The integrated multi-omics analysis of nontuberculous mycobacteria using neural network algorithms to construct a predictive model of the pathological features

• Project/Area Number: 18KT0019
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Multi-year Fund
• Section: 特設分野
• Research Field: Complex Systems Disease Theory
• Research Institution: Niigata University
• Principal Investigator: Kikuchi Toshiaki 新潟大学, 医歯学系, 教授 (10280926)
• Co-Investigator(Kenkyū-buntansha): 阿部 貴志 新潟大学, 自然科学系, 教授 (30390628)
• Project Period (FY): 2018-07-18 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000); Fiscal Year 2020: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2019: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000); Fiscal Year 2018: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
• Keywords: 非結核性抗酸菌 / サイトカイン / 機械学習 / オミックス解析 / 一括学習型自己組織化マップ / 深層学習

Outline of Final Research Achievements

Nontuberculous mycobacteria (NTM) are widely distributed in the environment, and the environmental exposures cause chronic pulmonary infection due to NTM. A clinical problem for the NTM pulmonary disease is that classification of pathological states is uncertain. To address the issue, in this study, we analyzed the clinical courses of patients with NTM pulmonary disease together with the pathogenic mycobacteria, and have developed a mathematical model for predicting the type of pathological states on the basis of the pathogenic mycobacteria. This research accomplishment is anticipated to help us understand clinical classification and its characteristics of the NTM pulmonary disease.

Academic Significance and Societal Importance of the Research Achievements

浴室や土壌に広く生息している非結核性抗酸菌 (NTM)を吸入することによって、慢性呼吸器感染症であるNTM症を発症する。近年中高年女性を中心に、NTM症患者の増加が指摘されている。その病態は不明な点が多く、診療上の課題となっている。本研究では、NTM症の起因菌からその病態を予想できる数理モデルを開発した。本研究成果によって、NTM症の診療をより円滑に行えるようになることが期待される。

Research Products

• [Journal Article] Clinical Aspects of Pulmonary Nontuberculous Mycobacteriosis (2022)
  • Author(s): Moro H, Kikuchi T.
  • Journal Title: Internal Medicine Volume: 61 Issue: 1 Pages: 23-27
  • DOI: 10.2169/internalmedicine.4361-19
  • NAID: 130008139078
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2022-01-01
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic significance of procalcitonin in small cell lung cancer. (2022)
  • Author(s): Ichikawa K, Watanabe S, Miura S, Ohtsubo A, Shoji S, Nozaki K, Tanaka T, Saida Y, Kondo R, Hokari S, Aoki N, Ohshima Y, Koya T, Kikuchi T.
  • Journal Title: Transl Lung Cancer Res. Volume: 11 Issue: 1 Pages: 43-52
  • DOI: 10.21037/tlcr-21-838
  • Peer Reviewed / Open Access
• [Journal Article] STAT3 inhibition suppresses adaptive survival of ALK-rearranged lung cancer cells through transcriptional modulation of apoptosis. (2022)
  • Author(s): Yanagimura N, Takeuchi S, Fukuda K, Arai S, Tanimoto A, Nishiyama A, Ogo N, Takahashi H, Asai A, Watanabe S, Kikuchi T, Yano S.
  • Journal Title: NPJ Precis Oncol Volume: 6 Issue: 1 Pages: 11-11
  • DOI: 10.1038/s41698-022-00254-y
  • Peer Reviewed / Open Access
• [Journal Article] Effect of Dupilumab on Depression in Asthma with Eosinophilic Chronic Rhinosinusitis in the Japanese Population. (2022)
  • Author(s): Koya T, Sakai N, Sasaki T, Shinbori K, Nagai A, Kimura Y, Toyama M, Hayashi M, Saito A, Nishiyama Y, Hasegawa T, Muramatsu Y, Muramatsu K, Horii A, Kikuchi T.
  • Journal Title: Int Arch Allergy Immunol. Volume: 183 Issue: 3 Pages: 289-297
  • DOI: 10.1159/000519296
  • Peer Reviewed / Open Access
• [Journal Article] Effectiveness of afatinib in an NSCLC patient with EGFR mutation and early progression to osimertinib: a case report. (2022)
  • Author(s): Nozaki K, Watanabe S, Nishio K, Sakai K, Kikuchi T.
  • Journal Title: Transl Cancer Res. Volume: 11 Issue: 1 Pages: 295-298
  • DOI: 10.21037/tcr-21-1850
  • Peer Reviewed / Open Access
• [Journal Article] 呼吸器疾患（気管支喘息・COPD）の心身相関． (2022)
  • Author(s): 真島一郎，菊地利明．
  • Journal Title: 心身医学． Volume: 62 Pages: 29-36
  • Peer Reviewed / Open Access
• [Journal Article] Chronic Hypercapnic Respiratory Failure in an Adult Patient with Silver-Russell Syndrome (2021)
  • Author(s): Hakamata M, Hokari S, Ohshima Y, Kagami M, Saito S, Motoike IN, Abe T, Aoki N, Hayashi M, Watanabe S, Koya T, Kikuchi T.
  • Journal Title: Internal Medicine Volume: 60 Issue: 12 Pages: 1921-1926
  • DOI: 10.2169/internalmedicine.5479-20
  • NAID: 130008052515
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2021-06-15
  • Peer Reviewed / Open Access
• [Journal Article] Disseminated Varicella-zoster Virus Infection Causing Fatal Pneumonia in an Immunocompromised Patient with Chronic Interstitial Pneumonia (2021)
  • Author(s): Ueno H, Hayashi M, Nagumo S, Ichikawa K, Aoki N, Ohshima Y, Watanabe S, Koya T, Abテゥ T, Ohashi R, Ajioka Y, Kikuchi T.
  • Journal Title: Internal Medicine Volume: 60 Issue: 7 Pages: 1077-1082
  • DOI: 10.2169/internalmedicine.5396-20
  • NAID: 130008014362
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2021-04-01
  • Peer Reviewed / Open Access
• [Journal Article] Valuable Insights into the Immune Responses against Coronavirus Disease 2019 (2021)
  • Author(s): Kikuchi T.
