Modelling of Antibiotics Behavior in the Water Environment of the Thees River, England

• Project/Area Number: 18KK0290
• Research Category: Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 63:Environmental analyses and evaluation and related fields
• Research Institution: Kyoto University
• Principal Investigator: 田中 宏明 京都大学, 工学研究科, 名誉教授 (70344017)
• Co-Investigator(Kenkyū-buntansha): 花本 征也 金沢大学, 環境保全センター, 准教授 (10727580) ; 小川 文章 国立研究開発法人土木研究所, 土木研究所(つくば中央研究所), 上席研究員 (60589133) ; 山下 洋正 国立研究開発法人土木研究所, 土木研究所(つくば中央研究所), 上席研究員 (80355940)
• Project Period (FY): 2018-10-09 – 2024-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000); Fiscal Year 2020: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000); Fiscal Year 2019: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000); Fiscal Year 2018: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 抗生物質 / 河川 / 流域 / 環境動態 / 畜産排水 / 生活排水 / 下水道 / 浄化槽 / 化学物質 / 畜産 / 河川水 / 底質 / 下水処理水 / 分配 / 吸着 / 分解 / 予測モデル / 桂川 / テムズ川 / 減衰速度 / 収着 / 環境予測モデル

Outline of Annual Research Achievements

人や家畜に投与された抗生物質が水環境中に排出され、水生生物への生態影響や薬剤耐性菌の環境での水平伝搬が懸念されている。特に薬剤耐性菌は、2050年に世界の健康被害を生じる化学物質の最大リスク因子と認識されており、世界保健機関は、薬剤の適正使用と薬剤耐性菌の発生対策の取り組みを各国に要求している。しかし、抗生物質の使用は不可欠であり、環境を含めた抗生物質の適性管理が必要である。環境分野では、抗生物質の水環境中濃度の実態把握が行われ始めたが、モニタリングには限界があり、水環境中濃度の予測システムとの連携が必要である。排出量の予測に必要な廃水処理での知見は徐々に明らかになってきたが、底質を含めた河川流下過程における抗生物質の水質変換の知見が不足している。このため、日英の流域での抗生物質の存在の相違の原因を検討することを目的に研究を行ってきた。
新型コロナ禍のため、英国への研究者受け入れに制限があったため、主に肝属川での抗生物質等の存在調査を継続した。その結果、汚濁負荷量の実測値と予測値はオーダーが一致しており、豚舎に散布されたDDACの多くが糞尿中に溶出している可能性が示された。
これまで構築してきた日英共同研究の研究スキームを維持発展するため、日英内分泌乱化学物質共同研究ワークショップに参加し、流域からの抗生物質流出機構についての情報と意見交換を継続して実施した。新型コロナウイルスの渡航制限が解除された2023年9月、英国に渡航し、カウンターパートCEH、Andrew Johnson博士、Monika　Jorgensen博士の協力により、テムズ川と下水処理場でのでの採水と医薬品類の分析を行った。

