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蛋白質相互作用における多重特異性の定量的記述と応用

Research Project

Project/Area Number 19021011
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionThe University of Tokyo

Principal Investigator

津本 浩平  The University of Tokyo, 大学院・新領域創成科学研究科, 准教授 (90271866)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,800,000 (Direct Cost: ¥4,800,000)
Fiscal Year 2008: ¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 2007: ¥2,300,000 (Direct Cost: ¥2,300,000)
Keywords蛋白質 / 分子認識 / 生物物理 / 生体分子 / シグナル伝達 / バイオテクノロジー / 生物・生体工学 / 相互作用 / 特異性
Research Abstract

(1)多重特異性相互作用の速度論的・熱力学的解析ならびに結晶構造解析 : 前年度までに確立した発現・調製系ならびに相互作用解析システムを用いて、サイトカイン、IL-15Rα、Tob1と各種相互作用分子との相互作用を、表面プラズモン共鳴法、等温滴定型熱量測定に加えて、TEM、DLS、GPC-MALS等により解析した。これらの解析結果を基に、蛋白質相互作用における、多重特異性を定量的記述により議論することができた。
(2)相互作用を特異的にブロックできる抗体、ペプチドのファージディスプレイを用いた選択とその機能・構造評価 : 前年度取得した抗体の構造・機能評価を進めた。アミロイド線維Aβ1-42について、ファージディスプレイを用いたペプチドライブラリーならびにヒト抗体無作為変異導入ライブラリーから特異的に結合する分子種を取得した。得られた分子の機能・構造評価を行い、線維形成制御と蛋白質高次構造との関連を議論することができた。

Report

(2 results)
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (102 results)

All 2009 2008 2007 Other

All Journal Article (49 results) (of which Peer Reviewed: 47 results) Presentation (51 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Activation of Leukemia-associated RhoGEF by Galphal3 with significant conformational rearrangements in the interface2009

    • Author(s)
      Nobuchika Suzuki, et.al.
    • Journal Title

      J. Biol. Chem (印刷中)(掲載決定)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of intrinsic cooperative thermodynamics of peptide-MHC corn plexes on antiviral activity of HIV-specific cytotoxic T lymphocytes2009

    • Author(s)
      Chihiro Motozono, et.al.
    • Journal Title

      J. Immunol (印刷中)(掲載決定)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contributions of interfacial residues of human Interleukin 15 to the specificity and affinity for its private alpha-receptor2009

    • Author(s)
      Sakamoto, et.al.
    • Journal Title

      J. Mol. Biol (印刷中)(掲載決定)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular Glues Carrying Multiple Guanidinium Ion Pendants via an Oligc ether Spacer : Stabilization of Microtubules against Depolymerization2009

    • Author(s)
      Okuro, et.al.
    • Journal Title

      J. Amer. Chem. Soc (印刷中)(掲載決定)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] To be excluded or to bind, that is the question : Arginine effects on proteins2009

    • Author(s)
      Nakakido, et.al.
    • Journal Title

      Cur. Pharm. Biotechnol (印刷中)(掲載決定)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Utilization of an arginine-elution method for FLAG-tag chromatography2009

    • Author(s)
      Futatsumori-Sugai, et.al.
    • Journal Title

      Protein Expr. Purif (印刷中)(掲載決定)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The interaction of hyperthermophilic TATA-box binding protein with single-stranded DNA is entropically favorable and exhibits a large negative heat capacity change at high salt concentration2009

    • Author(s)
      Nagatoishi, et.al.
    • Journal Title

      Mol. Biosyst (印刷中)(掲載決定)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immobilized metal affinity chromatography in the presence of arginine2009

    • Author(s)
      Abe, et.al.
    • Journal Title

      Biochem. Biophys. Res. Commun (印刷中)(掲載決定)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thermodynamic consequences of mutations in vernier zone residues of a humanized anti-human epidermal growth factor receptor murine antibody, 5282008

