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Development of biomarkers for predicting disease progression and treatment response for schizophrenia using large-scale patient resources and iPS technology.

Research Project

Project/Area Number 18KT0022
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeMulti-year Fund
Section特設分野
Research Field Complex Systems Disease Theory
Research InstitutionNational Center of Neurology and Psychiatry

Principal Investigator

Hashimoto Ryota  国立研究開発法人国立精神・神経医療研究センター, 精神保健研究所 精神疾患病態研究部, 部長 (10370983)

Co-Investigator(Kenkyū-buntansha) 中澤 敬信  東京農業大学, 生命科学部, 教授 (00447335)
Project Period (FY) 2018-07-18 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2020: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2019: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2018: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Keywords精神疾患 / バイオリソース / iPS細胞 / バイオマーカー
Outline of Final Research Achievements

In iPS cell-derived differentiated neurons from patients with treatment-resistant schizophrenia and discordant responses to clozapine (10 patients in total, including monozygotic twins), the expression levels of genes encoding cell adhesion molecules, transcription factors and molecules regulating circadian rhythms are correlated with clozapine responsiveness in these patients. Importantly, we also found virtually the same results in the samples from blood cells of these patients. We also found that differences in synaptic functions, such as excitatory synaptic transmission, may be involved in the discordant responses to clozapine in these patients. Together with the results of the analysis of the clinical data of these patients, this study has provided basic data that will lead not only to the elucidation of the molecular pathogenesis of schizophrenia but also to the development of biomarkers for predicting disease progression and treatment response for schizophrenia.

Academic Significance and Societal Importance of the Research Achievements

統合失調症患者からiPS細胞を樹立した報告は、現在までに数十報程度あり、患者由来神経細胞における分化・発達の異常やシナプス機能の異常等が明らかになっている。しかし、遺伝学的データや臨床データを保持する統合失調症患者について、本研究のようなiPS細胞のみならず血液サンプルも併せて用いる融合的な解析は、これまでに報告例は極めて少ない。本研究で得られた成果は、不明な点が多く残されている精神疾患の分子病態の解明に貢献するのみならず、治療反応性、病態予測等に役立つ客観的なバイオマーカーの開発のための基礎データを提供するものである。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report

Research Products

(201 results)

All 2021 2020 2019 2018 Other

All Journal Article (66 results) (of which Int'l Joint Research: 24 results,  Peer Reviewed: 66 results,  Open Access: 66 results) Presentation (109 results) (of which Int'l Joint Research: 12 results,  Invited: 20 results) Book (24 results) Remarks (2 results)

  • [Journal Article] 1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans2021

    • Author(s)
      Van der Meer D, Kikuchi M (70 in 143 authors), Boen R.
    • Journal Title

      Transl Psychiatry

      Volume: 11 Pages: 1-16

    • DOI

      10.1038/s41398-021-01213-0

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Intranasal oxytocin administration ameliorates social behavioral deficits in a POGZWT/Q1038R mouse model of autism spectrum disorder2021

    • Author(s)
      Kitagawa Kohei、Matsumura Kensuke、Baba Masayuki、Kondo Momoka、Takemoto Tomoya、Nagayasu Kazuki、Ago Yukio、Seiriki Kaoru、Hayata-Takano Atsuko、Kasai Atsushi、Takuma Kazuhiro、Hashimoto Ryota、Hashimoto Hitoshi、Nakazawa Takanobu
    • Journal Title

      Mol Brain

      Volume: 14 Pages: 56-56

    • DOI

      10.1186/s13041-021-00769-8

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Facilitative Effects of Transcranial Direct Current Stimulation on Semantic Memory Examined by Text-Mining Analysis in Patients With Schizophrenia2021

    • Author(s)
      Sumiyoshi Chika、Narita Zui、Inagawa Takuma、Yamada Yuji、Sueyoshi Kazuki、Hasegawa Yumi、Shirama Aya、Hashimoto Ryota、Sumiyoshi Tomiki
    • Journal Title

      Front Neurol, section Neurorehabilitation

      Volume: 12 Pages: 1-1

    • DOI

      10.3389/fneur.2021.583027

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Impaired inhibition of return during free-viewing behaviour in patients with schizophrenia2021

    • Author(s)
      Okada K, Miura K, Fujimoto M, Morita K, Yoshida M, Yamamori H, Yasuda Y, Iwase M, Shinozaki T, Fujita I, Hashimoto R
    • Journal Title

      Sci Rep

      Volume: 11 Pages: 2327-2327

    • DOI

      10.1038/s41598-021-82253-w

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Platelet-derived growth factor BB: A potential diagnostic blood biomarker for differentiating bipolar disorder from major depressive disorder.2021

    • Author(s)
      Idemoto K, Ishima T, Niitsu T, Hata T, Yoshida S, Hattori K, Horai T, Otsuka I, Yamamori H, Toda S, Kameno Y, Ota K, Oda Y, Kimura A, Hashimoto T, Mori N, Kikuchi M, Minabe Y, Hashimoto R, Hishimoto A, Nakagome K, Iyo M, Hashimoto K.
    • Journal Title

      J Psychiat Res

      Volume: 134 Pages: 48-56

    • DOI

      10.1016/j.jpsychires.2020.12.051

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders2021

    • Author(s)
      Writing Committee for the Attention-Deficit/Hyperactivity Disorder; Autism Spectrum Disorder; Bipolar Disorder; Major Depressive Disorder; Obsessive-Compulsive Disorder; and Schizophrenia ENIGMA Working Groups; Patel Y, Hirano Y, Nakagawa A, Shimizu E et al.
    • Journal Title

      JAMA Psychiatry

      Volume: 78 Pages: 47-47

    • DOI

      10.1001/jamapsychiatry.2020.2694

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prediction of lithium response using genomic data.2021

    • Author(s)
      Stone W, (20名中略), Hashimoto R,(52名中22番目) (30名中略) Alda M.
    • Journal Title

      Sci Rep

      Volume: 11(1) Pages: 1155-1155

    • DOI

      10.1038/s41598-020-80814-z

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Relationship between white matter microstructure and work hours2021

    • Author(s)
      Matsumoto Junya、Fukunaga Masaki、Miura Kenichiro、Nemoto Kiyotaka、Koshiyama Daisuke、Okada Naohiro、Morita Kentaro、Yamamori Hidenaga、Yasuda Yuka、Fujimoto Michiko、Hasegawa Naomi、Watanabe Yoshiyuki、Kasai Kiyoto、Hashimoto Ryota
    • Journal Title

      Neurosci Lett

      Volume: 740 Pages: 135428-135428

    • DOI

      10.1016/j.neulet.2020.135428

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Delayed Prefrontal Hemodynamic Response Associated With Suicide Risk in Autism Spectrum Disorder2021

    • Author(s)
      Ota T, Iida J, Okazaki K, Ishida R, Takahashi M, Okamura K, Yamamuro K, Kishimoto N, Kimoto S, Yasuda Y, Hashimoto R, Makinodan M, Kishimoto T.
    • Journal Title

      Psychiatry Res

      Volume: 289 Pages: 112971-112971

    • DOI

      10.1016/j.psychres.2020.112971

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Unmet needs of patients with major depressive disorder ? Findings from the ‘Effectiveness of Guidelines for Dissemination and Education in Psychiatric Treatment (EGUIDE)’ project: A nationwide dissemination, education, and evaluation study2020

    • Author(s)
      Iida Hitoshi、Iga Junichi、Hasegawa Naomi、(45番目)Fujimoto Michiko、et al.
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 74 Pages: 667-669

    • DOI

      10.1111/pcn.13143

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ethnicity-Dependent Effects of Schizophrenia Risk Variants of the OLIG2 Gene on OLIG2 Transcription and White Matter Integrity2020

    • Author(s)
      Komatsu H, Takeuchi H, Kikuchi Y, Ono C, Yu Z, Iizuka K, Takano Y, Kakuto Y, Funakoshi S, Ono T, Ito J, Kunii Y, Hino M, Nagaoka A, Iwasaki Y, Tomita H, et al.
    • Journal Title

      Schizophrenia Bulletin

      Volume: - Pages: 1619-1628

    • DOI

      10.1093/schbul/sbaa049

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Promoter Activity-Based Case-Control Association Study on SLC6A4 Highlighting Hypermethylation and Altered Amygdala Volume in Male Patients With Schizophrenia2020

    • Author(s)
      Ikegame T, Bundo M, Okada N, Murata Y, Koike S, Sugawara H, Saito T, Ikeda M, Owada K, Fukunaga M, Yamashita F, Koshiyama D, Natsubori T, Iwashiro N, Asai T, Yoshikawa A, Nishimura F, Kawamura Y, Ishigooka J, Kakiuchi C, Sasaki T, Abe O, Hashimoto R, Iwata N, Yamasue H, Kato T, Kasai K, Iwamoto K
    • Journal Title

      Schizophr Bull

      Volume: 46 Pages: 1577-1586

    • DOI

      10.1093/schbul/sbaa075

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lipocalin-type prostaglandin D synthase regulates light-induced phase advance of the central circadian rhythm in mice2020

    • Author(s)
      Kawaguchi, C., Shintani, N., Hayata-Takano, A., Hatanaka, M., Kuromi, A., Nakamura, R., Yamano, Y., Shintani, Y., Nagai, K., Tsuchiya, S., Sugimoto, Y., Ichikawa, A., Okuno, Y., Urade, Y., Hirai, H., Nagata, K., Nakamura, M., Narumiya, S., Nakazawa, T., Kasai, A., Ago, Y., Takuma, K., Baba, A., and Hashimoto, H.
    • Journal Title

