How to predict the collapse of homeostasis in circulatory regulation

• Project/Area Number: 18KT0073
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 特設分野
• Research Field: Complex Systems Disease Theory
• Research Institution: Yokohama City University
• Principal Investigator: ISHIKAWA Yoshihiro 横浜市立大学, 医学研究科, 教授 (40305470)
• Co-Investigator(Kenkyū-buntansha): 藤田 孝之 横浜市立大学, 医学部, 講師 (40468202) ; 横山 詩子 東京医科大学, 医学部, 主任教授 (70404994) ; 梅村 将就 横浜市立大学, 医学部, 講師 (50595353) ; 齋藤 純一 横浜市立大学, 医学研究科, 客員研究員 (30779301)
• Project Period (FY): 2018-07-18 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 心筋細胞 / アデニル酸シクラーゼ / カルシウム / 不整脈 / 数理モデル

Outline of Final Research Achievements

Sympathetic nervous system is a major mechanism of regulating cardiac function. It is mostly made of cAMP signal that is essential for intracellular signal in the heart. In this study, we have addressed mathematical and physical characteristics of cAMP and calcium signal in the heart, which are known to play a major role in regulating cardiac arrythmia and thus cardiac homeostasis. In particular, overactivation of the sympathetic nervous system and pressure overload in congestive heart failure are major reasons to induce cardiac pathophysiology. We have analyzed spacial and sequential role of gene expression as well as its deletion, that leads to altered enzymatic activity. We found that pharmacologically they are important at the level of both cell and body.

Academic Significance and Societal Importance of the Research Achievements

心臓の機能が上がったり下がったりは、交感神経という神経でコントロールされている。交感神経は、細胞の中のカルシウムやcAMPという名前の物質の制御をおこなう。この変化を時間的、空間的に検討した。これは我々の研究室の長年のテーマである。心機能が悪くなる不整脈や心不全の状態において、これらの物質の制御が大事な役割を果たすことが分かった。これらの所見は、心臓の機能が落ちてしまったときにどのように補っていったらよいのか、不整脈が現れた時にどのように治療していったらよいのかの方法を開発するのに役に立つことが考えられた。

Research Products

• [Journal Article] Scaffold-free tissue-engineered arterial grafts derived from human skeletal myoblasts. (2021)
  • Author(s): Saito J, Yokoyama U, Nakamura T, Kanaya T, Ueno T, Naito Y, Takayama T, Kaneko M, Miyagawa S, Sawa Y, and Ishikawa Y
  • Journal Title: Artif Organs Volume: - Issue: 8 Pages: 919-932
  • DOI: 10.1111/aor.13930
  • Peer Reviewed / Open Access
• [Journal Article] Excessive EP4 signaling in smooth muscle cells induces abdominal aortic aneurysm by amplifying inflammation (2020)
  • Author(s): Hiromi T, Yokoyama U, Kurotaki D, Mamun A, Ishiwata R, Ichikawa Y, Nishihara H, Umemura M, Fujita T, Yasuda S, Minami T, Goda M, Uchida K, Suzuki S, Takeuchi I, Masuda M, Breyer M, Tamura T, and Ishikawa Y
  • Journal Title: Arteriosclerosis, Thrombosis, and Vascular Biology Volume: 40 Issue: 6 Pages: 1559-1573
  • DOI: 10.1161/atvbaha.120.314297
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Fibulin-1 Integrates Subendothelial Extracellular Matrices and Contributes to Anatomical Closure of the Ductus Arteriosus. (2020)
  • Author(s): Ito S, Yokoyama U, Nakakoji T, Cooley MA, Sasaki T, Hatano S, Kato Y, Saito J, Nicho N, Iwasaki S, Umemura M, Fujita T, Masuda M, Asou T, and Ishikawa Y
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 40 Issue: 9 Pages: 2212-2226
  • DOI: 10.1161/atvbaha.120.314729
  • NAID: 130008001539
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 心不全と血管モデルの研究開発． (2020)
  • Author(s): 石川義弘，中村 隆，小嶋朋之，横山詩子.
