Phospholipid metabolism and lipid mediators

• Project/Area Number: 19002011
• Research Category: Grant-in-Aid for Specially Promoted Research
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo
• Principal Investigator: SHIMIZU Takao 東京大学, 大学院・医学系研究科, 教授 (80127092)
• Co-Investigator(Kenkyū-buntansha): YANAGIDA Keisuke 東京大学, 大学院・医学系研究科, 助教 (00583882) ; TAKAHASHI Toshie 東京大学, 大学院・医学系研究科, 助手 (80236299) ; HAMANO Fumie 東京大学, 大学院・医学系研究科, 助教 (80548511) ; KITA Yoshihiro 東京大学, 大学院・医学系研究科, 助教 (20401028) ; NAKAMURA Motonao 東京大学, 大学院・医学系研究科, 准教授 (40431762) ; SHINDOU Hideo 東京大学, 大学院・医学系研究科, 助教 (10401027)
• Co-Investigator(Renkei-kenkyūsha): SHINDOU Hideo 東京大学, 大学院・医学系研究科, 助教 (10401027) ; NAKAMURA Motonao 東京大学, 大学院・医学系研究科, 准教授 (40431762) ; KITA Yoshihiro 東京大学, 大学院・医学系研究科, 特任准教授 (20401028)
• Project Period (FY): 2007 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥774,670,000 (Direct Cost: ¥595,900,000、Indirect Cost: ¥178,770,000); Fiscal Year 2011: ¥130,000,000 (Direct Cost: ¥100,000,000、Indirect Cost: ¥30,000,000); Fiscal Year 2010: ¥141,180,000 (Direct Cost: ¥108,600,000、Indirect Cost: ¥32,580,000); Fiscal Year 2009: ¥158,990,000 (Direct Cost: ¥122,300,000、Indirect Cost: ¥36,690,000); Fiscal Year 2008: ¥164,450,000 (Direct Cost: ¥126,500,000、Indirect Cost: ¥37,950,000); Fiscal Year 2007: ¥180,050,000 (Direct Cost: ¥138,500,000、Indirect Cost: ¥41,550,000)
• Keywords: 脂質メディエーター / ロイコトリエン / アシル転移酵素 / ホスホリパーゼ A2 / 遺伝子欠損マウス / G タンパク共役型受容体 / 脂質メタボローム / 肺サーファクタント / ホスホリパーゼＡ２ / ホスホリパーゼA2 / Gタンパク共役型受容体 / Gタンパク質共役型受容体 / 脂質メタポローム / ロイトコイエン / Gタンパク共益型受容体

Research Abstract

Glycerophospholipids are a major constituent of biological membranes. The study was aimed to elucidate biochemical mechanism and outcome of the membrane diversity and asymmetry. We discovered about 10 different lysophospholipid acyltransferases and characterized them. We also developed new methods to profile membrane phospholipids (over 1,500) by LC-MS. We obtained molecular and methodological tools now to uncover the biological significance and disease relevance of membrane diversity.

Assessment Rating

Verification Result (Rating)

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Research Products

• [Journal Article] Human FcγRIIA induces anaphylactic and allergic reactions (2012)
  • Author(s): Jonsson, F., Mancardi, DA., Zhao, W., Kita, Y., Iannascoli, B., Khun, H., van Rooijen, N., Shimizu, T., Schwartz, LB., Daeron, M., and Bruhns, P
  • Journal Title: Blood Volume: 119 Issue: 11 Pages: 2533-2544
  • DOI: 10.1182/blood-2011-07-367334
  • Peer Reviewed
• [Journal Article] Polyunsaturated fatty acids are incorporated into maturating malemouse germ cells by lysophosphatidic acid acyltransferase 3 (2012)
  • Author(s): Koeberle, A., Shindou, H., Harayama, T., Yuki, K., and Shimizu, T
  • Journal Title: FASEB J Volume: 26 Issue: 1 Pages: 169-180
  • DOI: 10.1096/fj.11-184879
  • Peer Reviewed
• [Journal Article] Disruption of group IVA cytosolic phospholipase A2 attenuates myocardial ischemia-reperfusion injury partly through inhibition of TNFa-mediated pathway. (2012)
  • Author(s): Saito, Y., Watanabe, K., Fujioka, D., Nakamura, T., Obata, J., Kawabata, K., Watanabe, Y., Mishina, H., Tamaru, S., Kita, Y., Shimizu, T., Kugiyama, K.
  • Journal Title: Heart Circ. Physiol. Volume: 302 Issue: 10 Pages: H2018-H2030
  • DOI: 10.1152/ajpheart.00955.2011
  • Peer Reviewed
• [Journal Article] Phospholipase A2 superfamily members play divergent roles after spinal cord injury (2011)
  • Author(s): Lopez-Vales, R., Ghasemlou, N., Redensek, A., Kerr, BJ., Barbayianni, E., Antonopoulou, G., Baskakis, C., Rathore, KI., Constantinou-Kokotou, V., Stephens, D., Shimizu, T., Dennis,EA., Kokotos, G., and David, S.
  • Journal Title: FASEB J Volume: 25 Pages: 4240-4252
  • Peer Reviewed
• [Journal Article] Prostaglandin E2-prostoglandin E receptor subtype 4 (EP4) signaling mediates UV irradiation-induced systemic immunosuppression (2011)
  • Author(s): Kitipong Soontrapa, Tetsuya Honda, Daiji Sakata, Chengcan Yao, Takako Hirata, Shohei Hori, Toshiyuki Matsuoka, Yoshihiro Kita, Takao Shimizu, Kenji Kabashima, Shuh Narumiya
  • Journal Title: Proc Natl Acad Sci U S A Volume: 108 Issue: 16 Pages: 668-667
  • DOI: 10.1073/pnas.1018625108
  • Peer Reviewed
• [Journal Article] Cytosolic Phospholipase A2α Contributes to Blood Pressure Increases and Endothelial Dysfunction Under Chronic NO Inhibition. Arterioscler (2011)
  • Author(s): Tanaka, K., Yamamoto, Y., Ogino, K., Tsujimoto, S., Saito, M., Uozumi, N., Shimizu, T., and Hisatome, I
  • Journal Title: Thromb. Vasc. Biol Volume: 31 Issue: 5 Pages: 1133-1138
  • DOI: 10.1161/atvbaha.110.218370
  • Peer Reviewed
• [Journal Article] Leukotriene Receptors (2011)
  • Author(s): Nakamura,M., and Shimizu,T
  • Journal Title: Chem.Rev Volume: 111 Pages: 6231-6298
  • Peer Reviewed
• [Journal Article] Analysis of two major intracellular phospholipase A2s in mast cells reveals crucial contribution of cPLA2alpha, not iPLA2beta, to lipid mobilization in proximal mast cells and distal fibroblasts. (2011)
  • Author(s): Ueno, N., Taketomi, Y., Yamamoto, K., Hirabayashi, T., Kamei, D., Kita, Y., Shimizu, T., Shinzawa, K., Tsujimoto, Y., Ikeda, K., Taguchi, R., Murakami, M.
  • Journal Title: J. Biol. Chem. Volume: 186 Issue: 43 Pages: 37249-37263
  • DOI: 10.1074/jbc.m111.290312
  • Peer Reviewed
• [Journal Article] Phospholipase A2 superfamily members play divergent roles after spinal cord injury. (2011)
  • Author(s): Lopez-Vales, R.,.... D., Shimizu, T., et al.
  • Journal Title: FASEB J. Volume: 25 Issue: 12 Pages: 4240-4252
  • DOI: 10.1096/fj.11-183186
  • Peer Reviewed
• [Journal Article] Leukotriene Receptors. (2011)
  • Author(s): Nakamura, M., and Shimizu, T.
  • Journal Title: Chem. Rev. Volume: 111 Issue: 10 Pages: 6231-6298
  • DOI: 10.1021/cr100392s
  • Peer Reviewed
• [Journal Article] Mouse and human neutrophils induce anaphylaxis. (2011)
  • Author(s): Jonson, F., Mancardi, DA., Kita, Y., Karasuyama, H., Iannascoli, B., Rooijen, NV., Shimizu, T., Daeron, M., and Bruhns, P.
  • Journal Title: J. Clin. Invest. Volume: 121 Issue: 4 Pages: 1484-1496
  • DOI: 10.1172/jci45232
  • Peer Reviewed
• [Journal Article] Identification and characterization of a novel zebrafish semaphorin (2011)
  • Author(s): Taniguchi, M., Masuda, T., Mikami, Y., Kimura, M., Yoshida, T., Mishina, M., Shimizu, T.
  • Journal Title: Neurosci.Lett. Volume: 488 Pages: 215-220
  • Peer Reviewed
• [Journal Article] Role of leukotriene B4 in accelerated hyperlipidaemic renal injury (2011)
  • Author(s): Doi, K., Hamasaki, Y., Noiri, E., Nosaka, K., Suzuki, T., Toda, A., Shimizu, T., Fujita, T., Nakao, A.