      Commun Biol

      Volume: 3 Pages: 557-557

    • DOI

      10.1038/s42003-020-01281-w

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Polygenic Risk Scores for Late Smoking Initiation Associated with the Risk of Schizophrenia2020

    • Author(s)
      Ohi K, Nishizawa D, Muto Y, Sugiyama S, Hasegawa J, Soda M, Kitaichi K, Hashimoto R, Shioiri T, Ikeda K
    • Journal Title

      NPJ Schizophr

      Volume: 6 Issue: 1 Pages: 36-36

    • DOI

      10.1038/s41537-020-00126-z

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between the superior longitudinal fasciculus and perceptual organization and working memory : A diffusion tensor imaging study2020

    • Author(s)
      Koshiyama D., Fukunaga M., Okada N., Morita K., Nemoto K., Yamashita F., Yamamori H., Yasuda Y., Matsumoto J., Fujimoto M., Kudo N., Azechi H., Watanabe Y., Kasai K., Hashimoto R.
    • Journal Title

      Neuroscience Letters

      Volume: 738 Pages: 135349-135349

    • DOI

      10.1016/j.neulet.2020.135349

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increased Dendritic Orientation Dispersion in the Left Occipital Gyrus is Associated with Atypical Visual Processing in Adults with Autism Spectrum Disorder.2020

    • Author(s)
      Matsuoka K, Hashimoto R, Kishimoto T, et al.
    • Journal Title

      Cereb Cortex

      Volume: 30 Pages: 5617-5625

    • DOI

      10.1093/cercor/bhaa121

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An overlapping pattern of cerebral cortical thinning is associated with both positive symptoms and aggression in schizophrenia via the ENIGMA consortium2020

    • Author(s)
      Wong Ting Yat、Radua Joaquim、Pomarol-Clotet Edith、Salvador Raymond、...、Hashimoto Ryota、Fukunaga Masaki、...、van Erp Theo G. M.、Gur Ruben C.、Nickl-Jockschat Thomas
    • Journal Title

      Psychol Med

      Volume: 16 Pages: 1-12

    • DOI

      10.1017/s0033291719002149

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prescription patterns in patients with schizophrenia in Japan: First-quality indicator data from the survey of "Effectiveness of Guidelines for Dissemination and Education in psychiatric treatment (EGUIDE)" project2020

    • Author(s)
      Ichihashi K, Hori H, Hasegawa N, Yasuda Y, Yamamoto T, Tsuboi T, Iwamoto K, Kishimoto T, Horai T, Yamada H, Sugiyama N, Nakamura T, Tsujino N, Nemoto K, Oishi S, Usami M, Katsumoto E, Yamamori H, Tomita H, Suwa T, Furihata R, Inagaki T, Fujita J, Onitsuka T, Miura K, Matsumoto J, Ohi K, Matsui Y, Takaesu Y, et al.
    • Journal Title

      Neuropsychopharmacology Reports

      Volume: 40 Pages: 281-286

    • DOI

      10.1002/npr2.12122

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Activation of the VPAC2 Receptor Impairs Axon Outgrowth and Decreases Dendritic Arborization in Mouse Cortical Neurons by a PKA-Dependent Mechanism2020

    • Author(s)
      Takeuchi Shuto、Kawanai Takuya、Yamauchi Ryosuke、Chen Lu、Miyaoka Tatsunori、Yamada Mei、Asano Satoshi、Hayata-Takano Atsuko、Nakazawa Takanobu、Yano Koji、Horiguchi Naotaka、Nakagawa Shinsaku、Takuma Kazuhiro、Waschek James A.、Hashimoto Hitoshi、Ago Yukio
    • Journal Title

      Front Neurosci

      Volume: 14 Pages: 521-521

    • DOI

      10.3389/fnins.2020.00521

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Associations of childhood experiences with event-related potentials in adults with autism spectrum disorder2020

    • Author(s)
      Okazaki Kosuke、Ota Toyosaku、Makinodan Manabu、Kishimoto Naoko、Yamamuro Kazuhiko、Ishida Rio、Takahashi Masato、Yasuda Yuka、Hashimoto Ryota、Iida Junzo、Kishimoto Toshifumi
    • Journal Title

      Sci Rep

      Volume: 10 Pages: 1-1

    • DOI

      10.1038/s41598-020-70409-z

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk.2020

    • Author(s)
      Sekiguchi M, Sobue A, Kushima I, et al.
    • Journal Title

      Transl Psychiatry.

      Volume: 10 Pages: 1-15

    • DOI

      10.1038/s41398-020-00917-z

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Investigating DNA Methylation of <i>SHATI/NAT8L</i> Promoter Sites in Blood of Unmedicated Patients with Major Depressive Disorder2020

    • Author(s)
      Miyanishi Hajime、Uno Kyosuke、Iwata Mina、Kikuchi Yuu、Yamamori Hidenaga、Yasuda Yuka、Ohi Kazutaka、Hashimoto Ryota、Hattori Kotaro、Yoshida Sumiko、Goto Yu-ichi、Sumiyoshi Tomiki、Nitta Atsumi
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 43 Issue: 7 Pages: 1067-1072

    • DOI

      10.1248/bpb.b19-01099

    • NAID

      130007867923

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Self-Construal Scale: A Potential Tool for Predicting Subjective Well-Being of Individuals With Autism Spectrum Disorder2020

    • Author(s)
      Sachie Kaneko 1 2 3 , Takahiro A Kato 1 , Manabu Makinodan 4 , Takashi Komori 4 , Rio Ishida 4 , Naoko Kishimoto 4 , Masato Takahashi 4 , Yuka Yasuda 4 5 6 , Ryota Hashimoto 6 7 , Hidemi Iwasaka 3 , Ayumi Tanaka 8 , Yukiko Uchida 2 , Shigenobu Kanba 1 , Toshifumi Kishimoto 4
    • Journal Title

      Autism Research

      Volume: in press Pages: 947-958

    • DOI

      10.1002/aur.2242

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Plasma levels of matrix metalloproteinase‐9 (MMP‐9) are associated with cognitive performance in patients with schizophrenia2020

    • Author(s)
      Kudo Noriko、Yamamori Hidenaga、Ishima Tamaki、Nemoto Kiyotaka、Yasuda Yuka、Fujimoto Michiko、Azechi Hirotsugu、Niitsu Tomihisa、Numata Shusuke、Ikeda Manabu、Iyo Masaomi、Ohmori Tetsuro、Fukunaga Masaki、Watanabe Yoshiyuki、Hashimoto Kenji、Hashimoto Ryota
    • Journal Title

      Neuropsychopharmacol Rep

      Volume: - Pages: 150-156

    • DOI

      10.1002/npr2.12098

    • NAID

      120007027668

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Human leukocyte antigen DRB1*04:05 and clozapine-induced agranulocytosis/granulocytopenia2020

    • Author(s)
      Saito Takeo、Ikeda Masashi、Mushiroda Taisei、Iwata Nakao、Clozapine Pharmacogenomics Consortium of Japan (CPC-J)
    • Journal Title

      Aust NZJ Psychiatry

      Volume: 54(5) Pages: 545-546

    • DOI

      10.1177/0004867419900296

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of Copy Number Variation of the 15q11.2 BP1-BP2 Region With Cortical and Subcortical Morphology and Cognition2020

    • Author(s)
      Writing Committee for the ENIGMA-CNV Working Group、van der Meer Dennis、S?nderby Ida E.、Kaufmann Tobias、Walters G. Bragi、...、Fukunaga Masaki、....、Hashimoto Ryota、...、Dale Anders M.、Djurovic Srdjan、Agartz Ingrid、Westlye Lars T.、Stefansson Hreinn、Stefansson K、Thompson Paul M.、Andreassen Ole A.
    • Journal Title

      JAMA Psychiatry

      Volume: 77 Pages: 420-420

    • DOI

      10.1001/jamapsychiatry.2019.3779

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Polygenetic risk scores for major psychiatric disorders among schizophrenia patients, their first-degree relatives, and healthy participants.2020

    • Author(s)
      Ohi K, Nishizawa D, Shimada T, Kataoka Y, Hasegawa J, Shioiri T, Kawasaki Y, Hashimoto R, Ikeda K
    • Journal Title

      International Journal of Neuropsychopharmacology

      Volume: 23 Pages: 157-164

    • DOI

      10.1093/ijnp/pyz073

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Polygenic Architecture of Human Neuroanatomical Diversity2020

    • Author(s)
      Biton Anne, Kikuchi Masataka (13 of 25 authors), Toro Roberto
    • Journal Title

      Cereb Cortex

      Volume: 30 Pages: 2307-2320

    • DOI

      10.1093/cercor/bhz241

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] White matter microstructural alterations across four major psychiatric disorders : mega-analysis study in 2937 individuals2020

    • Author(s)
      Koshiyama D., Fukunaga M., Okada N., Morita K., Nemoto K., Usui K., Yamamori H., Yasuda Y., Fujimoto M., Kudo N., Azechi H., Watanabe Y., Hashimoto N., Narita H., Kusumi I., Ohi K., Shimada T., Kataoka Y., Yamamoto M., Ozaki N., Okada G., Okamoto Y., Harada K., Matsuo K., Yamasue H., Abe O., Hashimoto R., Takahashi T., Hori T., Nakataki M., Onitsuka T., Holleran L., Jahanshad N., van Erp T. G. M.,
    • Journal Title