  • Journal Title: 循環器内科 Volume: 87 Pages: 495-500
  • NAID: 40022230510
  • Peer Reviewed
• [Journal Article] Antenatal Administration of Betamethasone Contributes to Intimal Thickening of the Rat Ductus Arteriosus (2019)
  • Author(s): Kemmotsu T., Yokoyama U., Saito J., Ito S., Uozumi A., Nishimaki S., Iwasaki S., Seki K., Ito S., Ishikawa Y
  • Journal Title: Circulation Journal Volume: 83 Issue: 3 Pages: 654-661
  • DOI: 10.1253/circj.CJ-18-1033
  • NAID: 130007604194
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2019-02-25
  • Peer Reviewed / Open Access
• [Journal Article] Usefulness of Exchanged Protein Directly Activated by cAMP (Epac)1-Inhibiting Therapy for Prevention of Atrial and Ventricular Arrhythmias in Mice (2019)
  • Author(s): Prajapati R, Fujita T, Suita K, Nakamura T, Cai W, Hidaka Y, Umemura M, Yokoyama U, Knollmann BC, Okumura S, Ishikawa Y
  • Journal Title: Circulation Journal Volume: 83 Issue: 2 Pages: 295-303
  • DOI: 10.1253/circj.CJ-18-0743
  • NAID: 130007557004
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2019-01-25
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Translationally controlled tumor protein (TCTP) plays a pivotal role in cardiomyocyte survival through a Bnip3-dependent mechanism. (2019)
  • Author(s): Cai W, Fujita T, Hidaka Y, Jin H, Suita K, Shigeta M, Kiyonari H, Umemura M, Yokoyama U, Sadoshima J, Ishikawa Y.
  • Journal Title: Cell Death Dis Volume: 10 Issue: 8 Pages: 549-549
  • DOI: 10.1038/s41419-019-1787-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Correction to: Epac activation inhibits IL-6-induced cardiac myocyte dysfunction. (2019)
  • Author(s): Jin H, Fujita T, Jin M, Kurotani R, Hidaka Y, Cai W, Suita K, Prajapati R, Liang C, Ohnuki Y, Mototani Y, Umemura M, Yokoyama U, Sato M, Okumura S, Ishikawa Y.
  • Journal Title: J Physiol Sci. Volume: - Issue: 3 Pages: 557-557
  • DOI: 10.1007/s12576-019-00661-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Epac1 deficiency inhibits basic fibroblast growth factor-mediated vascular smooth muscle cell migration (2019)
  • Author(s): Yuko Kato, Utako Yokoyama, Takayuki Fujita, Masanari Umemura, Tetsuo Kubota, Yoshihiro Ishikawa
  • Journal Title: The Journal of Physiological Sciences Volume: 69 Issue: 2 Pages: 175-184
  • DOI: 10.1007/s12576-018-0631-7
  • NAID: 40021818894
  • Peer Reviewed / Open Access
• [Journal Article] Doxorubicin induces trans-differentiation and MMP1 expression in cardiac fibroblasts via cell death-independent pathways. (2019)
  • Author(s): Narikawa M, Umemura M, Tanaka R, Hikichi M, Nagasako A, Fujita T, Yokoyama U, Ishigami T, Kimura K, Tamura K, Ishikawa Y.
  • Journal Title: PLoS One. Volume: 14 Issue: 9 Pages: e0221940-e0221940
  • DOI: 10.1371/journal.pone.0221940
  • Peer Reviewed / Open Access
• [Journal Article] An appropriately sized soft polyester external stent prevents enlargement and neointimal hyperplasia of a saphenous vein graft in a canine model (2019)
  • Author(s): Yasuda Shota、Goda Motohiko、Shibuya Taisuke、Uchida Keiji、Suzuki Shinichi、Noishiki Yasuharu、Yokoyama Utako、Ishikawa Yoshihiro、Masuda Munetaka
  • Journal Title: Artificial Organs Volume: 印刷中 Issue: 6 Pages: 577-583
  • DOI: 10.1111/aor.13399
  • Peer Reviewed / Open Access
• [Journal Article] Prostaglandin E2 receptor EP4 regulates cell migration through Orai1. (2019)
  • Author(s): Osawa K, Umemura M, Nakakaji R, Tanaka R, Islam RM, Nagasako A, Fujita T, Yokoyama U, Koizumi T, Mitsudo K, Ishikawa Y.