  • Journal Title: JMA Journal Volume: 4 Issue: 1 Pages: 61-62
  • DOI: 10.31662/jmaj.2020-0095
  • NAID: 130007987357
  • ISSN: 2433-328X, 2433-3298
  • Year and Date: 2021-01-29
  • Peer Reviewed / Open Access
• [Journal Article] An outbreak of serotype 19A pneumococcal pneumonia in a relief facility in Japan. (2021)
  • Author(s): Nagano K, Kawasaki S, Moro H, Chang B, Bamba Y, Yamamoto A, Morita M, Ohnishi M, Shibata S, Koizumi T, Aoki N, Honma Y, Abe T, Koya T, Aoki N, Kikuchi T.
  • Journal Title: Infect Control Hosp Epidemiol. Volume: - Issue: 12 Pages: 1-3
  • DOI: 10.1017/ice.2021.328
  • Peer Reviewed / Open Access
• [Journal Article] Subsequent systemic therapy for non-small cell lung cancer patients with immune checkpoint inhibitor-related interstitial lung disease. (2021)
  • Author(s): Sato Y, Watanabe S, Ota T, Kushiro K, Fujisaki T, Takahashi M, Ohtsubo A, Shoji S, Nozaki K, Ichikawa K, Hokari S, Kondo R, Hayashi M, Ishikawa H, Miyabayashi T, Abe T, Miura S, Tanaka H, Okajima M, Terada M, Ishida T, Iwashima A, Sato K, Yoshizawa H, Aoki N, Ohshima Y, Koya T, Kikuchi T.
  • Journal Title: Transl Lung Cancer Res. Volume: 10 Issue: 7 Pages: 3132-3143
  • DOI: 10.21037/tlcr-21-198
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy of the new β-D-glucan measurement kit for diagnosing invasive fungal infections, as compared with that of four conventional kits. (2021)
  • Author(s): Bamba Y, Nagano K, Moro H, Ogata H, Hakamata M, Shibata S, Koizumi T, Aoki N, Ohshima Y, Watanabe S, Nakamura T, Kobayashi S, Hoshiyama Y, Koya T, Takada T, Kikuchi T.
  • Journal Title: PLoS One. Volume: 16 Issue: 8 Pages: e0255172-e0255172
  • DOI: 10.1371/journal.pone.0255172
  • Peer Reviewed / Open Access
• [Journal Article] Optogenetic activation of DRN 5-HT neurons induced active wakefulness, not quiet wakefulness. (2021)
  • Author(s): Moriya R, Kanamaru M, Okuma N, Yoshikawa A, Tanaka KF, Hokari S, Ohshima Y, Yamanaka A, Honma M, Onimaru H, Kikuchi T, Izumizaki M.
  • Journal Title: Brain Res Bull. Volume: 177 Pages: 129-142
  • DOI: 10.1016/j.brainresbull.2021.09.019
  • Peer Reviewed / Open Access
• [Journal Article] The Prognostic Significance of the Continuous Administration of Anti-PD-1 Antibody via Continuation or Rechallenge After the Occurrence of Immune-Related Adverse Events. (2021)
  • Author(s): Fujisaki T, Watanabe S, Ota T, Kushiro K, Sato Y, Takahashi M, Ohtsubo A, Shoji S, Nozaki K, Ichikawa K, Hokari S, Kondo R, Miyabayashi T, Abe T, Miura S, Tanaka H, Okajima M, Terada M, Matsumoto N, Ishida T, Iwashima A, Sato K, Yoshizawa H, Aoki N, Hayashi M, Ohshima Y, Koya T, Kikuchi T.
  • Journal Title: Front Oncol. Volume: 11 Pages: 704475-704475
  • DOI: 10.3389/fonc.2021.704475
  • Peer Reviewed / Open Access
• [Journal Article] PD-1 blockade therapy augments the antitumor effects of lymphodepletion and adoptive T cell transfer. (2021)
  • Author(s): Takahashi M, Watanabe S, Suzuki R, Arita M, Sato K, Sato M, Sekiya Y, Abe Y, Fujisaki T, Ohtsubo A, Shoji S, Nozaki K, Ichikawa K, Kondo R, Saida Y, Hokari S, Aoki N, Hayashi M, Ohshima Y, Koya T, Kikuchi T.
  • Journal Title: Cancer Immunol Immunother. Volume: - Issue: 6 Pages: 1357-1369
  • DOI: 10.1007/s00262-021-03078-0
  • Peer Reviewed / Open Access
• [Journal Article] A case of bronchiolitis obliterans after living-donor renal transplantation (2021)
  • Author(s): Hayashi M, Hokari S, Aoki N, Ohshima Y, Watanabe S, Koya T, Tasaki M, Saito K, Kikuchi T.
  • Journal Title: Respir Investig Volume: 59 Issue: 3 Pages: 367-371
  • DOI: 10.1016/j.resinv.2020.12.003
  • Peer Reviewed / Open Access
• [Journal Article] A case of eosinophilic granulomatosis with polyangiitis showing multiple white lichen lesions on the airway mucosa. (2021)
  • Author(s): Kimura Y, Ito R, Hayashi Y, Kazawa T, Endo Y, Iwashima A, Ohshima Y, Watanabe S, Koya T, Kikuchi T.
  • Journal Title: Respir Med Case Rep. Volume: 33 Pages: 101451-101451
  • DOI: 10.1016/j.rmcr.2021.101451
  • Peer Reviewed / Open Access
• [Journal Article] 医療従事者の HIV 感染者受け入れへの不安―HIV 出張研修アンケートからの検討―． (2021)
  • Author(s): 中川雄真，茂呂寛，川口玲，内山正子，新保明日香，三枝祐美，野田順子，鈴木啓記，柴田怜，張仁美，佐藤瑞穂，菊地利明．
  • Journal Title: 日本エイズ学会誌． Volume: 23 Pages: 113-121
  • NAID: 40022695208
  • Peer Reviewed / Open Access
• [Journal Article] A Phase II Study of Osimertinib Combined With Platinum Plus Pemetrexed in Patients With EGFR-Mutated Advanced Non-Small-cell Lung Cancer: The OPAL Study (NEJ032C/LOGIK1801) (2021)
  • Author(s): Asahina H, Tanaka K, Morita S, Maemondo M, Seike M, Okamoto I, Oizumi S, Kagamu H, Takahashi K, Kikuchi T, Isobe T, Sugio K, Kobayashi K.