      Molecular Psychiatry

      Volume: 25 Pages: 883-895

    • DOI

      10.1038/s41380-019-0553-7

    • NAID

      120006980539

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clozapineによる薬疹を疑われ中止した後に再投与した治療抵抗性統合失調症の1例2020

    • Author(s)
      垰夲大喜、藤本美智子、近江翼、片上茂樹、岩瀬真生、橋本亮太、山森英長、安田由華、阿古目純、中川幸延、池田学、
    • Journal Title

      精神医神経学雑誌

      Volume: 122(6) Pages: 424-430

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of eye movements in schizophrenia and autism spectrum disorder.2020

    • Author(s)
      Shiino T, Miura K, Fujimoto M, Kudo N, Yamamori H, Yasuda Y,Ikeda M, Hashimoto R.
    • Journal Title

      Neuropsychopharmacology Reports

      Volume: 40(1) Pages: 92-95

    • DOI

      10.1002/npr2.12085

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Brain morphological and functional features in cognitive subgroups of schizophrenia2020

    • Author(s)
      Yasuda Y., Okada N., Nemoto K., Fukunaga M., Yamamori H., Ohi K., Koshiyama D., Kudo N., Shiino T., Morita S., Morita K., Azechi H., Fujimoto M., Miura K., Watanabe Y., Kasai K., Hashimoto R.
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 74(3) Pages: 191-203

    • DOI

      10.1111/pcn.12963

    • NAID

      120007132757

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Eye movement characteristics in schizophrenia : A recent update with clinical implications2020

    • Author(s)
      Morita K., Miura K., Kasai K., Hashimoto R.
    • Journal Title

      Neuropsychopharmacology Reports

      Volume: 40(1) Pages: 2-9

    • DOI

      10.1002/npr2.12087

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia.2020

    • Author(s)
      Sonderby IE,  (50名中略) Hashimoto R(151名中52番目), (108名中略) Andreassen OA,
    • Journal Title

      Molecular Psychiatry

      Volume: 25(3) Pages: 584-602

    • DOI

      10.1038/s41380-018-0118-1

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The genetic architecture of the human cerebral cortex.2020

    • Author(s)
      Grasby KL, (297名中略) Hashimoto R〈299番目360 名中), (60名中略) Medland SE,
    • Journal Title

      Science

      Volume: 367(6484) Pages: 1340-1340

    • DOI

      10.1126/science.aay6690

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes.2020

    • Author(s)
      Matsumura K, Nakazawa T, et al.
    • Journal Title

      Nature Commun

      Volume: 11(1) Pages: 1-16

    • DOI

      10.1038/s41467-020-14697-z

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differentiation of schizophrenia using structural MRI with consideration of scanner differences: A real-world multi-site study.2020

    • Author(s)
      Nemoto K, Shimokawa T, Fukunaga M, Yamashita F, Tamura M, Yamamori H, Yasuda Y, Azechi H, Kudo N, Watanabe Y, Kido M, Takahashi T, Koike S, Okada N, Hirano Y, Onitsuka T, Yamasue H, Suzuki M, Kasai K, Hashimoto R, Arai T.
    • Journal Title

      Psychiat Clin Neurosci

      Volume: 74(1) Pages: 56-63

    • DOI

      10.1111/pcn.12934

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Psychiatric-disorder-related behavioral phenotypes and cortical hyperactivity in a mouse model of 3q29 deletion syndrome.2019

    • Author(s)
      Baba M, Nakazawa T, et al.
    • Journal Title

      Neuropsychopharmacology

      Volume: 44(12) Pages: 2125-2135

    • DOI

      10.1038/s41386-019-0441-5

    • NAID

      130007811380

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Autism-associated protein kinase D2 regulates embryonic cortical neuron development.2019

    • Author(s)
      Matsumura K, Nakazawa T, et al.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 519(3) Pages: 626-632

    • DOI

      10.1016/j.bbrc.2019.09.048

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Improvement of psychiatrists’ clinical knowledge of the treatment guidelines for schizophrenia and major depressive disorders using the “Effectiveness of Guidelines for Dissemination and Education in psychiatric treatment (EGUIDE) ” project: a nationwide dissemination, education and evaluation study.2019

    • Author(s)
      Takaesu Y, Watanabe K, (44名中略) Inada K, Hashimoto R.
    • Journal Title

      Psychiat Clin Neurosci

      Volume: 73(10) Pages: 642-648

    • DOI

      10.1111/pcn.12911

    • NAID

      120007029981

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy and safety of lithium and lamotrigine for the maintenance treatment of clinically stable patients with bipolar disorder: A systematic review and meta-analysis of double-blind, randomized, placebo-controlled trials with an enrichment design.2019

    • Author(s)
      Oya K, Sakuma K, Esumi S, Hashimoto Y, Hatano M, Matsuda Y, Matsui Y, Miyake N, Nomura I, Okuya M, Iwata N, Kato M, Hashimoto R, Mishima K, Watanabe N, Kishi T.
    • Journal Title

      Neuropsychopharmacol Rep

      Volume: 39(3) Pages: 241-246

    • DOI

      10.1002/npr2.12056

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Current Perspective: Modeling of psychiatric disorders using induced pluripotent stem cell-related technologies.2019

    • Author(s)
      Nakazawa T, Hashimoto R, Takuma K, Hashimoto H.
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 140(4) Pages: 321-324

    • DOI

      10.1016/j.jphs.2019.06.002

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A 1.5-year longitudinal study of social activity in patients with schizophrenia.2019

    • Author(s)
      Ohi K, Sumiyoshi C, Fujino H, Yasuda Y, Yamamori H, Fujimoto M, Sumiyoshi T, Hashimoto R.
    • Journal Title

      Frontiers in Psychiatry

      Volume: 10 Pages: 567-567

    • DOI

      10.3389/fpsyt.2019.00567

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Eye movement characteristics of schizophrenia and their association with cortical thickness.2019

    • Author(s)
      Morita K, Miura K, Fujimoto M, Yamamori H, Yasuda Y, Kudo N, Azechi H, OkadaN, Koshiyama D, Shiino T, Fukunaga M, Watanabe Y, Ikeda M, Kasai K, Hashimoto R.
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 73(8) Pages: 508-509

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Eye movement abnormalities and their association with cognitive impairments in schizophrenia.2019

    • Author(s)
      Morita K, Miura K, Fujimoto M, Yamamori H, Yasuda Y, Kudo N, Azechi H, Okada N, Koshiyama D, Ikeda M, Kasai K, Hashimoto R.
    • Journal Title

      Schizophrenia Research

      Volume: 209 Pages: 255-262

    • DOI

      10.1016/j.schres.2018.12.051

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect2019

    • Author(s)
      Ikeda M,Takahashi A,Kamatani Y,Momozawa Y,Saito T,Kondo K,Shimasaki A,Kawase K,Sakusabe T,Iwayama Y,Toyota T,Wakuda T,Kikuchi M,Kanahara N,Yamamori H,Yasuda Y,Watanabe Y,Hoya S,Aleksic B,Kushima I,Arai H,Takaki M,Hattori K,Kunugi H,Okahisa Y,Ohnuma T,Ozaki N,Someya T,Hashimoto R,Yoshikawa T,Kubo M,Iwata N
    • Journal Title

      Schizophr Bull

      Volume: 印刷中 Pages: 824-834

    • DOI

      10.1093/schbul/sby140

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Whole-brain Block-Face Serial Microscopy Tomography at Subcellular Resolution Using FAST2019

    • Author(s)
      Seiriki K, Kasai A, Nakazawa T, Niu M, Naka Y, Tanuma M, Igarashi H, Yamaura K, Hayata-Takano A, Ago Y, Hashimoto H.
    • Journal Title

      Nat Protoc

      Volume: 印刷中 Issue: 5 Pages: 1509-1529

    • DOI

      10.1038/s41596-019-0148-4

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pituitary Adenylate Cyclase-Activating Polypeptide Modulates Dendritic Spine Maturation and Morphogenesis via MicroRNA-132 Upregulation2019

    • Author(s)
      Hayata-Takano A, Kamo T, Kijima H, Seiriki K, Ogata K, Ago Y, Nakazawa T, Shintani Y, Higashino K, Nagayasu K, Shintani N, Kasai A, Waschek JA, Hashimoto H.
    • Journal Title

      Journal of Neuroscience

      Volume: 印刷中 Issue: 22 Pages: 4208-4220

    • DOI

      10.1523/jneurosci.2468-18.2019

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Reply to: New Meta- and Mega-analyses of Magnetic Resonance Imaging Findings in Schizophrenia: Do They Really Increase Our Knowledge About the Nature of the Disease Process?2019

    • Author(s)
      van Erp Theo G.M.、Walton Esther、Hibar Derrek P.、Schmaal Lianne、Jiang Wenhao、Glahn David C.、Pearlson Godfrey D.、Yao Nailin、Fukunaga Masaki、Hashimoto Ryota、Okada Naohiro、Yamamori Hidenaga、et al.
    • Journal Title

      Biol Psychiatry

      Volume: 85

    • DOI

      10.1016/j.biopsych.2018.10.003

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Frequency of mental disorders among chronic pain patients with or without fibromyalgia in Japan.2019

    • Author(s)
      Miki K, Nakae A, Shi K, Yasuda Y, Yamamori H, Fujimoto M, Ikeda M, Shibata M, Yukioka M, Hashimoto R.
    • Journal Title

      Neuropsychopharmacology Reports

      Volume: 38(4) Pages: 167-174

    • DOI

      10.1002/npr2.12025

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of frontal white matter and corpus callosum on social function in schizophrenia2018

