Developmental regulation and dysregulation of immunological self

• Project/Area Number: 19059007
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: KARASUYAMA Hajime Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 教授 (60195013)
• Project Period (FY): 2007 – 2011
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥50,400,000 (Direct Cost: ¥50,400,000); Fiscal Year 2009: ¥16,800,000 (Direct Cost: ¥16,800,000); Fiscal Year 2008: ¥16,800,000 (Direct Cost: ¥16,800,000); Fiscal Year 2007: ¥16,800,000 (Direct Cost: ¥16,800,000)
• Keywords: アレルギー・ぜんそく / 感染症 / 細胞・組織 / シグナル伝達 / 蛋白質 / B細胞 / プレB細胞レセプター / 発現調節 / 好塩基球 / アレルギー / 炎症 / B-1細胞 / リソソーム / マクロファージ / 自己反応性抗体 / レパートリー / 胎児肝臓 / アナフィラキシー / IgG

Research Abstract

リンパ球が骨髄、胸腺で分化・成熟してくる過程で、抗原レセプター遺伝子の再構成がおこり多様性が生み出されるが、それとともに多数の自己反応性細胞も誕生する。このような自己反応性細胞を中枢性あるいは末梢性に除去・抑制することで、自己免疫疾患の発症が回避されていると考えられているが、その機序に関してはまだまだ未知の部分が多い。
B-1と呼ばれる細胞は、腹腔に局在するユニークなB細胞で、自己反応性抗体の産生など自己免疫疾患との関連で注目されている。通常B細胞とは異なり、胎児肝臓由来であることが示されているが、このような自己反応性B-1細胞が、どのようにして胎児肝臓で選別、維持されるのかに関してはほとんどわかっていない。そこで本研究では、B-1細胞において高頻度で使用される特徴的なH鎖に注目して、胎児肝臓での遺伝子、蛋白質、細胞レベルでの選択・制御機構を明らかにする。
これまで、自己免疫疾患に関してT細胞を中心とした研究が進められてきたが、最近、関節リウマチや多発性硬化症などの自己免疫疾患において、自然免疫系のマスト細胞がその発症に大きく貢献していること、制御性T細胞とマスト細胞に相互作用があることが報告された。そこで本研究では、マスト細胞や好塩基球など典型的な自然免疫系細胞が単に炎症のエフェクター細胞としてのみならず、獲得免疫系の制御細胞として機能しているという仮説を立てて、その制御機構を明らかにし、自己免疫やアレルギー、免疫不全など免疫異常病態の解明をめざす。

Research Products

• [Journal Article] The transfer of maternal antigen-specific IgG regulates the development of allergic airway inflammation early in life in an FcRn-dependent manner (2010)
  • Author(s): Nakata, K.
  • Journal Title: Biochem.Biophys.Res.Commun. (印刷中)
  • Peer Reviewed
• [Journal Article] 急性ならびに慢性アレルギー発症における好塩基球の新たな役割 (2010)
  • Author(s): 烏山一
  • Journal Title: 炎症と免疫 18 Pages: 23-27
• [Journal Article] 好塩基球が主役を演じるIgE依存性慢性アレルギー炎症 (2010)
  • Author(s): 烏山一
  • Journal Title: IgE practice in asthma Pages: 1-5
• [Journal Article] Basophils preferentially express mouse mast cell protease 11 among the mast cell tryptase family in contrast to mast cells. (2009)
  • Author(s): Ugajin, T., Kojima, T., Mukai, K., Obata K., Kawano, Y., Minegishi, Y., Eishi Y., Yokozeki, H., Karasuyama, H.
  • Journal Title: J. Leukoc. Biol. 86 Pages: 1417-1425
  • Peer Reviewed
• [Journal Article] The skewed heavy-chain repertoire in peritoneal B-1 cells is predetermined by the selection via pre-B cell receptor during B cell ontogeny in the fetal liver. (2009)
  • Author(s): Yoshikawa, S., Kawano, Y., Minegishi, Y., Karasuyama, H.
  • Journal Title: Int. Immunol. 21 Pages: 43-52
  • NAID: 10025383848
  • Peer Reviewed
• [Journal Article] Fc receptorγ-chain, a constitutive component of the interleukin 3 receptor is required for interleukin 3-induced interleukin 4. (2009)
  • Author(s): Hida, S., Yamasaki, S., Sakamoto, Y., Takamoto, M., Obata, K., Takai, T., Karasuyama, H., Sugane, K., Saito, T., Taki, S.
