Development of Statistical Methods for Life Course Approaches Applied to Environmental Epidemiology

• Project/Area Number: 18KK0466
• Research Category: Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine
• Research Institution: Chuo University (2022-2024); Keio University (2018-2021)
• Principal Investigator: Takeuchi Ayano 中央大学, 理工学部, 准教授 (80511196)
• Project Period (FY): 2019 – 2024
• Project Status: Completed (Fiscal Year 2024)
• Budget Amount: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
• Keywords: ライフコース疫学 / コホート研究 / 時間依存性交絡 / 疫学統計学 / 生物統計 / 因果効果推定

Outline of Research at the Start

本研究では、環境化学物質のように成長発達段階における特定の時期の曝露や複合的・経時的な曝露の影響が問題となるようなリスク因子の健康影響を定量することを目指す疫学研究のための生物統計学的手法の開発を実施する。
手法の開発は大きく3つに分けて実施する．①経時的なリスク因子への曝露が測定
されている場合②疾患状態が連続的に評価され，曝露と疾患状態が互いに影響しあっ
て推移する場合に③曝露状態が経時的に変化する場合
これらについて、数値実験（シミュレーション研究）と実データ解析の両方を実施することで，統計学的な性質の確認および議論と，実データ適用による応用可能性や公衆衛生学的なメッセージを同時に発信していく。

Outline of Final Research Achievements

The aim of this study was to accelerate the progress of the Basic Research (B) project on life course epidemiology titled “Focused Development and Application of Life Course Statistical Methods for Large-Scale Environmental Epidemiologic Studies.” To achieve this, research activities were conducted at two major international sites. The first was the International Childhood Cancer Cohort Consortium (I4C) in the United Kingdom, and the second was the Multiethnic Cohort Study (MEC) in the United States.
Through partial access to data and discussions with researchers at both sites, this study explored the applicability of G-methods, Latent Growth Modeling, and Marginal Structural Modeling to situations involving time-dependent exposures and repeatedly measured outcomes. Simulation studies and applications using actual data were also conducted.

Academic Significance and Societal Importance of the Research Achievements

本研究では、ライフコース疫学に関する基盤研究（B）研究「大規模環境疫学研究のためのライフコース統計解析手法の重点的開発と実データ適用」を加速させることを目的とし、英国・米国2拠点の大規模疫学調査の実施主体に滞在して一部データへのアクセスおよび研究関係者との議論を通じて、時間依存性曝露及び反復測定アウトカムが生じる状況に対する統計解析手法のまとめ及び適用を実施した。具体的にはG-methods、Latent Growth Modeling、Marginal Structural Modelingの可能性を探索し、シミュレーション研究及び実データ適用を実施した。

