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Mechanisms underlying sexual dimorphism of the brain

Research Project

Project/Area Number 19040025
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionToyo University

Principal Investigator

OHTANI-KANEKO Ritsuko  Toyo University, 生命科学部, 教授 (00161183)

Co-Investigator(Kenkyū-buntansha) OGAWA Sonoko  筑波大学, 人間総合科学研究科, 教授 (50396610)
KATO Tomohiro  聖マリアンナ医大, 生化学, 教授 (80233807)
TSUKAHARA Shinji  環境研, 環境リスクセンター, 研究員 (90318824)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥6,900,000 (Direct Cost: ¥6,900,000)
Fiscal Year 2008: ¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2007: ¥3,400,000 (Direct Cost: ¥3,400,000)
Keywords雌雄差 / 視床下部 / プロテオミクス解析 / 脳の性分化 / ラット / 臨界期 / 蛋白質 / 性的二型核 / mRNA発現 / 時期・部位特異性 / 神経科学 / 発生・分化 / 脳・神経 / プロテオミクス / 女性ホルモン / 性分化
Research Abstract

生殖行動や生殖周期を調節する脳部位は、オス・メスで異なる神経回路網を発生中の特定の時期に形成する。本研究ではラットの脳を用いて、雌雄で異なる神経回路網がどのようなメカニズムで形成されるのかを、蛋白質のレベルで解明しようとした。その結果、オスとメスで違いがある脳部位で、雌雄差が作られている時期にだけ雌雄差を生じる蛋白質を複数個見つけることができた。この研究によって、脳の雌雄差形成メカニズムを解く手懸りが得られた。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (41 results)

All 2009 2008 2007 Other

All Journal Article (27 results) (of which Peer Reviewed: 27 results) Presentation (14 results)

  • [Journal Article] Sex differences and roles of sex steroids in apoptosis of sexually dimorphic nuclei of preoptic area in postnatal rats2009

    • Author(s)
      Tsukahara S
    • Journal Title

      Journal of Neuroendocrinology 21

      Pages: 370-376

    • Related Report
      2008 Annual Research Report 2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] regulation of prolactin cell development in the fetal pituitary gland of the mouse2009

    • Author(s)
      Ogasawara K, Nogami H, Mumeko C. Tsuda, J-A, Gustafsson K, Korach S, Ogawa S, Harigaya T, and Hisano S
    • Journal Title

      Endocrinology 150

      Pages: 1061-8

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Korach S, Ogawa S, Harigaya T, and Hisano S. Hormonal regulati on of prolactin cell development in the fetal pituitary gland of the mouse2009

    • Author(s)
      Ogasawara K., et.al.
    • Journal Title

      Endocrinology 150

      Pages: 1061-1068

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of post-translational modification of neuronal plasticity-related proteins in hyperalgesia revealed by a proteomic analysis2008

    • Author(s)
      Fujisawa H, Ohtani-Kaneko R, Naiki M, Okada T, Masuko K, Yudoh K, Suematsu N, Okamoto K, Nishioka K, Kato T
    • Journal Title

      Proteomics 8

      Pages: 1706-19

    • NAID

      130007000219

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Estrogen and environmental estrogenic chemicals exert developmental effects on rat hypothalamic neurons and glias2008

    • Author(s)
      Yokosuka M, Ohtani-Kaneko R, Yamashita K, Muraoka D, Kuroda Y, Watanabe C
    • Journal Title

      Toxicolgy In Vitro 22

      Pages: 1-9

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Estrogen modulates Bcl-2 family protein expression in the sexually dimorphic nucleus of the preoptic area of postnatal rats2008

    • Author(s)
      Tsukahara S, Hojo R, Kuroda Y, & Fujimaki H
    • Journal Title

      Neuroscience Letters 432

      Pages: 58-63

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppressive effects of cadmium on neurons and affected protein s in cultured developing cortical cells2008

    • Author(s)
      Ohtani-Kaneko R., et.al.
    • Journal Title

      Toxicology 253

      Pages: 110-116

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of unoprostone on phosphorylated extracellular signal-regulated kinase expression in endothelin-l-induced retinal an d optic nerve damage2008

    • Author(s)
      Munemasa Y., et.al.
    • Journal Title

      Vis Neurosci 25

      Pages: 197-208

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of post-translational modification of neuronal pla sticity-related proteins in hyperalgesia revealed by a proteom is analysis2008

    • Author(s)
      Fui isawa H., et.al.
    • Journal Title

      Proteomics 8

      Pages: 1706-1719

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estrogen and environmental estrogenic chemicals exert developm ental effects on rat hypothalamic neurons and glias2008