  • Journal Title: Nat. Immunol 10 Pages: 214-222
  • Peer Reviewed
• [Journal Article] Newly-discovered roles for basophils: a neglected minority gains new respect. (2009)
  • Author(s): Karasuyama, H., Mukai, K., Tsujimura, Y., Obata, K.
  • Journal Title: Nat. Rev. Immunol. 9 Pages: 9-13
  • Peer Reviewed
• [Journal Article] Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome (2009)
  • Author(s): 峯岸克行
  • Journal Title: J.Exp.Med. 206 Pages: 1291-1301
  • Peer Reviewed
• [Journal Article] The study of allergy by Japanese researchers : a historical perspective (2009)
  • Author(s): Takai, T.
  • Journal Title: Int.Immunol. 21 Pages: 1311-1316
  • Peer Reviewed
• [Journal Article] Basophils preferentially express mouse mast cell protease 11 among the mast cell tryptase family in contrast to mast cells (2009)
  • Author(s): Ugajin, T.
  • Journal Title: J.Leukoc.Biol. 86 Pages: 1417-1425
  • Peer Reviewed
• [Journal Article] 慢性アレルギー炎症ならびにアナフィラキシーにおける好塩基球のあらたな役割 (2009)
  • Author(s): 烏山一
  • Journal Title: 医学のあゆみ別冊「最新免疫研究 Update」 Pages: 77-82
• [Journal Article] 好塩基球・マスト細胞の機能とCD200R3 (2009)
  • Author(s): 小島利之
  • Journal Title: 臨床免疫アレルギー科 52 Pages: 49-57
• [Journal Article] 自己免疫現象と疾患発症 (2009)
  • Author(s): 烏山一
  • Journal Title: ひらかれた小児リウマチ診療(日本小児リウマチ学会) Pages: 13-16
• [Journal Article] 高IgE症候群の原因遺伝子は何か (2009)
  • Author(s): 峯岸克行
  • Journal Title: 分子リウマチ治療 2 Pages: 19-21
• [Journal Article] 好塩基球とアレルギー (2009)
  • Author(s): 向井香織
  • Journal Title: 日本臨床 67 Pages: 2095-2099
• [Journal Article] アレルギーにおける好塩基球の新たな役割 (2009)
  • Author(s): 烏山一
  • Journal Title: 実験医学増刊「アレルギー疾患の免疫機構」 27 Pages: 68-74
• [Journal Article] Newly-discovered roles for basophils : a neglected minority gains new respect (2009)
  • Author(s): Karasuyama, H
  • Journal Title: Nat. Rev. Immunol 9 Pages: 9-13
  • Peer Reviewed
• [Journal Article] Fc receptor γ-chain, a constitutive component of the interleukin 3 receptor is required for interleukin 3-induced interleukin 4 (2009)
  • Author(s): Hida, S
  • Journal Title: Nat. Immunol 10 Pages: 214-222
  • Peer Reviewed
• [Journal Article] The skewed heavy-chain repertoire in peritoneal B-1 cells is predeter mined by the selection via pre-B cell receptor during B cell ontogeny in the fetal liver (2009)
  • Author(s): Yoshikawa, S
  • Journal Title: Int. Immunol 21 Pages: 43-52
  • Peer Reviewed
• [Journal Article] New insights into the roles for basophils in acute and chronic allergy (2009)
  • Author(s): Mukai, K
  • Journal Title: Allergol.Int 58 Pages: 11-19
  • Peer Reviewed
• [Journal Article] Defects in Jak-STAT-mediated cytokine signals cause hyper-IgE syndrome : lessons from a primary human immunodeficiency (2009)
  • Author(s): Minegishi, Y
  • Journal Title: Int. Immunol 21 Pages: 105-112
  • Peer Reviewed
• [Journal Article] Peanuts can contribute to anaphylactic shock by activating complement (2009)
  • Author(s): Khodoun, M
  • Journal Title: J. Allergy Clin. Immunol 58 Pages: 11-19
  • Peer Reviewed
• [Journal Article] LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosnhorylation (2009)
  • Author(s): Belkina N. V
  • Journal Title: Proc. Natl. Acad. Sci. USA 106 Pages: 4707-4712
  • Peer Reviewed
• [Journal Article] アレルギーにおける好塩基球の新たな役割 (2009)
  • Author(s): 烏山一
  • Journal Title: Annual Review 2009呼吸器 (中外医学社) Pages: 44-51
• [Journal Article] 免疫アレルギー研究の表舞台に躍り出た好塩基球 (2009)
  • Author(s): 烏山一
  • Journal Title: アレルギー・免疫 16(3) Pages: 9-10
• [Journal Article] CD200R3を介した好塩基球とマスト細胞の活性化 (2009)
  • Author(s): 小島利之
  • Journal Title: アレルギー・免疫 16(3) Pages: 44-51
• [Journal Article] 好塩基球によるIgG型アナフィラキシーの誘導 (2009)
  • Author(s): 辻村祐佑
  • Journal Title: アレルギー・免疫 16(3) Pages: 62-71
• [Journal Article] 好塩基球が主役を演じる慢性アレルギー炎症 (2009)
  • Author(s): 向井香織
  • Journal Title: アレルギー・免疫 16(3) Pages: 72-77
• [Journal Article] Basophils play a pivotal role in immunoglobulin G- but not immunoglobulin E-mediated systemic anaphylaxis (2008)
  • Author(s): Tsujimura, Y., Obata, K., Mukai, K., Shindou, H., Yoshida, M., Nishikado, H., Kawano, Y., Minegishi, Y., Shimizu, T., Karasuyama, H.