  • Journal Title: Nephrology Volume: 16 Pages: 304-309
  • Peer Reviewed
• [Journal Article] Cytosolic Phospholipase A2{alpha} Contributes to Blood Pressure Increases and Endothelial Dysfunction Under Chronic NO Inhibition (2011)
  • Author(s): Tanaka, K., Yamamoto, Y., Ogino, K., Tsujimoto, S., Saito, M., Uozumi, N., Shimizu, T., Hisatome, I.
  • Journal Title: Arterioscler.Thromb.Vasc.Biol. Volume: 31 Pages: 1133-1138
  • Peer Reviewed
• [Journal Article] Protective role of the leukotriene B₄ receptor BLT2 in murine inflammatory colitis (2010)
  • Author(s): Iizuka, Y., Okuno, T., Saeki, K., Uozaki, H., Okada, S., Misaka, T., Sato, T., Toh, H., Fukayama, M.,Takeda, N., Kita, Y., Shimizu, T., Nakamura, M., and Yokomizo, T.
  • Journal Title: FASEB J Volume: 24 Issue: 12 Pages: 4678
  • DOI: 10.1096/fj.10-165050
  • Peer Reviewed
• [Journal Article] Phosphorylation of lysophosphatidylcholine acyltransferase 2 at Ser34 enhances platelet-activating factor production in endotoxin-stimulated macrophages (2010)
  • Author(s): Morimoto, R., Shindou, H., Oda, Y., and Shimizu, T
  • Journal Title: J. Biol. Chem Volume: 285 Issue: 39 Pages: 29857-29862
  • DOI: 10.1074/jbc.m110.147025
  • NAID: 40019474398
  • Peer Reviewed
• [Journal Article] Role of lysophosphatidic acid acyltransferase 3 for the supply of highly polyunsaturated fatty acids in TM4 Sertoli cells (2010)
  • Author(s): Koeberle, A., Shindou, H., Harayama T., and Shimizu T
  • Journal Title: FASEB J Volume: 24 Issue: 12 Pages: 4929-4938
  • DOI: 10.1096/fj.10-162818
  • Peer Reviewed
• [Journal Article] LPA4 regulates blood and lymphatic vessel formation during mouse embryogenesis (2010)
  • Author(s): Sumida, H., Noguchi, K., Kihara, Y., Abe, M., Yanagida, K., Hamano, F., Sato, S., Tamaki, K., Morishita, Y., Kano, MR., Iwata, C., Miyazono, K., Sakimura, K., Shimizu, T., and Ishii, S
  • Journal Title: Blood Volume: 116 Issue: 23 Pages: 5060-5070
  • DOI: 10.1182/blood-2010-03-272443
  • Peer Reviewed
• [Journal Article] The G protein-coupled receptor T-cell death-associated gene8 (TDAG8) facilitates tumor development by serving as anextracellular pH sensor (2010)
  • Author(s): Ihara, Y., Kihara, Y., Hamano, F., Yanagida, K., Morishita, Y., Kunita, A., Yamori, T., Fukayama, M., Aburatani, H., Shimizu, T., and Ishii, S
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 107 Issue: 40 Pages: 17309-17314
  • DOI: 10.1073/pnas.1001165107
  • Peer Reviewed
• [Journal Article] Amino acid residues critical for endoplasmic reticulum export and trafficking of platelet-activating factor receptor (2010)
  • Author(s): Hirota, N., Yasuda, D., Hashidate, T., Yamamoto, T., Yamaguchi, S., Nagamune, T., Nagase, T., Shimizu, T., and Nakamura, M
  • Journal Title: J. Biol. Chem Volume: 285 Issue: 8 Pages: 5931-5940
  • DOI: 10.1074/jbc.m109.066282
  • Peer Reviewed
• [Journal Article] Liquid chromatography/mass spectrometry analysis revealing preferential occurrence of non-arachidonate-containing phosphatidylinositol bisphosphate species in nuclei and changes in their levels during cell cycle (2010)
  • Author(s): Ogiso, H., Nakamura, K., Yatomi, Y., Shimizu, T., and Taguchi, R
  • Journal Title: Rapid. Commun. Mass Spectrom Volume: 24 Pages: 436-442
  • URL: http://onlinelibrary.wiley.com/doi/10.1002/rcm.4415/abstract;jsessionid=78A69D3B4E51ABDE608A6EC7110D6CCE.d01t01
  • Peer Reviewed
• [Journal Article] Lipid signaling incytosolic phospholipaseA2α-cyclooxygenase-2 cascade mediates cerebellar long-term depression and motor learning Proc (2010)
  • Author(s): Le, T. D., Shirai, Y., Okamoto, T., Tatsukawa, T., Nagao, S., Shimizu, T., and Ito, M
  • Journal Title: Natl. Acad. Sci. USA Volume: 107 Issue: 7 Pages: 3198-3203
  • DOI: 10.1073/pnas.0915020107
  • Peer Reviewed
• [Journal Article] The endocannabinoid2-arachidonoylglycerol produced by diacylglycerol lipase α mediates retrograde suppression of synaptictransmission (2010)
  • Author(s): Tanimura, A., Yamazaki, M., Hashimotodani, Y., Uchigashima, M., Kawata, S., Abe, M., Kita, Y., Hashimoto, K., Shimizu, T., Watanabe, M., Sakimura, K., Kano, M
  • Journal Title: Neuron Volume: 65 Pages: 320-327
  • Peer Reviewed
• [Journal Article] Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1 (2010)
  • Author(s): Iwabu, M., Yamauchi, T., Okada-Iwabu, M., Sato, K., Nakagawa, T., Funata, M., Yamaguchi, M., Namiki, S., Nakayama, R., Tabata, M., Ogata, H., Kubota, N.,Takamoto, I., Hayashi, YK., Yamauchi, N., Waki, H., Fukayama, M., Nishino, I., Tokuyama, K., Ueki, K., Oike, Y., Ishii, S., Hirose, K., Shimizu, T., Touhara, K., and Kadowaki, T
  • Journal Title: Nature Volume: 464 Issue: 7293 Pages: 1313-1319
  • DOI: 10.1038/nature08991
  • Peer Reviewed
• [Journal Article] Cytosolic phospholipase A2alpha mediates Pseudomonas aeruginosa LPS-induced airway constriction of CFTR-/-mice (2010)
  • Author(s): Wu, YZ., Aholhassani, M., Ollero, M., Dif, F., Uozumi, N., Lagranderie, M., Shimizu, T., Chignard, M., Touqui, L.
  • Journal Title: Respir.Res. Volume: 11 Pages: 49-49
  • Peer Reviewed
• [Journal Article] Role of PAF receptor in proinflammatory cytokine expression in the dorsal root ganglion and tactile allodynia in a rodent model of neuropathic pain (2010)
  • Author(s): Hasegawa, S., Kohro, Y., Shiratori, M., Ishii, S., Shimizu, T., Tsuda, M., Inoue, K.
  • Journal Title: PLoS One Volume: 5
  • Peer Reviewed
• [Journal Article] Protective role of the leukotriene B4 receptor BLT2 in murine inflammatory colitis (2010)
  • Author(s): Iizuka, Y., Okuno, T., Saeki, K., Uozaki, H., Okada, S., Misaka, T., Sato, T., Toh, H., Fukayama, M., Takeda, N., Kita, Y., Shimizu, T., Nakamura, M., Yokomizo, T.
  • Journal Title: FASEB J. Volume: 24 Pages: 4678-4690
  • Peer Reviewed
• [Journal Article] Phosphorylation of lysophosphatidylcholine acyltransferase 2 at Ser34 enhances platelet-activating factor production in endotoxin-stimulated macrophages (2010)
  • Author(s): Morimoto, R., Shindou, H., Oda, Y., Shimizu, T.
  • Journal Title: J.Biol.Chem Volume: 285 Pages: 29857-29862
  • NAID: 40019474398
  • Peer Reviewed
• [Journal Article] Role of lysophosphatidic acid acyltransferase 3 for the supply of highly polyunsaturated fatty acids in TM4 Sertoli cells. 24 (2010)
  • Author(s): Koeberle A., Shindou H., Harayama T., Shimizu T.
  • Journal Title: FASEB J. Volume: 24 Pages: 4929-4938
  • Peer Reviewed
• [Journal Article] PA4 regulates blood and lymphatic vessel formation during mouse embryogenesis (2010)
  • Author(s): Sumida, H., Noguchi, K., Kihara, Y., Abe, M., Yanagida, K., Hamano, F., Sato, S., Tamaki, K., Morishita, Y., Kano, MR., Iwata, C., Miyazono, K., Sakimura, K., Shimizu, T., Ishii, S.
  • Journal Title: Blood Volume: 116 Pages: 5060-5070
  • Peer Reviewed
• [Journal Article] The G protein-coupled receptor T-cell death-associated gene 8 (TDAG8) facilitates tumor development by serving as an extracellular pH sensor (2010)
  • Author(s): Ihara, Y., Kihara, Y., Hamano, F., Yanagida, K., Morishita, Y., Kunita, A., Yamori, T., Fukayama, M., Aburatani, H., Shimizu, T., Ishii, S.