    • Author(s)
      Makabe, et.al.
    • Journal Title

      J Biol Chem 283

      Pages: 1156-1166

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Grafting of material-binding function into antibodies : Functionalization by peptide grafting2008

    • Author(s)
      Hattori T, et.al.
    • Journal Title

      Biochem Biophys Res Commun 365

      Pages: 751-757

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] critical contribution of VH-VL interaction to reshaping of en antibody2008

    • Author(s)
      Nakanishi T, et.al.
    • Journal Title

      Protein Sci 17

      Pages: 261-270

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical contribution of aromatic rings to specific recognition of polyether rings2008

    • Author(s)
      Tsumoto K, et.al.
    • Journal Title

      J Biol Chem 283

      Pages: 12259-12266

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A helical string of alternately connected three-helix bundles for the cell wall-associated adhesion protein Ebh from Staphylococcus aureus2008

    • Author(s)
      Tanaka Y., et.al.
    • Journal Title

      Structure 16

      Pages: 488-496

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thermodynamic analysis reveals that, GTP binding affects the interaction between the alpha-and gamma-subunits of translation initiation factor 22008

    • Author(s)
      Nakakido, et.al.
    • Journal Title

      Biochem Biophys Res Commun 371

      Pages: 596-599

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of an amyloidogenic sequence attached to yellow fluorescent protein2008

    • Author(s)
      Hamada D, et.al.
    • Journal Title

      Proteins Struct. Funct. Bioinfor 72

      Pages: 811-821

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression, Purification, Crystallization, and Primary Diffraction Analysis of CapF, a Capsular Polysaccharide Synthesis Enzyme from Staphylococcus aureus2008

    • Author(s)
      Miyafusa, et.al.
    • Journal Title

      Acta Crystallogr. F 64

      Pages: 512-515

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] How Protein Recognizes Ladder-like Polycyclic Ethers : Interactions between Ciguatoxin (CTX3C) Fragments and Its specific antibody 10C92008

    • Author(s)
      Ui, et.al.
    • Journal Title

      J. Biol. Chem 283

      Pages: 19440-19447

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electron microscopy and computational studies of Ebh, a giant cell-wall-associated protein from Staphylococcus aureus2008

    • Author(s)
      Sakamoto, et.al.
    • Journal Title

      Biochem Biophys Res Commun 376

      Pages: 261-266

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure-based analysis reveals hydration changes induced by arginine hydrochloride2008

    • Author(s)
      Nakakido, et.al.
    • Journal Title

      Biophys. Chem 137

      Pages: 105-109

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural basis for multimeric heme complexation through a specific protein-heme interaction : the case of the third NEAT domain of IsdH from Staphylococcus aureus2008

    • Author(s)
      Watanabe, et.al.
    • Journal Title

      J. Biol. Chem 283

      Pages: 28649-59

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Staphylococcus aureus giant protein Ebh is involved in tolerance to transient hyperosmotic pressure2008

    • Author(s)
      Kuroda M, et.al.
    • Journal Title

      Biochem. Biophys. Res. Commun 374

      Pages: 237-41

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective expansion of genetically modified T cells using an antibody/interleukin-2 receptor chimera2008

    • Author(s)
      Sogo, et.al.
    • Journal Title

      J. Immunol. Methods 337

      Pages: 16-23

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thermodynamic consequences of mutations in vernier zone residues of a humanized anti-human epidermal growth factor receptor murine antibody, 528.2008

    • Author(s)
      Makabe, et. al.
    • Journal Title

      J Biol Chem. 283

      Pages: 1156-1166

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Grafting of material-binding function into antibodies Functionalization by peptide grafting.2008

    • Author(s)
      Hattori, et. al.
    • Journal Title

      Biochem Biophys Res Commun 365

      Pages: 751-757

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical contribution of VH-VL interaction to reshaping of an antibody: the case of humanization of anti-lysozyme antibody, HyHEL-10.2008

