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How to predict the collapse of homeostasis in circulatory regulation

Research Project

Project/Area Number 18KT0073
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section特設分野
Research Field Complex Systems Disease Theory
Research InstitutionYokohama City University

Principal Investigator

ISHIKAWA Yoshihiro  横浜市立大学, 医学研究科, 教授 (40305470)

Co-Investigator(Kenkyū-buntansha) 藤田 孝之  横浜市立大学, 医学部, 講師 (40468202)
横山 詩子  東京医科大学, 医学部, 主任教授 (70404994)
梅村 将就  横浜市立大学, 医学部, 講師 (50595353)
齋藤 純一  横浜市立大学, 医学研究科, 客員研究員 (30779301)
Project Period (FY) 2018-07-18 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords心筋細胞 / アデニル酸シクラーゼ / カルシウム / 不整脈 / 数理モデル
Outline of Final Research Achievements

Sympathetic nervous system is a major mechanism of regulating cardiac function. It is mostly made of cAMP signal that is essential for intracellular signal in the heart. In this study, we have addressed mathematical and physical characteristics of cAMP and calcium signal in the heart, which are known to play a major role in regulating cardiac arrythmia and thus cardiac homeostasis. In particular, overactivation of the sympathetic nervous system and pressure overload in congestive heart failure are major reasons to induce cardiac pathophysiology. We have analyzed spacial and sequential role of gene expression as well as its deletion, that leads to altered enzymatic activity. We found that pharmacologically they are important at the level of both cell and body.

Academic Significance and Societal Importance of the Research Achievements

心臓の機能が上がったり下がったりは、交感神経という神経でコントロールされている。交感神経は、細胞の中のカルシウムやcAMPという名前の物質の制御をおこなう。この変化を時間的、空間的に検討した。これは我々の研究室の長年のテーマである。心機能が悪くなる不整脈や心不全の状態において、これらの物質の制御が大事な役割を果たすことが分かった。これらの所見は、心臓の機能が落ちてしまったときにどのように補っていったらよいのか、不整脈が現れた時にどのように治療していったらよいのかの方法を開発するのに役に立つことが考えられた。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (54 results)

All 2021 2020 2019 2018 2016 Other

All Journal Article (24 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 24 results,  Open Access: 22 results) Presentation (22 results) (of which Int'l Joint Research: 9 results,  Invited: 1 results) Book (1 results) Remarks (3 results) Patent(Industrial Property Rights) (4 results)

  • [Journal Article] Scaffold-free tissue-engineered arterial grafts derived from human skeletal myoblasts.2021

    • Author(s)
      Saito J, Yokoyama U, Nakamura T, Kanaya T, Ueno T, Naito Y, Takayama T, Kaneko M, Miyagawa S, Sawa Y, and Ishikawa Y
    • Journal Title

      Artif Organs

      Volume: - Issue: 8 Pages: 919-932

    • DOI

      10.1111/aor.13930

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Excessive EP4 signaling in smooth muscle cells induces abdominal aortic aneurysm by amplifying inflammation2020

    • Author(s)
      Hiromi T, Yokoyama U, Kurotaki D, Mamun A, Ishiwata R, Ichikawa Y, Nishihara H, Umemura M, Fujita T, Yasuda S, Minami T, Goda M, Uchida K, Suzuki S, Takeuchi I, Masuda M, Breyer M, Tamura T, and Ishikawa Y
    • Journal Title

      Arteriosclerosis, Thrombosis, and Vascular Biology

      Volume: 40 Issue: 6 Pages: 1559-1573

    • DOI

      10.1161/atvbaha.120.314297

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fibulin-1 Integrates Subendothelial Extracellular Matrices and Contributes to Anatomical Closure of the Ductus Arteriosus.2020

    • Author(s)
      Ito S, Yokoyama U, Nakakoji T, Cooley MA, Sasaki T, Hatano S, Kato Y, Saito J, Nicho N, Iwasaki S, Umemura M, Fujita T, Masuda M, Asou T, and Ishikawa Y
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 40 Issue: 9 Pages: 2212-2226