  • Journal Title: Immunity 28 Pages: 581-589
  • Peer Reviewed
• [Journal Article] Basophils play a pivotal role in immunoglobulin G- but not immunoglobulin E-mediated systemic anaphylaxis (2008)
  • Author(s): Tsujimura, Y
  • Journal Title: Immunity 28 Pages: 581-589
  • Peer Reviewed
• [Journal Article] Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion (2008)
  • Author(s): Yasuda, T
  • Journal Title: Immunity 28 Pages: 499-508
  • Peer Reviewed
• [Journal Article] Genetic origins of hyper-IgE syndrome (2008)
  • Author(s): Minegishi, Y
  • Journal Title: Curr. Allergy Asthma Rep 8(5) Pages: 386-391
  • Peer Reviewed
• [Journal Article] Overproduction of IgE induces macrophage-derived chemokine (CCL22) secretion from basophils (2008)
  • Author(s): Watanabe, M
  • Journal Title: J. Immunol 181 Pages: 5653-5659
  • Peer Reviewed
• [Journal Article] A novel hairless mouse model on an atopic dermatitis-prone genetic background generated by receptor-mediated transgenesis (2008)
  • Author(s): Takada, T
  • Journal Title: Transgenic Res 17(6) Pages: 1155-1162
  • Peer Reviewed
• [Journal Article] アレルギー疾患関連遺伝子〜サイトカイン・シグナル伝達分子 (Tyk2,STAT3) の遺伝子変異による高IgE症候群の発症〜 (2008)
  • Author(s): 峯岸克行
  • Journal Title: 感染炎症免疫 38(1) Pages: 24-31
• [Journal Article] 皮膚アレルギーと好塩基球 (2008)
  • Author(s): 横関博雄
  • Journal Title: 皮膚アレルギーフロンティア 6(2) Pages: 118-125
• [Journal Article] 好塩基球の21世紀ルネサンス-生体内における好塩基球のユニークな役割が次々と明らかに- (2008)
  • Author(s): 辻村祐佑
  • Journal Title: 臨床血液 49(7) Pages: 489-497
• [Journal Article] STAT像シグナルと免疫疾患 (2008)
  • Author(s): 峯岸克行
  • Journal Title: 実験医学増刊「シグナル伝達研究」実験医学 26(15) Pages: 132-136
• [Journal Article] アナフィラキシー・ショックを引き起こす新たな仕組み-好塩基球の知られざる役割が明らかに (2008)
  • Author(s): 烏山一
  • Journal Title: Dental Diamond 33 Pages: 66-70
• [Journal Article] アナフィラキシー・ショックを引き起こす新たなメカニズム-好塩基球・IgG・血小板活性化因子を介した即時型アレルギー (2008)
  • Author(s): 辻村祐佑
  • Journal Title: 細胞工学 27(10) Pages: 1030-1031
• [Journal Article] アナフィラキシーショック発症の新たなメカニズム (2008)
  • Author(s): 烏山一
  • Journal Title: 日本医事新報 4402 Pages: 45-48
• [Journal Article] 危険なアレルギー反応の新たな仕組みが明らかに (2008)
  • Author(s): 烏山一
  • Journal Title: 科学 (岩波書店) 78(11) Pages: 1246-1251
• [Journal Article] 慢性アレルギー炎症ならびにアナフィラキシーにおける好塩基球のあらたな役割 (2008)
  • Author(s): 烏山一
  • Journal Title: 医学のあゆみ 227(5) Pages: 361-366
• [Journal Article] 好塩基球とマスト細胞に発現するCD200R3 (2008)
  • Author(s): 小畑一茂
  • Journal Title: 臨床免疫・アレルギー科 50(5) Pages: 595-602
• [Journal Article] Basophils play a pivotal role in immunoglobulin G-but not immunoglobulin E-mediated systemic anaphylaxis. (2008)
  • Author(s): Tsujimura, Y., Obata, K., Mukai, K., Shindou, H., Yoshida, M., Nishikado, H., Kawano, Y., Minegishi, Y., Shimizu, T. and Karasuyama, H.