Research Products

• [Int'l Joint Research] University of Cambridge(英国) (2020)
  • Year and Date: 2020-09-30
• [Journal Article] Study Profile of the Tsuruoka Metabolomics Cohort Study (TMCS) (2024)
  • Author(s): Harada S, Iida M, Miyagawa N, Hirata A, Kuwabara K, Matsumoto M, Okamura T,...Hirayama A, Ishikawa T, Saito R, Sato A, Soga T, Sugimoto M, Tomita M, Komaki S, Ohmomo H, Ono K, Otsuka-Yamasaki Y, Shimizu A, Sutoh Y, Hozawa A, Kinoshita K, Koshiba S, Kumada K, Ogishima S, Sakurai-Yageta M, Tamiya G, Takebayashi T.
  • Journal Title: Journal of Epidemiology Volume: 34 Issue: 8 Pages: 393-401
  • DOI: 10.2188/jea.JE20230192
  • ISSN: 0917-5040, 1349-9092
  • Year and Date: 2024-08-05
  • Peer Reviewed / Open Access
• [Journal Article] Association of longitudinal pet ownership with wheezing in 3-year-old children using the distributed lag model: the Japan Environment and Children’s Study (2024)
  • Author(s): Shirato Kota、Oba Koji、Matsuyama Yutaka、Hagiwara Yasuhiro、The Japan Environment and Children’s Study (JECS) Group
  • Journal Title: Environmental Health Volume: 23 Issue: 1 Pages: 53-53
  • DOI: 10.1186/s12940-024-01087-x
  • Peer Reviewed
• [Journal Article] Optimal Machine Learning Models for Developing Prognostic Predictions in Patients With Advanced Cancer (2024)
  • Author(s): Hamano Jun、Takeuchi Ayano、Keyaki Tomoya、Nose Hidemasa、Hayashi Kenichi
  • Journal Title: Cureus Volume: -
  • DOI: 10.7759/cureus.76227
  • Peer Reviewed / Open Access
• [Journal Article] Applying a Motivational Instructional Design Model to Stroke Rehabilitation: A Feasibility Study on Occupational and Swallowing Therapies (2024)
  • Author(s): Oyake Kazuaki、Watanabe Shota、Takeuchi Ayano、Yoshida Taiki、Shigematsu Takashi、Natsume Yuuki、Tsuzuku Shigeki、Kondo Kunitsugu、Fujishima Ichiro、Otaka Yohei、Tanaka Satoshi
  • Journal Title: Archives of Rehabilitation Research and Clinical Translation Volume: 6 Issue: 3 Pages: 100344-100344
  • DOI: 10.1016/j.arrct.2024.100344
• [Journal Article] Evaluation of Medication Adherence Among Prevalent Users in Hypertension, Dyslipidemia, and Diabetes Using Health Insurance Claims: A Population-Based Cohort Study in Japan (2024)
  • Author(s): Matsumoto M.Harada S.Ikuta H.Iida M.Kato S.Sata M.Shibuki T.Ishibashi Y.Miyagawa N.Hisamatsu M.Hirata A.Kuwabara K.Takeuchi A.Sugiyama D.Suzuki S.Nakamura T.Okamura T.Takebayashi T
  • Journal Title: Pharmacoepidemiology and Drug Safety Volume: 33(8) Issue: 8
  • DOI: 10.1002/pds.5855
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of medication adherence in hypertension, dyslipidemia, and diabetes using health insurance claims: a population-based cohort study in Japan (2024)
  • Author(s): Matsumoto Minako、Harada Sei、Ikuta Harufumi、Iida Miho、Kato Suzuka、Sata Mizuki、Takuma Shibuki、Ishibashi Yoshiki、Miyagawa Naoko、Hisamatsu Moeko、Hirata Aya、Kuwabara Kazuyo、Takeuchi Ayano、Sugiyama Daisuke、Suzuki Sayo、Nakamura Tomonori、Okamura Tomonori、Takebayashi Toru
  • Journal Title: Motivational Design for Rehabilitation Volume: ‐
  • DOI: 10.22541/au.170995066.61253851/v1
• [Journal Article] Applying a Motivational Instructional Design Model to Stroke Rehabilitation: A Feasibility Study in Occupational Therapy and Swallowing Therapy Settings (2024)
  • Author(s): Oyake Kazuaki、Watanabe Shota、Takeuchi Ayano、Yoshida Taiki、Shigematsu Takashi、Natsume Yuuki、Tsuzuku Shigeki、Kondo Kunitsugu、Fujishima Ichiro、Otaka Yohei、Tanaka Satoshi
  • Journal Title: Archives of Rehabilitation Research and Clinical Translation Volume: ‐
  • DOI: 10.1101/2024.01.10.24301094
  • Open Access
• [Journal Article] Comparison of survival times of advanced cancer patients with palliative care at home and in hospital (2023)