Research Products

• [Int'l Joint Research] Centre for Ecology ＆Hydrology/Oxford University(英国)
• [Int'l Joint Research] Centre for Ecology and Hydrology(英国)
• [Int'l Joint Research] Center for Ecology and Hyrology(英国)
• [Int'l Joint Research] Center for Ecology and Hydrology(英国)
• [Journal Article] Spatiotemporal distribution of veterinary and human drugs and its predictability in Japanese catchments (2023)
  • Author(s): Seiya Hanamoto, Ryoko Yamamoto-Ikemoto, Hiroaki Tanaka
  • Journal Title: Science of The Total Environment Volume: 867 Pages: 161514-161514
  • DOI: 10.1016/j.scitotenv.2023.161514
  • Peer Reviewed
• [Journal Article] Localized pollution of veterinary antibiotics in watersheds receiving treated effluents from swine farms (2023)
  • Author(s): Hanamoto Seiya、Minami Yuki、Hnin Su Su Thet、Yao Dingwen
  • Journal Title: Science of The Total Environment Volume: 902 Pages: 166211-166211
  • DOI: 10.1016/j.scitotenv.2023.166211
  • Peer Reviewed
• [Journal Article] In-stream sorption of azithromycin and levofloxacin in a river receiving sewage treatment plant effluent (2022)
  • Author(s): Hanamoto Seiya、Yamamoto-Ikemoto Ryoko
  • Journal Title: Environmental Pollution Volume: 307 Pages: 119568-119568
  • DOI: 10.1016/j.envpol.2022.119568
  • Peer Reviewed / Open Access
• [Journal Article] Biological Activity-Based Prioritization of Pharmaceuticals in Wastewater for Environmental Monitoring: G Protein-Coupled Receptor Inhibitors (2020)
  • Author(s): Zhang Han、Ihara Mariko O.、Nakada Norihide、Tanaka Hiroaki、Ihara Masaru
  • Journal Title: Environmental Science & Technology Volume: 54 Issue: 3 Pages: 1720-1729
  • DOI: 10.1021/acs.est.9b05768
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Wastewater‐derived antagonistic activities of G protein‐coupled receptor‐acting pharmaceuticals in river water (2020)
  • Author(s): Ihara Masaru、Hanamoto Seiya、Ihara Mariko O.、Zhang Han、Tanaka Hiroaki
  • Journal Title: Journal of Applied Toxicology Volume: 2020 Issue: 7 Pages: 32077112-32077112
  • DOI: 10.1002/jat.3952
  • Peer Reviewed
• [Journal Article] Predicting the sorption of azithromycin and levofloxacin to sediments from mineral and organic components (2019)
  • Author(s): Hanamoto Seiya、Ogawa Fumiaki
  • Journal Title: Environmental Pollution Volume: 255 Pages: 113180-113180
  • DOI: 10.1016/j.envpol.2019.113180
  • Peer Reviewed
• [Journal Article] The different fate of antibiotics in the Thames River, UK, and the Katsura River, Japan (2018)
  • Author(s): Hanamoto, S., Nakada, N., Johnson, AC., Jürgens, MD., Yamashita, N., Tanaka, H.
  • Journal Title: Environmental Science and Pollution Research Volume: 25 Issue: 2 Pages: 1903-1913
  • DOI: 10.1007/s11356-017-0523-z
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Source estimation of pharmaceuticals based on catchment population and in-stream attenuation in Yodo River watershed, Japan (2018)
  • Author(s): Hanamoto, S., Nakada, N., Yamashita, N., Tanaka, H.
  • Journal Title: Science of the Total Environment Volume: 615 Pages: 964-971
  • DOI: 10.1016/j.scitotenv.2017.10.013
  • Peer Reviewed
• [Presentation] Prediction and management of emerging chemicals in the water environment (2023)
  • Author(s): Hiroaki TANAKA, Masaru IHARA, Norihide NAKADA, Han ZHANG, Hiromasa YAMASHITA, Seiya HANAMOTO, Andrew JOHNSON, Monika JORGENS
  • Organizer: The 23rd UK-Japan Annual Scientific Workshop Research into Environmental Endocrine Disrupting Chemicals & Chemicals of Emerging Concern
  • Int'l Joint Research
• [Presentation] Prediction and management of emerging chemicals in the water environment (2022)