    • DOI

      10.1161/atvbaha.120.314729

    • NAID

      130008001539

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 心不全と血管モデルの研究開発.2020

    • Author(s)
      石川義弘,中村 隆,小嶋朋之,横山詩子.
    • Journal Title

      循環器内科

      Volume: 87 Pages: 495-500

    • NAID

      40022230510

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antenatal Administration of Betamethasone Contributes to Intimal Thickening of the Rat Ductus Arteriosus2019

    • Author(s)
      Kemmotsu T., Yokoyama U., Saito J., Ito S., Uozumi A., Nishimaki S., Iwasaki S., Seki K., Ito S., Ishikawa Y
    • Journal Title

      Circulation Journal

      Volume: 83 Issue: 3 Pages: 654-661

    • DOI

      10.1253/circj.CJ-18-1033

    • NAID

      130007604194

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2019-02-25
    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Usefulness of Exchanged Protein Directly Activated by cAMP (Epac)1-Inhibiting Therapy for Prevention of Atrial and Ventricular Arrhythmias in Mice2019

    • Author(s)
      Prajapati R, Fujita T, Suita K, Nakamura T, Cai W, Hidaka Y, Umemura M, Yokoyama U, Knollmann BC, Okumura S, Ishikawa Y
    • Journal Title

      Circulation Journal

      Volume: 83 Issue: 2 Pages: 295-303

    • DOI

      10.1253/circj.CJ-18-0743

    • NAID

      130007557004

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2019-01-25
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Translationally controlled tumor protein (TCTP) plays a pivotal role in cardiomyocyte survival through a Bnip3-dependent mechanism.2019

    • Author(s)
      Cai W, Fujita T, Hidaka Y, Jin H, Suita K, Shigeta M, Kiyonari H, Umemura M, Yokoyama U, Sadoshima J, Ishikawa Y.
    • Journal Title

      Cell Death Dis

      Volume: 10 Issue: 8 Pages: 549-549

    • DOI

      10.1038/s41419-019-1787-7

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Correction to: Epac activation inhibits IL-6-induced cardiac myocyte dysfunction.2019

    • Author(s)
      Jin H, Fujita T, Jin M, Kurotani R, Hidaka Y, Cai W, Suita K, Prajapati R, Liang C, Ohnuki Y, Mototani Y, Umemura M, Yokoyama U, Sato M, Okumura S, Ishikawa Y.
    • Journal Title

      J Physiol Sci.

      Volume: - Issue: 3 Pages: 557-557

    • DOI

      10.1007/s12576-019-00661-0

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Epac1 deficiency inhibits basic fibroblast growth factor-mediated vascular smooth muscle cell migration2019

    • Author(s)
      Yuko Kato, Utako Yokoyama, Takayuki Fujita, Masanari Umemura, Tetsuo Kubota, Yoshihiro Ishikawa
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 69 Issue: 2 Pages: 175-184

    • DOI

      10.1007/s12576-018-0631-7

    • NAID

      40021818894

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Doxorubicin induces trans-differentiation and MMP1 expression in cardiac fibroblasts via cell death-independent pathways.2019

    • Author(s)
      Narikawa M, Umemura M, Tanaka R, Hikichi M, Nagasako A, Fujita T, Yokoyama U, Ishigami T, Kimura K, Tamura K, Ishikawa Y.
    • Journal Title

      PLoS One.

      Volume: 14 Issue: 9 Pages: e0221940-e0221940

    • DOI

      10.1371/journal.pone.0221940

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] An appropriately sized soft polyester external stent prevents enlargement and neointimal hyperplasia of a saphenous vein graft in a canine model2019

    • Author(s)
      Yasuda Shota、Goda Motohiko、Shibuya Taisuke、Uchida Keiji、Suzuki Shinichi、Noishiki Yasuharu、Yokoyama Utako、Ishikawa Yoshihiro、Masuda Munetaka
    • Journal Title

      Artificial Organs

      Volume: 印刷中 Issue: 6 Pages: 577-583

    • DOI

      10.1111/aor.13399

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prostaglandin E2 receptor EP4 regulates cell migration through Orai1.2019

    • Author(s)
      Osawa K, Umemura M, Nakakaji R, Tanaka R, Islam RM, Nagasako A, Fujita T, Yokoyama U, Koizumi T, Mitsudo K, Ishikawa Y.
    • Journal Title

      Cancer Sci.