  • Journal Title: Clin Lung Cancer Volume: 22 Issue: 2 Pages: 147-151
  • DOI: 10.1016/j.cllc.2020.09.023
  • Peer Reviewed / Open Access
• [Journal Article] Clinical manifestations of adult patients requiring influenza-associated hospitalization: A prospective multicenter cohort study in Japan via internet surveillance (2021)
  • Author(s): Ishida T, Seki M, Oishi K, Tateda K, Fujita J, Kadota JI, Kawana A, Izumikawa K, Kikuchi T, Ohmagari N, Yamada M, Maruyama T, Takazono T, Miki M, Miyazaki Y, Yamazaki Y, Kakeya H, Ogawa K, Nagai H, Watanabe A.
  • Journal Title: J Infect Chemother Volume: 27 Issue: 3 Pages: 480-485
  • DOI: 10.1016/j.jiac.2020.10.021
  • Peer Reviewed / Open Access
• [Journal Article] Association between extended-spectrum ホイ-lactamase-producing Escherichia coli and oral third-generation cephalosporins (2021)
  • Author(s): Hosokawa H, Mitsuboshi S, Isobe H, Kobayashi K, Moro H, Kikuchi T.
  • Journal Title: Infect Control Hosp Epidemiol Volume: - Issue: 2 Pages: 261-263
  • DOI: 10.1017/ice.2020.1400
  • Peer Reviewed / Open Access
• [Journal Article] Combination therapy of cisplatin with cilastatin enables an increased dose of cisplatin, enhancing its antitumor effect by suppression of nephrotoxicity (2021)
  • Author(s): Arita M, Watanabe S, Aoki N, Kuwahara S, Suzuki R, Goto S, Abe Y, Takahashi M, Sato M, Hokari S, Ohtsubo A, Shoji S, Nozaki K, Ichikawa K, Kondo R, Hayashi M, Ohshima Y, Kabasawa H, Hosojima M, Koya T, Saito A, Kikuchi T.
  • Journal Title: Sci Rep Volume: 11 Issue: 1 Pages: 750-750
  • DOI: 10.1038/s41598-020-80853-6
  • Peer Reviewed / Open Access
• [Journal Article] A prospective phase II study of multimodal prophylactic treatment for afatinib-induced adverse events in advanced non-small cell lung cancer (Niigata Lung Cancer Treatment Group 1401) (2021)
  • Author(s): Okajima M, Miura S, Watanabe S, Tanaka H, Ito K, Ishida T, Makino M, Iwashima A, Matsumoto N, Sato K, Ichikawa K, Abe T, Yoshizawa H, Kikuchi T.
  • Journal Title: Transl Lung Cancer Res Volume: 10 Issue: 1 Pages: 252-260
  • DOI: 10.21037/tlcr-20-649
  • Peer Reviewed / Open Access
• [Journal Article] ONO-7475, a Novel AXL Inhibitor, Suppresses the Adaptive Resistance to Initial EGFR-TKI Treatment in EGFR-Mutated Non?Small Cell Lung Cancer (2020)
  • Author(s): Okura N, Nishioka N, Yamada T, Taniguchi H, Tanimura K, Katayama Y, Yoshimura A, Watanabe S, Kikuchi T, Shiotsu S, Kitazaki T, Nishiyama A, Iwasaku M, Kaneko Y, Uchino J, Uehara H, Horinaka M, Sakai T, Tanaka K, Kozaki R, Yano S, Takayama K.
  • Journal Title: Clinical Cancer Research Volume: 26 Issue: 9 Pages: 2244-2256
  • DOI: 10.1158/1078-0432.ccr-19-2321
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic significance of the radiologic features of pneumonitis induced by anti‐PD‐1 therapy (2020)
  • Author(s): Watanabe Satoshi、Ota Takeshi、Hayashi Masachika、Ishikawa Hiroyuki、Otsubo Aya、Shoji Satoshi、Nozaki Koichiro、Ichikawa Kosuke、Kondo Rie、Miyabayashi Takao、Miura Satoru、Tanaka Hiroshi、Abe Tetsuya、Okajima Masaaki、Terada Masaki、Ishida Takashi、Iwashima Akira、Sato Kazuhiro、Yoshizawa Hirohisa、Kikuchi Toshiaki
  • Journal Title: Cancer Medicine Volume: 9 Issue: 9 Pages: 3070-3077
  • DOI: 10.1002/cam4.2974
  • Peer Reviewed / Open Access
• [Journal Article] Management of Exercise-Induced Bronchoconstriction in Athletes (2020)
  • Author(s): Koya T, Ueno H, Hasegawa T, Arakawa M, Kikuchi T.
  • Journal Title: J Allergy Clin Immunol Pract Volume: 8 Issue: 7 Pages: 2183-2192
  • DOI: 10.1016/j.jaip.2020.03.011
  • Peer Reviewed / Open Access
• [Journal Article] COVID-19 outbreak: An elusive enemy (2020)
  • Author(s): Kikuchi T.
  • Journal Title: Respir Investig Volume: 58 Issue: 4 Pages: 225-226
  • DOI: 10.1016/j.resinv.2020.03.006
  • Peer Reviewed / Open Access
• [Journal Article] Distribution of Legionella species and serogroups in patients with culture-confirmed Legionella pneumonia (2020)
  • Author(s): Miyashita N, Higa F, Aoki Y, Kikuchi T, Seki M, Tateda K, Maki N, Uchino K, Ogasawara K, Kiyota H, Watanabe A.
  • Journal Title: J Infect Chemother Volume: 26 Issue: 5 Pages: 411-417
  • DOI: 10.1016/j.jiac.2019.12.016
  • Peer Reviewed / Open Access
• [Journal Article] Does the gut microbiota play a key role in PD-1/PD-L1 blockade therapy? (2020)
  • Author(s): Watanabe S, Kikuchi T.
  • Journal Title: Transl Lung Cancer Res Volume: 9 Issue: 3 Pages: 438-440
  • DOI: 10.21037/tlcr.2020.03.31
  • Peer Reviewed / Open Access
• [Journal Article] Higher genome mutation rates of Beijing lineage of Mycobacterium tuberculosis during human infection (2020)
  • Author(s): Hakamata M, Takihara H, Iwamoto T, Tamaru A, Hashimoto A, Tanaka T, Kaboso SA, Gebretsadik G, Ilinov A, Yokoyama A, Ozeki Y, Nishiyama A, Tateishi Y, Moro H, Kikuchi T, Okuda S, Matsumoto S.
