| Outline of Final Research Achievements |
We developed a novel and comprehensive approach to evaluate intracranial condition by integrating biomechanical and hydrodynamic properties of the brain. Our method combines data from two MRI techniques: fluctuation MRI, which provides insights into biomechanical property, perfusion, and cellular structure of the brain, and phase-contrast MRI, which assesses intracranial pressure and compliance. This innovative approach eliminates the need for contrast agents or specialized pulse sequences, making it a potentially valuable non-invasive diagnostic tool. Our method may contribute to a better understanding of the pathophysiology of diseases that alter brain biomechanics and hydrodynamics, e.g., brain tumors, and has the potential for clinical application.
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