  • Author(s): Hamano Jun、Takeuchi Ayano、Mori Masanori、Saitou Yasuhiro、Yamaguchi Takahide、Miyata Nobuyuki、Shimizu Masakatsu、Yamamoto Ryo、Kimura Yousuke、Kamiyama Yoshiyuki、Arai Yasuyuki、Matsuo Hiroshi、Shishido Hideki、Nakano Kazushi、Yokomichi Naosuke、Maeda Isseki、Yamaguchi Takashi、Morita Tatsuya
  • Journal Title: PLOS ONE Volume: 18 Issue: 4 Pages: e0284147-e0284147
  • DOI: 10.1371/journal.pone.0284147
  • Peer Reviewed / Open Access
• [Journal Article] Changes in Smoking Habits and Behaviors Following the Introduction and Spread of Heated Tobacco Products in Japan and Its Effect on FEV₁ Decline: A Longitudinal Cohort Study (2022)
  • Author(s): Harada Sei、Sata Mizuki、Matsumoto Minako、Iida Miho、Takeuchi Ayano、Kato Suzuka、Hirata Aya、Kuwabara Kazuyo、Shibuki Takuma、Ishibashi Yoshiki、Sugiyama Daisuke、Okamura Tomonori、Takebayashi Toru
  • Journal Title: Journal of Epidemiology Volume: 32 Issue: 4 Pages: 180-187
  • DOI: 10.2188/jea.JE20210075
  • NAID: 130008104930
  • ISSN: 0917-5040, 1349-9092
  • Year and Date: 2022-04-05
  • Peer Reviewed / Open Access
• [Journal Article] Effects of maternal exposure to lead on secondary sex ratio in Japan: The Japan Environment and Children’s Study (2022)
  • Author(s): Tatsuta Nozomi、Nakai Kunihiko、Nakayama Shoji F.、Takeuchi Ayano、Arima Takahiro、Yaegashi Nobuo、Kamijima Michihiro、Yamazaki Shin、Ohya Yukihiro、Kishi Reiko、Hashimoto Koichi、Mori Chisato、Ito Shuichi、Yamagata Zentaro、Inadera Hidekuni、Nakayama Takeo、Iso Hiroyasu、Shima Masayuki、Kurozawa Youichi
  • Journal Title: Science of The Total Environment Volume: 817 Pages: 152726-152726
  • DOI: 10.1016/j.scitotenv.2021.152726
  • Peer Reviewed / Open Access
• [Journal Article] Accumulated unhealthy behaviours and insomnia in Japanese dwellers with and without cardiovascular risk factors: a cross-sectional study (2022)
  • Author(s): Kato Suzuka、Harada Sei、Iida Miho、Kuwabara Kazuyo、Sugiyama Daisuke、Takeuchi Ayano、Sata Mizuki、Matsumoto Minako、Kurihara Ayako、Hirata Aya、Okamura Tomonori、Takebayashi Toru
  • Journal Title: BMJ Open Volume: 12 Issue: 4 Pages: e052787-e052787
  • DOI: 10.1136/bmjopen-2021-052787
  • Peer Reviewed / Open Access
• [Journal Article] Metabolic profiling of charged metabolites in association with menopausal status in Japanese community-dwelling midlife women: Tsuruoka Metabolomic Cohort Study. (2022)
  • Author(s): Watanabe K, Iida M, Harada S, Kato S, Kuwabara K, Kurihara A, Takeuchi A, Sugiyama D, Okamura T, Suzuki A, Amano K, Hirayama A, Sugimoto M, Soga T, Tomita M, Kobayashi Y, Banno K, Aoki D, Takebayashi T.
  • Journal Title: Maturitas Volume: 155 Pages: 54-62
  • DOI: 10.1016/j.maturitas.2021.10.004
  • Peer Reviewed / Open Access
• [Journal Article] Exposure to PM_2.5 and Lung Function Growth in Pre- and Early-Adolescent Schoolchildren: A Longitudinal Study Involving Repeated Lung Function Measurements in Japan (2022)
  • Author(s): Takebayashi Toru、Taguri Masataka、Odajima Hiroshi、Hasegawa Shuichi、Asakura Keiko、Milojevic Ai、Takeuchi Ayano、Konno Satoshi、Morikawa Miki、Tsukahara Teruomi、Ueda Kayo、Mukai Yasufumi、Minami Mihoko、Nishiwaki Yuuji、Yoshimura Takesumi、Nishimura Masaharu、Nitta Hiroshi
  • Journal Title: Annals of the American Thoracic Society Volume: 19 Issue: 5 Pages: 763-772
  • DOI: 10.1513/annalsats.202104-511oc
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association of the Estimated Coronary Artery Incidence Risk According to the Japan Atherosclerosis Society Guidelines 2017 with Cardio-Ankle Vascular Index (2021)
  • Author(s): Sata Mizuki、Okamura Tomonori、Harada Sei、Sugiyama Daisuke、Kuwabara Kazuyo、Hirata Aya、Takeuchi Ayano、Iida Miho、Kato Suzuka、Matsumoto Minako、Kurihara Ayako、Takebayashi Toru
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 28 Issue: 12 Pages: 1266-1274
  • DOI: 10.5551/jat.58719
  • NAID: 130008123360
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2021-12-01
  • Peer Reviewed / Open Access