    • Author(s)
      Nakanishi, et. al.
    • Journal Title

      Protein Sci. 17

      Pages: 261-270

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical contribution of aromatic rings to specific recognition of polyether rings: The case of ciguatoxin CTX3C-ABC and its specific antibody 1C49.2008

    • Author(s)
      Tsumoto, et. al.
    • Journal Title

      J Biol Chem. (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A helical string of alternately connected three-helix bundles for the cell wall-associated adhesion protein Ebh from Staphylococcus aureus2008

    • Author(s)
      Tanaka, et. al.
    • Journal Title

      Structure 16

      Pages: 488-496

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thermodynamic analysis reveals that GTP binding affects the interaction between the alpha- and gamma-subunits of translation initiation factor 2.2008

    • Author(s)
      Nakakido, et. al.
    • Journal Title

      Biochem Biophys Res Commun. (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of an amyloidogenic sequence attached to yellow fluorescent protein.2008

    • Author(s)
      Hamada, et. al.
    • Journal Title

      Proteins Struct. Funct. Bioinfor. (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression, Purification, Crystallization, and Primary Diffraction Analysis of CapF, a Capsulaz Polysaccharide Synthesis Enzyme from Staphylococcus aureus2008

    • Author(s)
      Miyafusa, et. al.
    • Journal Title

      Acta Crystallogr. F (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] How Protein Recognizes Ladder-like Polycyclic Ethers: Interactions between Ciguatoxin (CTX3C) Fragments and Its specific antibody 10C9.2008

    • Author(s)
      Ui, et. al.
    • Journal Title

      J. Biol. Chem. (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] クロマトグラフィーにおける溶媒制御2008

    • Author(s)
      Arakawa, et. al.
    • Journal Title

      生化学 80

      Pages: 45-51

    • Related Report
      2007 Annual Research Report
  • [Journal Article] アミノ酸を利用したクロマトグラフィー2008

    • Author(s)
      工藤、津本
    • Journal Title

      月刊バイオテクノロジー (印刷中)

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Effects of acid exposure on the conformation, stability, and aggregation of monoclonal antibodies.2007

    • Author(s)
      Ejima, et. al.
    • Journal Title

      Proteins: Structure, Function, and Bioinformatics 66

      Pages: 954-962

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural consequences of mutations in interfacial Tyr residues of a protein antigen-antibody complex: The case of HyHEL-10-HEL.2007

    • Author(s)
      Shiroishi, et. al.
    • Journal Title

      J.Biol. Chem. 282

      Pages: 6783-6791

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Human Antibody Fragment with High Affinity for Biodegradable Polymer Film.2007

    • Author(s)
      Watanabe, et. al.
    • Journal Title

      Bioconjugate Chem. 18

      Pages: 645-651

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improved performance of column chromatography by arginine: Dye-affinity chromatography.2007

    • Author(s)
      Arakawa, et. al.
    • Journal Title

      Protein Expr. Purif. 52

      Pages: 410-414

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Arginine improves protein elution in hydrophobic interaction chromatography. The cases of human interleukin-6 and activin-A.2007

    • Author(s)
      Tsumoto, et. al.
    • Journal Title

      J.Chromatogr. A 1154

      Pages: 81-86

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Circular dichroism spectra demonstrate formation of the thrombin-binding DNA aptamer G-quadruplex under stabilizing-cation-deficient conditions.2007

    • Author(s)
      Nagatoishi, et. al.
    • Journal Title

      Biochem. Biophys. Res. Comm. 352

      Pages: 812-817

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The N-terminal dormain of elastin-binding protein of Staphylococcus aureus changes its secondary structure in a membrane-mimetic environment.2007

    • Author(s)
      Nagatoishi, et. al.
    • Journal Title

      J.Biochem. 142

      Pages: 131-134

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural and Mutational analyses of Drp35 from Staphylococcus aureus: a possible mechanism for its lactonase activity.2007