    • Author(s)
      Koshiyama D., Fukunaga M., Okada N., Morita K., Nemoto K., Yamashita F., Yamamori H., Yasuda Y., Fujimoto M., Kelly S., Jahanshad N., Kudo N., Azechi H., Watanabe Y., Donohoe G., Thompson P. M., Kasai K., Hashimoto R.
    • Journal Title

      Schizophrenia Research

      Volume: 202 Pages: 180-187

    • DOI

      10.1016/j.schres.2018.07.009

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Abnormalities of eye movement are associated with work hours in schizophrenia.2018

    • Author(s)
      Morita K, Miura K, Fujimoto M, Shishido E, Shiino T, Takahashi J, Yamamori H, Yasuda Y, Kudo N, Hirano Y, Koshiyama D, Okada N, Ikeda M, Onitsuka T, Ozaki N, Kasai K, Hashimoto R.
    • Journal Title

      Schizophr Res,

      Volume: 202 Pages: 420-422

    • DOI

      10.1016/j.schres.2018.06.064

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Predicting work outcome in patients with schizophrenia: Influence of IQ decline.2018

    • Author(s)
      Sumiyoshi C, Fujino H, Yamamori H, Kudo N, Azechi H, Fujimoto M, Yasuda Y, Ohi K, Sumiyoshi T, Hashimoto R.
    • Journal Title

      Schizophrenia Research

      Volume: 201 Pages: 172-179

    • DOI

      10.1016/j.schres.2018.05.042

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium.2018

    • Author(s)
      van Erp TGM, Walton E, Hibar DP, Schmaal L, Jiang W, Glahn DC, Pearlson GD, Yao N, Fukunaga M, Hashimoto R,(178名中10番目), et al.
    • Journal Title

      Biological Psychiatry

      Volume: 84(9) Pages: 644-654

    • DOI

      10.1016/j.biopsych.2018.04.023

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comparative Analyses of Copy-Number Variation in Autism Spectrum Disorder and Schizophrenia Reveal Etiological Overlap and Biological Insights.2018

    • Author(s)
      Kushima I, (27名中略), Hashimoto R,(80名中29番目) , et al.
    • Journal Title

      Cell Rep.

      Volume: 24(11) Pages: 2838-2838

    • DOI

      10.1016/j.celrep.2018.08.022

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Longer telomeres in elderly schizophrenia are associated with long-term hospitalization in the Japanese population.2018

    • Author(s)
      Zhang Y, Hishimoto A, Otsuka I, Watanabe Y, Numata S, Yamamori H, Boku S, Horai T, Someya T, Ohmori T, Hashimoto R, Sora I.
    • Journal Title

      Journal of Psychiatric Research

      Volume: 103 Pages: 161-166

    • DOI

      10.1016/j.jpsychires.2018.05.014

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genome-wide Association Analysis of Eye Movement Dysfunction in Schizophrenia.2018

    • Author(s)
      Kikuchi M, Miura K, Morita K, Yamamori H, Fujimoto M, Ikeda M, Yasuda Y, Nakaya A, uHashimoto R.
    • Journal Title

      Scientific Reports

      Volume: 8(1) Pages: 12347-12347

    • DOI

      10.1038/s41598-018-30646-9

    • NAID

      120006549303

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Plasma Levels of Soluble Tumor Necrosis Factor Receptor 2 (sTNFR2) Are Associated with Hippocampal Volume and Cognitive Performance in Patients with Schizophrenia.2018

    • Author(s)
      Kudo N, Yamamori H, Ishima T, Nemoto K, Yasuda Y, Fujimoto M, Azechi H, Niitsu T, Numata S, Ikeda M, Iyo M, Ohmori T, Fukunaga M, Watanabe Y, Hashimoto K, Hashimoto R.
    • Journal Title

      International Journal of Neuropsychopharmacology

      Volume: 21(7) Pages: 631-639

    • DOI

      10.1093/ijnp/pyy013

    • NAID

      120006772559

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Significant concordance of genetic variation that increases both the risk for obsessive-compulsive disorder and the volumes of the nucleus accumbens and putamen.2018

    • Author(s)
      Hibar DP, (12名中略)ENIGMA Consortium, IOCDF-GC
    • Journal Title

      Br J Psychiatry,

      Volume: 213(1) Pages: 430-436

    • DOI

      10.1192/bjp.2018.62

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Convergence of placenta biology and genetic risk for schizophrenia.2018

    • Author(s)
      Ursini G, Punzi G, Chen Q, Marenco S, Robinson JF, Porcelli A, Hamilton EG, Mitjans M, Maddalena G, Begemann M, Seidel J, Yanamori H, Jaffe AE, Berman KF, Egan MF, Straub RE, Colantuoni C, Blasi G, Hashimoto R, Rujescu D, Ehrenreich H, Bertolino A, Weinberger DR.
    • Journal Title

      Nat Med,

      Volume: 24(6) Pages: 792-801

    • DOI

      10.1038/s41591-018-0021-y

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group.2018

    • Author(s)
      Kelly S, (46名中略), Hashimoto R, (158名中48番目), et al.
    • Journal Title

      Mol Psychiatry,

      Volume: 23(5) Pages: 1261-1269

    • DOI

      10.1038/mp.2017.170

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Analysis of the Influence of microRNAs in Lithium Response in Bipolar Disorder.2018

    • Author(s)
      Reinbold CS, (37名中略)Hashimoto R,(121名中39番目) , et al.
    • Journal Title

      Frontiers in Psychiatry

      Volume: 9 Pages: 207-207

    • DOI

      10.3389/fpsyt.2018.00207

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Decreased serum pyridoxal levels in schizophrenia: meta-analysis and Mendelian randomization analysis2018

    • Author(s)
      Tomioka Y, Numata S, Kinoshita M, Umehara H, Watanabe S, Nakataki M, Iwayama Y, Toyota T, Ikeda M, Yamamori H, Shimodera S, Tajima A, Hashimoto R, Iwata N, Yoshikawa T, Ohmori T
    • Journal Title

      J Psychiatry Neurosci,

      Volume: 43 Pages: 170053-170053

    • DOI

      10.1503/jpn.170053

    • NAID

      120006772558

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic Overlap between General Cognitive Function and Schizophrenia: A Review of Cognitive GWASs.2018

    • Author(s)
      Ohi K, Sumiyoshi C, Fujino H, Yasuda Y, Yamamori H, Fujimoto M, Shiino T, Sumiyoshi T, Hashimoto R.
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 19(12) Pages: 3822-3822

    • DOI

      10.3390/ijms19123822

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clozapine Pharmacogenetic Studies in Schizophrenia: Efficacy and Agranulocytosis.2018

    • Author(s)
      Numata S, Umehara H, Ohmori T, Hashimoto R.
    • Journal Title

      Front Pharmacol.

      Volume: 9 Pages: 1049-1049

    • DOI

      10.3389/fphar.2018.01049

    • NAID

      120006869522

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 統合失調症患者における認知機能障害の推定:多施設共同研究2018

    • Author(s)
      藤野陽生、住吉チカ、安田由華、山森英長、藤本美智子、福永雅喜、三浦健一郎、竹林佑人、岡田直大、磯村周一、河野直子、 豊巻敦人、久我弘典、磯部昌憲、大矢一登、岡久祐子、髙木学、橋本直樹、加藤正樹、鬼塚俊明、上野雄文、大沼徹、笠井清登、尾崎紀夫、住吉太幹、井村修、橋本亮太、COCORO、
    • Journal Title

      精神神経学雑誌

      Volume: 120(4) Pages: 244-261

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Polygenetic Risk Scores for Major Psychiatric Disorders among Schizophrenia Patients, Their First-Degree Relatives and Healthy Subjects.2021

    • Author(s)
      Ohi K, Nishizawa D, Shimada T, Kataoka Y, Hasegawa J, Shioiri T, Kawasaki Y, Hashimoto R, Ikeda K.
    • Organizer
      CINP(The International College of Neuropsychopharmacology (CINP)) 2021 Virtual Congress
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 統合失調症薬物治療ガイドラインを精神科臨床で生かすために2021

    • Author(s)
      橋本亮太
    • Organizer
      2020年度第5回日本精神薬学会Web講演会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] ヒトiPS細胞技術を用いた精神疾患および発達障害モデルの開発2021

    • Author(s)
      中澤敬信
    • Organizer
      第94回 日本薬理学会年会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 人工知能技術を活用した精神疾患の層別化―病態の理解と新たな診断体系の構築に向けて―2021

    • Author(s)
      三浦健一郎、松本純弥、長谷川尚美、藤本美智子、山森英長、安田由華、橋本亮太、
    • Organizer
      NCNP令和2年度精神保健研究所研究報告会
    • Related Report
      2020 Annual Research Report
  • [Presentation] EGUIDEプロジェクトメンバーズ、統合失調症とうつ病の治療に対するEGUIDEプロジェクトの効果2021

    • Author(s)
      長谷川 尚美、松本 純弥、三浦 健一郎、橋本 亮太
    • Organizer
      NCNP令和2年度精神保健研究所研究報告会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 精神・神経・筋難病の克服を目指した研究開発2021

    • Author(s)
      橋本亮太、青木吉嗣
    • Organizer
      第5回国立研究開発法人イノベーション戦略会議
    • Related Report
      2020 Annual Research Report
  • [Presentation] 気分障害のバイオマーカーとしての血清中血小板由来増殖因子(PDGF-BB) に関する多施設共同研究2021