      Volume: 111 Issue: 1 Pages: 160-174

    • DOI

      10.1111/cas.14247

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reactive fibrosis precedes doxorubicin-induced heart failure through sterile inflammation.2019

    • Author(s)
      Tanaka R, Umemura M, Narikawa M, Hikichi M, Osaw K, Fujita T, Yokoyama U, Ishigami T, Tamura K, Ishikawa Y.
    • Journal Title

      ESC Heart Fail.

      Volume: 7 Issue: 2 Pages: 588-603

    • DOI

      10.1002/ehf2.12616

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Usefulness of Exchanged Protein Directly Activated by cAMP (Epac)1-2019

    • Author(s)
      Prajapati R, Fujita T, Suita K, Nakamura T, Cai W, Hidaka Y, Umemura M, Yokoyama U, Knollmann BC, Okumura S, Ishikawa Y.
    • Journal Title

      Circ J.

      Volume: 83 Pages: 295-303

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Simultaneous hyperthermia-chemotherapy effect by arterial injection of Fe(Salen) for femur tumor2018

    • Author(s)
      Umemura Masanari、Islam Md. Rafikul、Fukumura Hidenobu、Sato Itaru、Kawabata Yusuke、Matsuo Kousuke、Nakakaji Rina、Nagasako Akane、Ohtake Makoto、Takayuki Fujita、Yokoyama Utako、Nakayama Tomohiro、Eguchi Haruki、Ishikawa Yoshihiro
    • Journal Title

      Cancer Science

      Volume: 110 Issue: 1 Pages: 356-365

    • DOI

      10.1111/cas.13851

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Alternating magnetic field (AMF) enhances cytotoxicity of compound c.2018

    • Author(s)
      Akimoto T, Umemura M, Nagasako A, Ohtake M, Fujita T, Yokoyama U, Eguchi H, Yamamoto T, Ishikawa Y.
    • Journal Title

      Cancer Sci.

      Volume: 109 Issue: 11 Pages: 3483-3493

    • DOI

      10.1111/cas.13781

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A selective antagonist of prostaglandin E receptor subtype 4 attenuates abdominal aortic aneurysm.2018

    • Author(s)
      Mamun A, Yokoyama U, Saito J, Ito S, Hiromi T, Umemura M, Fujita T, Yasuda S, Minami T, Goda M, Uchida K, Suzuki S, Masuda M, Ishikawa Y.
    • Journal Title

      Physiol Rep.

      Volume: 6 Issue: 18

    • DOI

      10.14814/phy2.13878

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Treatment of oral cancer using magnetized paclitaxel2018

    • Author(s)
      Nakakaji Rina、Umemura Masanari、Mitsudo Kenji、Kim Jeong-Hwan、Hoshino Yujiro、Sato Itaru、Masuda Takatsugu、Yamamoto Masahiro、Kioi Mitomu、Koizumi Toshiyuki、Fujita Takayuki、Yokoyama Utako、Iida Masaki、Sato Motohiko、以下7名
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 21 Pages: 15591-15605

    • DOI

      10.18632/oncotarget.24570

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Acute hyperthermia inhibits TGF-β1-induced cardiac fibroblast activation via uppression of Akt Signaling.2018

    • Author(s)
      Narikawa M, Umemura M, Tanaka R, Fujita T, Yokoyama U, Ishigami T, Kimura K, Tamura K, Ishikawa Y.
    • Journal Title

      Sci Rep.