  • Author(s): Hiroaki TANAKA, Masaru IHARA, Norihide NAKADA, Han ZHANG，Hiromasa YAMASHITA, Seiya HANAMOTO
  • Organizer: The 24rd UK-Japan Annual Scientific Workshop on Research into Environmental Endocrine Disrupting Chemicals, On-line, 31st, October, 2022.
  • Int'l Joint Research
• [Presentation] 都市河川における陽イオン界面活性剤の存在実態と動態 (2022)
  • Author(s): 花本征也、南雄己
  • Organizer: 第57回日本水環境学会年会、2023年3月15日
• [Presentation] 浅野川における塩基性医薬品の懸濁物質への吸着 (2022)
  • Author(s): 花本征也、池本良子
  • Organizer: 第 5 6 回日本水環 境学会年会
• [Presentation] Prediction and management of emerging chemicals in the water environment (2021)
  • Author(s): Hiroaki TANAKA, Masaru IHARA, Norihide NAKADA, Han ZHANG Hiromasa YAMASHITA, Seiya HANAMOTO
  • Organizer: The 2 3 rd UK Japan Annual Scientific Workshop on Research into Environmental Endocrine Disrupting Chemicals, O n line , 29 th , November, 20 21
• [Presentation] 大淀川における動物用医薬品の通年調査と排出量予測 (2021)
  • Author(s): 花本征也、池本良子
  • Organizer: 第 55 回日本水 環境学会年会、
• [Presentation] Prediction and management of emerging chemicals in the water environment (2020)
  • Author(s): Hiroaki Tanaka, Masaru Ihara , Hiromasa Yamashita, Seiya Hanamoto
  • Organizer: The 22nd UK-Japan Annual Scientific Workshop Research into Environmental Endocrine Disrupting Chemicals & Chemicals of Emerging Concern
  • Int'l Joint Research
• [Presentation] Prediction and management of emerging chemicals in the water environment (2019)
  • Author(s): Hiroaki TANAKA, Masaru IHARA, Norihide NAKADA, Han ZHANG，Hiromasa YAMASHITA, Seiya HANAMOTO
  • Organizer: The 21th UK-Japan Annual Scientific Workshop on Research into Environmental Endocrine Disrupting Chemicals, Otsu, Japan, 12th, November, 2019.
  • Int'l Joint Research
• [Presentation] Modelling the Sorption of Quinolone Antibiotic Levofloxacin on Sediments (2019)
  • Author(s): Hanamoto Seiya, Ogawa Fumiaki
  • Organizer: Water and Environmental Technology Conference 2019, Osaka, Japan, 2019 年7 月13 日
  • Int'l Joint Research
• [Presentation] Modelling the sorption of macrolide antibiotic azithromycin on sediments (2019)
  • Author(s): Hanamoto Seiya, Ogawa Fumiaki.
  • Organizer: 11th Micropol & Ecohazard Conference 2019, Seoul, Korea, 2019 年10 月21 日
  • Int'l Joint Research
• [Presentation] Detection of biological 20 activity of antidepressants in wastewater treatment plant effluents in Japan and UK using in vitro assay (2019)
  • Author(s): Daisuke Kato, Mariko Ihara, Han Zhang, Hiroaki Tanaka, Masaru Ihara
  • Organizer: The 21th UK-Japan Annual Scientific Workshop on Research into Environmental Endocrine Disrupting Chemicals, Otsu, Japan, 12th, November, 2019
  • Int'l Joint Research
• [Presentation] In vitro アッセイによる日本およびイギ リスの下水放流水中の抗うつ薬様活性の検出 (2019)
  • Author(s): 加藤大典、Zhang Han、井原満理子、田中宏明、井原賢
  • Organizer: 第22 回環境ホルモン学会研究発表会、 2019 年12 月12 日、要旨集p55.
• [Presentation] Biological-activity-based prioritization of pharmaceuticals in wastewater in Japan and England (2019)
  • Author(s): Han Zhang, Masaru Ihara, Hiroaki Tanaka
  • Organizer: 第22 回環境ホルモン学会研究発表 会、2019 年12 月12 日、要旨集p64.
• [Presentation] Prediction and management of emerging chemicals in the water environment (2018)
  • Author(s): Hiroaki TANAKA, Masaru IHARA, Norihide NAKADA, Han ZHANG, Fumiaki OGAWA, Seiya HANAMOTO, Andrew JOHNSON, Monika JURGENS
  • Organizer: The 20th UK-Japan Annual Scientific Workshop on Research into Environmental Endocrine Disrupting Chemicals
  • Int'l Joint Research
• [Book] ,Attenuation and fate of pharmaceuticals in river environments. in: Manish KumarFrancisco Munoz-ArriolaHiroaki FurumaiTushara Chaminda:resilience, response, and risk in water systems. (2020)
  • Author(s): Hanamoto, S.
  • Publisher: Springer-Link
  • ISBN: 9789811546686