  • Journal Title: Cancer Sci. Volume: 111 Issue: 1 Pages: 160-174
  • DOI: 10.1111/cas.14247
  • Peer Reviewed / Open Access
• [Journal Article] Reactive fibrosis precedes doxorubicin-induced heart failure through sterile inflammation. (2019)
  • Author(s): Tanaka R, Umemura M, Narikawa M, Hikichi M, Osaw K, Fujita T, Yokoyama U, Ishigami T, Tamura K, Ishikawa Y.
  • Journal Title: ESC Heart Fail. Volume: 7 Issue: 2 Pages: 588-603
  • DOI: 10.1002/ehf2.12616
  • Peer Reviewed / Open Access
• [Journal Article] Usefulness of Exchanged Protein Directly Activated by cAMP (Epac)1- (2019)
  • Author(s): Prajapati R, Fujita T, Suita K, Nakamura T, Cai W, Hidaka Y, Umemura M, Yokoyama U, Knollmann BC, Okumura S, Ishikawa Y.
  • Journal Title: Circ J. Volume: 83 Pages: 295-303
  • Peer Reviewed
• [Journal Article] Simultaneous hyperthermia-chemotherapy effect by arterial injection of Fe(Salen) for femur tumor (2018)
  • Author(s): Umemura Masanari、Islam Md. Rafikul、Fukumura Hidenobu、Sato Itaru、Kawabata Yusuke、Matsuo Kousuke、Nakakaji Rina、Nagasako Akane、Ohtake Makoto、Takayuki Fujita、Yokoyama Utako、Nakayama Tomohiro、Eguchi Haruki、Ishikawa Yoshihiro
  • Journal Title: Cancer Science Volume: 110 Issue: 1 Pages: 356-365
  • DOI: 10.1111/cas.13851
  • Peer Reviewed / Open Access
• [Journal Article] Alternating magnetic field (AMF) enhances cytotoxicity of compound c. (2018)
  • Author(s): Akimoto T, Umemura M, Nagasako A, Ohtake M, Fujita T, Yokoyama U, Eguchi H, Yamamoto T, Ishikawa Y.
  • Journal Title: Cancer Sci. Volume: 109 Issue: 11 Pages: 3483-3493
  • DOI: 10.1111/cas.13781
  • Peer Reviewed / Open Access
• [Journal Article] A selective antagonist of prostaglandin E receptor subtype 4 attenuates abdominal aortic aneurysm. (2018)
  • Author(s): Mamun A, Yokoyama U, Saito J, Ito S, Hiromi T, Umemura M, Fujita T, Yasuda S, Minami T, Goda M, Uchida K, Suzuki S, Masuda M, Ishikawa Y.
  • Journal Title: Physiol Rep. Volume: 6 Issue: 18
  • DOI: 10.14814/phy2.13878
  • Peer Reviewed / Open Access
• [Journal Article] Treatment of oral cancer using magnetized paclitaxel (2018)
  • Author(s): Nakakaji Rina、Umemura Masanari、Mitsudo Kenji、Kim Jeong-Hwan、Hoshino Yujiro、Sato Itaru、Masuda Takatsugu、Yamamoto Masahiro、Kioi Mitomu、Koizumi Toshiyuki、Fujita Takayuki、Yokoyama Utako、Iida Masaki、Sato Motohiko、以下7名
  • Journal Title: Oncotarget Volume: 9 Issue: 21 Pages: 15591-15605
  • DOI: 10.18632/oncotarget.24570
  • Peer Reviewed / Open Access
• [Journal Article] Acute hyperthermia inhibits TGF-β1-induced cardiac fibroblast activation via uppression of Akt Signaling. (2018)
  • Author(s): Narikawa M, Umemura M, Tanaka R, Fujita T, Yokoyama U, Ishigami T, Kimura K, Tamura K, Ishikawa Y.