      Volume: 8 Issue: 1 Pages: 6277-6277

    • DOI

      10.1038/s41598-018-24749-6

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tissue-type plasminogen activator contributes to remodeling of the rat ductus arteriosus.2018

    • Author(s)
      Saito J, Yokoyama U, Nicho N, Zheng YW, Ichikawa Y, Ito S, Umemura M, Fujita T, Ito S, Taniguchi H, Asou T, Masuda M, Ishikawa Y.
    • Journal Title

      PLoS One

      Volume: 13(1) Issue: 1 Pages: e0190871-e0190871

    • DOI

      10.1371/journal.pone.0190871

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vidarabine, an anti-herpesvirus agent, prevents catecholamine-induced arrhythmias without adverse effect on heart function in mice2018

    • Author(s)
      Suita Kenji、Fujita Takayuki、Cai Wenqian、Hidaka Yuko、Jin Huiling、Prajapati Rajesh、Umemura Masanari、Yokoyama Utako、Sato Motohiko、Knollmann Bj?rn C.、Okumura Satoshi、Ishikawa Yoshihiro
    • Journal Title

      Pfl?gers Archiv - European Journal of Physiology

      Volume: 未定 Issue: 6 Pages: 923-935

    • DOI

      10.1007/s00424-018-2121-4

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hydrostatic pressure suppressed fibrotic change via Akt/GSK-3 signaling in human cardiac fibroblasts.2018

    • Author(s)
      Tanaka R, Umemura M, Narikawa M, Fujita T, Yokoyama U, Ishigami T, Kimura K, Tamura K, Ishikawa Y.
    • Journal Title

      Physiol Rep.

      Volume: 6 Issue: 9 Pages: e13687-e13687

    • DOI

      10.14814/phy2.13687

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Proteomic analysis of aortic smooth muscle cell secretions reveals an association of myosin heavy chain 11 with abdominal2018

    • Author(s)
      Yokoyama U, Arakawa N, Ishiwata R, Yasuda S, Minami T, Goda M, Uchida K, Suzuki S, Matsumoto M, Koizumi N, Taguri M, Hirano H, Yoshimura K, Ogino H, Masuda M, Ishikawa Y.
    • Journal Title

      Am J Physiol Heart Circ Physiol.

      Volume: 315 Issue: 4 Pages: H1012-H1018

    • DOI

      10.1152/ajpheart.00329.2018

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epac activation inhibits IL-6-induced cardiac myocyte dysfunction.2016

    • Author(s)
      Jin H,Fujita T,Jin M,Kurotani R,Hidaka Y,Cai W,Suita K,Prajapati R,Liang C,Ohnuki Y,Mototani Y,Umemura M,Yokoyama U,Sato M,Okumura S,Ishikawa Y.
    • Journal Title

      J Physiol Sci.

      Volume: 印刷中 Issue: 1 Pages: 77-87

    • DOI

      10.1007/s12576-016-0509-5

    • NAID

      40021443658

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Increased plasma level of myosin heavy chain 11 is associated with atherosclerosis.2020

    • Author(s)
      Takahashi, L., Ishigami, T., Tomiyama, H., Chikamori, T., Ishikawa, Y., & Yokoyama, U..
    • Organizer
      The Asian Pacific Society of Cardiology Congress 2020..
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A new biomarker for abdominal aortic aneurysm.2020

    • Author(s)
      Ishikawa Y, Yokoyama U
    • Organizer
      The 97th Annual Meeting of the Physiological Society of Japan.(誌上開催)
    • Related Report
      2019 Research-status Report
  • [Presentation] Development of human arterial graft with mechanically functional extracellular matrices.2020

    • Author(s)
      Yokoyama U, Tomoyuki K, Junichi S, Takanori Y, Takashi N, Yoshinobu S, Kentaro K, Etsuko M, Ishikawa Y.
    • Organizer
      The 97th Annual Meeting of the Physiological Society of Japan.(誌上開催)
    • Related Report
      2019 Research-status Report
  • [Presentation] Heart Failure and More; From the Bed to the Benchtop,2019

    • Author(s)
      Ishikawa Y.
    • Organizer
      24th Iranian and 3rd International Congress of Physiology.
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Prostaglandin E receptor EP4-mediated regulation of vascular elasticity,2019

    • Author(s)
      Yokoyama U, Hiromi T, Ishikawa Y.
    • Organizer
      The 50th NIPS International Symposium.
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Role of endothelial cells in the ductus arteriosus remodeling.2019