  • Journal Title: Proc.Natl.Acad.Sci.U.S.A. Volume: 107 Pages: 17309-17314
  • Peer Reviewed
• [Journal Article] Amino acid residues critical for endoplasmic reticulum export and trafficking of platelet-activating factor receptor (2010)
  • Author(s): Hirota, N., Yasuda, D., Hashidate, T., Yamamoto, T., Yamaguchi, S., Nagamune, T., Nagase, T., Shimizu, T., Nakamura, M.
  • Journal Title: J.Biol.Chem. 285 Pages: 5931-5940
  • Peer Reviewed
• [Journal Article] The cyclooxygenase-2-selective inhibitor, etodolac, but not aspirin reduces neovascularization in a murine ischemic hind limb model (2010)
  • Author(s): Tanaka, K., Yamamoto, Y., Uozumi, N., Kita, Y., Yoshida, A., Shimizu, T., Hisatome, I.
  • Journal Title: Eur.J.Pharmacol. 627 Pages: 223-228
  • Peer Reviewed
• [Journal Article] Liquid chromatography/mass spectrometry analysis revealing preferential occurrence of non-arachidonate-containing phosphatidylinositol bisphosphate species in nuclei and changes in their levels during cell cycle (2010)
  • Author(s): Ogiso, H., Nakamura, K., Yatomi, Y., Shimizu, T., Taguchi, R.
  • Journal Title: Rapid.Commun.Mass Spectrom. 24 Pages: 436-442
  • Peer Reviewed
• [Journal Article] Lipid signaling in cytosolic phospholipase A2alpha-cyclooxygenase-2 cascade mediates cerebellar long-term depression and motor learning (2010)
  • Author(s): Le, T.D., Shirai, Y., Okamoto, T., Tatsukawa, T., Nagao, S., Shimizu, T., Ito, M.
  • Journal Title: Proc.Natl.Acad.Sci.U.S.A. 107 Pages: 3198-3203
  • Peer Reviewed
• [Journal Article] The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase(alpha)mediates retrograde suppression of synaptic transmission (2010)
  • Author(s): Tanimura, A., Yamazaki, M., Hashimotodani, Y., Uchigashima, M., Kawata, S., Abe, M., Kita, Y., Hashimoto, K., Shimizu, T., Watanabe, M., Sakimura, K., Kano, M.
  • Journal Title: Neuron 65 Pages: 320-327
  • Peer Reviewed
• [Journal Article] Decrease in Expression or Activity of Cytosolic Phospholipase A2 Increases Cyclooxygenase-1 Action : A Cross-talk between Key Enzymes in Arachidonic Acid Pathway in Prostate Cancer Cells (2010)
  • Author(s): Niknami, M., Vignarajan, S., Yao, M., Hua, S., Witting, P.K., Kita, Y., Shimizu, T., Sved, P., Patel, M.I., Dong, Q.
  • Journal Title: Biochim.Biophys.Acta. (掲載確定(印刷中), in press)
  • Peer Reviewed
• [Journal Article] Expression, purification and characterization of leukotriene B4 receptor, BLT1 in Pichia pastors (2010)
  • Author(s): Hori, T., Sato, Y., Takahashi, N., Takio, K., Yokomizo, T., Nakamura, M., Shimizu, T., Miyano, M.
  • Journal Title: Protein Expr.Purif. (掲載確定(印刷中), in press)
  • Peer Reviewed
• [Journal Article] Specific ligands as pharmacological chaperons : The transport of misfolded G-protein coupled receptors to the cell surface (2010)
  • Author(s): Nakamura, M., Yasuda, D., Hirota, N., Shimizu, T.
  • Journal Title: IUBMB Life (掲載確定(印刷中), in press)
  • Peer Reviewed
• [Journal Article] Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+)and AMPK/SIRT1 (2010)
  • Author(s): Iwabu, M., Yamauchi, T., Okada-Iwabu, M., Sato, K., Nakagawa, T., Funata, M., Yamaguchi, M., Namiki, S., Nakayama, R., Tabata, M., Ogata, H., Kubota, N., Takamoto, I., Hayashi, YK., Yamauchi, N., Waki, H., Fukayama, M., Nishino, I., Tokuyama, K., Ueki, K., Oike, Y., Ishii, S., Hirose, K., Shimizu, T., Touhara, K., Kadowaki, T.
  • Journal Title: Nature (掲載確定(印刷中), in press)
  • Peer Reviewed
• [Journal Article] Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6 (2009)
  • Author(s): Yanagida, K., Masago, K., Nakanishi, H., Kihara, Y., Hamano, F., Tajima, Y., Taguchi, R., Shimizu, T., and Ishii, S
  • Journal Title: J. Biol. Chem Volume: 284 Issue: 26 Pages: 17731-17741
  • DOI: 10.1074/jbc.m808506200
  • Peer Reviewed
• [Journal Article] Global analysis of triacylglycerols including oxidizedmolecular species by reverse-phase high resolution LC/ESI-QTOF MS/MS (2009)
  • Author(s): Ikeda, K., Oike, Y., Shimizu, T., and Taguchi, R
  • Journal Title: J. Chromatogr. B Analyt. Technol. Biomed. Life. Sci Volume: 877 Pages: 2639-2647
  • URL: http://www.sciencedirect.com/science/article/pii/S1570023209002530
  • Peer Reviewed
• [Journal Article] A distinctive role of the leukotriene B4 receptor BLT1 in osteoclastic activity during bone loss (2009)
  • Author(s): Hikiji, H., Ishii, S., Yokomizo, T., Takato, T., and Shimizu, T
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 106 Issue: 50 Pages: 21294-21299
  • DOI: 10.1073/pnas.0905209106
  • Peer Reviewed
• [Journal Article] Targeted lipidomics reveals mPGES-1-PGE2 as a therapeutic target for multiple sclerosis (2009)
  • Author(s): Kihara, Y., Matsushita, T., Kita, Y., Uematsu, S., Akira, S., Kira, J.-i., Ishii, S., and Shimizu, T
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 106 Issue: 51 Pages: 21807-21812
  • DOI: 10.1073/pnas.0906891106
  • Peer Reviewed
• [Journal Article] Prostaglandin F2α receptor signaling facilitates bleomycin-induced pulmonary fibrosis independently of transforming growth factor-ss (2009)
  • Author(s): Oga, T., Matsuoka, T., Yao, C., Nonomura, K., Kitaoka, S., Sakata, D., Kita, Y., Tanizawa, K., Taguchi, Y.,Chin, K., Mishima, M., Shimizu, T., and Narumiya, S
  • Journal Title: Nature Med Volume: 15 Issue: 12 Pages: 1426-1430
  • DOI: 10.1038/nm.2066
  • Peer Reviewed
• [Journal Article] Acyl-CoA:lysophospholipid acyltransferases (2009)
  • Author(s): Shindou H., and Shimizu T
  • Journal Title: J. Biol. Chem Volume: 284 Pages: 1-5
  • DOI: 10.1194/jlr.r800035-jlr200
  • Peer Reviewed
• [Journal Article] Helix 8 of leukotriene B4 type-2 receptor is required for the folding to pass the quality control in the endoplasmic reticulum (2009)
  • Author(s): Yasuda, D., Okuno, T., Yokomizo, T., Hori, T., Hirota, N., Hashidate, T., Miyano, M., Shimizu, T., and Nakamura, M
  • Journal Title: FASEB J Volume: 23 Issue: 5 Pages: 1470-1481
  • DOI: 10.1096/fj.08-125385
  • Peer Reviewed
• [Journal Article] Characterization of mouse lysophosphatidic acid acyltransferase 3: An enzyme with dual functions in the testis (2009)
  • Author(s): Yuki, K., Shindou, H., Hishikawa, D., and Shimizu, T
  • Journal Title: J. Lipid Res Volume: 50 Issue: 5 Pages: 860-869
  • DOI: 10.1194/jlr.m800468-jlr200
  • Peer Reviewed
• [Journal Article] Lipid mediators in health and diseases (2009)
  • Author(s): Shimizu, T
  • Journal Title: Ann. Rev. Pharmacol. Toxicol Volume: 49 Issue: 1 Pages: 123-150
  • DOI: 10.1146/annurev.pharmtox.011008.145616
  • Peer Reviewed
• [Journal Article] Prostaglandin F2α receptor signaling facilitates bleomycin-induced pulmonary fibrosis independently of transforming growth factor-β. (2009)
  • Author(s): Oga, T., Matsuoka, T., Yao, C., Nonomura, K., Kitaoka, S., Sakata, D., Kita, Y., Tanizawa, K., Taguchi, Y., Chin, K., Mishima, M., Shimizu, T., Narumiya, S.
  • Journal Title: Nature Med. 12 Pages: 1426-1430
  • Peer Reviewed
• [Journal Article] Targeted lipidomics reveals mPGES-1-PGE2 as a therapeutic target for multiple sclerosis. (2009)
  • Author(s): Kihara, Y., Matsushita, T., Kita, Y., Uematsu, S., Akira, S., Kira, J.-i., Ishii, S., Shimizu, T.