    • Author(s)
      井手本啓太、石間環、新津富央、畑達記、小田靖典、木村敦史、亀野陽亮、蓬莱政、山森英長、戸田重誠、菱本明豊、橋本亮太、中込和幸、伊豫雅臣、橋本謙二
    • Organizer
      第17回日本うつ病学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 多施設共同研究体制の構築2021

    • Author(s)
      橋本亮太
    • Organizer
      第15回COCORO会議
    • Related Report
      2020 Annual Research Report
  • [Presentation] EGUIDEプロジェクトの概要2021

    • Author(s)
      橋本亮太、EGUIDEプロジェクトメンバーズ
    • Organizer
      第30回臨床精神神経薬理学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Partnering International Consortium:COCORO2020

    • Author(s)
      Hashimoto R, Matsumoto J, Hasegawa N, Miura K.
    • Organizer
      The ENIGMA Consortium All-Hands Virtual Meeting 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Facilitative Effects of Transcranial Direct Current Stimulation on Semantic Memory Examined by Text-mining Analysis in Patients with Schizophrenia.2020

    • Author(s)
      Sumiyoshi C, Narita Z, Inagawa T, Yamada Y, Sueyoshi K, Hasegawa Y, Shirama A, Hashimoto R, Sumiyoshi T.
    • Organizer
      SIRS(Schizophrenia International Research Society)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脳神経画像のメガアナリシスによる病態解明研究とEGUIDEプロジェクトによるガイドラインの普及教育効果の検証2020

    • Author(s)
      橋本亮太、長谷川尚美、松本純弥、三浦健一郎
    • Organizer
      NCNP令和元年度精神保健研究所研究報告会
    • Related Report
      2020 Annual Research Report
  • [Presentation] EGUIDEプロジェクトによる退院時処方への効果~クロザピンと医療の質(Quality Indicator)の関係に着目して~2020

    • Author(s)
      長谷川尚美、松本純弥、三浦健一郎、橋本亮太、EGUIDEプロジェクトメンバーズ
    • Organizer
      NCNP令和元年度精神保健研究所研究報告会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 精神疾患の多施設共同研究~病態解明から治療法の社会実装まで~2020

    • Author(s)
      橋本亮太
    • Organizer
      Mist seminer in GIFU
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 3q29領域欠失変異を有する精神疾患患者のiPS神経細胞の機能解析2020

    • Author(s)
      近藤百香、栗生俊彦、馬場優志、北川航平、竹本智哉、永安一樹、山森英長、安田由華、藤本美智子、田熊一敞、小野富三人、橋本亮太、橋本均、中澤敬信
    • Organizer
      第138回日本薬理学会近畿部会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ヒト染色体3q29欠失モデルマウスを用いた精神疾患の分子病態研究2020

    • Author(s)
      馬場優志、勢力薫,、近藤百香、北川航平、竹本智哉、笠井淳司、吾郷由希夫、 永安一樹、森大輔、尾崎紀夫、山本雅、田熊一敞、橋本亮太、橋本均、中澤敬信
    • Organizer
      第138回日本薬理学会近畿部会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 臨床研究者の立場から2020

    • Author(s)
      橋本亮太
    • Organizer
      第116回日本精神神経学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 統合失調症患者、非罹患近親者、健常者間における各精神疾患のポリジェニックリスクスコア2020

    • Author(s)
      大井一高、西澤大輔、嶋田貴充、片岡譲、長谷川準子、塩入俊樹、川﨑康弘、橋本亮太、池田和隆、
    • Organizer
      第116回日本精神神経学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 統合失調症薬物治療ガイドライン改訂版の概要2020

    • Author(s)
      橋本亮太
    • Organizer
      第116回日本精神神経学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 大脳白質の軸索の髄鞘化、大脳白質の成熟と、認知機能・社会機能の指標である労働時間との関連2020

    • Author(s)
      松本純弥、福永雅喜、根本清貴、越山大輔、三浦健一郎、岡田直大、森田健太郎、山森英長、安田由華、藤本美智子、工藤紀子、笠井清登、渡邉嘉之、橋本亮太
    • Organizer
      第116回日本精神神経学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 統合失調症におけるバイオマーカーとしての眼球運動スコアの臨床的意義2020

    • Author(s)
      藤本美智子、三浦健一郎、森田健太郎、工藤紀子、畦地裕統、山森英長、安田由華、池田学、橋本亮太
    • Organizer
      第50回日本神経精神薬理学会年会・第42回日本生物学的精神医学会年会・第4回日本精神薬学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 治療の指針となる診断法の開発研究の真のゴールとその道のり2020

    • Author(s)
      橋本亮太、松本純弥、長谷川尚美、三浦健一郎
    • Organizer
      第50回日本神経精神薬理学会年会・第42回日本生物学的精神医学会年会・第4回日本精神薬学会総会・学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 統合失調症薬物治療ガイドラインの作成・普及・教育・検証活動:日本神経精神薬理学会から世界を変える!2020

    • Author(s)
      橋本亮太
    • Organizer
      第50回日本神経精神薬理学会年会・第42回日本生物学的精神医学会年会・第4回日本精神薬学会総会・学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 疾患iPS細胞を用いた精神疾患の分子病態研究2020

    • Author(s)
      中澤敬信
    • Organizer
      第50回日本神経精神薬理学会年会・第42回日本生物学的精神医学会年会・第4回日本精神薬学会総会・学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 眼球運動特徴による自己組織化マップを用いた統合失調症の層別化2020

    • Author(s)
      三浦健一郎、松本純弥、長谷川尚美、藤本美智子、山森英長、安田由華、橋本亮太
    • Organizer
      第50回日本神経精神薬理学会年会・第42回日本生物学的精神医学会年会・第4回日本精神薬学会総会・学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 統合失調症のbiotypeである認知機能障害と大脳白質統合性の関連2020

    • Author(s)
      松本純弥、三浦健一郎、坂元竜馬、福永雅喜、越山太輔、根本清貴、岡田直大、森田健太郎、大井一高、長谷川尚美、藤本美智子、山森英長、安田由華、笠井清登、渡邉嘉之、橋本亮太
    • Organizer
      第50回日本神経精神薬理学会年会・第42回日本生物学的精神医学会年会・第4回日本精神薬学会総会・学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 統合失調症患者と健常被験者における拡散テンソル画像を用いた大脳白質微細構造と認知機能、認知機能障害、労働時間との関連2020

    • Author(s)
      松本純弥、三浦健一郎、福永雅喜、越山太輔、根本清貴、大井一高、岡田直大、長谷川尚美、山森英長、安田由華、藤本美智子、鬼塚俊明、高橋努、尾崎紀夫、渡邉嘉之、橋本亮太
    • Organizer
      第50回日本神経精神薬理学会年会・第42回日本生物学的精神医学会年会・第4回日本精神薬学会総会・学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 暴力の既往のある統合失調症罹患者の、認知機能、精神病理、心理社会的背景の特徴2020

    • Author(s)
      柏木宏子、三浦健一郎、松本純弥、坂元竜馬、竹田康二、山田悠至、藤本美智子、安田由華、山森英長、池田学、平林直次、橋本亮太
    • Organizer
      第50回日本神経精神薬理学会年会・第42回日本生物学的精神医学会年会・第4回日本精神薬学会総会・学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 気分障害のバイオマーカーとしての血清中血小板由来増殖因子(PDGF-BB) に関する多施設共同研究2020

    • Author(s)
      井手本啓太、石間環、新津富央、畑達記、小田靖典、木村敦史、亀野陽亮、蓬莱政、山森英長、戸田重誠、菱本明豊、橋本亮太、中込和幸、伊豫雅臣、橋本謙二
    • Organizer
      第50回日本神経精神薬理学会年会・第42回日本生物学的精神医学会年会・第4回日本精神薬学会総会・学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 精神疾患の病態解明研究のトレンドウォッチ:ビッグデータと仮説検証研究2020

    • Author(s)
      橋本亮太
    • Organizer
      第43回日本神経科学大会、
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] フリービューイング時のマカクサルの視覚探索行動:ヒトとの比較2020

    • Author(s)
      三浦健一郎、吉田正俊、藤本美智子、山森英長、安田由華、長谷川尚美、松本純弥、橋本亮太、竹村文
    • Organizer
      第43回日本神経科学大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 精神疾患の克服とその障害の支援2020

    • Author(s)
      橋本亮太
    • Organizer
      NCNP EDICS/精神科共催セミナー
    • Related Report
      2020 Annual Research Report
  • [Presentation] International neuroimaging big data collaborations:ENIGMA and COCORO2019

    • Author(s)
      Hashimoto R,
    • Organizer
      AsCNP (6th Congress of Asian College of Neuropsychopharmacology)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Clozapine-induced seizure complicated with vertebral fracture, leg paralysis and pulmonary embolism in a patient with treatment-resistant schizophrenia.2019

    • Author(s)
      Fujimoto M, Taomoto D, Katakami S, Omi T, Hashimoto R, Yamamori H, Yasuda Y, Makino T, Yoshikawa H, Iwase M, Ikeda M.
    • Organizer
      AsCNP (6th Congress of Asian College of Neuropsychopharmacology)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Association between Work Status and Subjective Aspects of Recovery in Patients with Schizophrenia: A longitudinal study.2019

    • Author(s)
      Sumiyoshi C, Ohi K, Fujino H, Yamamori H, Kudo N, Azechi H, Fujimoto M, Yasuda Y, Sumiyoshi T, Hashimoto R.
    • Organizer
      SIRS(Schizophrenia International Research Society)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 精神疾患のバイオタイプによる診断・治療法の開発2019