  • Journal Title: Sci Rep. Volume: 8 Issue: 1 Pages: 6277-6277
  • DOI: 10.1038/s41598-018-24749-6
  • Peer Reviewed / Open Access
• [Journal Article] Tissue-type plasminogen activator contributes to remodeling of the rat ductus arteriosus. (2018)
  • Author(s): Saito J, Yokoyama U, Nicho N, Zheng YW, Ichikawa Y, Ito S, Umemura M, Fujita T, Ito S, Taniguchi H, Asou T, Masuda M, Ishikawa Y.
  • Journal Title: PLoS One Volume: 13(1) Issue: 1 Pages: e0190871-e0190871
  • DOI: 10.1371/journal.pone.0190871
  • Peer Reviewed / Open Access
• [Journal Article] Vidarabine, an anti-herpesvirus agent, prevents catecholamine-induced arrhythmias without adverse effect on heart function in mice (2018)
  • Author(s): Suita Kenji、Fujita Takayuki、Cai Wenqian、Hidaka Yuko、Jin Huiling、Prajapati Rajesh、Umemura Masanari、Yokoyama Utako、Sato Motohiko、Knollmann Bj?rn C.、Okumura Satoshi、Ishikawa Yoshihiro
  • Journal Title: Pfl?gers Archiv - European Journal of Physiology Volume: 未定 Issue: 6 Pages: 923-935
  • DOI: 10.1007/s00424-018-2121-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hydrostatic pressure suppressed fibrotic change via Akt/GSK-3 signaling in human cardiac fibroblasts. (2018)
  • Author(s): Tanaka R, Umemura M, Narikawa M, Fujita T, Yokoyama U, Ishigami T, Kimura K, Tamura K, Ishikawa Y.
  • Journal Title: Physiol Rep. Volume: 6 Issue: 9 Pages: e13687-e13687
  • DOI: 10.14814/phy2.13687
  • Peer Reviewed / Open Access
• [Journal Article] Proteomic analysis of aortic smooth muscle cell secretions reveals an association of myosin heavy chain 11 with abdominal (2018)
  • Author(s): Yokoyama U, Arakawa N, Ishiwata R, Yasuda S, Minami T, Goda M, Uchida K, Suzuki S, Matsumoto M, Koizumi N, Taguri M, Hirano H, Yoshimura K, Ogino H, Masuda M, Ishikawa Y.
  • Journal Title: Am J Physiol Heart Circ Physiol. Volume: 315 Issue: 4 Pages: H1012-H1018
  • DOI: 10.1152/ajpheart.00329.2018
  • Peer Reviewed / Open Access
• [Journal Article] Epac activation inhibits IL-6-induced cardiac myocyte dysfunction. (2016)
  • Author(s): Jin H，Fujita T，Jin M，Kurotani R，Hidaka Y，Cai W，Suita K，Prajapati R，Liang C，Ohnuki Y，Mototani Y，Umemura M，Yokoyama U，Sato M，Okumura S，Ishikawa Y.
  • Journal Title: J Physiol Sci. Volume: 印刷中 Issue: 1 Pages: 77-87
  • DOI: 10.1007/s12576-016-0509-5
  • NAID: 40021443658
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Increased plasma level of myosin heavy chain 11 is associated with atherosclerosis. (2020)
  • Author(s): Takahashi, L., Ishigami, T., Tomiyama, H., Chikamori, T., Ishikawa, Y., & Yokoyama, U..
  • Organizer: The Asian Pacific Society of Cardiology Congress 2020..
  • Int'l Joint Research
• [Presentation] A new biomarker for abdominal aortic aneurysm. (2020)
  • Author(s): Ishikawa Y, Yokoyama U
  • Organizer: The 97th Annual Meeting of the Physiological Society of Japan.（誌上開催）
• [Presentation] Development of human arterial graft with mechanically functional extracellular matrices. (2020)
  • Author(s): Yokoyama U, Tomoyuki K, Junichi S, Takanori Y, Takashi N, Yoshinobu S, Kentaro K, Etsuko M, Ishikawa Y.
  • Organizer: The 97th Annual Meeting of the Physiological Society of Japan.（誌上開催）
• [Presentation] Heart Failure and More; From the Bed to the Benchtop, (2019)
  • Author(s): Ishikawa Y.
