also identified that ammonia stimulation induces the production of amyloid beta, a critical initiator that triggers the progression of Alzheimer’s disease. Using primary cultured astrocytes prepared from rat embryo, we found the mechanisms of amyloid beta production; ammonia enhances amyloid precursor protein (APP) endocytosis from the plasma membrane, induces transportation of APP to the endoplasmic reticulum, where two enzymes cleave APP to generate amyloid beta peptides. We reported these mechanisms as a novel mechanism driving Alzheimer’s disease.
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