Project/Area Number |
18KT0018
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Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Multi-year Fund |
Section | 特設分野 |
Research Field |
Complex Systems Disease Theory
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Research Institution | National Rehabilitation Center for Persons with Disabilities |
Principal Investigator |
Shinohara Masahiro 国立障害者リハビリテーションセンター(研究所), 研究所 運動機能系障害研究部, 研究室長 (60345733)
|
Co-Investigator(Kenkyū-buntansha) |
味八木 茂 広島大学, 病院(医), 講師 (10392490)
岩見 真吾 九州大学, 理学研究院, 准教授 (90518119)
野下 浩司 九州大学, 理学研究院, 助教 (10758494)
|
Project Period (FY) |
2018-07-18 – 2021-03-31
|
Project Status |
Completed (Fiscal Year 2020)
|
Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2020: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2019: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2018: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
|
Keywords | 骨粗鬆症 / 変形性関節症 / 血中マーカー / 数理モデル / 画像解析 / 骨代謝マーカー / 予測シミュレーション / 数理シミュレーション / 骨代謝 / 軟骨代謝 / シミュレーション |
Outline of Final Research Achievements |
Bone and cartilage tissues have central roles in daily activities, and diseases associated with a destruction of these tissues such as osteoporosis or osteoarthritis lead to deterioration of daily activity or quality of life. In this study, we established a multidiscipline research team of bone and cartilage researchers with researchers in mathematical science, and developed a basis of epoch-making systems that make prediction of disease onset and early diagnosis possible by analyzing changes over time of serum markers or tissue microstructures.
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Academic Significance and Societal Importance of the Research Achievements |
本研究成果をさらに発展させることにより、血液検査や骨密度測定、CT画像といった低侵襲・非侵襲の簡易的な検査から疾患の予防や早期治療が実現する。例えば、骨・軟骨代謝マーカーを利用するシステムからは、定期健康診断による定期的なマーカー測定を行うことによりマーカー変動値から将来の骨・軟骨破壊の進行具合が予測することが可能となるため、疾患発症前にアラートを出すことで予防や早期治療が可能となる。本研究成果は将来的な要介護者数を減少させ、喫緊の社会的な要請に答えるシステムの構築・提供が可能になる。
|
Report
(4 results)
Research Products
(12 results)
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[Journal Article] Histological scoring system for subchondral bone changes in murine models of joint aging and osteoarthritis2020
Author(s)
Nagira Keita, Ikuta Yasunari, Shinohara Masahiro, Sanada Yohei, Omoto Takenori, Kanaya Haruhisa, Nakasa Tomoyuki, Ishikawa Masakazu, Adachi Nobuo, Miyaki Shigeru, Lotz Martin
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Journal Title
Scientific Reports
Volume: 10
Issue: 1
Pages: 10077-10077
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Mechanical regulation underlies effects of exercise on serotonin-induced signaling in the prefrontal cortex neurons.2020
Author(s)
Ryu Y, Maekawa T, Yoshino D, Sakitani N, Takashima A, Inoue T, Suzurikawa J, Toyohara J, Tago T, Fujita N, Sawada K, Murase S, Watanave M, Sakai T, Yoshikawa Y, Ogata T, Shinohara M, Nagao M, Sawada Y
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Journal Title
iScience
Volume: 23
Issue: 2
Pages: 100874-100874
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Mechanical regulation of bone homeostasis through p130Cas-mediated alleviation of NF-κB activity.2019
Author(s)
Miyazaki T, Zhao Z, Ichihara Y, Yoshino D, Imamura T, Sawada K, Hayano S, Kamioka H, Mori S, Hirata H, Araki K, Kawauchi K, Shigemoto K, Tanaka S, Bonewald LF, Honda H, Shinohara M, Nagao M, Ogata T, Harada I, Sawada Y
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Journal Title
Sci Adv
Volume: 5
Issue: 9
Pages: 7802-7802
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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