    • Author(s)
      橋本亮太
    • Organizer
      第18回IGC第14回COCORO合同会議
    • Related Report
      2019 Research-status Report
  • [Presentation] 多施設共同研究体制の構築2019

    • Author(s)
      橋本亮太
    • Organizer
      第18回IGC第14回COCORO合同会議
    • Related Report
      2019 Research-status Report
  • [Presentation] 統合失調症の治療法の最近の動向とクロザピン治療2019

    • Author(s)
      橋本亮太
    • Organizer
      大精神・大阪弁護士会合同勉強会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 統合失調症の認知社会機能の測定法とその臨床応用2019

    • Author(s)
      橋本亮太
    • Organizer
      第39回静岡県東部精神科医会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Clozapine投与中の治療抵抗性統合失調症患者における簡易認知機能検査の実践2019

    • Author(s)
      藤本美智子、山森英長、三浦健一郎、安田由華、工藤紀子、畦地裕統、住吉チカ、藤野陽生、住吉太幹、池田学、橋本亮太
    • Organizer
      第19回精神疾患と認知機能研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] カテゴリ流暢性課題を利用した統合失調症患者の高次認知機能の評価:最近の研究動向2019

    • Author(s)
      住吉チカ、松井三枝、倉知正佳、橋本亮太、吉村直記、住吉太幹
    • Organizer
      第19回精神疾患と認知機能研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] 大脳白質の成熟性と社会機能の指標である労働時間との関連2019

    • Author(s)
      松本純弥、福永雅喜、根本清貴、越山太輔、三浦健一郎、宇野洋太、岡田直大、森田健太郎、山森英長、安田由華、藤本美智子、工藤紀子、畦地裕統、笠井清登、渡邉嘉之、橋本亮太、
    • Organizer
      第49回日本神経精神薬理学会年会
    • Related Report
      2019 Research-status Report
  • [Presentation] 精神疾患のバイオタイプ概説2019

    • Author(s)
      橋本亮太、宇野洋太、松本純弥、住吉チカ、森田健太郎、越山太輔、岡田直大、藤野陽生、大井一高、藤本美智子、安田由華、山森英長、住吉太幹、根本清貴、福永雅喜、三浦健一郎
    • Organizer
      第49回日本神経精神薬理学会・第29回日本臨床精神神経薬理学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 眼球運動による精神疾患のバイオタイプ分類は可能か2019

    • Author(s)
      森田健太郎、三浦健一郎、藤本美智子、宍戸恵美子、高橋潤一、山森英長、安田由華、工藤紀子、畦地裕統、平野羊嗣、越山太輔、岡田直大、鬼塚俊明、尾崎紀夫、笠井清登、池田学、橋本亮太
    • Organizer
      第49回日本神経精神薬理学会・第29回日本臨床精神神経薬理学会
    • Related Report
      2019 Research-status Report
  • [Presentation] The comparison of q-space myelin map, fractional anisotropy and apparent diffusion coefficient values between normal young and old ages.2019

    • Author(s)
      Shixing B, Watanabe Y, Tomiyama N, Takahashi H, Hashimoto R, Hata J.
    • Organizer
      第47回日本磁気共鳴医学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 精神科診断が乗り越えるべきもの:未来への展望2019

    • Author(s)
      橋本亮太
    • Organizer
      第39回日本精神科診断学会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 統合失調症における眼球運動特性の診断補助的指標としての再現性2019

    • Author(s)
      藤本美智子、三浦健一郎、森田健太郎、工藤紀子、畦地裕統、山森英長、安田由華、池田学、橋本亮太
    • Organizer
      第39回日本精神科診断学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 統合失調症でみられる眼球運動特徴の神経基盤の検討2019

    • Author(s)
      森田健太郎、三浦健一郎、藤本美智子、山森英長、安田由華、工藤紀子、畦地裕統、岡田直大、越山大輔、椎野智子、福永雅喜、渡邉嘉之、笠井清登、池田学、橋本亮太
    • Organizer
      第3回ヒト脳イメージング研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] DTIによる大脳白質の髄鞘化/成熟性の評価と社会機能の指標としての労働時間との関連2019

    • Author(s)
      松本純弥、福永雅喜、根本清貴、越山大輔、三浦健一郎、岡田直大、森田健太郎、山森英長、宇野洋太、安田由華、藤本美智子、工藤紀子、畦地裕統、渡邉嘉之、笠井清登、橋本亮太
    • Organizer
      第3回ヒト脳イメージング研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] Multi-site Harmonization of Resting-state functional connectivity MRI data improves classification of major depressive disorder2019

    • Author(s)
      Takamura T, Nakamura T, Yoshinaga K, Ogata Y, Ozaki N, Kasai K, Hashimoto R, Hanakawa T.
    • Organizer
      第3回ヒト脳イメージング研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] 体の痛みを考える~精神科の立場から~2019

    • Author(s)
      橋本亮太
    • Organizer
      第45回日本整形外科スポーツ医学会学術集会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 精神疾患病態研究におけるDSMとRDoCの功罪2019

    • Author(s)
      橋本亮太
    • Organizer
      第6回NCNPメディア塾
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Comparison of eye movement in Autism Spectrum Disorder and Schizophrenia.2019

    • Author(s)
      Shiino T, Miura K, Fujimoto M, Kudo N, Yamamori H, Yasuda Y, Ikeda M, Hashimoto R
    • Organizer
      第42回日本神経科学大会・第62回日本神経化学会大会(Neuro2019)
    • Related Report
      2019 Research-status Report
  • [Presentation] Pathological analysis of neurons from iPS cells derived from patients with schizophrenia in a multiple family.2019

    • Author(s)
      Yamamoto K, Kuriu T, Nakazawa T, Matsumura K, Nayasu K, Baba M, Yamamori H, Yasuda Y, Fujimoto M, Tsurusaki Y, Matsumoto N, Takuma K, Hashimoto R, Hashimoto H.
    • Organizer
      第42回日本神経科学大会・第62回日本神経化学会大会(Neuro2019)
    • Related Report
      2019 Research-status Report
  • [Presentation] 気分障害のバイオマーカーとしての血清中グリア細胞株由来神経栄養因子(GDNF)に関する多施設共同研究2019

    • Author(s)
      井出本啓太、新津富央、畑発達記、小田靖典、木村敦史、橋本佐、亀野陽亮、蓬莱政、山森英長、戸田重誠、菱本明豊、橋本亮太、中込和幸、橋本謙二、伊豫雅臣
    • Organizer
      第16回日本うつ病学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 大うつ病性障害における眼球運動2019

    • Author(s)
      高橋潤一、三浦健一郎、森田健太郎、藤本美智子、山森英長、安田由華、工藤紀子、宍戸恵美子、岡崎康輔、椎野智子、笠井清登、平野羊嗣、橋本亮太、鬼塚俊明
    • Organizer
      第16回日本うつ病学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 精神疾患における認知機能障害と社会時間活動との関連2019

    • Author(s)
      宇野洋太、(28名中略)橋本亮太
    • Organizer
      第16回日本うつ病学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 大うつ病性障害における眼球運動異常2019

    • Author(s)
      高橋潤一、三浦健一郎、森田健太郎、藤本美智子、山森英長、安田由華、工藤紀子、宍戸恵美子、岡崎康輔、椎野智子、笠井清登、平野羊嗣、橋本亮太、鬼塚俊明
    • Organizer
      第41回日本生物学的精神医学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 統合失調症における眼球運動・認知機能・社会機能の縦断的関係性の検討、2019

    • Author(s)
      森田健太郎、三浦健一郎、藤本美智子、山森英長、安田由華、工藤紀子、畦地裕統、岡田直大、越山太輔、池田学、笠井清登、橋本亮太
    • Organizer
      第41回日本生物学的精神医学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 自閉スペクトラム症と統合失調症の眼球運動特性の検討2019

    • Author(s)
      椎野智子、三浦健一郎、藤本美智子、工藤紀子、山森英長、安田由華、池田学、橋本亮太
    • Organizer
      第41回日本生物学的精神医学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 精神疾患における認知機能障害と社会活動時間との関連2019

    • Author(s)
      宇野洋太、(28名中略)橋本亮太
    • Organizer
      第41回日本生物学的精神医学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 統合失調症におけるバイオマーカーとしての眼球運動スコアの臨床的意義、2019

    • Author(s)
      藤本美智子、三浦健一郎、森田健太郎、工藤紀子、畦地裕統、山森英長、安田由華、池田学、橋本亮太
    • Organizer
      第41回日本生物学的精神医学会
    • Related Report
      2019 Research-status Report
  • [Presentation] Clozapine により好酸球増加症が生じたが継続投与が可能であった治療抵抗性統合失調症の一例2019

    • Author(s)
      藤本美智子、山森英長、安田由華、加藤恒、金倉譲、岩瀬真生、池田学、橋本亮太
    • Organizer
      第115回日本精神神経学会学術総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 生来の白血球数・顆粒球数とクロザピン誘発性顆粒球減少症:Mendelian Randomization解析2019

    • Author(s)
      島崎愛夕、齋藤竹生、大河内智、谷口賢、二宮光平、橋本亮太、池田匡志、岩田仲生、CPC-J
    • Organizer
      第115回日本精神神経学会学術総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 精神疾患のバイオタイプによる診断・治療法の開発2019

    • Author(s)
      橋本亮太
    • Organizer
      第17回IGC第13回COCORO合同会議、
    • Related Report
      2019 Research-status Report
  • [Presentation] 多施設共同研究体制の構築2019

