| Outline of Final Research Achievements |
An obesity is related to the ineffectiveness of leptin, i.e; the formation of leptin resistance. We have revealed that endoplasmic reticulum stress is involved in the cause of leptin resistance. In this study, we investigated the mechanism of leptin resistance. As a result, IRE1α, one of the endoplasmic reticulum stress sensor proteins, interacted with the OB-R leptin receptor and affected leptin signaling. On the other hand, glial derived factor, released during endoplasmic reticulum stress/chronic inflammation, induced leptin resistance by acting on the downstream pathway of leptin signaling without affecting OB-R leptin receptor activity.
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