• [Journal Article] Validity Assessment of Self-reported Medication Use for Hypertension, Diabetes, and Dyslipidemia in a Pharmacoepidemiologic Study by Comparison With Health Insurance Claims (2021)
  • Author(s): Matsumoto Minako、Harada Sei、Iida Miho、Kato Suzuka、Sata Mizuki、Hirata Aya、Kuwabara Kazuyo、Takeuchi Ayano、Sugiyama Daisuke、Okamura Tomonori、Takebayashi Toru
  • Journal Title: Journal of Epidemiology Volume: 31 Issue: 9 Pages: 495-502
  • DOI: 10.2188/jea.JE20200089
  • NAID: 130008084668
  • ISSN: 0917-5040, 1349-9092
  • Year and Date: 2021-09-05
  • Peer Reviewed / Open Access
• [Journal Article] Long-Term Exposure to Particulate Matter and Mortality from Cardiovascular Diseases in Japan: The Ibaraki Prefectural Health Study (IPHS) (2021)
  • Author(s): Takeuchi Ayano、Nishiwaki Yuji、Okamura Tomonori、Milojevic Ai、Ueda Kayo、Asakura Keiko、Takebayashi Toru、Hasegawa Shuichi、Sairenchi Toshimi、Irie Fujiko、Ota Hitoshi、Nitta Hiroshi
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 28 Issue: 3 Pages: 230-240
  • DOI: 10.5551/jat.54148
  • NAID: 130007993131
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2021-03-01
• [Journal Article] Reliability of urinary charged metabolite concentrations in a large-scale cohort study using capillary electrophoresis-mass spectrometry (2021)
  • Author(s): Ishibashi Yoshiki、Harada Sei、Takeuchi Ayano、Iida Miho、Kurihara Ayako、Kato Suzuka、Kuwabara Kazuyo、Hirata Aya、Shibuki Takuma、Okamura Tomonori、Sugiyama Daisuke、Sato Asako、Amano Kaori、Hirayama Akiyoshi、Sugimoto Masahiro、Soga Tomoyoshi、Tomita Masaru、Takebayashi Toru
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 7407-7407
  • DOI: 10.1038/s41598-021-86600-9
  • Peer Reviewed / Open Access
• [Journal Article] Effect of Asian dust on respiratory symptoms among children with and without asthma, and their sensitivity (2021)
  • Author(s): Hasunuma Hideki、Takeuchi Ayano、Ono Rintaro、Amimoto Yuko、Hwang Yoon Ha、Uno Itsushi、Shimizu Atsushi、Nishiwaki Yuji、Hashizume Masahiro、Askew David J.、Odajima Hiroshi
  • Journal Title: Science of The Total Environment Volume: 753 Pages: 141585-141585
  • DOI: 10.1016/j.scitotenv.2020.141585
  • Peer Reviewed / Open Access
• [Journal Article] Risk of bladder cancer in male Japanese workers exposed to ortho-toluidine and other aromatic amines (2021)
  • Author(s): Nakano Makiko、Shinagawa Takafumi、Eitaki Yoko、Omae Kazuyuki、Takeuchi Ayano、Iwasawa Satoko、Fukai Kota、Yoshioka Noriyuki、Tanaka Shigeru、Koda Shigeki、Sobue Tomotaka、Takebayashi Toru
  • Journal Title: International Archives of Occupational and Environmental Health Volume: - Issue: 6 Pages: 1427-1439
  • DOI: 10.1007/s00420-021-01658-2
  • Peer Reviewed / Open Access
• [Journal Article] Association between Asian dust exposure and respiratory function in children with bronchial asthma in Nagasaki Prefecture, Japan (2020)
  • Author(s): Nakamura Takahiro、Nishiwaki Yuji、Hashimoto Kunio、Takeuchi Ayano、Kitajima Tasuku、Komori Kazuhiro、Tashiro Kasumi、Hasunuma Hideki、Ueda Kayo、Shimizu Atsushi、Odajima Hiroshi、Moriuchi Hiroyuki、Hashizume Masahiro
  • Journal Title: Environmental Health and Preventive Medicine Volume: 25 Issue: 1
  • DOI: 10.1186/s12199-020-00846-9
  • NAID: 120006823920
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Impact of Tobacco Smoking on Outcomes After Posterior Decompression Surgery in Patients With Cervical Spondylotic Myelopathy (2020)
  • Author(s): Nagoshi Narihito、Kono Hitoshi、Tsuji Osahiko、Aoyama Ryoma、Fujiyoshi Kanehiro、Shiono Yuta、Ishikawa Masayuki、Daimon Kenshi、Hosogane Naobumi、Takeuchi Ayano、Okada Eijiro、Fujita Nobuyuki、Yagi Mitsuru、Nakamura Masaya、Matsumoto Morio、Watanabe Kota、Ishii Ken、Yamane Junichi
  • Journal Title: Clinical Spine Surgery: A Spine Publication Volume: 33 Issue: 10 Pages: E493-E498
  • DOI: 10.1097/bsd.0000000000000984