    • Author(s)
      Saito J, Yokoyama U, Ishikawa Y,
    • Organizer
      The 64th Japan Society for Neonatal Health and Development.
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] EP4 signaling in smooth muscle cells causes abdominal aortic aneurysm by attraction of immune infiltrates.2019

    • Author(s)
      Hiromi T, Yokoyama U, Takeuchi I, Ishikawa Y.
    • Organizer
      American Heart Association and Scientific Session 2019.
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] プロスタグランディンE受容体EP4シグナルはLysyl oxydaseの発現を抑制し大動脈瘤の進行に関与する.2019

    • Author(s)
      廣見太郎, 横山詩子, 竹内一郎, 石川義弘,
    • Organizer
      第47回日本救急医学会総 会・学術集会.
    • Related Report
      2019 Research-status Report
  • [Presentation] 内皮細胞が誘導する一方向性平滑筋細胞遊走が動脈管内膜肥厚を形成する.2019

    • Author(s)
      伊藤智子, 横山詩子, 中川路太, 齋藤純一, 二町尚樹, 益田宗孝, 麻生俊英, 石川義弘,
    • Organizer
      第55回日本小児循環器学会総会・学術集会.
    • Related Report
      2019 Research-status Report
  • [Presentation] 動脈管平滑筋細胞間由来Fibulin-1は内皮由来Versicanと共役して動脈管内膜肥厚形成を促進する.2019

    • Author(s)
      伊藤智子、横山詩子、石川義弘
    • Organizer
      第51回日本結合組織学会学術大会.
    • Related Report
      2019 Research-status Report
  • [Presentation] Tissue-type plasminogen activator promotes intimal thickening formation of the ductus arteriosus.2018

    • Author(s)
      Saito J,Yokoyama U,Nicho N,Zheng YW,Ito S,Ito S,Taniguchi H,Asou T,Masuda M,Ishikawa Y.
    • Organizer
      Weinstein 2018 Cardiovascular Development and Regeneration Conference.
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Antenatal administration of betamethasone promotes closure of the preterm ductus arteriosus via intimal thickening formation.2018

    • Author(s)
      Kemmotsu T,Yokoyama U,Azuma S,Saito J,Ito S,Uozumi A,Nishimaki S,Iwasaki S,Seki K,Ito S,Ishikawa Y.
    • Organizer
      Weinstein 2018 Cardiovascular Development and Regeneration Conference.
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Prostaglandin E-EP4 signaling-mediated fibulin-1 integrates extracellular matrices to promote smooth muscle cell migration of the ductus arteriosus.2018

    • Author(s)
      Ito S,Yokoyama U,Saito J,Masuda M,Asou T,Ishikawa Y.
    • Organizer
      Weinstein 2018 Cardiovascular Development and Regeneration Conference.
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Mechanoresponse to periodic hydrostatic pressure enables fabrication of human arterial graft.2018

    • Author(s)
      Saito J,Yokoyama U,Takayama T,Horade M,Ito H,Sugo Y,Kurasawa K,Ogawa M,Miyagi E,Kaneko M,Ishikawa Y.
    • Organizer
      American Society for Matrix Biology Biennial Meeting 2018.
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 胎盤由来プロスタグランディンEはFibulin-1を介した動脈管リモデリングを促進する.2018

    • Author(s)
      横山詩子,伊藤智子,石川義弘.
    • Organizer
      第50回日本結合組織学会学術大会.
    • Related Report
      2018 Research-status Report
  • [Presentation] The role of Epac1 in the development of ventricular arrhythmia in mice.2018

    • Author(s)
      Prajapati R,Fujita T,Suita K,Nakamura T,Cai W,Hidaka Y,Okumura S,Ishikawa Y.
    • Organizer
      第28回日本病態生理学会大会.
    • Related Report
      2018 Research-status Report
  • [Presentation] 線維芽細胞と組織内圧からみた心臓障害修復過程の病態生理.2018

    • Author(s)
      田中 遼,梅村将就,成川雅俊,石川義弘.
    • Organizer
      第28回日本病態生理学会大会.
    • Related Report
      2018 Research-status Report
  • [Presentation] Fibulin-1の動脈管内膜肥厚形成における役割.2018