    • Author(s)
      橋本亮太
    • Organizer
      第17回IGC第13回COCORO合同会議、
    • Related Report
      2019 Research-status Report
  • [Presentation] 統合失調症の眼球運動研究2019

    • Author(s)
      森田健太郎、三浦健一郎、藤本美智子、宍戸恵美子、椎野智子、高橋潤一、山森英長、工藤紀子、畦地裕統、平野羊嗣、越山大輔、岡田直大、鬼塚俊明、尾崎紀夫、笠井清登、池田学、橋本亮太
    • Organizer
      第14回日本統合失調症学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 精神疾患の病態解明とその障害への支援に関する研究、2019

    • Author(s)
      橋本亮太、椎野智子、
    • Organizer
      平成30年度精神保健研究所研究報告会、
    • Related Report
      2018 Research-status Report
  • [Presentation] 統合失調症の眼球運動研究、2019

    • Author(s)
      橋本亮太
    • Organizer
      平成30年度京都大学霊長類研究所共同利用研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] 精神疾患の克服と障害支援への挑戦、2019

    • Author(s)
      橋本亮太
    • Organizer
      第四回認知機能をチーム医療で考える会、
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 精神疾患の克服とその障害支援への挑戦2019

    • Author(s)
      橋本亮太
    • Organizer
      むさしの会:1月の例会・学習会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 統合失調症ー薬物治療の基本を学ぶ、2019

    • Author(s)
      橋本亮太
    • Organizer
      新宿区精神障害者家族会新宿フレンズ昼の家族会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Cross-disorder analysis of neuroimaging data in Psychiatry,2019

    • Author(s)
      Hashimoto R,
    • Organizer
      Japan-UK Neuroscience Symposium 2019
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 精神疾患のバイオタイプによる診断・治療法の開発2018

    • Author(s)
      橋本亮太
    • Organizer
      第16回IGC第12回COCORO合同会議
    • Related Report
      2018 Research-status Report
  • [Presentation] 多施設共同研究体制の構築2018

    • Author(s)
      橋本亮太
    • Organizer
      第16回IGC第12回COCORO合同会議
    • Related Report
      2018 Research-status Report
  • [Presentation] 統合失調症の眼球運動障害のゲノム解析2018

    • Author(s)
      橋本亮太
    • Organizer
      H30年度AMED「疾病克服に向けたゲノム医療実現プロジェクト」研究交流会
    • Related Report
      2018 Research-status Report
  • [Presentation] 統合失調症における認知機能障害評価法の臨床応用2018

    • Author(s)
      椎野智子、住吉チカ、藤野陽生、山森英長、藤本美智子、安田由華、大井一高、住吉太幹、橋本亮太、
    • Organizer
      第22回日本精神保健・予防学会
    • Related Report
      2018 Research-status Report
  • [Presentation] リエゾン精神科医のためのガイドライン活用術2018

    • Author(s)
      橋本亮太、市橋加代
    • Organizer
      第31回総合病院精神医学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 精神疾患の克服とその障害支援への挑戦2018

    • Author(s)
      橋本亮太
    • Organizer
      横浜YPSピアスタッフの集い
    • Related Report
      2018 Research-status Report
  • [Presentation] 統合失調症薬物治療ガイド作成の趣旨2018

    • Author(s)
      橋本亮太
    • Organizer
      第28回日本臨床精神神経薬理学会・第48回日本神経精神薬理学会合同年会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] iPS細胞関連技術とヒト型疾患モデルマウスを用いた精神疾患の分子病態解析、2018

    • Author(s)
      中澤敬信、橋本亮太、田熊一敞、橋本均、
    • Organizer
      第28回日本臨床精神神経薬理学会・第48回日本神経精神薬理学会合同年会
    • Related Report
      2018 Research-status Report
  • [Presentation] 統合失調症患者のクロザピン治療による中間表現型の変化2018

    • Author(s)
      藤本美智子、三浦健一郎、森田健太郎、工藤紀子、畦地裕統、山森英長、安田由華、池田学、橋本亮太、
    • Organizer
      第28回日本臨床精神神経薬理学会・第48回日本神経精神薬理学会合同年会
    • Related Report
      2018 Research-status Report
  • [Presentation] 統合失調症患者の労働状態:推定精度に関わる要因2018

    • Author(s)
      住吉 チカ、藤野陽生、山森英長、工藤紀子、畦地裕統、藤本美智子、安田由華、大井一高、住吉太幹、橋本亮太、
    • Organizer
      精神疾患と認知機能研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] 簡易認知機能検査をアセスメントに用いた支援の実践2018

    • Author(s)
      佐田あゆ美、福留隆志、釘抜利明、橋本亮太、
    • Organizer
      日本デイケア学会第23回年次大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 精神科医療における標準治療と臨床経験との関係、2018

    • Author(s)
      橋本亮太
    • Organizer
      第7回日本精神科医学会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 統合失調症薬物治療を正しく理解し正確に伝えるために、2018

    • Author(s)
      橋本亮太
    • Organizer
      埼玉県精神障害者家族会連合会 精神障害者家族間の支援者(ピアサポート)養成研修会
    • Related Report
      2018 Research-status Report
  • [Presentation] 慢性疼痛と精神疾患:「やるべきこと」と「やってはならないこと」2018

    • Author(s)
      橋本亮太
    • Organizer
      日本線維筋痛症学会第10回学術集会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 統合失調症薬物治療ガイドラインとは-ガイドラインの概念と使い方-2018

    • Author(s)
      橋本亮太
    • Organizer
      第2回日本精神薬学会総会・学術総会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 共同研究の上手な進め方‐多施設共同研究ってどうやるの?2018

    • Author(s)
      橋本亮太
    • Organizer
      第40日本生物学的精神医学会・第61会日本神経化学会大会合同年会
    • Related Report
      2018 Research-status Report
  • [Presentation] 統合失調症の皮質下体積と認知・社会機能の相関解析2018

    • Author(s)
      越山太輔、福永雅喜、岡田直大、山下典生、山森英長、安田由華、藤本美智子、大井一高、藤野陽生、渡邉嘉之、笠井清登、橋本亮太、
    • Organizer
      第40日本生物学的精神医学会・第61会日本神経化学会大会合同年会
    • Related Report
      2018 Research-status Report
  • [Presentation] Eye Movement Abnormalities in Major Depressive Disorder.2018

    • Author(s)
      Takahashi J, Miura K, Morita K, Fujimoto M, Yamamori H, Yuka Y, Kudo N, Shishido E, Okazaki K, Kasai K, Hirano Y, Hashimoto R, Onitsuka T.
    • Organizer
      第40日本生物学的精神医学会・第61会日本神経化学会大会合同年会
    • Related Report
      2018 Research-status Report
  • [Presentation] Abnormalities of eye movement are associated with work hours in schizophrenia.2018

    • Author(s)
      Morita K, Miura K, Fujimoto M, Shishido E, Shiino T, Takahashi J, Yamamori H, Yasuda Y, Kudo N, Hirano Y, Koshiyama D, Okada N, Ikeda M, Onitsuka T, Ozaki N, Kasai K, Hashimoto R.
    • Organizer
      第40日本生物学的精神医学会・第61会日本神経化学会大会合同年会
    • Related Report
      2018 Research-status Report
  • [Presentation] 統合失調症における労働状態の予測因子:確率予測による検討2018

    • Author(s)
      住吉チカ、藤野陽生、住吉太幹、山森英長、工藤紀子、畦地裕統、藤本美智子、安田由華、橋本亮太、
    • Organizer
      第40日本生物学的精神医学会・第61会日本神経化学会大会合同年会
    • Related Report
      2018 Research-status Report
  • [Presentation] 過去の注視位置が統合失調症患者の視覚探索に与える影響2018

    • Author(s)
      岡田研一、三浦健一郎、藤本美智子、森田健太郎、山森英長、安田由華、稲垣未来男、篠崎隆志、藤田一郎、橋本亮太、
    • Organizer
      視覚科学フォーラム
    • Related Report
      2018 Research-status Report
  • [Presentation] 統合失調症は治るのか~リカバリー概念から2018

    • Author(s)
      橋本亮太、中込和幸
    • Organizer
      第5回NCNPメディア塾
    • Related Report
      2018 Research-status Report
  • [Presentation] 統合失調症・うつについて、2018

    • Author(s)
      橋本亮太
    • Organizer
      平成30年度第一回薬物療法専門薬剤師集中講義
    • Related Report
      2018 Research-status Report
  • [Presentation] 炭酸リチウムと抗精神病薬が感情障害患者の皮質下脳体積に与える影響についての検討2018

    • Author(s)
      橋本直樹、成田尚、岡田直大、福永雅喜、橋本亮太、久住一郎、
    • Organizer
      第15回日本うつ病学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] Eyemovement abnormalities and their association with cognitive impairments in schizophrenia2018

    • Author(s)
      Morita K, Miura K, Fujimoto M, Yamamori H, Yasuda Y, Kudo N, Azehi H, Okada N, Koshiyama D, Kawakami S, Morita S, Ikeda M, Kasai K, Hashimoto R.
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 日本医療機能評価機構Mindsによる診療ガイドラインの精神疾患への適用2018

    • Author(s)
      橋本亮太
    • Organizer
      第114回日本精神神経学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 精神疾患のバイオタイプによる診断・治療法の開発2018

    • Author(s)
      橋本亮太
    • Organizer
      第15回IGC第11回COCORO合同会議
    • Related Report
      2018 Research-status Report
  • [Presentation] 多施設共同研究体制の構築2018