  • Journal Title: Sci Rep Volume: 10 Issue: 1 Pages: 17997-17997
  • DOI: 10.1038/s41598-020-75028-2
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• [Journal Article] A study of factors related to asthma exacerbation using a questionnaire survey in Niigata Prefecture, Japan (2020)
  • Author(s): Ueno H, Koya T, Hasegawa T, Hayashi M, Yoshizawa K, Suzuki E, Kikuchi T; the Niigata Asthma Treatment Study Group.
  • Journal Title: Asian Pac J Allergy Immunol Volume: 38 Pages: 108-113
  • DOI: 10.12932/ap-080918-0404
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of Cytokine Profiles Between anti-ARS Antibody-Positive Interstitial Lung Diseases and Those With anti-MDA-5 Antibodies. (2020)
  • Author(s): Asakawa K, Yoshizawa K, Aoki A, Kimura Y, Tanaka T, Ohashi K, Hayashi M, Kikuchi T, Sato S, Takada T.
  • Journal Title: Clin Rheumatol. Volume: in press Issue: 7 Pages: 2171-2178
  • DOI: 10.1007/s10067-020-04984-x
  • Peer Reviewed / Open Access
• [Journal Article] Cysteinyl Leukotriene synthesis via Phospholipase A2 Group IV Mediates Exercise-induced Bronchoconstriction and Airway Remodeling (2020)
  • Author(s): Ueno Hiroshi、Koya Toshiyuki、Takeuchi Hiroyuki、Tsukioka Keisuke、Saito Akira、Kimura Yosuke、Hayashi Masachika、Watanabe Satoshi、Hasegawa Takashi、Arakawa Masaaki、Kikuchi Toshiaki
  • Journal Title: American Journal of Respiratory Cell and Molecular Biology Volume: in press Issue: 1 Pages: 57-66
  • DOI: 10.1165/rcmb.2019-0325oc
  • Peer Reviewed / Open Access
• [Journal Article] Frequent Germline and Somatic Single Nucleotide Variants in the Promoter Region of the Ribosomal RNA Gene in Japanese Lung Adenocarcinoma Patients (2020)
  • Author(s): Ohashi R, Umezu H, Sato A, Abテゥ T, Kondo S, Daigo K, Sato S, Hara N, Miyashita A, Ikeuchi T, Motoyama T, Kishi M, Nagaoka T, Horiuchi K, Shiga A, Okuda S, Sekiya T, Ohtsubo A, Ichikawa K, Kagamu H, Kikuchi T, Watanabe S, Tanuma JI, Schraml P, Hamakubo T, Tsuchida M, Ajioka Y.
  • Journal Title: Cells Volume: 9 Issue: 11 Pages: 2409-2409
  • DOI: 10.3390/cells9112409
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The impact of mepolizumab on the sputum level of eosinophil-derived protein in three cases of severe asthma (2020)
  • Author(s): Koya T, Kimura Y, Hayashi M, Hasegawa T, Kikuchi T.
  • Journal Title: Allergol Int Volume: 69 Issue: 4 Pages: 639-641
  • DOI: 10.1016/j.alit.2020.03.009
  • NAID: 130007926231
  • Peer Reviewed / Open Access
• [Journal Article] Serum Anti-Interferon-γ autoantibody 1 titer as a potential biomarker of disseminated non-tuberculous mycobacterial infection. (2020)
  • Author(s): Yoshizawa K, Aoki A, Shima K, Tanabe Y, Koya T, Hasegawa T, Kikuchi T, Sakagami T.
  • Journal Title: J Clin Immunol. Volume: 40 Issue: 2 Pages: 399-405
  • DOI: 10.1007/s10875-020-00762-1
  • Peer Reviewed / Open Access
• [Journal Article] First-line osimertinib treatment in patients with lung squamous cell carcinoma harboring active epidermal growth factor receptor mutations (2020)
  • Author(s): Shoji Satoshi、Watanabe Satoshi、Takamura Kaori、Umezu Hajime、Kikuchi Toshiaki
  • Journal Title: Lung Cancer Volume: 140 Pages: 113-115
  • DOI: 10.1016/j.lungcan.2019.11.012
  • Peer Reviewed
• [Journal Article] Characterization of low adherence population in asthma patients from Japan using Adherence Starts with Knowledge-12 (2020)
  • Author(s): Kimura Yuka、Koya Toshiyuki、Hasegawa Takashi、Ueno Hiroshi、Yoshizawa Kazutaka、Kimura Yosuke、Hayashi Masachika、Watanabe Satoshi、Kikuchi Toshiaki
  • Journal Title: Allergology International Volume: 69 Issue: 1 Pages: 61-65
  • DOI: 10.1016/j.alit.2019.07.006
  • NAID: 130007788673
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed
• [Journal Article] Association of upper and lower airway eosinophilic inflammation with response to omalizumab in patients with severe asthma (2020)
  • Author(s): Kurokawa Makoto、Koya Toshiyuki、Takeuchi Hiroyuki、Hayashi Masachika、Sakagami Takuro、Ishioka Kojiro、Gon Yasuhiro、Hasegawa Takashi、Kikuchi Toshiaki
  • Journal Title: Journal of Asthma Volume: 57 Issue: 1 Pages: 71-78
  • DOI: 10.1080/02770903.2018.1541357
  • Peer Reviewed
• [Journal Article] Should pulmonologists be gatekeepers or supporters for preoperative patients? (2020)
  • Author(s): Hokari Satoshi、Kikuchi Toshiaki
  • Journal Title: Respiratory Investigation Volume: 58 Issue: 1 Pages: 4-6
  • DOI: 10.1016/j.resinv.2019.09.001
  • Peer Reviewed
• [Journal Article] Comparative analysis of TTF‐1 binding DNA regions in small‐cell lung cancer and non‐small‐cell lung cancer (2019)
  • Author(s): Hokari Satoshi、Tamura Yusuke、Kaneda Atsushi、Katsura Akihiro、Morikawa Masato、Murai Fumihiko、Ehata Shogo、Tsutsumi Shuichi、Ishikawa Yuichi、Aburatani Hiroyuki、Kikuchi Toshiaki、Miyazono Kohei、Koinuma Daizo
  • Journal Title: Molecular Oncology Volume: 14 Issue: 2 Pages: 277-293
  • DOI: 10.1002/1878-0261.12608
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• [Journal Article] Correlation of prechemotherapy urinary megalin ectodomain (A-megalin) levels with the development of cisplatin-induced nephrotoxicity: a prospective observational study (2019)