    • Author(s)
      Tanaka, et. al.
    • Journal Title

      J. Biol. Chem. 282

      Pages: 5770-5780

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of protein interactions by arginine: A proposed mechanism of arginine effects.2007

    • Author(s)
      Arakawa, et. al.
    • Journal Title

      Biophys Chem. 127

      Pages: 1-8

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular properties of two proteins homologous to PduO-type ATP:cob(I)alamin adenosyltransferase from Sulfolobus tokodaii.2007

    • Author(s)
      Tanaka, et. al.
    • Journal Title

      Proteins: Structure, Function, and Bioinformatics 68

      Pages: 446-457

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effects of arginine on protein binding and elution in hydrophobic interaction and ion-exchange chromatography.2007

    • Author(s)
      Watanabe, et. al.
    • Journal Title

      Protein Expr. Purif. 54

      Pages: 110-116

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of salts on protein-surface interactions: applications for column chromatography.2007

    • Author(s)
      Tsumoto, et. al.
    • Journal Title

      J Pharmaceut. Sci. 96

      Pages: 1677-1690

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induced binding of proteins by ammonium sulfate in affinity and ion-exchange column chromatography.2007

    • Author(s)
      Arakawa, et. al.
    • Journal Title

      J. Biochem. Biophys. Methods 70

      Pages: 493-498

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystal structure analysis reveals a novel forkhead-associated(FHA) domain of ESAT-6 secretion system C (EssC) protein in Staphylococcus aureus.2007

    • Author(s)
      Tanaka, et. al.
    • Journal Title

      Proteins: Structure, Function, and Bioinformatics 69

      Pages: 659-664

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aggregation Analysis of Therapeutic Proteins, Part 2. Analytical Ultracentrifugation and Dynamic Light Scattering.2007

    • Author(s)
      Arakawa, et. al.
    • Journal Title

      Biotechnol. International 5(4)

      Pages: 36-47

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aggregation Analysis of Therapeutic Proteins, Part 3. Principles and Optimization of Field-Flow Fractionation (FFF).2007

    • Author(s)
      Arakawa, et. al.
    • Journal Title

      Biotechnol. International 5(11)

      Pages: 52-70

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 構造・物性解析に基づいた抗体の環状ポリエーテル系毒素ciguatoxin認識機構の解明2009

    • Author(s)
      宇井美穂子
    • Organizer
      日本化学会第89春季年会
    • Place of Presentation
      日本大学船橋キャンパス
    • Related Report
      2008 Annual Research Report
  • [Presentation] 材料・医療への展開を目指した蛋白質相互作用解析2008

    • Author(s)
      津本
    • Organizer
      日本分析化学会東北支部会
    • Place of Presentation
      東北大学
    • Year and Date
      2008-03-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] IL15受容体α鎖が示す多重特異性に関する速度論解析2008

    • Author(s)
      坂本
    • Organizer
      第10回日本化学会生命化学研究会シンポジウム
    • Place of Presentation
      熊本大学
    • Year and Date
      2008-01-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] 抗体10C9が示すポリエーテル系海洋毒素シガトキシン認識機構2008

    • Author(s)
      宇井
    • Organizer
      第10回日本化学会生命化学研究会シンポジウム
    • Place of Presentation
      熊本大学
    • Year and Date
      2008-01-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] 二本鎖DNA-超好熱菌由来TBP蛋白質間の相互作用が示す熱力学的特性2008

    • Author(s)
      長門石
    • Organizer
      第10回日本化学会生命化学研究会シンポジウム
    • Place of Presentation
      熊本大学
    • Year and Date
      2008-01-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] 「蛋白質相互作用解析:材料・医療への展開」2008

    • Author(s)
      津本
    • Organizer
      第10回日本化学会生命化学研究会シンポジウム
    • Place of Presentation
      熊本大学
    • Year and Date
      2008-01-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] 超好熱菌由来TATA-box結合蛋白質に対するDNAの認識特性2008

