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Study of lipid metabolism network between Toxoplasma and hosts

Research Project

Project/Area Number 19041008
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionObihiro University of Agriculture and Veterinary Medicine

Principal Investigator

NISHIKAWA Yoshifumi  Obihiro University of Agriculture and Veterinary Medicine, 原虫病研究センター, 准教授 (90431395)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,500,000 (Direct Cost: ¥4,500,000)
Fiscal Year 2008: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,600,000)
Keywordsトキソプラズマ / 脂質代謝 / コレステロール / アポトーシス / プロテオーム / 抗原虫薬 / カルシウム
Research Abstract

本研究計画は、人獣共通感染症を引き起こすトキソプラズマにおける、原虫.宿主間での脂質代謝ネットワークの解明を目指したものである。本研究で、トキソプラズマは利己的に宿主脂質代謝を制御し、増殖ステージに応じてコレステロール資源を使い分けていることが明らかとなった。さらに、非感染細胞での過剰な脂質の蓄積は宿主細胞死を誘導することを見出した。本結果は、トキソプラズマの生存戦略の一つとして宿主脂質代謝の制御が関与していることを示している。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (44 results)

All 2009 2008 2007 Other

All Journal Article (15 results) (of which Peer Reviewed: 12 results) Presentation (23 results) Book (1 results) Remarks (3 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Prevalence of Neospora caninum and Toxoplasma gondii Antibodies in Northern Egypt2009

    • Author(s)
      Hany Ibrahim
    • Journal Title

      Am J Trop Med Hyg 80

      Pages: 273-277

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dissemination of extracellular and intracellular Toxoplasma gondii tachyzoites in the blood flow.2008

    • Author(s)
      Unno A, Suzuki K, Xuan X, Nishikawa Y, Kitoh K, Takashima Y.
    • Journal Title

      Parasitol Int. 57

      Pages: 515-518

    • NAID

      10025329661

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Programmed Cell Death 5 from Toxoplasma gondii: a secreted molecule that exertsa pro-apoptotic effect on host cells.2008

    • Author(s)
      Bannai H, Nishikawa Y, Matsuo T, Kawase O, Watanabe J, Sugimoto C, Xuan X.
    • Journal Title

      Mol Biochem Parasitol. 159

      Pages: 112-120

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detection of the initial site of Toxoplasma gondii reactivation in brain tissue.2008

    • Author(s)
      Takashima Y, Suzuki K, Xuan X, Nishikawa Y, Unno A, Kitoh K.
    • Journal Title

      Int J Parasitol. 38

      Pages: 601-607

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Construction of Toxoplasma gondii bradyzoite expressing the green fluorescent protein.2008

    • Author(s)
      Nishikawa Y, Zhang H, Ibrahim MH, Ui F, Ogiso A, Xuan X.
    • Journal Title

      Parasitol. Int. 57

      Pages: 219-222

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dissemination of extracellular and intracellular Toxoplasma gondii tachyzoites in the blood flow2008

    • Author(s)
      Akihiro Unno
    • Journal Title

      Parasitol Int. 57

      Pages: 515-518

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of the initial site of Toxoplasma gondii reactivation in brain tissue2008

    • Author(s)
      Yasuhiro Takashima
    • Journal Title

      Int J Parasitol 38

      Pages: 601-607

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Construction of Toxoplasma gondii bradyzoite expressing the green fluorescent protein2008

    • Author(s)
      Yoshifumi Nishikawa
    • Journal Title

      Parasitol. Int. 57

      Pages: 219-222

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 総説「トキソプラズマの脂質代謝ネットワーク」2007

    • Author(s)
      西川義文
    • Journal Title

      獣医寄生虫学会誌 6巻

      Pages: 21-24

    • Related Report
      2008 Final Research Report
  • [Journal Article] Proteomic analysis of calcium-dependent secretion in Toxoplasma gondii.2007

    • Author(s)
      Kawase O, Nishikawa Y, Bannai H, Zhang H, Zhang G, Jin S, Lee EG, Xuan X.
    • Journal Title

      Proteomics 7

      Pages: 3718-3725

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Toxoplasma gondii infection induces apoptosis in non-infected macrophages: role of nitric oxide and other soluble factors.2007

    • Author(s)
      Nishikawa Y, Kawase O, Vielemeyer O, Suzuki H, Joiner K.A Xuan X, Nagasawa H.
    • Journal Title

      Parasite Immunol. 29

      Pages: 375-385

    • Related Report
      2008 Final Research Report
  • [Journal Article] 総説「トキソプラズマの脂質代謝ネットワーク」2007

    • Author(s)
      西川義文
    • Journal Title

      獣医寄生虫学会誌 6

      Pages: 21-24

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Proteomic analysis of calcium-dependent secretion in Toxoplasma gondii2007