    • Author(s)
      橋本亮太
    • Organizer
      第15回IGC第11回COCORO合同会議
    • Related Report
      2018 Research-status Report
  • [Presentation] Abnormalities of eye movement are associated with work hours in schizophrenia: A multi-site study.2018

    • Author(s)
      Morita K, Miura K, Fujimoto M, Shishido E, Shiino T, Takahashi J, Yamamori H, Yasuda Y, Kudo N, Hirano Y, Koshiyama D, Okada N, Ikeda M, Onitsuka T, Ozaki N, Kasai K, Hashimoto R.
    • Organizer
      7th BESETO International Psychiatry Conference
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Behavior/Self-Reports/Paradigms based on RDoC focusing on cognitive impairment2018

    • Author(s)
      Hashimoto R,
    • Organizer
      WFSBP Asia Pacific Regional Congress of Biological Psychiatry
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Circuits/Physiology biomarkers based on RDoC.2018

    • Author(s)
      Okada N, Hashimoto R, Ozaki N, Kasai K.
    • Organizer
      WFSBP Asia Pacific Regional Congress of Biological Psychiatry
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Cross disorder analysis of brain measures: implication of new diagnosis.2018

    • Author(s)
      Hashimoto R, Yasuda Y, Ohi K, Fukunaga M.
    • Organizer
      Laboratory Seminar, Imaging Genetics Center, University of Southern California
    • Related Report
      2018 Research-status Report
  • [Presentation] Cross disorder analysis of brain measures: implication of new diagnosis.2018

    • Author(s)
      Hashimoto R, Yasuda Y, Ohi K, Fukunaga M.
    • Organizer
      UCI Medical Center Ground Rounds,
    • Related Report
      2018 Research-status Report
  • [Presentation] Cross disorder analysis of brain measures: implication of new diagnosis.2018

    • Author(s)
      Hashimoto R, Yasuda Y, Ohi K, Fukunaga M.
    • Organizer
      Luncheon Seminar, Department of Psychology,Georgia State University
    • Related Report
      2018 Research-status Report
  • [Presentation] The de novo Q1042R POGZ mutation in sporadic ASD disrupts the neuronal differentiation.2018

    • Author(s)
      Matsumura K, Nakazawa T, Okada S, Nagayasu K, Miura H, Kasai A, Takuma K, Yamamori H, Yasuda Y, Hashimoto R, Hashimoto H.
    • Organizer
      WCP2018 Kyoto
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] A 1.5-year longitudinal study on social activity in schizophrenia.2018

    • Author(s)
      Ohi K, Sumiyoshi C, Fujino H, Yasuda Y, Yamamori H, Fujimoto M, Sumiyoshi T, Hashimoto R.
    • Organizer
      CINP 2018 World Congress
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Book] Clozapineのモニタリング制度の現在と未来、臨床精神薬理2021

    • Author(s)
      古郡規雄、橋本亮太
    • Publisher
      星和書店
    • Related Report
      2020 Annual Research Report
  • [Book] クロザピンモニタリング制度に関する学会での活動、臨床精神薬理2021

    • Author(s)
      古郡規雄、西村勝治、久住一郎、新津富央、稲田健、上野雄文、木下利彦、三村將、中込和幸、下田和孝、橋本亮太
    • Publisher
      星和書店
    • Related Report
      2020 Annual Research Report
  • [Book] 疾患別 統合失調症、IIガイドラインに基づく外来での精神科薬物療法、調剤と情報 臨時増刊号2021

    • Author(s)
      長谷川尚美、橋本亮太
    • Publisher
      じほう
    • Related Report
      2020 Annual Research Report
  • [Book] ケースでわかる!精神科治療ガイドラインのトリセツ、2020

    • Author(s)
      EGUIDEプロジェクト
    • Total Pages
      138
    • Publisher
      医学書院
    • ISBN
      9784260042925
    • Related Report
      2020 Annual Research Report
  • [Book] 気分症群(講座 精神疾患の臨床), EGUIDEプロジェクト2020

    • Author(s)
      橋本亮太、渡邊衡一郎
    • Publisher
      中山書店
    • ISBN
      9784521748214
    • Related Report
      2020 Annual Research Report
  • [Book] クロザピン患者モニタリングサービスの国際比較ーCOVID-19対応を含めてー、臨床精神薬理2020

    • Author(s)
      古郡規雄、内田裕之、水野裕也、橋本亮太
    • Publisher
      星和書店
    • Related Report
      2020 Annual Research Report
  • [Book] スポーツとこころの関係~精神科の立場から体の痛みを考える~、日本整形外科スポーツ医学会雑誌、2020

    • Author(s)
      橋本亮太
    • Publisher
      日本整形外科スポーツ医学会
    • Related Report
      2020 Annual Research Report
  • [Book] EGUIDEプロジェクトの概要、日本精神神経科診療所協会誌日精診ジャーナル、第24回通算45回学術研究会2018年淡路大会特集号2020

    • Author(s)
      橋本亮太
    • Publisher
      公益財団法人日本精神神経科診療所協会
    • Related Report
      2020 Annual Research Report
  • [Book] 精神疾患のバイオマーカーを考察する、精神医学2020

    • Author(s)
      橋本亮太、松本純弥、長谷川尚美、三浦健一郎
    • Publisher
      医学書院
    • Related Report
      2020 Annual Research Report
  • [Book] 統合失調症薬物治療ガイドライン、精神医学2020

    • Author(s)
      稲田健、橋本亮太、中込和幸
    • Publisher
      医学書院
    • Related Report
      2020 Annual Research Report
  • [Book] 精神科診断が乗り越えるべきもの:未来への展望、精神科診断学2020

    • Author(s)
      橋本亮太
    • Publisher
      日本精神科診断学会
    • Related Report
      2019 Research-status Report
  • [Book] 精神科治療ガイドラインの普及・教育・検証活動:EGUIDEプロジェクト、医学のあゆみ2020

    • Author(s)
      橋本亮太、稲田健
    • Publisher
      医歯薬出版社
    • Related Report
      2019 Research-status Report
  • [Book] 精神科医療における標準治療の課題と展望、日本精神科病院協会雑誌2019

    • Author(s)
      橋本亮太
    • Publisher
      公益社団法人日本精神科病院協会
    • Related Report
      2019 Research-status Report
  • [Book] 統合失調症の診療におけるAIの活用、臨床精神医学2019

    • Author(s)
      三浦健一郎、橋本亮太
    • Publisher
      アークメディア
    • Related Report
      2019 Research-status Report
  • [Book] 指導医に求められる薬物療法の教育方法、臨床精神薬理、2019

    • Author(s)
      橋本亮太、中込和幸
    • Publisher
      星和書店
    • Related Report
      2019 Research-status Report
  • [Book] 統合失調症薬物治療の新たな原則と注意点2019

    • Author(s)
      稲田健、村岡寛之、橋本亮太
    • Publisher
      星和書店
    • Related Report
      2019 Research-status Report
  • [Book] 統合失調症薬物治療ガイドラインとは-ガイドラインの概念と使い方-、日本精神薬学会誌2019

    • Author(s)
      橋本亮太
    • Publisher
      一般社団法人日本精神薬学会
    • Related Report
      2018 Research-status Report
  • [Book] Conference Report:第31回国際神経精神薬理学会(CINP)、臨床Legato2018

    • Author(s)
      大井一高、嶋田貴充、片岡譲、桒田有紀、橋本亮太、
    • Publisher
      メディカルレビュー社
    • Related Report
      2018 Research-status Report
  • [Book] わかりやすい「統合失調症薬物治療ガイドライン」、メンタルヘルスマガジン こころの元気+2018

    • Author(s)
      橋本亮太
    • Publisher
      認定特定非営利活動法人 地域精神保健福祉機構
    • Related Report
      2018 Research-status Report
  • [Book] ガイドラインにおけるclozapine、臨床精神薬理2018

    • Author(s)
      橋本亮太
    • Publisher
      星和書店
    • Related Report
      2018 Research-status Report
  • [Book] EGUIDEプロジェクトによる精神科医療の普及と教育、Depression Strategyうつ病治療の新たなストラテジー2018

    • Author(s)
      橋本亮太
    • Publisher
      先端医学社
    • Related Report
      2018 Research-status Report
  • [Book] 本邦での統合失調症ガイドライン、月刊精神科2018

    • Author(s)
      橋本亮太
    • Publisher
      科学評論社
    • Related Report
      2018 Research-status Report
  • [Book] 非定型抗精神病薬単剤に非反応な統合失調症患者への抗精神病薬使用、臨床精神薬理2018

    • Author(s)
      橋本亮太
    • Publisher
      星和書店
    • Related Report
      2018 Research-status Report
  • [Book] 統合失調症薬物治療ガイド―患者さん・ご家族・支援者のために―2018

    • Author(s)
      統合失調症薬物治療ガイド作成メンバー
    • Total Pages
      121
    • Publisher
      じほう
    • Related Report
      2018 Research-status Report
  • [Remarks] 国立精神・神経医療研究センター精神保健研究所精神疾患病態研究部

    • URL

      https://byoutai.ncnp.go.jp/

    • Related Report
      2020 Annual Research Report
  • [Remarks] 国立研究開発法人 国立精神・神経医療研究センター 精神保健研究所 精神疾患病態研究部

    • URL

      https://byoutai.ncnp.go.jp/

    • Related Report
      2019 Research-status Report 2018 Research-status Report

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Published: 2018-07-20   Modified: 2022-12-28  

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