Drug-diagnostic co-development in Tropical Medicine, combating Human African Trypanosomiasis
| Project/Area Number |
18KK0454
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| Research Category |
Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
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| Allocation Type | Multi-year Fund |
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| Research Field |
Parasitology (including sanitary zoology)
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| Research Institution | Osaka City University |
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Principal Investigator |
Kido Yasutoshi 大阪市立大学, 大学院医学研究科, 准教授 (90511395)
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| Project Period (FY) |
2019 – 2021
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
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| Keywords | トリパノソーマ症 / 顧みられない熱帯病 / アフリカトリパノソーマ症 / ヒトアフリカトリパノソーマ症 / 人獣共通感染症 / アフリカ睡眠病 / アスコフラノン / シアン耐性酸素呼吸 / 中枢神経感染動物モデル / 分子マーカー探索 / 薬剤開発 / 熱帯感染症（マラリア、エボラ出血熱） / トランスレーショナルリサーチ |
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| Outline of Final Research Achievements |
We have succeeded in establishing an animal model that mimics the human chronic phase of human African trypanosomiasis, which is one of the Neglected Tropical Diseases that human beings should control. In therapeutic experiments with Ascofuranone and its derivatives, AF was effective even in the chronic model using clinical isolates. Furthermore, it has been known that AF is sensitized in the presence of glycerol, clarifying that glycerol increased the sensitivity by changing protozoan energy metabolism.
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| Academic Significance and Societal Importance of the Research Achievements |
人類が制圧すべき感染症の1つであるヒトアフリカトリパノソーマ症のヒト慢性期疾患に対する新規医薬品候補を見出した。本研究は、流行地である海外でのみ実施可能な研究であり、新規医薬品候補の報告は、今後の感染症対策にとって重要な一歩となる。また、本研究の遂行には、日本とコンゴ民主共和国の両国の若手研究者が多く従事した。感染流行に即応できる研究者育成にも貢献することとなった。
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Therapeutic targeting of mitochondrial ROS ameliorates murine model of volume overload cardiomyopathy.2019
Author(s)
Okamura K, Nakagama Y, Takeda N, Soma K, Sato T, Isagawa T, Kido Y, Sakamoto M, Manabe I, Hirata Y, Komuro I, Ono M
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Journal Title
Journal of Pharmacological Sciences
Volume: 141
Issue: 1
Pages: 56-63
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Characterization of a novel Helicobacter pylori East Asian-type CagA ELISA for detecting patients infected with various cagA genotypes2019
Author(s)
Doohan D, Miftahussurur M, Matsuo Y, Kido Y, Akada J, Matsuhisa T, Yee TT, Htet K, Aftab H, Vilaichone RK, Mahachai V, Ratanachu-Ek T, Tshering L, Waskito LA, Fauzia KA, Uchida T, Syam AF, Rezkitha YAA, Yamaoka Y
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Journal Title
Med Microbiol Immunol
Volume: 209(1)
Pages: 29-40
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Discovery of trypanocidal coumarins with dual inhibition of both the glycerol kinase and alternative oxidase of Trypanosoma brucei brucei.2019
Author(s)
Balogun EO, Inaoka DK, Shiba T, Tsuge C, May B, Sato T, Kido Y, Nara T, Aoki T, Honma T, Tanaka A, Inoue M, Matsuoka S, Michels PAM, Watanabe YI, Moore AL, Harada S, Kita K.
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Journal Title
FASEB J
Volume: 33
Issue: 11
Pages: 13002-13013
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] シアン耐性呼吸を標的とした抗トリパノソーマ症薬の早期臨床開発計画2021
Author(s)
加来 奈津子, 中釜 悠, 仁田原 裕子, 道向 優, 稲岡 健ダニエル, 山本 雅一, 斎本 博之, 上村 尚人, 金子 明, 北 潔, 城戸 康年
Organizer
日本寄生虫学会・日本臨床寄生虫学会合同大会
Related Report
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