  • Journal Title: Proc. Natl. Acad. Sci. U.S.A. 106 Pages: 21807-21812
  • Peer Reviewed
• [Journal Article] A distinctive role of the leukotriene B4 receptor BLT1 in osteoclastic activity during bone loss. (2009)
  • Author(s): Hikiji, H., Ishii, S., Yokomizo, T., Takato, T., Shimizu, T.
  • Journal Title: Proc. Natl. Acad. Sci. U.S.A. 106 Pages: 21294-21299
  • Peer Reviewed
• [Journal Article] Biosynthesis of phosphatidylcholine by human lysophosphatidylcholine acyltransferase 1. (2009)
  • Author(s): Harayama, T., Shindou, H., Shimizu, T.
  • Journal Title: J.Lipid Res. 50 Pages: 1824-1831
  • Peer Reviewed
• [Journal Article] Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6 (2009)
  • Author(s): Yanagida, K., Masago, K., Nakanishi, H., Kihara, Y., Hamano, F., Tajima, Y., Taguchi, R., Shimizu T., Ishii, S.
  • Journal Title: J.Biol.Chem. 284 Pages: 17731-17741
  • Peer Reviewed
• [Journal Article] Global analysis of triacylglycerols including oxidized molecular species by reverse-phase high resolution LC/ESI-QTOF MS/MS (2009)
  • Author(s): Ikeda, K., Oike, Y., Shimizu, T., Taguchi, R.
  • Journal Title: J.Chromatogr.B Analyt.Technol.Biomed.Life.Sci. 877 Pages: 2639-2647
  • NAID: 10028022559
  • Peer Reviewed
• [Journal Article] Separation and quantification of sn-1 and sn-2 fatty acid positional isomers in phosphatidylcholine by RPLC-ESIMS/MS (2009)
  • Author(s): Nakanishi, H., Iida, Y., Shimizu, T., Taguchi, R.
  • Journal Title: J.Biochem. 147 Pages: 245-256
  • NAID: 10027873917
  • Peer Reviewed
• [Journal Article] Transcriptional regulation of human G2A in monocytes/macrophages : involvement of c/EBPs, Runx and Pu.1 (2009)
  • Author(s): Murakami, N., Hashidate, T., Harayama, T., Yokomizo, T., Shimizu, T., Nakamura, M.
  • Journal Title: Genes Cells 14 Pages: 1441-1455
  • Peer Reviewed
• [Journal Article] Demethylallosamidin, a chitinase inhibitor, suppresses airway inflammation and hyperresponsiveness (2009)
  • Author(s): Matsumoto, T., Inoue, H., Sato, Y., Kita, Y., Nakano, T., Noda, N., Eguchi-Tsuda, M., Moriwaki, A., Kan-O, K., Matsumoto, K., Shimizu, T., Nagasawa, H., Sakuda, S., Nakanishi, Y.
  • Journal Title: Biochem.Biophys.Res.Commun. 390 Pages: 103-108
  • Peer Reviewed
• [Journal Article] A distinctive role of the leukotriene B4 receptor BLT1 in osteoclastic activity during bone loss (2009)
  • Author(s): Hikiji, H., Ishii, S., Yokomizo, T., Takato, T., Shimizu, T.
  • Journal Title: Proc.Natl.Acad.Sci.U.S.A. 106 Pages: 21294-21299
  • Peer Reviewed
• [Journal Article] Targeted lipidomics reveals mPGES-1-PGE2 as a therapeutic target for multiple sclerosis (2009)
  • Author(s): Kihara, Y., Matsushita, T., Kita, Y., Uematsu, S., Akira, S., Kira, J.-i., Ishii, S., Shimizu, T.
  • Journal Title: Proc.Natl.Acad.Sci.U.S.A. 106 Pages: 21807-21812
  • Peer Reviewed
• [Journal Article] Attenuated Th1 induction by dendritic cells from mice deficient in the leukotriene B4 receptor 1 (2009)
  • Author(s): Toda, A., Terawaki, K., Yamazaki, S., Saeki, K., Shimizu, T., Yokomizo, T.
  • Journal Title: Biochimie (掲載確定(印刷中), in press)
  • Peer Reviewed
• [Journal Article] Prostaglandin F2alpha receptor signaling facilitates bleomycin-induced pulmonary fibrosis independently of transforming growth factor-beta (2009)
  • Author(s): Oga, T., Matsuoka, T., Yao, C., Nonomura, K., Kitaoka, S., Sakata, D., Kita, Y., Tanizawa, K., Taguchi, Y., Chin, K., Mishima, M., Shimizu, T., Narumiya, S.
  • Journal Title: Nature Med. 12 Pages: 1426-1430
  • Peer Reviewed
• [Journal Article] Acyl-CoA : lysophospholipid acyltransferases. (2009)
  • Author(s): Shindou H., Shimizu T.
  • Journal Title: J.Biol.Chem. 284 Pages: 1-5
  • Peer Reviewed
• [Journal Article] Opposing Effects of Platelet-activating Factor and Lyso-Platelet-activating Factor on Neutrophil and Platelet Activation. (2009)
  • Author(s): Welch, E.J., Naikawadi, R.P., Li, Z., Lin, P., Ishii, S., Shimizu, T., Tiruppathi, C., Du, X., Subbaiah, P.V., Ye, R.D.
  • Journal Title: Mol.Pharmacol. 75 Pages: 227-234
  • Peer Reviewed
• [Journal Article] Helix 8 of leukotriene B4 type-2 receptor is required for the folding to pass the ER quality control. (2009)
  • Author(s): Yasuda, D., Okuno, T., Yokomizo, T., Hori, T., Hirota, N., Hashidate, T., Miyano, M., Shimizu, T., Nakamura, M.
  • Journal Title: FASEB J. 23 Pages: 1470-1481
  • Peer Reviewed
• [Journal Article] Characterization of mouse lysophosphatidic acid acyltransferase 3 : Anenzyme with dual functions in the testis. (2009)
  • Author(s): Yuki, K., Shindou, H., Hishikawa, D., Shimizu, T.
  • Journal Title: J.Lipid Res. 50 Pages: 860-869
  • Peer Reviewed
• [Journal Article] Lipid mediators in health and diseases. (2009)
  • Author(s): Shimizu, T.
  • Journal Title: Ann.Rev.Pharmacol.Toxicol. 49 Pages: 123-150
  • Peer Reviewed
• [Journal Article] Identification of membrane O-acyltransferase family motifs. (2009)
  • Author(s): Shindou, H., Eto, M., Morimoto, R., Shimizu, T.