    • Author(s)
      長門石曉
    • Organizer
      第8回日本蛋白質科学会年会
    • Place of Presentation
      タワーホール船堀
    • Related Report
      2008 Annual Research Report
  • [Presentation] 抗シガトキシン抗体10C9の分子認識機構2008

    • Author(s)
      宇井美穂子
    • Organizer
      第8回日本蛋白質科学会年会
    • Place of Presentation
      タワーホール船堀
    • Related Report
      2008 Annual Research Report
  • [Presentation] 翻訳開始因子サブユニット間相互作用の熱力学的解析2008

    • Author(s)
      中木戸誠
    • Organizer
      第8回日本蛋白質科学会年会
    • Place of Presentation
      タワーホール船堀
    • Related Report
      2008 Annual Research Report
  • [Presentation] 黄色ブドウ球菌由来Isd蛋白質によるヘム結合能の解析2008

    • Author(s)
      渡邊正人
    • Organizer
      第8回日本蛋白質科学会年会
    • Place of Presentation
      タワーホール船堀
    • Related Report
      2008 Annual Research Report
  • [Presentation] アルギニン存在下での金属キレートアフィニティークロマトグラフィー2008

    • Author(s)
      安部良太
    • Organizer
      第8回日本蛋白質科学会年会
    • Place of Presentation
      タワーホール船堀
    • Related Report
      2008 Annual Research Report
  • [Presentation] ワクチンの創成を目指した黄色ブドウ球菌毒素改変体の分子特性解析2008

    • Author(s)
      谷中冴子
    • Organizer
      第8回日本蛋白質科学会年会
    • Place of Presentation
      タワーホール船堀
    • Related Report
      2008 Annual Research Report
  • [Presentation] ポリエーテル系海洋毒素シガトキシン認識抗体10C9の構造学・熱力学的解析2008

    • Author(s)
      宇井美穂子
    • Organizer
      第55回毒素シンポジウム-山中湖畔シンポジウム-
    • Place of Presentation
      ラフォーレ山中湖
    • Related Report
      2008 Annual Research Report
  • [Presentation] 好熱性蛋白質に対する温度に対応したDNAの相互作用特性2008

    • Author(s)
      長門石曉
    • Organizer
      第3回バイオ関連化学合同シンポジウム
    • Place of Presentation
      東京工業大学
    • Related Report
      2008 Annual Research Report
  • [Presentation] 抗ciguatoxin抗体とポリエーテル環相互作用解析2008

    • Author(s)
      宇井美穂子
    • Organizer
      第3回バイオ関連化学合同シンポジウム2008
    • Place of Presentation
      東京工業大学
    • Related Report
      2008 Annual Research Report
  • [Presentation] 黄色ブドウ球菌由来Isd蛋白質によるヘム結合能の解析2008

    • Author(s)
      渡邊正人
    • Organizer
      第3回バイオ関連化学合同シンポジウム2008
    • Place of Presentation
      東京工業大学
    • Related Report
      2008 Annual Research Report
  • [Presentation] ワクチンの創成を目指した黄色ブドウ球菌毒素改変体の分子特性解析2008

    • Author(s)
      谷中冴子
    • Organizer
      第3回バイオ関連化学合同シンポジウム2008
    • Place of Presentation
      東京工業大学
    • Related Report
      2008 Annual Research Report
  • [Presentation] 超好熱古細菌由来TATA-box結合蛋白質のSELEX解析2008

    • Author(s)
      長門石曉
    • Organizer
      第46回日本生物物理学会年会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2008 Annual Research Report
  • [Presentation] 抗ciguatoxin抗体10C9Fabの抗原認識機構-変異体解析と低分子スクリーン-2008

    • Author(s)
      宇井美穂子
    • Organizer
      第46回日本生物物理学会年会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2008 Annual Research Report
  • [Presentation] IL15とIL15R受容体α鎖の相互作用の精査2008