  • Peer Reviewed
• [Journal Article] Pre-hepatectomy type IV collagen 7S predicts post-hepatectomy liver failure and recovery (2020)
  • Author(s): Ishii Masatsugu、Itano Osamu、Shinoda Masahiro、Kitago Minoru、Abe Yuta、Hibi Taizo、Yagi Hiroshi、Takeuchi Ayano、Tsujikawa Hanako、Abe Tokiya、Kitagawa Yuko
  • Journal Title: World Journal of Gastroenterology Volume: 26 Issue: 7 Pages: 725-739
  • DOI: 10.3748/wjg.v26.i7.725
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The association between gestational use of personal care products and neonatal urological abnormality at birth: The Japan Environment and Children’s Study (2020)
  • Author(s): Nishihama Yukiko、Tatsuta Nozomi、Iwai-Shimada Miyuki、Nakai Kunihiko、Arima Takahiro、Fujiwara Ikuma、Yaegashi Nobuo、Takeuchi Ayano、Nakayama Shoji F.
  • Journal Title: Reproductive Toxicology Volume: 93 Pages: 83-88
  • DOI: 10.1016/j.reprotox.2020.01.005
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Association of blood cadmium levels in pregnant women with infant birth size and small for gestational age infants: The Japan Environment and Children's study (2020)
  • Author(s): Inadera Hidekuni、Takamori Ayako、Matsumura Kenta、Tsuchida Akiko、Cui Zheng-Guo、Hamazaki Kei、Tanaka Tomomi、Ito Mika、Kigawa Mika、Origasa Hideki、Michikawa Takehiro、Nakayama Shoji F.、Isobe Tomohiko、Takeuchi Ayano、Sato Tosiya、Nitta Hiroshi、Yamazaki Shin
  • Journal Title: Environmental Research Volume: 191 Pages: 110007-110007
  • DOI: 10.1016/j.envres.2020.110007
  • Peer Reviewed
• [Journal Article] Non-GABA sleep medications, suvorexant as risk factors for falls: Case-control and case-crossover study (2020)
  • Author(s): Ishibashi Yoshiki、Nishitani Rie、Shimura Akiyoshi、Takeuchi Ayano、Touko Mamoru、Kato Takashi、Chiba Sahoko、Ashidate Keiko、Ishiwata Nobuo、Ichijo Tomoyasu、Sasabe Masataka
  • Journal Title: PLOS ONE Volume: 15 Issue: 9 Pages: e0238723-e0238723
  • DOI: 10.1371/journal.pone.0238723
  • Peer Reviewed
• [Journal Article] Control of a Nosocomial Outbreak of COVID-19 in a University Hospital (2020)
  • Author(s): Harada Sei、Uno Shunsuke、Ando Takayuki、Iida Miho、Takano Yaoko、Ishibashi Yoshiki、Uwamino Yoshifumi、Nishimura Tomoyasu、Takeda Ayano、Uchida Sho、Hirata Aya、Sata Mizuki、Matsumoto Minako、Takeuchi Ayano et al
  • Journal Title: Open Forum Infectious Diseases Volume: 7 Issue: 12
  • DOI: 10.1093/ofid/ofaa512
  • Peer Reviewed / Open Access
• [Presentation] Comparing palliative care survival time at home versus in hospital (2024)
  • Author(s): Hidemasa Nose, Ayano Takeuchi
  • Organizer: American Statistical Association Joint Statistical Meeting 2023
  • Int'l Joint Research
• [Presentation] Multi-trajectory modeling approach to prognosis in cancer patients (2024)
  • Author(s): Keita Sugizaki, Ayano Takeuchi
  • Organizer: International Biometric Conference 2024
  • Int'l Joint Research
• [Presentation] Considerations for multiple imputation of exposure with missing observations, followed by propensity score and survival analyses. (2023)
  • Author(s): Ayano Takeuchi, Hidemasa Nose
  • Organizer: American Statistical Association The Joint Statistical Meetings
  • Int'l Joint Research
• [Presentation] Consideration of appropriate analyzing methods for incomplete data (2023)
  • Author(s): Mirai Anzai, Ayano Takeuchi
  • Organizer: American Statistical Association The Joint Statistical Meetings（国際学会）
  • Int'l Joint Research
• [Presentation] シフトガンマフレイルティモデルを伴う加速時間治癒モデルとその疫学研究への応用． (2020)
  • Author(s): 会田晴郎、林賢一、竹内文乃、岡村智教
  • Organizer: 2020年度統計関連学会連合大会
• [Presentation] Apply Joint model to life course epidemiological data -birth cohort in Japan-. (2020)
  • Author(s): Takeuchi A, Narita M, Yamamoto K, Ohya Y.
  • Organizer: 41st Annual Conference of International Society for Clinical Biostatistics.
  • Int'l Joint Research