  • Author(s): Shoji Satoshi、Hosojima Michihiro、Kabasawa Hideyuki、Kondo Rie、Miura Satoru、Watanabe Satoshi、Aoki Nobumasa、Kaseda Ryohei、Kuwahara Shoji、Tanabe Naohito、Hirayama Yoshiaki、Narita Ichiei、Kikuchi Toshiaki、Kagamu Hiroshi、Saito Akihiko
  • Journal Title: BMC Cancer Volume: 19 Issue: 1 Pages: 1170-1170
  • DOI: 10.1186/s12885-019-6398-2
  • Peer Reviewed
• [Journal Article] Efficacy of EGFR‐TKIs with or without upfront brain radiotherapy for EGFR ‐mutant NSCLC patients with central nervous system metastases (2019)
  • Author(s): Saida Yu、Watanabe Satoshi、Abe Tetsuya、Shoji Satoshi、Nozaki Koichiro、Ichikawa Kosuke、Kondo Rie、Koyama Kenichi、Miura Satoru、Tanaka Hiroshi、Okajima Masaaki、Terada Masaki、Ishida Takashi、Tsukada Hiroki、Makino Masato、Iwashima Akira、Sato Kazuhiro、Matsumoto Naoya、Yoshizawa Hirohisa、Kikuchi Toshiaki
  • Journal Title: Thoracic Cancer Volume: 10 Issue: 11 Pages: 2106-2116
  • DOI: 10.1111/1759-7714.13189
  • Peer Reviewed / Open Access
• [Journal Article] Moxifloxacin resistance and genotyping of Mycobacterium avium and Mycobacterium intracellulare isolates in Japan (2019)
  • Author(s): Yamaba Yusuke、Ito Yutaka、Suzuki Katsuhiro、Kikuchi Toshiaki、Ogawa Kenji、Fujiuchi Satoru、Hasegawa Naoki、Kurashima Atsuyuki、Higuchi Takeshi、Uchiya Kei-ichi、Watanabe Akira、Niimi Akio
  • Journal Title: Journal of Infection and Chemotherapy Volume: 25 Issue: 12 Pages: 995-1000
  • DOI: 10.1016/j.jiac.2019.05.028
  • Peer Reviewed / Open Access
• [Journal Article] Retrospective analysis of antitumor effects and biomarkers for nivolumab in NSCLC patients with EGFR mutations (2019)
  • Author(s): Sato Miyuki、Watanabe Satoshi、Tanaka Hiroshi、Nozaki Koichiro、Arita Masashi、Takahashi Miho、Shoji Satoshi、Ichikawa Kosuke、Kondo Rie、Aoki Nobumasa、Hayashi Masachika、Ohshima Yasuyoshi、Koya Toshiyuki、Ohashi Riuko、Ajioka Yoichi、Kikuchi Toshiaki
  • Journal Title: PLOS ONE Volume: 14 Issue: 4 Pages: e0215292-e0215292
  • DOI: 10.1371/journal.pone.0215292
  • Peer Reviewed / Open Access
• [Journal Article] Validation of a diagnostic score model for the prediction of Legionella pneumophila pneumonia (2019)
  • Author(s): Miyashita Naoyuki、Horita Nobuyuki、Higa Futoshi、Aoki Yosuke、Kikuchi Toshiaki、Seki Masafumi、Tateda Kazuhiro、Maki Nobuko、Uchino Kazuhiro、Ogasawara Kazuhiko、Kiyota Hiroshi、Watanabe Akira
  • Journal Title: Journal of Infection and Chemotherapy Volume: 25 Issue: 6 Pages: 407-412
  • DOI: 10.1016/j.jiac.2019.03.009
  • Peer Reviewed
• [Journal Article] Retrospective efficacy analysis of immune checkpoint inhibitors in patients with EGFR‐mutated non‐small cell lung cancer (2019)
  • Author(s): Yamada Tadaaki、Hirai Soichi、Katayama Yuki、Yoshimura Akihiro、Shiotsu Shinsuke、Watanabe Satoshi、Kikuchi Toshiaki、Hirose Kazuki、Kubota Yutaka、Chihara Yusuke、Harada Taishi、Tanimura Keiko、Takeda Takayuki、Tamiya Nobuyo、Kaneko Yoshiko、Uchino Junji、Takayama Koichi
  • Journal Title: Cancer Medicine Volume: 8 Issue: 4 Pages: 1521-1529
  • DOI: 10.1002/cam4.2037
  • Peer Reviewed / Open Access
• [Journal Article] Multiplex cytokine analysis in Mycobacterium avium complex lung disease: relationship between CXCL10 and poor prognostic factors (2019)
  • Author(s): Bamba Yuuki、Moro Hiroshi、Aoki Nobumasa、Koizumi Takeshi、Ohshima Yasuyoshi、Watanabe Satoshi、Sakagami Takuro、Koya Toshiyuki、Takada Toshinori、Kikuchi Toshiaki
  • Journal Title: BMC Infectious Diseases Volume: 19 Issue: 1 Pages: 263-263
  • DOI: 10.1186/s12879-019-3888-4
  • Peer Reviewed / Open Access
• [Journal Article] An α-Lipoic acid derivative, and anti-ROS agent, prevents the acquisition of multi-drug resistance in clinical isolates of Pseudomonas aeruginosa (2019)
  • Author(s): Hayakawa Sachiko、Kawamura Masato、Sato Takumi、Hirano Taizou、Kikuchi Toshiaki、Watanabe Akira、Fujimura Shigeru
  • Journal Title: Journal of Infection and Chemotherapy Volume: 25 Issue: 1 Pages: 28-33
  • DOI: 10.1016/j.jiac.2018.10.003
  • Peer Reviewed / Open Access
• [Journal Article] Baloxavir heralds a new era in influenza virus biology (2019)
  • Author(s): Kikuchi Toshiaki、Watanabe Akira
  • Journal Title: Respiratory Investigation Volume: 57 Issue: 1 Pages: 1-2
  • DOI: 10.1016/j.resinv.2018.10.002
  • Peer Reviewed
• [Journal Article] Pneumocystis pneumonia in HIV-1-infected patients (2019)
  • Author(s): Shibata Satoshi、Kikuchi Toshiaki
  • Journal Title: Respiratory Investigation Volume: 57 Issue: 3 Pages: 213-219
  • DOI: 10.1016/j.resinv.2019.01.009
  • Peer Reviewed
• [Journal Article] Influence of Adherence to Inhaled Corticosteroids and Inhaler Handling Errors on Asthma Control in a Japanese Population (2018)
  • Author(s): Koya Toshiyuki、Hasegawa Takashi、Takasawa Junko、Yoshimine Fumitoshi、Sakagami Takuro、Hayashi Masachika、Suzuki Eiichi、Kikuchi Toshiaki、Niigata Inhalation Treatment Study Group
  • Journal Title: Internal Medicine Volume: 57 Issue: 23 Pages: 3357-3363
  • DOI: 10.2169/internalmedicine.0986-18
  • NAID: 130007539662
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2018-12-01
  • Peer Reviewed / Open Access
• [Journal Article] A Cluster Analysis of Bronchial Asthma Patients with Depressive Symptoms (2018)
  • Author(s): Seino Y, Hasegawa T, Koya T, Sakagami T, Mashima I, Shimizu N, Muramatsu Y, Muramatsu K, Suzuki E, Kikuchi T.
