Malaria parasite pattern recognition mechanism of Anopheline mosquito
| Project/Area Number |
19041007
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Obihiro University of Agriculture and Veterinary Medicine |
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Principal Investigator |
FUKUMOTO Shinya Obihiro University of Agriculture and Veterinary Medicine, 原虫病研究センター, 講師 (50376422)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥8,500,000 (Direct Cost: ¥8,500,000)
Fiscal Year 2008: ¥4,300,000 (Direct Cost: ¥4,300,000)
Fiscal Year 2007: ¥4,200,000 (Direct Cost: ¥4,200,000)
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| Keywords | マラリア / ハマダラカ / Furrowed / ショウジョウバエ |
|---|
| Research Abstract |
ショウジョウバエを蚊の代替生物として用いることにより、蚊の体内における新規のマラリア原虫認識分子Furrowed の同定を行い、ハマダラカ中腸におけるパターン認識分子としてマラリア原虫排除因子として機能していることを明らかにした。また、吸血時に、腸内細菌数の一過性の急激な増加が起こることが明らかになり、これはFurrowed の発現上昇パターンと高い相関性を示し、ハマダラカにおけるマラリア原虫の排除には腸内細菌が関与している可能性が示唆された。
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Report
(3 results)
Research Products
(39 results)
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[Journal Article] Rapid recruitment of innate immunity regulates variation of intracellular pathogen resistance2009
Author(s)
Okado, K., Shinzawa, N., Aonuma, H., Nelson, B., Fukumoto, S., Fujisaki, K., Kawazu, S., Kanuka, H.
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Journal Title
Drosophila 379
Pages: 6-10
Related Report
Peer Reviewed
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[Journal Article] Rapid identification of virus-carrying mosquitoes using reverse transcription-loop-mediated isothermal amplification2009
Author(s)
Perera, N., Aonuma, H., Yoshimura, A., Teramoto, T., Iseki, H., Nelson, B., Igarashi, I., Yagi, T., Fukumoto, S., Kanuka, H.
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Journal Title
J Virol Methods. 156
Pages: 32-6
Related Report
Peer Reviewed
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[Journal Article] Loop-mediated isothermal amplification applied to filarial parasites detection in the mosquito vectors: Dirofilaria immitis as a study model.2009
Author(s)
Aonuma, H., Yoshimura, A., Perera, N., Shinzawa, N., Bando, H., Oshiro, S., Nelson, B., Fukumoto, S., Kanuka, H.
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Journal Title
Parasit Vectors 2
Pages: 15-15
Related Report
Peer Reviewed
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[Journal Article] Rapid identification of viruscarrying mosquitoes using reverse transcription-loopmediated isothermal amplification2009
Author(s)
Perera, N. Aonuma, H. Yoshimura, A. Teramoto, T. Iseki, H. Nelson, B. Igarashi, I. Yagi, T. Fukumoto, S. Kanuka, H.
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Journal Title
J Virol Methods 156
Pages: 32-36
Related Report
Peer Reviewed
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[Journal Article] Rapid Identification of Plasmodium-carrying mosquitoes using loop-mediated isothermal amplification2008
Author(s)
Aonuma, H., Suzuki, M., Iseki, H., Perera, N., Nelson, B., Igarashi, I., Yagi, T., Kanuka, H., Fukumoto, S.
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Journal Title
Biochem Biophys Res Commun. 376
Pages: 671-6
Related Report
Peer Reviewed
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