| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
It has been reported that endoplasmic reticulum stress may be involved in various diseases. In this study, we investigated the stress response system of the living body caused by endoplasmic reticulum stress and its detection. We found that exosomes secreted extracellularly contained a higher proportion of spliced form of XBP1 that is elevated by endoplasmic reticulum stress compared to intracellular compartment. Therefore, it is suggested that the storage of the spliced form of XBP1 in exosomes may contribute to stress transmission, and at the same time, it may be possible to monitor the stress state of the living body by detecting spliced form of XBP1 in exosomes in the future.
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