  • Journal Title: Internal Medicine Volume: 57 Issue: 14 Pages: 1967-1975
  • DOI: 10.2169/internalmedicine.9073-17
  • NAID: 130007404908
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2018-07-15
  • Peer Reviewed / Open Access
• [Journal Article] Taniguchi H, Yamada T, Wang R, Tanimura K, Adachi Y, Nishiyama A, Tanimoto A, Takeuchi S, Araujo LH, Boroni M, Yoshimura A, Shiotsu S, Matsumoto I, Watanabe S, Kikuchi T, Miura S, Tanaka H, Kitazaki T, Yamaguchi H, Mukae H, Uchino J, Uehara H, Takayama K, Yano S. (2018)
  • Author(s): Taniguchi H, Yamada T, Wang R, Tanimura K, Adachi Y, Nishiyama A, Tanimoto A, Takeuchi S, Araujo LH, Boroni M, Yoshimura A, Shiotsu S, Matsumoto I, Watanabe S, Kikuchi T, Miura S, Tanaka H, Kitazaki T, Yamaguchi H, Mukae H, Uchino J, Uehara H, Takayama K, Yano S.
  • Journal Title: Nat Commun. Volume: 10 Issue: 1 Pages: 259-259
  • DOI: 10.1038/s41467-018-08074-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Increased presepsin levels are associated with the severity of fungal bloodstream infections (2018)
  • Author(s): Bamba Yuuki、Moro Hiroshi、Aoki Nobumasa、Koizumi Takeshi、Ohshima Yasuyoshi、Watanabe Satoshi、Sakagami Takuro、Koya Toshiyuki、Takada Toshinori、Kikuchi Toshiaki
  • Journal Title: PLOS ONE Volume: 13 Issue: 10 Pages: e0206089-e0206089
  • DOI: 10.1371/journal.pone.0206089
  • Peer Reviewed / Open Access
• [Journal Article] Phase I Study Evaluating the Combination of Afatinib with Carboplatin and Pemetrexed After First-line EGFR-TKIs (2018)
  • Author(s): WATANABE SATOSHI、YAMAGUCHI OU、MASUMOTO AI、MAENO YURI、KAWASHIMA YOSUKE、ISHIMOTO OSAMU、SUGAWARA SHUNICHI、YOSHIZAWA HIROHISA、KIKUCHI TOSHIAKI、NUKIWA TOSHIHIRO、KOBAYASHI KUNIHIKO
  • Journal Title: Anticancer Research Volume: 38 Issue: 8 Pages: 4699-4704
  • DOI: 10.21873/anticanres.12776
  • Peer Reviewed / Open Access
• [Journal Article] Role of IL-15 in interstitial lung diseases in amyopathic dermatomyositis with anti-MDA-5 antibody (2018)
  • Author(s): Takada Toshinori、Ohashi Kazumasa、Hayashi Masachika、Asakawa Katsuaki、Sakagami Takuro、Kikuchi Toshiaki、Sato Shinji
  • Journal Title: Respiratory Medicine Volume: 141 Pages: 7-13
  • DOI: 10.1016/j.rmed.2018.06.012
  • Peer Reviewed / Open Access
• [Journal Article] In vitro activity of various antibiotics against clinical strains of Legionella species isolated in Japan. (2018)
  • Author(s): Miyashita N, Kobayashi I, Higa F, Aoki Y, Kikuchi T, Seki M, Tateda K, Maki N, Uchino K, Ogasawara K, Kurachi S, Ishikawa T, Ishimura Y, Kanesaka I, Kiyota H, Watanabe A.