    • Author(s)
      坂本壮
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2008 Annual Research Report
  • [Presentation] Structure-based analysis reveals hydration changes induced by Areinine hydrochloride2008

    • Author(s)
      Nakakido Makoto
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2008 Annual Research Report
  • [Presentation] Transducer of ErbB2, 1(TOB1)とCNOT7間相互作用の精密解析2008

    • Author(s)
      渡邊正人
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2008 Annual Research Report
  • [Presentation] 黄色ブドウ球菌由来ヘム鉄取り込み蛋白質におけるヘム鉄受け渡し機構の解析2008

    • Author(s)
      安部良太
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2008 Annual Research Report
  • [Presentation] 抗アミロイドβ抗体を用いた生体超分子構造形成制御2008

    • Author(s)
      有里樹理
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2008 Annual Research Report
  • [Presentation] 黄色ブドウ球菌由来莢膜合成蛋白質CapE, CapFの構造・機能解析2008

    • Author(s)
      宮房孝光
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2008 Annual Research Report
  • [Presentation] ワクチンの創成を目指した黄色ブドウ球菌毒素改変体の分子特性解析2008

    • Author(s)
      谷中冴子
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2008 Annual Research Report
  • [Presentation] タンパク質の構造に与えるアルギニンの効果2008

    • Author(s)
      工藤
    • Organizer
      第89回 日本化学会春期年会
    • Place of Presentation
      立教大学
    • Related Report
      2007 Annual Research Report
  • [Presentation] 黄色ブドウ球菌由来膜表面蛋白質EbpSの構造・物性解析2008

    • Author(s)
      中木戸
    • Organizer
      第89回 日本化学会春期年会
    • Place of Presentation
      立教大学
    • Related Report
      2007 Annual Research Report
  • [Presentation] 構造情報を基盤とした黄色ブドウ球菌由来莢膜合成蛋白質CapFの機能解析2008

    • Author(s)
      宮房
    • Organizer
      第89回 日本化学会春期年会
    • Place of Presentation
      立教大学
    • Related Report
      2007 Annual Research Report
  • [Presentation] 黄色ブドウ球菌由来蛋白質によるヘム受け渡し機構の解析2008

    • Author(s)
      安部
    • Organizer
      第89回 日本化学会春期年会
    • Place of Presentation
      立教大学
    • Related Report
      2007 Annual Research Report
  • [Presentation] ワクチンの創成を目指した黄色ブドウ球菌毒素改変体の分子特性解析2008

    • Author(s)
      谷中
    • Organizer
      第89回 日本化学会春期年会
    • Place of Presentation
      立教大学
    • Related Report
      2007 Annual Research Report
  • [Presentation] さらに進化した蛋白質相互作用の熱力学解析2007

    • Author(s)
      津本
    • Organizer
      第45回日本生物物理学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-12-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] Crystal structure and heme binding property of the third NEAT domain of IsdH from Staphylococcus aureus.2007

    • Author(s)
      Tanaka, et. al.
    • Organizer
      The 2nd International Symposium on Diffraction Structure Biology
    • Place of Presentation
      船堀ホール
    • Year and Date
      2007-11-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] 癌免疫療法の現状と今後2007

    • Author(s)
      津本
    • Organizer
      日本癌学会シンポジウム
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-10-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] 不安定な二本鎖DNA条件下における蛋白質・DNA間相互作用の熱力学的解析2007

    • Author(s)
      長門石
    • Organizer
      第22回生体機能関連化学シンポジウム若手フォーラム
    • Place of Presentation
      東北大学
    • Year and Date
      2007-09-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] アルギニンを用いたクロマトグラフィー:抗体を中心に2007

    • Author(s)
      津本
    • Organizer
      第204回液体クロマトグラフィー研究懇談会
    • Place of Presentation
      東京理科大学
    • Year and Date
      2007-06-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] Role of Arginine in Handling Proteins.2007