  • Journal Title: Immunity (印刷中)
  • Peer Reviewed
• [Journal Article] Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion. (2008)
  • Author(s): Yasuda, T., Sanjo, H., Pages, G., Kawano, Y., Karasuyama, H. Pouyssegur, J., Ogata, M. and Kurosaki, T.
  • Journal Title: Immunity (印刷中)
  • Peer Reviewed
• [Journal Article] Basophils are essential initiators of a novel type of chronic allergic inflammation. (2007)
  • Author(s): Obata, K., Mukai, K., Tsujimura, Y., Ishiwata, K., Kawano, Y., Minegishi, Y., Watanabe, N., Karasuyama, H.
  • Journal Title: Blood 110 Pages: 913-920
  • Peer Reviewed
• [Journal Article] Basophils are essential initiators of a novel type of chronic allergic inflammation. (2007)
  • Author(s): Obata, K., Mukai, K., Tsujimura, Y., Ishiwata, K., Kawano, Y., Minegishi, Y., Watanabe, N., and Karasuyama, H.
  • Journal Title: Blood 110 Pages: 913-920
  • Peer Reviewed
• [Journal Article] Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome. (2007)
  • Author(s): Minegishi, Y., Saito, M., Tsuchiya, S., Tsuge, I., Takada, H., Hara T., Kawamura, N., Ariga, T., Pasic, S., Stojkovic, O., Metin, A., and Karasuyama, H.
  • Journal Title: Nature 448 Pages: 1058-1062
  • Peer Reviewed
• [Journal Article] Mast cells and basophils are selectively activated in vitro and in vivo through CD200R3 in an IgE-independent manner. (2007)
  • Author(s): Kojima, T., Obata, K., Mukai, K., Sato, S., Takai, T., Minegishi, Y., and Karasuyama, H.
  • Journal Title: J. Immunol 179 Pages: 7093-7100
  • Peer Reviewed
• [Journal Article] Hyperimmunoglobulin E syndrome and tyrosine kinasae 2 deficiency. (2007)
  • Author(s): Minegishi, Y. and Karasuyama, H.
  • Journal Title: Curr. Opin. Allergy Clin Immunol 7 Pages: 506-509
  • Peer Reviewed
• [Journal Article] 好塩基球によるIgE依存性慢性アレルギー炎症 (2007)
  • Author(s): 向井香織、烏山 一
  • Journal Title: アレルギー・免疫(医薬ジャーナル) 14(2) Pages: 40-45
• [Journal Article] 慢性アレルギー炎症における好塩基球の役割 (2007)
  • Author(s): 向井香織、烏山 一
  • Journal Title: 皮膚アレルギーフロンティア 5(1) Pages: 25-29
• [Journal Article] 好塩基球と慢性アレルギー炎症 (2007)
  • Author(s): 鳥山 一
  • Journal Title: 医学のあゆみ 220(12) Pages: 949-952
• [Journal Article] 好塩基球が主役を演じる慢性アレルギー炎症 (2007)
  • Author(s): 烏山 一
  • Journal Title: メディカル・サイエンス・ダイジェスト 33(7) Pages: 26-29
• [Journal Article] 慢性アレルギー炎症における好塩基球の新たな役割 (2007)
  • Author(s): 烏山 一
  • Journal Title: 生化学 79(8) Pages: 761-767
  • NAID: 10019550519
• [Journal Article] 重症アトピーをともなう難病の原因遺伝子をついに発見 (2007)
  • Author(s): 峯岸克行・烏山 一
  • Journal Title: メディカル・バイオ Pages: 14-15
• [Journal Article] 高IgE症候群の原因遺伝子 (2007)
  • Author(s): 峯岸克行・烏山 一
  • Journal Title: Annual Review免疫2008 Pages: 288-294
• [Journal Article] アレルギーと好塩基球 (2007)
  • Author(s): 烏山 一
  • Journal Title: Medical Tribune 40 Pages: 43-45
• [Journal Article] アレルギー性炎症 (2007)
  • Author(s): 烏山 一
  • Journal Title: 免疫応答と免疫病態の総合的分子理解 Pages: 189-196
• [Presentation] Newly discovered roles for basophils in allergy and parasitic infections (2010)
  • Author(s): 烏山一
  • Organizer: US-Japan Joint Symposium : Adaptive and innate immune responses to neglected tropical diseases conference
  • Place of Presentation: San Diego, USA.