  • Journal Title: Biochem.Biophys.Res.Commun. 383 Pages: 320-325
  • Peer Reviewed
• [Journal Article] Cytosolic PLA2α activation in Purkinje neurons and its role in AMPA-receptor trafficking (2008)
  • Author(s): Mashimo, M., Hirabayashi, T., Murayama, T., and Shimizu, T
  • Journal Title: J. Cell Sci Volume: 121 Issue: 18 Pages: 3015-3024
  • DOI: 10.1242/jcs.032987
  • Peer Reviewed
• [Journal Article] Modulation of lipid and proteinmediators of inflammation by cytosolic phospholipase A2α during experimental sepsis (2008)
  • Author(s): Uozumi, N., Kita, Y., and Shimizu, T
  • Journal Title: J. Immunol Volume: 181 Pages: 3558-3566
  • URL: http://www.jimmunol.org/content/181/5/3558.abstract
  • Peer Reviewed
• [Journal Article] Platelet-Activating Factor Production in the Spinal Cord of Experimental Allergic Encephalomyelitis Mice via the Group IVA Cytosolic PLA2-LysoPAFAT Axis (2008)
  • Author(s): Kihara, Y., Yanagida, K., Masago, K., Kita, Y., Hishikawa, D., Shindou, H., Ishii, S., and Shimizu, T
  • Journal Title: J. Immunol Volume: 181 Pages: 5008-5014
  • URL: http://www.jimmunol.org/content/181/7/5008.abstract
  • Peer Reviewed
• [Journal Article] Cysteinyl leukotriene 2 receptor-mediated vascular permeability via transendothelial vesicle transport (2008)
  • Author(s): Moos, M. P. W., Mewburn, J. D., Kan, F. W. K., Ishii, S., Abe, M., Sakimura, K., Noguchi, K., Shimizu, T., and Funk, C. D
  • Journal Title: FASEB J Volume: 22 Issue: 12 Pages: 4352-4362
  • DOI: 10.1096/fj.08-113274
  • Peer Reviewed
• [Journal Article] Targeted analysis of ganglioside and sulfatide molecular species by LC/ESI-MS/MS with theoretically expanded multiplereaction monitoring (2008)
  • Author(s): Ikeda, K., Shimizu, T., and Taguchi, R
  • Journal Title: J. Lipid Res Volume: 49 Issue: 12 Pages: 2678-2689
  • DOI: 10.1194/jlr.d800038-jlr200
  • Peer Reviewed
• [Journal Article] Group IVA cytosolic phospholipase A2 (cPLA2) and integrin αIIb ss3 reinforce each other's functions during αIIb ss3 signaling in platelets (2008)
  • Author(s): Prevost, N., Mitsios, J., Kato, H., Burke, J. E., Dennis, E. A., Shimizu, T. and Shattil, S. J
  • Journal Title: Blood Volume: 133 Issue: 2 Pages: 447-457
  • DOI: 10.1182/blood-2008-06-162032
  • Peer Reviewed
• [Journal Article] Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity (2008)
  • Author(s): Hishikawa, D., Shindou, H., Kobayashi, S., Nakanishi, H., Taguchi, R., and Shimizu, T
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 105 Issue: 8 Pages: 2830-2835
  • DOI: 10.1073/pnas.0712245105
  • Peer Reviewed
• [Journal Article] Identification of a novel non inflammatory biosynthetic pathway of platelet-activating factor (2008)
  • Author(s): Harayama, T., Shindou, H., Ogasawara, R., Suwabe, A, and Shimizu, T
  • Journal Title: J. Biol. Chem Volume: 283 Issue: 17 Pages: 11097-11106
  • DOI: 10.1074/jbc.m708909200
  • Peer Reviewed
• [Journal Article] Basophils play a pivotal role in IgG-mediated, but not IgE-mediated systemic anaphylaxis (2008)
  • Author(s): Tsujimura, Y., Obata, K., Mukai, K.,Shindou, H., Yoshida, M., Nshikado, H., Kawano, Y., Minegishi, Y., Shimizu, T., and Karasuyama, H
  • Journal Title: Immunity Volume: 28 Pages: 581-589
  • URL: http://www.sciencedirect.com/science/article/pii/S1074761308000800
  • Peer Reviewed
• [Journal Article] 12(S)-Hydroxyheptadeca-5Z,8E, 10E-trienoic acid is a natural ligand for leukotriene B4 receptor 2 (2008)
  • Author(s): Okuno, T., Iizuka, Y., Okazaki, H., Yokomizo, T., Taguchi, R., and Shimizu, T
  • Journal Title: J. Exp. Med Volume: 205 Issue: 4 Pages: 759-766
  • DOI: 10.1084/jem.20072329
  • Peer Reviewed
• [Journal Article] Characterization of an orphan G protein-coupled receptor, GPR20, that constitutively activates Gi proteins (2008)
  • Author(s): Hase, M., Yokomizo, T., Shimizu, T., and Nakamura, M
  • Journal Title: J. Biol. Chem Volume: 283 Issue: 19 Pages: 12747-12755
  • DOI: 10.1074/jbc.m709487200
  • Peer Reviewed
• [Journal Article] The roles of prostanoids, leukotrienes, and platelet-activating factor in bone metabolism and disease (2008)
  • Author(s): Hikiji, H., Takato, T., Shimizu, T., and Ishii, S
  • Journal Title: Prog. Lipid Res Volume: 47 Pages: 107-126
  • URL: http://www.sciencedirect.com/science/article/pii/S0163782707000550
  • Peer Reviewed
• [Journal Article] 12(s)-Hydroxyheptadeca-5Z, 8E, 10E-trienoic acid is a natural ligand for leukotriene B4 receptor 2. (2008)
  • Author(s): Okuno, T., Iizuka, Y., Okazaki, H., Yokomizo, T., Taguchi, R., Shimizu, T.
  • Journal Title: J. Exp. Med. 205 Pages: 759-766
  • Peer Reviewed
• [Journal Article] Leukotriene B4/Leukotriene B4 Receptor Pathway Is Involved in Hepatic Microcirculatory Dysfunction Elicited by Endotoxin. (2008)
  • Author(s): Ito, S., Ito, Y., Katagiri, H., Suzuki, T., Hoka, S., Yokomizo, T., Shimizu, T., Majima, M.
  • Journal Title: Shock 30 Pages: 87-91
  • Peer Reviewed
• [Journal Article] Cytosolic PLA2a activation in Purkinje neurons and its role in AMPA-receptor trafficking (2008)
  • Author(s): Mashimo, M., Hirabayashi, T., Murayama, T., Shimizu, T.
  • Journal Title: J.Cell Sci. 121 Pages: 3015-3024
  • Peer Reviewed
• [Journal Article] Modulation of lipid and protein mediators of inflammation by cytosolic phospholipase A2alpha during experimental sepsis. (2008)
  • Author(s): Uozumi, N., Kita, Y., Shimizu, T.
  • Journal Title: J.Immunol 181 Pages: 3558-3566
  • Peer Reviewed
• [Journal Article] Platelet-Activating Factor Production in the Spinal Cord of Experimental Allergic Encephalomyelitis Mice via the Group IVA Cytosolic PLA2-LysoPAFAT Axis. (2008)
  • Author(s): Kihara, Y., Yanagida, K., Masago, K., Kita, Y., Hishikawa, D., Shindou, H., Ishii, S., Shimizu, T.
  • Journal Title: J.Immunol 181 Pages: 5008-5014
  • Peer Reviewed
• [Journal Article] Cysteinyl leukotriene 2 receptor-mediated vascular permeability viatransendothelial vesicle transport. (2008)
  • Author(s): Moos, M.P.W., Mewbum, J.D., Kan, F.W.K., Ishii, S., Abe, M., Sakimura, K., Noguchi, K., Shimizu, T., Funk, C.D.
  • Journal Title: FASEBJ. 22 Pages: 4352-4362
  • Peer Reviewed
• [Journal Article] Targeted analysis of ganglioside and sulfatide molecular species by LC/ESI-MS/MS with theoretically expanded multiple reaction monitoring. (2008)
  • Author(s): Ikeda, K., Shimizu, T., Taguchi, R.
  • Journal Title: J.Lipid Res. 49 Pages: 2678-2689
  • Peer Reviewed
• [Journal Article] Intracellular phospholipase A2 group IVA and group VIA play important roles in Wallerian degeneration and axon regeneration after peripheral nerve injury. (2008)
  • Author(s): Lopes-Vales, R., Navarro, X., Shimizu, T.., Baskakis, C., Kokotos, G., Constanious-Kokotou, V., Stephen, D., Dennis, E. A., David, S.
  • Journal Title: Brain 131 Pages: 2620-2631
  • Peer Reviewed
• [Journal Article] Arachidonic acid metabolites inhibit the stimulatory effect of angiotensin II in renal proximal tubules. (2008)
  • Author(s): Li, Y., Yamada, H., Kita, Y., Suzuki, M., Endo, Y., Horita, S., Yamazaki, O., Shimizu, T., Seki, G., Fujita, T.
  • Journal Title: Hypertens.Res. 31 Pages: 2155-2164
  • NAID: 10024828609
  • Peer Reviewed
• [Journal Article] Group IVA cytosolic phospholipase A2 (cPLA2) and integrin a IIbb3 reinforceeach other's functions during IIb3 signaling in platelets. (2008)
  • Author(s): Prevost, N., Mitsios, J., Kato, H., Burke, J.E., Dennis, E.A.,Shimizu, T., Shattil, S.J.
  • Journal Title: Blood 113 Pages: 447-457
  • Peer Reviewed
• [Journal Article] Recent progress on Acyl-CoA : lysophospholipid acyltransferase research. (2008)
  • Author(s): Shindou, H., Hishikawa, D., Harayama, T., Yuki, K., Shimizu, T.
  • Journal Title: J.Lipid Res. 50
  • Peer Reviewed
• [Journal Article] The roles of prostanoids, leukotrienes, and platelet-activating factor in bone metabolism and disease. (2008)
  • Author(s): Hikiji, H., Takato, T., Shimizu, T., and Ishii, S.
  • Journal Title: Prog. Lipid Res. 47 Pages: 107-126
  • Peer Reviewed
• [Journal Article] Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity. (2008)
  • Author(s): Hishikawa, D^*., Shindou, H^*. (*, equal contribution), Kobayashi, S., Nakanishi, H., Taguchi, R., and Shimizu, T.
  • Journal Title: Proc. Natl. Acad. Sci. USA 105 Pages: 2830-2835
  • Peer Reviewed
• [Journal Article] Identification of a novel non-inflammatory biosynthetic pathway of platelet-activating factor. (2008)
  • Author(s): Harayama, T^*., Shindou, H^*. (*, equal contribution), Ogasawara, R., Suwabe, A, and Shimizu, T.
  • Journal Title: J. Biol. Chem. (印刷中)
  • Peer Reviewed
• [Journal Article] Basophils play a pivotal role in IgG-, but not IgE-mediated systemic an aphylaxis in contrast to mast cells. (2008)
  • Author(s): Tsujimura, Y., Obata, K., Mukai, K., Shindou, H., Yoshida, M., Nshikado, H., Kawano, Y., Minegishi, Y., Shimizu, T., and Karasuyama, H.
  • Journal Title: Immunity 28 Pages: 581-589
  • Peer Reviewed
• [Journal Article] 12(S)-Hydroxyheptadeca-5Z, 8E, 10E-trienoic acid is a natural ligand for leukotriene B4 receptor 2. (2008)
  • Author(s): Okuno, T., Iizuka, Y., Okazaki, H., Yokomizo, T., Taguchi, R., and Shimizu, T.