    • Author(s)
      Tsumoto
    • Organizer
      第1回日本スイスケミカルバイオロジー会議
    • Place of Presentation
      スイスETH(ローザンヌ)
    • Year and Date
      2007-06-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] Thermodynamic analysis of the interaction between a hyperthermophilic TATA-BOX binding protein (TBP) and the promoter DNA at high temperature2007

    • Author(s)
      Nagatoishi, et. al.
    • Organizer
      Current Trends in Microcalorimetry Conference
    • Place of Presentation
      ボストンコルネドホテル
    • Related Report
      2007 Annual Research Report
  • [Presentation] Thermodynamic profiles of the interaction between DNA and DNA-binding protein at high temperature; the case of hyperthermostable TATA-box binding protein and the promoter DNA2007

    • Author(s)
      Nagatoishi, et. al.
    • Organizer
      The 2nd Iternational Workshop on Approaches to Single-Cell Analysis
    • Place of Presentation
      早稲田大学
    • Related Report
      2007 Annual Research Report
  • [Presentation] X線結晶構造解析による抗シガトキシン抗体の分子認識機構の解明2007

    • Author(s)
      宇井
    • Organizer
      第10回バイオテクノロジー部会シンポジウム
    • Place of Presentation
      早稲田大学
    • Related Report
      2007 Annual Research Report
  • [Presentation] 超好熱古細菌由来TATA-box結合蛋白質のDNA結合における熱力学的特性2007

    • Author(s)
      長門石
    • Organizer
      第10回バイオテクノロジー部会シンポジウム
    • Place of Presentation
      早稲田大学
    • Related Report
      2007 Annual Research Report
  • [Presentation] 抗シガトキシン抗体の分子認識機構:結晶構造と熱力学2007

    • Author(s)
      宇井
    • Organizer
      第22回生体機能関連化学シンポジウム
    • Place of Presentation
      東北大学
    • Related Report
      2007 Annual Research Report
  • [Presentation] 黄色ブドウ球菌由来莢膜合成蛋白質CapFのX線結晶構造解析2007

    • Author(s)
      宮房
    • Organizer
      第22回生体機能関連化学シンポジウム
    • Place of Presentation
      東北大学
    • Related Report
      2007 Annual Research Report
  • [Presentation] アルギニンの示す蛋白質凝集抑制効果:作用機序と応用2007

    • Author(s)
      田中
    • Organizer
      第22回生体機能関連化学シンポジウム
    • Place of Presentation
      東北大学
    • Related Report
      2007 Annual Research Report
  • [Presentation] 黄色ブドウ球菌由来接着関連蛋白質EbpSの構造・物性解析2007

    • Author(s)
      中木戸
    • Organizer
      第22回生体機能関連化学シンポジウム
    • Place of Presentation
      東北大学
    • Related Report
      2007 Annual Research Report
  • [Presentation] IL15受容体α鎖が示す多重特異性に関する相互作用解析2007

    • Author(s)
      坂本
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 相互作用解析を主としたTransducer of erbB2-1(TOB1)の機能解析2007

    • Author(s)
      渡邊
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 黄色ブドウ球菌由来莢膜合成蛋白質の構造機能解析2007

    • Author(s)
      宮房
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 抗シガトキシン抗体10C9 Fabの構造学的・熱力学的解析2007

    • Author(s)
      宇井
    • Organizer
      日本生物物理学会第45回年会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 高温領域における超好熱古細菌由来TATA-box binding proteinの二本鎖DNA認識機構2007

    • Author(s)
      長門石
    • Organizer
      日本生物物理学会第45回年会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 翻訳開始因子サブユニットの会合の熱力学的解析2007

    • Author(s)
      中木戸
    • Organizer
      日本生物物理学会第45回年会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2007 Annual Research Report
  • [Book] たんぱく質結晶の新展開2008

    • Author(s)
      津本、田中
    • Publisher
      シーエムシー出版(印刷中)
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.park.itc.u?tokyo/phys?biochem/

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2018-03-28  

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