  • Journal Title: J Infect Chemother. Volume: 24 Issue: 5 Pages: 325-329
  • DOI: 10.1016/j.jiac.2018.01.018
  • Peer Reviewed / Open Access
• [Journal Article] A Phase II Study of Irinotecan for Patients with Previously Treated Small-Cell Lung Cancer (2018)
  • Author(s): Kondo Rie、Watanabe Satoshi、Shoji Satoshi、Ichikawa Kosuke、Abe Tetsuya、Baba Junko、Tanaka Junta、Tsukada Hiroki、Terada Masaki、Sato Kazuhiro、Maruyama Yoshie、Makino Masato、Hirata Akira、Tanaka Hiroshi、Koya Toshiyuki、Yoshizawa Hirohisa、Kikuchi Toshiaki
  • Journal Title: Oncology Volume: 94 Issue: 4 Pages: 223-232
  • DOI: 10.1159/000486622
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Impact of Concurrent Genomic Alterations Detected by Comprehensive Genomic Sequencing on Clinical Outcomes in East-Asian Patients with EGFR-Mutated Lung Adenocarcinoma (2018)
  • Author(s): Sato Seijiro、Nagahashi Masayuki、Koike Terumoto、Ichikawa Hiroshi、Shimada Yoshifumi、Watanabe Satoshi、Kikuchi Toshiaki、Takada Kazuki、Nakanishi Ryota、Oki Eiji、Okamoto Tatsuro、Akazawa Kouhei、Lyle Stephen、Ling Yiwei、Takabe Kazuaki、Okuda Shujiro、Wakai Toshifumi、Tsuchida Masanori
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 1-10
  • DOI: 10.1038/s41598-017-18560-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Mycophenolate mofetil as a therapeutic agent for interstitial lung diseases in systemic sclerosis. (2018)
  • Author(s): Ueda T, Sakagami T, Kikuchi T, Takada T
  • Journal Title: Respiratory Investigation Volume: 56 Issue: 1 Pages: 14-20
  • DOI: 10.1016/j.resinv.2017.11.004
  • Peer Reviewed / Open Access
• [Journal Article] Diagnostic predictors of Legionella pneumonia in Japan (2018)
  • Author(s): Miyashita Naoyuki、Horita Nobuyuki、Higa Futoshi、Aoki Yosuke、Kikuchi Toshiaki、Seki Masafumi、Tateda Kazuhiro、Maki Nobuko、Uchino Kazuhiro、Ogasawara Kazuhiko、Kiyota Hiroshi、Watanabe Akira
  • Journal Title: Journal of Infection and Chemotherapy Volume: 24 Issue: 3 Pages: 159-163
  • DOI: 10.1016/j.jiac.2017.12.009
  • Peer Reviewed / Open Access
• [Presentation] 肺非結核性抗酸菌症に対するGM-CSF吸入療法の開発 (2022)
  • Author(s): 菊地利明
  • Organizer: 第2回BVAバイオインターフェース
• [Presentation] 当院におけるCPAPアドヒアランスに影響する因子の検討 (2021)
  • Author(s): 倉科健司，穂苅諭，永井明日香，鈴木涼子，大嶋康義，青木信将，林正周，渡部聡，小屋俊之，菊地利明
  • Organizer: 第61回日本呼吸器学会学術講演会
• [Presentation] 局所進行期非小細胞肺癌に対する根治的化学放射線療法後のデュルバルマブ維持療法の後方視的検討 (2021)
  • Author(s): 大坪亜矢，渡部聡，庄子聡，久代航平，佐藤佑輔，高橋美帆，野嵜幸一郎，市川紘将，近藤利恵，青木信将，林正周，大嶋康義，小屋俊之，菊地利明
  • Organizer: 第61回日本呼吸器学会学術講演会
• [Presentation] 神経回路網アルゴリズムを用いた肺非結核性抗酸菌症の病態予測 (2021)
  • Author(s): 菊地利明
  • Organizer: 第61回日本呼吸器学会学術講演会
  • Invited
• [Presentation] 好酸球性副鼻腔炎合併喘息症例におけるデュピルマブの効果について (2021)
  • Author(s): 齋藤暁，小屋俊之，田中健太郎，坪川史人，酒井菜摘，西山佑樹，島賢治郎，外山美央，木村陽介，林正周，長谷川隆志，菊地利明
  • Organizer: 第61回日本呼吸器学会学術講演会
• [Presentation] 多系統萎縮症に合併した閉塞性睡眠時無呼吸における呼吸不安定性の検討～ポリソムノグラフィを用いたエントロピー解析～ (2021)
  • Author(s): 穂苅諭，中山秀章，大嶋康義，松戸隆之，下畑享良，菊地利明
  • Organizer: 第61回日本呼吸器学会学術講演会
• [Presentation] 最新の呼吸器感染症治療 (2021)
  • Author(s): 菊地利明
  • Organizer: 日本病院総合診療医学会学術総会
  • Invited
• [Presentation] ニンテダニブは腫瘍微小環境を改善することでPD-1阻害剤の抗腫瘍効果を増強する (2021)
  • Author(s): 鈴木遼，渡部聡，久代航平，関谷友樹，藤崎俊哉，安部悠子，佐藤美由紀，大坪亜矢，庄子聡，田中知宏，野嵜浩一郎，才田優，穂苅諭，大嶋康義，小屋俊之，菊地利明
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] 新規抗菌薬の使い方 (2021)
  • Author(s): 菊地利明
  • Organizer: 第87回日本呼吸器学会・日本結核 非結核性抗酸菌症学会・日本サルコイドーシス/肉芽腫性疾患学会九州支部秋季学術講演会
  • Invited
• [Presentation] 抗酸菌感染症のマネジメント (2021)
  • Author(s): 菊地利明
  • Organizer: 第66回北海道支部生涯教育講演会
  • Invited
• [Presentation] To end tuberculosis epidemic in global (2021)
  • Author(s): Kikuchi T
  • Organizer: The 25th Congress of the Asian Pacific Society of Respirology
  • Int'l Joint Research / Invited
• [Presentation] 2型呼吸不全と抗ミトコンドリアM2抗体の関係性 (2021)
  • Author(s): 大嶋康義、倉科健司、穂苅諭、永井明日香、鈴木涼子、青木信将、林正周、渡部聡、小屋俊之、菊地利明
  • Organizer: 第30回日本呼吸ケア・リハビリテーション学会学術集会
• [Presentation] 増大するゲノム情報にどう対応するか イチから始めるゲノム感染症学 (2021)
  • Author(s): 菊地利明
  • Organizer: 第179回日本結核・非結核性抗酸菌症学会関東支部学会 第243回日本呼吸器学会関東地方会 合同学会
  • Invited
• [Presentation] A phase II and biomarker study of alectinib combined with bevacizumab in ALK-positive non-small cell lung cancer. (2020)
  • Author(s): 渡部聡、坂井和子、松本尚也、古塩純、石田晃、阿部徹哉、石川大輔、田中知宏、大坪亜矢、庄子聡、野嵜幸一郎、市川紘将、近藤利恵、青木亜美、梶原大季、小山建一、三浦理、吉澤弘久、西尾和人、菊地利明
  • Organizer: 第61回日本肺癌学会学術集会
• [Presentation] 小細胞肺癌細胞と非小細胞肺癌細胞におけるTTF-1結合領域の比較解析 (2020)
  • Author(s): 穂苅諭、田村佑介、金田篤志、桂彰宏、森川真大、江幡正悟、堤修一、石川雄一、油谷浩幸、菊地利明、宮園浩平、鯉沼代造
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] 肺非結核性抗酸菌症の菌側因子 (2020)
  • Author(s): 菊地利明
  • Organizer: 第60回日本呼吸器学会学術講演会
  • Invited
• [Presentation] 非結核性抗酸菌症 国内疫学データ、治療の現状と問題点 (2020)
  • Author(s): 菊地利明
  • Organizer: 第94回日本感染症学会総会学術講演会
  • Invited
• [Presentation] 世界の中のニッポン 日本の結核は再度増えるのか (2019)
  • Author(s): 菊地利明
  • Organizer: 第59回日本呼吸器学会学術講演会
  • Invited
• [Presentation] 肺MAC症の病型 FC型とNB型の根本的な違いは何か (2019)
  • Author(s): 菊地利明
  • Organizer: 第94回日本結核病学会総会
  • Invited
• [Presentation] The Relationship Between Social Capital and Asthma Control. (2019)
  • Author(s): A. Saito, T. Hasegawa, T. Koya, S. Nagumo, Y.Nishiyama, K. Yoshizawa, H. Ueno, Y. Kimura, M. Hayashi, Y. Shobugawa, R. Saito, T. Kikuchi.