    • Author(s)
      Yokosuka M., et.al.
    • Journal Title

      Toxicolgy In Vitro 22

      Pages: 1-9

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estrogen receptors in the medial amygdala inhibit the expressi on of male prosocial behavior2008

    • Author(s)
      Cushing B.S., et.al.
    • Journal Title

      J. Neurosci 28

      Pages: 10399-10403

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estrogen receptors alpha and beta mediate different aspects of the facilitatory effects of female cues on male risk taking2008

    • Author(s)
      Kavaliers M., et.al.
    • Journal Title

      Psychoneuroendocrinology 33

      Pages: 634-642

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic surveillance of retinal autoantigens in endogenous u veitis : implication of esterase D and brain type creatine kina se as novel autoantigens2008

    • Author(s)
      Okunuki Y., et.al.
    • Journal Title

      Molecular Vision 14

      Pages: 1094-1104

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estrogen modulates Bcl-2 family protein expression in the sex ually dimorphic nucleus of the preoptic area of postnatal rats2008

    • Author(s)
      Tsukahara S., et.al.
    • Journal Title

      Neuroscience Letters 432

      Pages: 58-63

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estrogen and environmental estrogenic chemicals exert developmental effects on rat hypothalamic neurons and glias.2008

    • Author(s)
      Yokosuka M., et. al.
    • Journal Title

      Toxicol In Vitro. 22

      Pages: 1-9

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of post-translational modification of neuronal plasticity-related proteins in hyperalgesia revealed by a proteomic analysis.2008

    • Author(s)
      Fujisawa, et. al.
    • Journal Title

      Proteomics 8

      Pages: 1706-1719

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estrogen modulates Bcl-2 family protein expression in the sexually dimorphic nucleus of the preoptic area of postnatal rats.2008

    • Author(s)
      Tsukahara S
    • Journal Title

      Neuroscience Letters 432

      Pages: 58-63

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuroprotective effect of 17β-estradiol against NMDA-induced retinal neurotoxicity via p-ERK induction. Journal of Neuroscience Research2007

    • Author(s)
      Hayashi Y, Kitaoka Y, Munemasa Y, Ohtani-Kaneko R, Kikusui T, Uematsu A, Takeda H, Hirata K, Mori Y, Ueno S
    • Journal Title

      85

      Pages: 386-494

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Silencing of estrogen receptor a in the ventromedial nucleus of hypothalamus leads to metabolic syndrome2007

    • Author(s)
      Musatov, S., Chen, W., Pfaff, D.W., Mobbs, C.V., Yang, X.-J., Clegg, D.J., Kaplitt, M.G., and Ogawa, S
    • Journal Title

      Proc Natl Acad Sci, U.S.A 104

      Pages: 2501-2507

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuroprotective effect of 17beta-estradiol against N-methyl-D-aspartate-induced retinal neurotoxicity via p-ERK induction.2007

    • Author(s)
      Hayashi Y., et. al.
    • Journal Title

      J. Neurosci Res. 85

      Pages: 386-94

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dorsal root ganglion regulates the transient ERK activation in the dorsal horn of the spinal cord during development.2007

    • Author(s)
      Kato. T., et. al.
    • Journal Title

      Neurosci Res. 58

      Pages: 402-5

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Silencing of estrogen receptor a in the ventromedial nucleus of hypothalamus leads to metabolic syndrome.2007

    • Author(s)
      Musatov, S., et. al.
    • Journal Title

      Proc Natl Acad Sci, U.S.A 104

      Pages: 2501-2507

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Social and sexual incentive properties of estrogen receptor alpha, estrogen receptor beta, or oxytocin knockout mice.2007

    • Author(s)
      Agmo, A., et. al.
    • Journal Title

      Genes Brain Behav. 7

      Pages: 70-77

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of cholecystokinin neurons in the dorsal pallium of the telencephalon is indispensable for the acquisition of chick imprinting behavior.2007

    • Author(s)
      Maekawa F., et. al.
    • Journal Title

      Journal of Neurochemistry 102

      Pages: 1645-1657

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative analysis of interindividual variations in the seminal plasma proteome of fertile men with identification of potential markers for azoospermia in infertile patien.2007

    • Author(s)
      Yamakawa K., et. al.
    • Journal Title

      J. Andrology 28

      Pages: 858-865

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estrogen receptors a and b mediate different aspects of the facilitatory effects of female cues on male risk taking.

    • Author(s)
      Kavaliers, M., et. al.
    • Journal Title

      Psychoneuroendocrinology (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immune cell cartilage interactions in arthritis.