  • Organizer: 24th Iranian and 3rd International Congress of Physiology.
  • Int'l Joint Research / Invited
• [Presentation] Prostaglandin E receptor EP4-mediated regulation of vascular elasticity, (2019)
  • Author(s): Yokoyama U, Hiromi T, Ishikawa Y.
  • Organizer: The 50th NIPS International Symposium.
  • Int'l Joint Research
• [Presentation] Role of endothelial cells in the ductus arteriosus remodeling. (2019)
  • Author(s): Saito J, Yokoyama U, Ishikawa Y,
  • Organizer: The 64th Japan Society for Neonatal Health and Development.
  • Int'l Joint Research
• [Presentation] EP4 signaling in smooth muscle cells causes abdominal aortic aneurysm by attraction of immune infiltrates. (2019)
  • Author(s): Hiromi T, Yokoyama U, Takeuchi I, Ishikawa Y.
  • Organizer: American Heart Association and Scientific Session 2019.
  • Int'l Joint Research
• [Presentation] プロスタグランディンE受容体EP4シグナルはLysyl oxydaseの発現を抑制し大動脈瘤の進行に関与する. (2019)
  • Author(s): 廣見太郎, 横山詩子, 竹内一郎, 石川義弘,
  • Organizer: 第47回日本救急医学会総 会・学術集会.
• [Presentation] 内皮細胞が誘導する一方向性平滑筋細胞遊走が動脈管内膜肥厚を形成する. (2019)
  • Author(s): 伊藤智子, 横山詩子, 中川路太, 齋藤純一, 二町尚樹, 益田宗孝, 麻生俊英, 石川義弘,
  • Organizer: 第55回日本小児循環器学会総会・学術集会.
• [Presentation] 動脈管平滑筋細胞間由来Fibulin-1は内皮由来Versicanと共役して動脈管内膜肥厚形成を促進する. (2019)
  • Author(s): 伊藤智子、横山詩子、石川義弘
  • Organizer: 第51回日本結合組織学会学術大会.
• [Presentation] Tissue-type plasminogen activator promotes intimal thickening formation of the ductus arteriosus． (2018)
  • Author(s): Saito J，Yokoyama U，Nicho N，Zheng YW，Ito S，Ito S，Taniguchi H，Asou T，Masuda M，Ishikawa Y.
  • Organizer: Weinstein 2018 Cardiovascular Development and Regeneration Conference．
  • Int'l Joint Research
• [Presentation] Antenatal administration of betamethasone promotes closure of the preterm ductus arteriosus via intimal thickening formation． (2018)
  • Author(s): Kemmotsu T，Yokoyama U，Azuma S，Saito J，Ito S，Uozumi A，Nishimaki S，Iwasaki S，Seki K，Ito S，Ishikawa Y.
  • Organizer: Weinstein 2018 Cardiovascular Development and Regeneration Conference.
  • Int'l Joint Research
• [Presentation] Prostaglandin E-EP4 signaling-mediated fibulin-1 integrates extracellular matrices to promote smooth muscle cell migration of the ductus arteriosus． (2018)
  • Author(s): Ito S，Yokoyama U，Saito J，Masuda M，Asou T，Ishikawa Y.
  • Organizer: Weinstein 2018 Cardiovascular Development and Regeneration Conference.
  • Int'l Joint Research
• [Presentation] Mechanoresponse to periodic hydrostatic pressure enables fabrication of human arterial graft． (2018)
  • Author(s): Saito J，Yokoyama U，Takayama T，Horade M，Ito H，Sugo Y，Kurasawa K，Ogawa M，Miyagi E，Kaneko M，Ishikawa Y.
  • Organizer: American Society for Matrix Biology Biennial Meeting 2018.
  • Int'l Joint Research
• [Presentation] 胎盤由来プロスタグランディンEはFibulin-1を介した動脈管リモデリングを促進する． (2018)
  • Author(s): 横山詩子，伊藤智子，石川義弘.
  • Organizer: 第50回日本結合組織学会学術大会.