  • Journal Title: J. Exp. Med. 205 Pages: 759-766
  • Peer Reviewed
• [Journal Article] Characterization of an orphan G protein-coupled receptor, GPR20, that constitutively activates Gi proteins. (2008)
  • Author(s): Hase, M., Yokomizo, T., Shimizu, T., and Nakamura, M.
  • Journal Title: J. Biol. Chem. (印刷中)
  • Peer Reviewed
• [Journal Article] Basic Analytical Systems for Lipidomics by Mass Spectrometry (2007)
  • Author(s): Taguchi, R., Nishijima, M., and Shimizu, T
  • Journal Title: Japan Methods Enzymol Volume: 432 Pages: 185-211
  • URL: http://www.sciencedirect.com/science/article/pii/S0076687907320089
  • Peer Reviewed
• [Journal Article] Reduced pain behaviors and ERK activation in primary sensory neurons by peripheral tissue injury in mice lacking platelet-activating factor receptor. (2007)
  • Author(s): Tsuda, M., Ishii, S., Masuda, T., Hasegawa, S., Nakamura, K., Nagata, K., Yamashita, T., Furue, H., Tozaki-Saito, H., Yoshimura, M., Koizumi, S., Shimizu, T., and Inoue, K.
  • Journal Title: J. Neurochem. 102 Pages: 1658-1668
  • Peer Reviewed
• [Journal Article] Role of platelet-activating factor in pneumolysin-induced acute lung injury. (2007)
  • Author(s): witzenrath, M., Gutbier, B., Owen, J. S, Schmeck, B., Mitchell, T. J., Mayer, K., Thomas, M. J., Ishii, S., Rosseau, S., Suttorp, N., and Schutte H.
  • Journal Title: Crit. Care Med. 35 Pages: 1756-1762
  • Peer Reviewed
• [Journal Article] Roles of nitric oxide as a vasodilator in neurovascular coupling of mouse somatosensory cortex. (2007)
  • Author(s): Kitaura, H., Uozumi, N., Tohmi, M., Yamazaki, M., Sakimura, K., Kudoh, M., Shimizu, T., and Shibuki. K.
  • Journal Title: Neurosci. Res. 59 Pages: 160-171
  • NAID: 10024417303
  • Peer Reviewed
• [Journal Article] Basic Analytical Systems for Lipidomics by Mass Spectrometry in Japan. (2007)
  • Author(s): Taguchi, R., Nishijima, M., and Shimizu. T.
  • Journal Title: Methods Enzymol. 432 Pages: 183-209
  • Peer Reviewed
• [Journal Article] Roles of ERK and group IVA cytosolic PLA2 in biphasic regulation of renalproximal transport by angiotensin II. (2007)
  • Author(s): Li, Y., Yamada, H., Kita, Y., Kunimi, M., Horita. S., Suzuki, M., Endo, Y., Shimizu, T., Seki, G. and Fujita. T.
  • Journal Title: J. Amer. Soc Nephrol. 19 Pages: 252-259
  • Peer Reviewed
• [Presentation] Turnover of Glycerophospholipids by Deacylation-Reacylation Cycle (2012)
  • Author(s): 清水孝雄
  • Organizer: Keystone Symposia:BaioactiveLipids:Biochemistry and Diseases2010(口頭・オーガナイザー)
  • Place of Presentation: ウェスティン都ホテル京都
  • Year and Date: 2012-06-07
• [Presentation] Lipidomics and phospholipid metabolism (2012)
  • Author(s): 清水孝雄
  • Organizer: 4th International Singapore Lipid Symposium(招待講演 )
  • Place of Presentation: National Singapore of Singapore(シンガポール)
  • Year and Date: 2012-03-15
• [Presentation] Discovery of lysophospholipid acyltransferases in theLands'cycle (2012)
  • Author(s): 進藤英雄
  • Organizer: 4th International Singapore Lipid Symposium(ポスター発表)
  • Place of Presentation: National Singapore of Singapore(シンガポール)
• [Presentation] Lipidomics and phospholipid metabolism. (2012)
  • Author(s): Takao Shimizu
  • Organizer: 4th International Singapore Lipid Symposium(口頭発表）
  • Place of Presentation: National University of Singapore（シンガポール・シンガポール）
  • Invited
• [Presentation] Discovery of lysophospholipid acyltransferases in the Lands’ cycle (2012)
  • Author(s): Hideo Shindou, Daisuke Hishikawa, Takeshi Harayama, Miki, Eto, Ryo Morimoto, Koichi Yuki, and Takao Shimizu.
  • Organizer: 4th International Singapore Lipid Symposium (ポスター発表）
  • Place of Presentation: National University of Singapore (シンガポール・シンガポール）
• [Presentation] 血小板活性化における5-リポキシゲナーゼ代謝産物の役割 (2012)
  • Author(s): 伊藤明博、柳田圭介、石井聡、斉藤延人、清水孝雄
  • Organizer: 第37回日本脳卒中学会（口頭発表）
  • Place of Presentation: 福岡国際会議場（日本・福岡県）
• [Presentation] Alternative arachidonic acid cascade in the brain (2012)
  • Author(s): Yoshihiro Kita, Takao Shimizu
  • Organizer: LIPID MAPS Annual Meeting 2012 (口頭発表）
  • Place of Presentation: Scripps Seaside Forum （アメリカ・カルフォルニア）
• [Presentation] Comparative phospholipid analysis by selected reaction monitoring of cultured cells that overexpress an enzyme involved in alkylglycerol metabolism (2012)
  • Author(s): Suzumi Tokuoka、 Yoshihiro Kita、 Hideo Shindou、Masaki Yamada、Takao Shimizu
  • Organizer: 60th ASMS Conference on Mass Spectrometry （第６０回北米質量分析学会）(ポスター発表）
  • Place of Presentation: Vancouver Convention Centre（カナダ・バンクーバー）
• [Presentation] Biochemistry and biology of LPA, a non-Edg receptor (2011)
  • Author(s): 清水孝雄
  • Organizer: FASEB SRC (口頭)
  • Place of Presentation: Il Ciocco Hotels& Resort (イタリア)
  • Year and Date: 2011-08-18
• [Presentation] 肺サーファクタント脂質組成調節酵素LPCAT1欠損マウスの解析 (2011)
  • Author(s): 原山武士、進藤英雄、清水孝雄
  • Organizer: 第10回肺サーファクタント分子病態研究会（口頭発表）
  • Place of Presentation: 札幌医科大学記念ホール（日本・札幌）
• [Presentation] LPCAT1は正常な肺サーファクタント脂質の合成に必須である (2011)
  • Author(s): 原山武士、進藤英雄、衛藤樹、清水孝雄
  • Organizer: 第53回日本脂質生化学会（口頭発表）
  • Place of Presentation: ホテル東京ガーデンパレス（日本・東京）
• [Presentation] システイニルロイコトリエンの血小板における役割 (2011)
  • Author(s): 伊藤明博、柳田圭介、石井聡、斉藤延人、清水孝雄
  • Organizer: 第53回日本脂質生化学会（口頭発表）
  • Place of Presentation: ホテル東京ガーデンパレス（日本・東京）
• [Presentation] 先天性貧毛症で報告されたp2y5/LPA6 変異体の機能異常 (2011)
  • Author(s): 柳田圭介、真砂佳代、清水孝雄、石井聡
  • Organizer: 第53回日本脂質生化学会（口頭発表）
  • Place of Presentation: ホテル東京ガーデンパレス（日本・東京）
• [Presentation] Lipid Mediators in health and disease. (2011)
  • Author(s): Takao Shimizu
  • Organizer: 1st Mac Planc Society & Univ. of Tokyo Joint Symposium（口頭発表）
  • Place of Presentation: Park hotel Schangenbad（ドイツ・フランクフルト）
• [Presentation] Analysis of Phospholipid Functions through the Investigation of Remodeling Enzymes (2011)
  • Author(s): Takeshi Harayama, Hideo Shindou, and Takao Shimizu
  • Organizer: 1st Mac Planc Society & Univ. of Tokyo Joint Symposium（口頭発表）
  • Place of Presentation: Park hotel Schangenbad（ドイツ・フランクフルト）
• [Presentation] Functional analysis of p2y5/LPA6 with missense mutations identified in familial hypotrichosis/woolly hair patients (2011)
  • Author(s): Keisuke Yanagida
  • Organizer: FASEB Semmer Research Conference（ポスター発表）
  • Place of Presentation: Il Ciocco Hotels & Resort (イタリア・ルッカ）
• [Presentation] Role of Cysteinyl leukotrines and their receptors in thrombosis and hemostasis. (2011)
  • Author(s): Akihiro Ito, Keisuke Yanagida, Satoshi Ishii, Nobuhito Saito, Takao Shimizu