    • Author(s)
      Xiang Y, Kato T.
    • Journal Title

      Curr. Opn. Orthopaedics (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 視床下部性的二型核における周生期での発現蛋白質の雌雄差2009

    • Author(s)
      大谷一金子律子
    • Organizer
      第114回解剖学会総会シンポジウム
    • Place of Presentation
      岡山
    • Year and Date
      2009-03-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] ティラピア脳のGnRHニューロンに見られた雌雄差2008

    • Author(s)
      倉持麻未, 他
    • Organizer
      日本解剖学会関東支部第96回学術集会
    • Place of Presentation
      筑波
    • Year and Date
      2008-11-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] マウス海馬神経培養細胞株(HT-22)に対するNMDA及びGlutmateの神経毒性2008

    • Author(s)
      荻野友佑, 他
    • Organizer
      日本解剖学会関東支部第96回学術集会
    • Place of Presentation
      筑波
    • Year and Date
      2008-11-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] ラットの網膜神経節細胞死における14-3-3zetaタンパク質の発現2008

    • Author(s)
      鈴木瑞穂, 他
    • Organizer
      日本解剖学会関東支部第96回学術集会
    • Place of Presentation
      筑波
    • Year and Date
      2008-11-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] Proteomics analysis of changesn Protein Profiles in rat sexual dimorphic nuclei during the critical period2008

    • Author(s)
      T. Iwakura, et.al.
    • Organizer
      COE 5th International Symposium on Bioscien ce and Nanotechnologv
    • Place of Presentation
      東京
    • Year and Date
      2008-11-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] Measurement of effects of physiologically active substances on neurons-Establishment of the primary culture system for medaka adult neurons2008

    • Author(s)
      J. Tanaka, et.al.
    • Organizer
      COE 5th International Symposium on Bioscien ce and Nanotechnology
    • Place of Presentation
      東京
    • Year and Date
      2008-11-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] Proteomics analysis of changes in protein profiles in rat AVPV and SDN-POA during the critical period2008

    • Author(s)
      T. Iwakura, et.al.
    • Organizer
      International Symposium on sexual different iation
    • Place of Presentation
      福岡
    • Year and Date
      2008-09-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] 発達期の性的二型核におけるアポトーシスに関する研究2008

    • Author(s)
      塚原伸治
    • Organizer
      第35回日本神経内分泌学会・第23回日本下垂体研究会合同学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-08-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] ラット性的二型核での臨界期における発現蛋白質の雌雄差-プロテオミクスを用いた解析-2008

    • Author(s)
      岩倉 聖, 他
    • Organizer
      日本動物学会関東支部会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] Proteomics analysis of changes in protein profiles in rat AVPV and SDN-POA during the critical period2008

    • Author(s)
      T. Iwakura, T. Kato, S. Tsukahara, M. Tsuda, K. Watai, T. Uchimura, Y. Kuroda, T. Shiga, S. Ogawa, R. Ohtani-Kaneko
    • Organizer
      International Symposium on sexual differentiation
    • Place of Presentation
      福岡
    • Related Report
      2008 Final Research Report
  • [Presentation] Proteomics analysis of changes n protein profiles in rat sexual dimorphic nuclei during the critical period2008

    • Author(s)
      T. Iwakura, T. Kato, S. Tsukahara, T. Shiga, S. Ogawa, R. Ohtani-Kaneko
    • Organizer
      COE 5th International Symposium on Bioscience and Nanotechnology
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] Sex difference in apoptosis and role of estrogen in the sexually dimorphic nucleus of the preoptic area(SDN-POA)in postnatal rats2008

    • Author(s)
      Tsukahara S
    • Organizer
      US/Japan Neurosteroid Symposium 2008
    • Place of Presentation
      Gifu
    • Related Report
      2008 Final Research Report
  • [Presentation] エストロゲン受容体ノックアウトマウスおよびアロマターゼノックアウトマウスにおける分界条床核主核の形態学的性差の消失2007

    • Author(s)
      塚原伸治、渡井浩太、黒田淑子、小澤貴明、福士碧沙、肖凱、津田夢芽子、戸田勝巳、藤巻秀和、小川園子
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] ラット性的二型核での臨界期における蛋白質発現の雌雄差-プロテオミクス法を用いた解析-2007

    • Author(s)
      岩倉聖、加藤智啓、塚原伸治、津田夢芽子、渡井浩太、内村太一、黒田淑子、小川園子、志賀隆、大谷ー金子律子
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2018-03-28  

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