    • Author(s)
      Osamu Kawase
    • Journal Title

      Proteomics 7

      Pages: 3718-3725

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Toxoplasma gondii infection induces apoptosis in non-infected macrophages: role of nitric oxide and other soluble factors2007

    • Author(s)
      Yoshifumi Nishikawa
    • Journal Title

      Parasite Immunol. 29

      Pages: 375-385

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Programmed Cell Death 5 from Toxoplasma gondii: A secreted molecule that exerts a pro-apoptotic effect on host cells

    • Author(s)
      Hiroshi Bannai
    • Journal Title

      Mol. Biochem. Paarasitol. (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] トキソプラズマにおける新規トロンボスポンジン関連タンパク質の解析2009

    • Author(s)
      西川義文
    • Organizer
      第78回日本寄生虫学会
    • Place of Presentation
      法政大学市ヶ谷キャンパス外濠校舎
    • Year and Date
      2009-03-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] トキソプラズマ由来Cyclophilin-18が誘導する一酸化窒素はCCR5依存的にブラディゾイト変換を誘導する2009

    • Author(s)
      バニーイブラヒム
    • Organizer
      第78回日本寄生虫学会
    • Place of Presentation
      法政大学市ヶ谷キャンパス外濠校舎
    • Year and Date
      2009-03-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] トキソプラズマにおける新規トロンボスポンジン関連タンパク質の解析2009

    • Author(s)
      西川 義文、川瀬 摂、坂内 天、松尾 智英、玄 学南
    • Organizer
      第78回日本寄生虫学会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] トキソプラズマ由来Cyclophilin-18 が誘導する一酸化窒素はCCR5依存的にブラディゾイト変換を誘導する2009

    • Author(s)
      イブラヒム ハニー、坂内 天、玄 学南、西川 義文
    • Organizer
      第78回日本寄生虫学会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] Manipulation of host apoptsis during infection with Toxoplasma gondii : Molecular mechanisms and role in pathogenesis2008

    • Author(s)
      西川義文
    • Organizer
      XVIIth International Congress for Tropical Medicine and Malaria
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2008-10-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] Enhancement of host cell apoptosis by a secreted molecule from Toxoplasma gondii, Programmed Cell Death 52008

    • Author(s)
      坂内天
    • Organizer
      16th Japanese-German Cooperative Symposium on Protozoan Diseases
    • Place of Presentation
      Gottingen, Germany
    • Year and Date
      2008-09-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] トキソプラズマの増殖における宿主細胞内コレステロールの役割2008

    • Author(s)
      西川義文
    • Organizer
      第77回日本寄生虫学会
    • Place of Presentation
      長崎ブリックホール
    • Year and Date
      2008-04-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] Toxoplasma gondii脳内再活性化原発部位の同定2008

    • Author(s)
      高島康弘
    • Organizer
      第77回日本寄隼虫学会
    • Place of Presentation
      長崎ブリックホール
    • Year and Date
      2008-04-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] トキソプラズマ原虫におけるカルシウム依存的分泌タンパク質の網羅的同定および動態解析2008

    • Author(s)
      西川義文
    • Organizer
      第144回日本獣医学会学術集会
    • Place of Presentation
      麻布大学
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] トキソプラズマ原虫におけるカルシウム依存的分泌タンパク質の網羅的同定および動態解析2008

    • Author(s)
      川瀬摂、西川義文、神繁樹、李應具、玄学南
    • Organizer
      第145回日本獣医学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] トキソプラズマの増殖における宿主細胞内コレステロールの役割2008

    • Author(s)
      西川義文、玄学南
    • Organizer
      第77回日本寄生虫学会
    • Place of Presentation
      長崎
    • Related Report
      2008 Final Research Report
  • [Presentation] Toxoplasma gondii脳内再活性化原発部位の同定2008

    • Author(s)
      高島康弘、鈴木和彦、玄学南,西川義文、海野明広,鬼頭克也
    • Organizer
      第77回日本寄生虫学会
    • Place of Presentation
      長崎
    • Related Report
      2008 Final Research Report
  • [Presentation] Enhancement of host-cell apoptosis by a secreted molecule from Toxoplasma gondii Programmed Cell Dearh 5.2008

    • Author(s)
      Yoshifumi Nishikawa, Hiroshi Bannai, Kyoko Yamada, Xuenan Xuan.
    • Organizer
      第7回あわじしま感染症・免疫フォーラム
    • Place of Presentation
      淡路島
    • Related Report
      2008 Final Research Report
  • [Presentation] Enhancement of host cell apoptosis by a secreted molecule from Toxoplasma gondii, Programmed Cell Death 5.2008