  • Organizer: FASEB Semmer Research Conference（ポスター発表）
  • Place of Presentation: Il Ciocco Hotels & Resort (イタリア・ルッカ）
• [Presentation] Biochemistry and biology of LPA, a non-Edg receptor. (2011)
  • Author(s): Takao Shimizu
  • Organizer: FASEB Semmer Research Conference（口頭発表）
  • Place of Presentation: Il Ciocco Hotels & Resort (イタリア・ルッカ）
• [Presentation] LPCAT1はリン脂質リモデリングを介して肺のホメオスタシスに寄与する (2011)
  • Author(s): 原山武士、進藤英雄、清水孝雄
  • Organizer: 第８４回日本生化学会（口頭発表・ポスター発表）
  • Place of Presentation: 国立京都国際会館（日本・京都府）
• [Presentation] ロイコトリエンB4第一受容体の遺伝子発現調節機構の解明 (2011)
  • Author(s): 吉田智美
  • Organizer: 第８４回日本生化学会（ポスター発表）
  • Place of Presentation: 国立京都国際会館（日本・京都府）
• [Presentation] マウス血小板におけるシステイニルロイコトリエンの役割 (2011)
  • Author(s): 伊藤明博、柳田圭介、石井聡、斉藤延人、清水孝雄
  • Organizer: 第84回日本生化学会大会（口頭発表・ポスター発表）
  • Place of Presentation: 国立京都国際会館（日本・京都府）
• [Presentation] メタボリックシンドロームにおけるリゾホスファチジン酸受容体LPA4の病態生理機能 (2011)
  • Author(s): 柳田圭介
  • Organizer: 第８４回日本生化学会（口頭発表・ポスター発表）
  • Place of Presentation: 国立京都国際会館（日本・京都府）
• [Presentation] システイニルロイコトリエンの血小板に及ぼす影響(The effect of Cysteinyl leukotriene in platelets) (2011)
  • Author(s): 伊藤明博、柳田圭介、石井聡、斉藤延人、清水孝雄
  • Organizer: 脳神経疾患横断的シンポジウム「分子イメージングとバイオマーカー」 第12回分子脳神経外科学会（口頭発表）
  • Place of Presentation: パシフィコ横浜（日本・神奈川県）
• [Presentation] Lysophosphatidylcholine acyltransferases: biochemistry and biology (2011)
  • Author(s): Takao Shimizu
  • Organizer: 第10回JBSバイオフロンティア国際シンポジウム(口頭発表）
  • Place of Presentation: ザ・ルイガンス（日本・福岡県）
• [Presentation] LPCAT1 regulates dipalmitoylphosphatidylcholine levels in vivo and prevents lung injury (2011)
  • Author(s): Takeshi Harayama, Hideo Shindou, and Takao Shimizu
  • Organizer: 第10回JBSバイオフロンティア国際シンポジウム(ポスター発表）
  • Place of Presentation: ザ・ルイガンス（日本・福岡県）
• [Presentation] 血小板活性化におけるシステイニルロイコトリエンの役割 (2011)
  • Author(s): 伊藤明博、柳田圭介、石井聡、斉藤延人、清水孝雄
  • Organizer: 第27回日本脳血管内治療学会（ポスター発表）
  • Place of Presentation: 幕張メッセ国際会議場（日本・千葉県）
• [Presentation] LPCAT2活性化メカニズムの解明 (2010)
  • Author(s): 進藤英雄
  • Organizer: 2010BMB日本生化学会
  • Place of Presentation: 神戸国際会議場(兵庫県、日本)(口頭発表)
  • Year and Date: 2010-12-09
• [Presentation] Characterization of two types of lyso-PAF acetyltransferases (2010)
  • Author(s): 原山武士・森本亮(共同口演)
  • Organizer: FASEB Summer Research Conferences 2010
  • Place of Presentation: Steamboat Springs (CO, USA)(口頭発表)
  • Year and Date: 2010-06-29
• [Presentation] Role of lysophosphatidic acid acyltransferase 3 in sertoli cell function (2010)
  • Author(s): Andreas Koebelre
  • Organizer: 第52回日本脂質生化学会
  • Place of Presentation: 森秋旅館(群馬県、日本)(口頭発表)
  • Year and Date: 2010-06-15
• [Presentation] Turnover of Glycerophospholipids by Deacylation-Reacylation Cycle (2010)
  • Author(s): 清水孝雄
  • Organizer: Keystone Symposia : Bioactive Lipids : Biochemistry and Diseases 2010(organizerとして、学会運営を行う)
  • Place of Presentation: ウェスティン都ホテル京都(京都府、日本)(口頭発表)
  • Year and Date: 2010-06-07
• [Presentation] Phospholipid metabolism and diseases (2010)
  • Author(s): 清水孝雄
  • Organizer: 第7回東京大学・ソウル大学共同カンファランス
  • Place of Presentation: Samsung Cancer Research Institute(ソウル市、韓国)(招待講演)(口頭発表)
  • Year and Date: 2010-05-28
• [Presentation] New Challenge for Lipid Mediators and Phospholipid Metabolism (2010)
  • Author(s): 清水孝雄
  • Organizer: Weill Medical College of Cornell University特別セミナー
  • Place of Presentation: Weill Medical College of Cornell University (NY, USA)(招待講演)(口頭発表)
  • Year and Date: 2010-05-11
• [Presentation] Helix 8 for ER Export of Leukotriene B4 type-2 Receptor (BLT2) (2010)
  • Author(s): 安田大恭・橋立(吉田)智美(共著)
  • Organizer: 2010 ASBMB ANNUAL MEETING
  • Place of Presentation: ANAHEIM Convention Center (CA, USA)(ポスター発表)
• [Presentation] Enzymatic characterization of lysophosphatidylcholine acyltransferase 1 and its possible involvement in pulmonary surfactant phosphatidylcholine biosynthesis (2010)
  • Author(s): 原山武士
  • Organizer: Keystone Symposia : Bioactive Lipids : Biochemistry and Diseases 2010
  • Place of Presentation: ウェスティン都ホテル京都(京都府、日本)(ポスター発表)
• [Presentation] LPA4 moduletes murine vascular development (2010)
  • Author(s): 住田隼一
  • Organizer: Keystone Symposia : Bioactive Lipids : Biochemistry and Diseases 2010
  • Place of Presentation: ウェスティン都ホテル京都(京都府、日本)(ポスター発表)
• [Presentation] Quantity and quality regulation of leukotriene B4 receptors (2010)
  • Author(s): 中村元直
  • Organizer: Keystone Symposia : Bioactive Lipids : Biochemistry and Diseases 2010
  • Place of Presentation: ウェスティン都ホテル京都(京都府、日本)(ポスター発表)
• [Presentation] Biochemical into the multiple molecular and functional properties of group X sPLA2 (2010)
  • Author(s): 北芳博
  • Organizer: Keystone Symposia : Bioactive Lipids : Biochemistry and Diseases 2010
  • Place of Presentation: ウェスティン都ホテル京都(京都府、日本)(ポスター発表)
• [Presentation] Functional characterization of human hypotrichosis/wooly hair-associated mutations in the lysophosphatidic receptor, p2y5/LPA6 (2010)
  • Author(s): 真砂佳代・柳田圭介(共著)
  • Organizer: Keystone Symposia : Bioactive Lipids : Biochemistry and Diseases 2010
  • Place of Presentation: ウェスティン都ホテル京都(京都府、日本)(ポスター発表)
• [Presentation] MK2を介したSer34リン酸化によるPAF生合成酵素(LPCAT2)活性化 (2010)
  • Author(s): 森本亮
  • Organizer: 2010BMB日本生化学会
  • Place of Presentation: 神戸国際会議場(兵庫県、日本)(口頭発表12/9)(ポスター発表)
• [Presentation] 先天性貧毛症患者で報告されたLPA6/p2y5変異体の機能解析 (2010)
  • Author(s): 真砂佳代・柳田圭介(共著)
  • Organizer: 2010BMB日本生化学会
  • Place of Presentation: 神戸国際会議場(兵庫県、日本)(ポスター発表)
• [Presentation] HL60細胞におけるロイコトリエンB4受容体(BLT1)の機能解析 (2010)
  • Author(s): 橋立(吉田)智美
  • Organizer: 2010BMB日本生化学会
  • Place of Presentation: 神戸国際会議場(兵庫県、日本)(ポスター発表)
• [Presentation] 生体膜リン脂質リモデリングにおける肺サーファクタント脂質の生合成 (2010)
  • Author(s): 原山武士
  • Organizer: 2010BMB日本生化学会
  • Place of Presentation: 神戸国際会議場(兵庫県、日本)(ポスター発表)
• [Presentation] Lipid Mediators in Neuroimmune Functions (2009)
  • Author(s): 木原泰行
  • Organizer: 11th International Conference
  • Place of Presentation: Casamagna Marriot Cancun Resort, Cancun, Mexico
  • Year and Date: 2009-10-26
• [Presentation] 実験的自己免疫性脳脊髄炎におけるPGE2合成酵素の役割 (2009)
  • Author(s): 木原泰行
  • Organizer: 日本生化学会
  • Place of Presentation: 神戸ポートアイランド、兵庫県
  • Year and Date: 2009-10-22
• [Presentation] Lipid Mediators in Health and Disease : A Forgotten Lipid, 12-HHT, Met Its Receptor after 40 years (2009)
  • Author(s): 清水孝雄
  • Organizer: National Health Research Institutes
  • Place of Presentation: National Health Research Institutes, Taipei
  • Year and Date: 2009-10-02