    • Author(s)
      中川路太一,横山詩子,伊藤智子,石川義弘.
    • Organizer
      第28回日本病態生理学会大会.
    • Related Report
      2018 Research-status Report
  • [Presentation] 母体ラットへのべタメタゾン投与が動脈管内膜肥厚に与える作用の検討.2018

    • Author(s)
      釼持孝博,横山詩子,齋藤純一,伊藤智子,魚住 梓,岩崎志穂,西巻 滋,関 和男,伊藤秀一,石川義弘.
    • Organizer
      第63回日本新生児成育医学科医・学術集会.
    • Related Report
      2018 Research-status Report
  • [Presentation] プロスタグランディンE受容体EP4シグナルは腹部大動脈瘤の増悪に関与する.2018

    • Author(s)
      廣見太郎,横山詩子,Al M,竹内一郎,石川義弘.
    • Organizer
      CCM輸液・栄養研究会.
    • Related Report
      2018 Research-status Report
  • [Presentation] プロスタグランディンE-EP4シグナルによる大動脈瘤進行の分子機序.2018

    • Author(s)
      横山詩子,廣見太郎,石川義弘.
    • Organizer
      心血管膜輸送研究会2018.
    • Related Report
      2018 Research-status Report
  • [Presentation] 周期的加圧培養による移植可能な血管グラフトの作製.2018

    • Author(s)
      齋藤純一,横山詩子,高山俊男,洞出光洋,伊藤弘明,須郷慶信,倉澤健太郎,宮城悦子,金子 真,石川義弘.
    • Organizer
      第17回日本心臓血管発生研究会.
    • Related Report
      2018 Research-status Report
  • [Book] ガイトン生理学 原著第13版2018

    • Author(s)
      John E. Hall (著), 石川義弘 (翻訳), 岡村康司 (翻訳), 尾仲達史 (翻訳), 河野憲二 (翻訳)
    • Total Pages
      1100
    • Publisher
      エルゼビア・ジャパン社
    • ISBN
      4860347749
    • Related Report
      2018 Research-status Report
  • [Remarks]

    • URL

      http://www-user.yokohama-cu.ac.jp/~seiri1/

    • Related Report
      2020 Annual Research Report
  • [Remarks] http://www-user.yokohama-cu.ac.jp/~seiri1/

    • Related Report
      2019 Research-status Report
  • [Remarks] 横浜市立大学大学院医学研究科 循環制御医学

    • URL

      http://www-user.yokohama-cu.ac.jp/~seiri1/

    • Related Report
      2018 Research-status Report
  • [Patent(Industrial Property Rights)] 電源装置及び磁界発生システム.2019

    • Inventor(s)
      石川義弘梅村将就秋本大輔岸和人高井正巳長谷川基和赤石昌隆.
    • Industrial Property Rights Holder
      公立大学法人横浜市立大学、株式会社リコー
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2019 Research-status Report
  • [Patent(Industrial Property Rights)] 動脈硬化病変の検出方法、検出キット.2019

    • Inventor(s)
      石川義弘・梅村将就・益田宗孝・鈴木伸一・小堀宏樹・大竹則久.
    • Industrial Property Rights Holder
      公立大学法人横浜市立大学、東ソー株式会社
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-216719
    • Filing Date
      2019
    • Related Report
      2019 Research-status Report
  • [Patent(Industrial Property Rights)] 電源装置及び磁界発生システム.2018

    • Inventor(s)
      石川義弘,梅村将就,秋本大輔,岸 和人 他
    • Industrial Property Rights Holder
      公立大学法人横浜市立大学,株式会社リコー
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-099149
    • Filing Date
      2018
    • Related Report
      2018 Research-status Report
  • [Patent(Industrial Property Rights)] 金属アセン錯体を含む薬剤送達システム.2018

    • Inventor(s)
      石川義弘,梅村将就,中鍛治里奈 他
    • Industrial Property Rights Holder
      公立大学法人横浜市立大学,慶応大学,株式会社IHI
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-233877
    • Filing Date
      2018
    • Related Report
      2018 Research-status Report

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Published: 2018-07-20   Modified: 2022-12-28  

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