    • Author(s)
      Bannnai H, Nishikawa Y, Matsuo T, Kawase O, Watanabe J, Sugimoto C, Xuan X.
    • Organizer
      16th Japanese-German Cooperative Symposium on Protozoan Diseases
    • Place of Presentation
      ドイツ
    • Related Report
      2008 Final Research Report
  • [Presentation] Manipulation of host apoptsis during infection with Toxoplasma gondii: Molecular mechanisms and role in pathogenesis(招待講演)2008

    • Author(s)
      Nishikawa Y, Bannnai H, Xuan X.
    • Organizer
      XVIIth International Congress for Tropical Medicine and Malaria
    • Place of Presentation
      韓国
    • Related Report
      2008 Final Research Report
  • [Presentation] Enhancement of host-cell apoptosis by a secreted molecule from Toxoplasma gondii, Programmed Cell Dearh 52008

    • Author(s)
      西川義文
    • Organizer
      第7回あわじしま感染症・免疫フォーラム
    • Place of Presentation
      淡路夢舞台国際会議場
    • Related Report
      2008 Annual Research Report
  • [Presentation] A secreted molecule, Programmed Cell Death 5 from Toxoplasma gondii, possesses pro-apoptotic activity on host cells2007

    • Author(s)
      西川義文
    • Organizer
      The 3rd International Zoonosis Seminar
    • Place of Presentation
      韓国済州島KALホテル
    • Year and Date
      2007-11-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] Toxoplasma gondii infection induces apoptosis in non-infected macrophages:role of nitric oxide and Programmed Cell Death 5 of the parasite2007

    • Author(s)
      西川義文
    • Organizer
      第7回あわじしま感染症・免疫フォーラム
    • Place of Presentation
      淡路夢舞台国際会議場
    • Year and Date
      2007-09-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] 細胞内寄生原虫の増殖メカニズムの解明に向けて:トキソプラズマの脂質代謝ネットワーク2007

    • Author(s)
      西川義文
    • Organizer
      第143回日本獣医学会学術集会
    • Place of Presentation
      つくば国際会議場
    • Year and Date
      2007-04-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] 細胞内寄生原虫の増殖メカニズムの解明に向けて:トキソプラズマの脂質代謝ネットワーク(ワークショップ)2007

    • Author(s)
      西川義文
    • Organizer
      第143回日本獣医学会学術集会
    • Place of Presentation
      つくば
    • Related Report
      2008 Final Research Report
  • [Presentation] Toxoplasma gondiiの全身伝播における血中Freetachyzoiteと末梢血細胞感染Tachyzoiteの関与2007

    • Author(s)
      海野明広、玄 学南、西川義文、鈴木和彦、鬼頭克也、高島康弘
    • Organizer
      第144回日本獣医学会学術集会
    • Place of Presentation
      北海道
    • Related Report
      2008 Final Research Report
  • [Presentation] Toxoplasma gondii infection induces apoptosis in non-infected macrophages: role of nitric oxide and Programmed Cell Death 5 of the parasite.2007

    • Author(s)
      Yoshifumi Nishikawa, Hiroshi Bannai, Osamu Kawase, Xuenan Xuan.
    • Organizer
      第7回あわじしま感染症・免疫フォーラム
    • Place of Presentation
      淡路島
    • Related Report
      2008 Final Research Report
  • [Presentation] A secreted molecule, Programmed Cell Death 5 from Toxoplasma gondii, possesses pro-apoptotic activity on host cells.2007

    • Author(s)
      Hiroshi Bannai, Yoshifumi Nishikawa, Tomohide Matsuo, Osamu Kawase, Junichi Watanabe, Chihiro Sugimoto, and Xuenan Xuan.
    • Organizer
      The 3rd International Zoonosis Seminar
    • Place of Presentation
      韓国
    • Related Report
      2008 Final Research Report
  • [Book] トキソプラズマ感染による宿主細胞アポトーシスの制御, 実験医学増刊号「感染症のサイエンス」2009

    • Author(s)
      西川義文
    • Publisher
      羊土社
    • Related Report
      2008 Final Research Report
  • [Remarks] 研究室ホームページ

    • URL

      http://www.obihiro.ac.jp/~geneticbiochem/

    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://www.obihiro.ac.jp/~geneticbiochem/

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.obihiro.ac.jp/~geneticbiochem/

    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 原虫病治療薬2008

    • Inventor(s)
      西川義文
    • Industrial Property Rights Holder
      帯広畜産大学
    • Industrial Property Number
      2008-064586
    • Filing Date
      2008-03-13
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 抗原虫効果を有するヒトデ抽出物2008

    • Inventor(s)
      川瀬摂、玄学南、西川義文
    • Industrial Property Rights Holder
      帯広畜産大学
    • Industrial Property Number
      2008-193166
    • Filing Date
      2008-07-28
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2018-03-28  

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