• [Presentation] Prostagrandins and their receptors (2009)
  • Author(s): 清水孝雄
  • Organizer: The 50th International Conference on the Bioscience of Lipid(招待講演)
  • Place of Presentation: Kolpinghaus Regensburg (ドイツ)
  • Year and Date: 2009-09-03
• [Presentation] Prostaglandings and their receptors (2009)
  • Author(s): 清水孝雄
  • Organizer: The 50^<th> International Conference on the Bioscience of Lipids
  • Place of Presentation: Kolpinghaus Regensburg, Germany
  • Year and Date: 2009-09-03
• [Presentation] Production of Lipid Mediators during Lands' Cycle (2009)
  • Author(s): 清水孝雄
  • Organizer: FASEB SRC(口頭)
  • Place of Presentation: Carefree Resort andVillas(アメリカ)
  • Year and Date: 2009-06-29
• [Presentation] Production of Lipid Mediators during Lands' Cycle (2009)
  • Author(s): 清水孝雄
  • Organizer: FASEB国際学会
  • Place of Presentation: Carefree Resort and Villas, CA, USA
  • Year and Date: 2009-06-29
• [Presentation] Lethality of LPA4-deficient embryos and neonates (2009)
  • Author(s): 住田隼一
  • Organizer: FASEB国際学会
  • Place of Presentation: Carefree Resort and Villas, CA, USA
  • Year and Date: 2009-06-29
• [Presentation] Phospholipid and Metabolism : phoshospholipase and Acyltransferases (2009)
  • Author(s): 清水孝雄
  • Organizer: KeystoneSymposia(口頭)
  • Place of Presentation: TheResort at Squaw Creek(アメリカ)
  • Year and Date: 2009-05-28
• [Presentation] Quantitative Lipidmics Strategy by LC-ESIMS : Methodology and Application Biological Studies (2009)
  • Author(s): 北芳博
  • Organizer: 4^<th> International Congress on Phospholipase A2 and Lipid Mediators
  • Place of Presentation: 東京 学術総合センター
  • Year and Date: 2009-05-28
• [Presentation] Phospholipid Metabolism: Phospholipases and Acyltransferases (2009)
  • Author(s): 清水孝雄
  • Organizer: Keystone国際学会
  • Place of Presentation: The Resort at Squaw Creek, CA, USA
  • Year and Date: 2009-04-22
• [Presentation] Phospholipid and Metabolism : Phospholipases and Acyltransferases (2009)
  • Author(s): 清水孝雄
  • Organizer: Keystone 国際学会
  • Place of Presentation: The Resort at Squaw Creek, CA, USA
  • Year and Date: 2009-04-22
• [Presentation] 雄性生殖器における細胞質型ホスホリパーゼA2zetaの機能解析 (2008)
  • Author(s): 大戸貴代
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートピアホテル、日本
  • Year and Date: 2008-12-11
• [Presentation] 生体膜リン脂質の多様性と非対称性を決める酵素ファミリー (2008)
  • Author(s): 清水孝雄
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートピアホテル、日本
  • Year and Date: 2008-12-09
• [Presentation] UPLC-ESIMSによるリン脂質ディファレンシャル解析法の開発および膜リン脂質代謝酵素解析への応用 (2008)
  • Author(s): 北芳博
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートピアホテル、日本
  • Year and Date: 2008-12-09
• [Presentation] Distinguished Lecture in Immunology Seminar Series (2008)
  • Author(s): 清水孝雄
  • Organizer: Distinguished Lecture in Immmunology SeminarSeries(招聘講演)
  • Place of Presentation: Cincinnati Children's Hospital Medical Center(アメリカ)
  • Year and Date: 2008-10-20
• [Presentation] Lipid mediators and phospholipid metabolism (2008)
  • Author(s): 清水孝雄
  • Organizer: Distinguished Lecture in Immunology Seminar Series
  • Place of Presentation: Cincinnati Children's Hospital Medical Center, Ohaio, USA
  • Year and Date: 2008-10-20
• [Presentation] Lysophosphatidylcholine acyltransferase 1 and 2 (2008)
  • Author(s): 清水孝雄
  • Organizer: FASEB SRC(口 頭)
  • Place of Presentation: Omni New Haven Hotel at Yale(アメリカ)
  • Year and Date: 2008-07-23
• [Presentation] Lysophosphatidylcholine acyltransferase 1 and 2 (2008)
  • Author(s): 清水孝雄
  • Organizer: 2008 FASEB Summer Research Conference
  • Place of Presentation: Omni New Haven Hotel at Yale, Conneticut, USA
  • Year and Date: 2008-07-23
• [Presentation] II型肺胞上皮細胞における非炎症性PAF生合成酵素の同定 (2008)
  • Author(s): 進藤英雄
  • Organizer: 第8回肺サーファクタント分子病態研究会
  • Place of Presentation: 札幌医科大学記念ホール、日本
  • Year and Date: 2008-07-05
• [Presentation] LC-MSによる脂質メディエーター産生プロファイルの包括的解析 (2008)
  • Author(s): 北 芳博
  • Organizer: 第128回日本薬学会シンポジウム
  • Place of Presentation: パシフィコ横浜、日本
  • Year and Date: 2008-03-26
• [Presentation] Biochemical and Pathophoysiological roles of Two Types of Leukotorien B4 Receptors (PLT1 and PLT2) (2008)
  • Author(s): 清水孝雄
  • Organizer: Keystone Symposia (口頭)
  • Place of Presentation: Big Sky Resort(アメリカ)
  • Year and Date: 2008-01-09
• [Presentation] Biochemical and Pathophysiological roles of Two Types of Leukotrien B4 Receptors (BLT1 and BLT2) (2008)
  • Author(s): 清水 孝雄
  • Organizer: KEYSTONE
  • Place of Presentation: Big Sky Resort, Montana USA
  • Year and Date: 2008-01-09
• [Presentation] リゾホスファチジルコリンアシル転移酵素(LPCAT1)とリゾPAFアセチル転移酵素(LysoPAFAT/LPCAT2)の解析 (2007)
  • Author(s): 進藤 英雄
  • Organizer: BMB2007(第30回日本分子生物学会・第80回日本生化学学会 合同大会)
  • Place of Presentation: パシフィコ横浜、ヨコハマグランドインターコンチネンタルホテル、日本
  • Year and Date: 2007-12-12
• [Presentation] LC-MSによる脂質メディエーターの網羅的解析手法の開発とその応用 (2007)
  • Author(s): 北 芳博
  • Organizer: BMB2007(第30回日本分子生物学会・第80回日本生化学学会 合同大会)
  • Place of Presentation: パシフィコ横浜、ヨコハマグランドインターコンチネンタルホテル、日本
  • Year and Date: 2007-12-11
• [Presentation] Phospholipase A2 and lysophospholipid acyltransferases (Lands'cycle). (2007)
  • Author(s): 清水 孝雄
  • Organizer: EICOSANOID
  • Place of Presentation: Le Centre Sheraton Hotel, Montreal, Canada
  • Year and Date: 2007-09-19
• [Presentation] Lipid Mediators and Phospholipid Metabolism (2007)
  • Author(s): 清水孝雄
  • Organizer: FASEB SRC(口頭)
  • Place of Presentation: Hilton Tuson(アメリカ)
  • Year and Date: 2007-06-09
• [Presentation] Lipid Mediators and Phospholipid Metabplism (2007)
  • Author(s): 清水 孝雄
  • Organizer: The FASEB Summer Research Conference
  • Place of Presentation: Hilton Tucson, Arizona, USA
  • Year and Date: 2007-06-09
• [Presentation] 新規酵素lyso-PAF acetyltransferaseとLPC aceltransferaseの解析 (2007)
  • Author(s): 進藤 英雄
  • Organizer: 第49回日本脂質生化学会
  • Place of Presentation: 北海道大学学術交流会館
  • Year and Date: 2007-06-06
• [Presentation] Pathway-oriented profiling of lipid mediator production. (2007)
  • Author(s): 北 芳博
  • Organizer: 3rd International Conference on Phospholipase A2 and Lipid Mediators
  • Place of Presentation: Grand Hotel Vesuvio, Sorrento (Naples), Italy
  • Year and Date: 2007-05-12
• [Remarks] 東京大学医学部細胞情報学 HP
  • URL: http://biochem2.umin.jp/index_j.html
• [Remarks] 東京大学医学部社会連携講座リピドミクス HP
  • URL: http://lipidomics.m.u-tokyo.ac.jp/
• [Remarks] 国立国際医療研究センター脂質シグナリン グプロジェクト HP
  • URL: http://www.ncgmlipidsp.jp/
• [Remarks]
  • URL: http://biochem2.umin.jp/index_j.html