  • Organizer: American Thoracic Society International Conference
  • Int'l Joint Research
• [Presentation] The Effect of Weight Loss on Bronchial Asthma Model. (2019)
  • Author(s): Y. Nishiyama, T. Koya, T. Hasegawa, H. Ueno, K. Yoshizawa, A. Saito, S. Nagumo, Y. Kimura, M. Hayashi, T. Kikuchi.
  • Organizer: American Thoracic Society International Conference
  • Int'l Joint Research
• [Presentation] Prognostic significance of radiologic features of pneumonitis induced by anti-PD-1 therapy. (2019)
  • Author(s): S. Watanabe, T. Ota, M. Hayashi, H. Ishikawa, T. Miyabayashi, M. Terada, K. Sato, T. Ishida, H. Tanaka, A. Iwashima, S. Shoji, K. Nozaki, K. Ichikawa, R. Kondo, H. Yoshizawa, T. Kikuchi
  • Organizer: 2019 American Society of Clinical Oncology Annual Meeting
  • Int'l Joint Research
• [Presentation] EGFR-TKI耐性症例の再生検の実施率、組織診と細胞診のCobas法による一致率を検討する観察研究 (2018)
  • Author(s): 小山建一、三浦理、庄子聡、佐藤和弘、石川大輔、宮林貴大、岡島正明、岩島明、牧野真人、市川紘将、野嵜幸一朗、近藤利恵、渡部聡、田中洋史、菊地利明
  • Organizer: 第59回日本肺癌学会学術集会
• [Presentation] 新潟市における慢性閉塞性肺疾患に対する地域医療連携の取り組み (2018)
  • Author(s): 藤戸信宏、大嶋康義、坂井邦彦、横田樹也、大平徹郎、渡部聡、小屋俊之、菊地利明
  • Organizer: 日本呼吸ケア・リハビリテーション学会学術集会
• [Presentation] 気道炎症による抗PD-1抗体の抗腫瘍効果への影響の解析 (2018)
  • Author(s): 有田将史、渡部聡、高橋美帆、庄子聡、野嵜幸一郎、市川紘将、近藤利恵、田中純太、小屋俊之、菊地利明
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] A phase II study evaluating continuation of EGFR-TKIs beyond progressive disease followed by the addition of CDDP+PEM+Bev (2018)
  • Author(s): S. Shoji, S. Watanabe, K. Nozaki, K. Ichikawa, R. Kondo, S. Miura, M. Okajima, T. Abe, H. Tanaka, J. Tanaka, H. Yoshizawa, H. Kagamu, T. Kikuchi;
  • Organizer: The 19th World Conference on Lung Cancer
  • Int'l Joint Research
• [Presentation] 非結核性抗酸菌症 (2018)
  • Author(s): 菊地利明
  • Organizer: 第93回日本結核病学会総会
  • Invited
• [Presentation] QuantiFERON-TB Gold® Is useful tool for estimation of neutralizing anti-IFN-g autoantibodies among patients with disseminated nontuberculous mycobacterial disease (2018)
  • Author(s): K. Yoshizawa, T. Sakagami, A. Aoki, K. Shima, N. Aoki, T. Koya, T.Hasegawa, T. Kikuchi
  • Organizer: American Thoracic Society International Conference
  • Int'l Joint Research
• [Book] 診療ガイドライン UP-TO-DATE 2022-2023 (2022)
  • Author(s): 茂呂寛，菊地利明
  • Total Pages: 1065
  • Publisher: メディカルレビュー社
  • ISBN: 9784779225802
• [Book] 内科学第12版 (2022)
  • Author(s): 菊地利明
  • Total Pages: 2486
  • Publisher: 朝倉書店
  • ISBN: 9784254322804
• [Book] 非結核性抗酸菌症マネジメント：咳と痰をどうみるか？ (2020)
  • Author(s): 菊地利明
  • Total Pages: 208
  • Publisher: 日本医事新報社
  • ISBN: 9784784949373
• [Book] 今日の治療指針 2020年版 (2020)
  • Author(s): 菊地利明
  • Total Pages: 2115
  • Publisher: 医学書院
  • ISBN: 9784260039390
• [Book] 診療ガイドライン UP-TO-DATE 2020-2021 (2020)
  • Author(s): 茂呂寛、菊地利明
  • Total Pages: 1060
  • Publisher: メディカルレビュー社
  • ISBN: 9784779222535
• [Book] 今日の処方（改訂第6版） (2019)
  • Author(s): 菊地利明
  • Total Pages: 904
  • Publisher: 南江堂
  • ISBN: 4524251197
• [Book] 呼吸器疾患最新の治療2019-2020 (2019)
  • Author(s): 小泉健、菊地利明
  • Total Pages: 534
  • Publisher: 南江堂
  • ISBN: 9784524245574
• [Book] 診療ガイドライン UP-TO-DATE 2018-2019 (2018)
  • Author(s): 茂呂寛，菊地利明
  • Total Pages: 1037
  • Publisher: メディカルレビュー社
  • ISBN: 9784779220081
• [Remarks] 新潟大学大学院医歯学総合研究科 呼吸器・感染症内科学分野
  • URL: https://www.med.niigata-u.ac.jp/resp/welcome.html