• [Presentation] The role of Epac1 in the development of ventricular arrhythmia in mice． (2018)
  • Author(s): Prajapati R，Fujita T，Suita K，Nakamura T，Cai W，Hidaka Y，Okumura S，Ishikawa Y.
  • Organizer: 第28回日本病態生理学会大会.
• [Presentation] 線維芽細胞と組織内圧からみた心臓障害修復過程の病態生理． (2018)
  • Author(s): 田中 遼，梅村将就，成川雅俊，石川義弘.
  • Organizer: 第28回日本病態生理学会大会.
• [Presentation] Fibulin-1の動脈管内膜肥厚形成における役割． (2018)
  • Author(s): 中川路太一，横山詩子，伊藤智子，石川義弘.
  • Organizer: 第28回日本病態生理学会大会.
• [Presentation] 母体ラットへのべタメタゾン投与が動脈管内膜肥厚に与える作用の検討． (2018)
  • Author(s): 釼持孝博，横山詩子，齋藤純一，伊藤智子，魚住 梓，岩崎志穂，西巻 滋，関 和男，伊藤秀一，石川義弘.
  • Organizer: 第63回日本新生児成育医学科医・学術集会.
• [Presentation] プロスタグランディンE受容体EP4シグナルは腹部大動脈瘤の増悪に関与する． (2018)
  • Author(s): 廣見太郎，横山詩子，Al M，竹内一郎，石川義弘.
  • Organizer: CCM輸液・栄養研究会.
• [Presentation] プロスタグランディンE-EP4シグナルによる大動脈瘤進行の分子機序. (2018)
  • Author(s): 横山詩子，廣見太郎，石川義弘.
  • Organizer: 心血管膜輸送研究会2018.
• [Presentation] 周期的加圧培養による移植可能な血管グラフトの作製． (2018)
  • Author(s): 齋藤純一，横山詩子，高山俊男，洞出光洋，伊藤弘明，須郷慶信，倉澤健太郎，宮城悦子，金子 真，石川義弘.
  • Organizer: 第17回日本心臓血管発生研究会.
• [Book] ガイトン生理学 原著第13版 (2018)
  • Author(s): John E. Hall (著), 石川義弘 (翻訳), 岡村康司 (翻訳), 尾仲達史 (翻訳), 河野憲二 (翻訳)
  • Total Pages: 1100
  • Publisher: エルゼビア・ジャパン社
  • ISBN: 4860347749
• [Remarks]
  • URL: http://www-user.yokohama-cu.ac.jp/~seiri1/
• [Remarks] http://www-user.yokohama-cu.ac.jp/~seiri1/
• [Remarks] 横浜市立大学大学院医学研究科 循環制御医学
  • URL: http://www-user.yokohama-cu.ac.jp/~seiri1/
• [Patent(Industrial Property Rights)] 電源装置及び磁界発生システム. (2019)
  • Inventor(s): 石川義弘梅村将就秋本大輔岸和人高井正巳長谷川基和赤石昌隆.
  • Industrial Property Rights Holder: 公立大学法人横浜市立大学、株式会社リコー
  • Industrial Property Rights Type: 特許
  • Filing Date: 2019
• [Patent(Industrial Property Rights)] 動脈硬化病変の検出方法、検出キット. (2019)
  • Inventor(s): 石川義弘・梅村将就・益田宗孝・鈴木伸一・小堀宏樹・大竹則久.
  • Industrial Property Rights Holder: 公立大学法人横浜市立大学、東ソー株式会社
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2019-216719
  • Filing Date: 2019
• [Patent(Industrial Property Rights)] 電源装置及び磁界発生システム. (2018)
  • Inventor(s): 石川義弘，梅村将就，秋本大輔，岸 和人 他
  • Industrial Property Rights Holder: 公立大学法人横浜市立大学，株式会社リコー
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2018-099149
  • Filing Date: 2018
• [Patent(Industrial Property Rights)] 金属アセン錯体を含む薬剤送達システム. (2018)
  • Inventor(s): 石川義弘，梅村将就，中鍛治里奈 他
  • Industrial Property Rights Holder: 公立大学法人横浜市立大学，慶応大学，株式会社IHI
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2018-233877
  • Filing Date: 2018