• [Presentation] Previously unrecognized roles for basophils in immune and allergic responses (2010)
  • Author(s): 烏山一
  • Organizer: 3^<rd> International Singapore symposium of immunology
  • Place of Presentation: Singapore
• [Presentation] アレルギーにおける好塩基球の二面性:悪玉細胞それとも善玉細胞? (2009)
  • Author(s): 烏山一
  • Organizer: 第28回漢方免疫アレルギー研究会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2009-06-27
• [Presentation] アレルギーならびに生体防御における好塩基球の新たな役割 (2009)
  • Author(s): 烏山一
  • Organizer: 第5回金沢小児・皮膚免疫アレルギー研究会
  • Place of Presentation: 金沢
  • Year and Date: 2009-06-24
• [Presentation] 高IgE症候群の責任遺伝子の同定と病態解明 (2009)
  • Author(s): 烏山一、峯岸克行
  • Organizer: 第3回千葉小児皮膚免疫アレルギー研究会
  • Place of Presentation: 千葉
  • Year and Date: 2009-05-14
• [Presentation] The role for basophils in IgG but not IgE-mediated systemic anaphylaxis (2009)
  • Author(s): 烏山一
  • Organizer: First Croatian Congdress of Allergology and Clinical Immunology
  • Place of Presentation: Zagreb, Croatia
• [Presentation] Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome (2009)
  • Author(s): 烏山一
  • Organizer: First Croatian Congdress of Allergology and Clinical Immunology
  • Place of Presentation: Zagreb, Croatia
• [Presentation] Newly discovered roles for basophils : a neglected minority gains new respect (2009)
  • Author(s): 烏山一
  • Organizer: 6^<th> Biennial Symposium International Eosinophil Society(Eosinophil 2009)
  • Place of Presentation: Bruges, Belgium
• [Presentation] Basophils play an important role in the resolution of inflammation by inducing alternative activation of macrophages through Th2 cytokine release (2009)
  • Author(s): 烏山一
  • Organizer: 2nd European Congress of Immunology(ECI 2009)
  • Place of Presentation: Berlin, Germany
• [Presentation] Basophils play a possible immunoregulatory role during Schistosoma mansoni infection in mice (2009)
  • Author(s): William Anyan K.
  • Organizer: 58^<th> Annual Meeting of American Society of Tropical Medicine and Hygiene
  • Place of Presentation: Washington DC.USA.
• [Presentation] 好塩基球と生体防御 (2009)
  • Author(s): 烏山一
  • Organizer: 第20回日本生体防御学会学術総会
  • Place of Presentation: 東京
• [Presentation] アレルギーにおける好塩基球の二面性:悪玉細胞それとも善玉細胞? (2009)
  • Author(s): 烏山一
  • Organizer: 第59回日本アレルギー学会秋季学術大会
  • Place of Presentation: 秋田
• [Presentation] アレルギー疾患における好塩基球の役割 (2009)
  • Author(s): 烏山一
  • Organizer: 第59回日本アレルギー学会秋季学術大会
  • Place of Presentation: 秋田
• [Presentation] Novel roles for basophils in allergy (2009)
  • Author(s): 烏山一
  • Organizer: 第59回日本アレルギー学会秋季学術大会 International Symposium
  • Place of Presentation: 秋田
• [Presentation] 好塩基球による皮膚慢性アレルギーの誘導と炎症終焉 (2009)
  • Author(s): 烏山一
  • Organizer: 第39回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
  • Place of Presentation: 京都
• [Presentation] Dyanamics of basophil behavior in immune and allergic responses : in vivo imaging analysis using basophil-specific GFP mice (2009)
  • Author(s): Yoshikawa, S.
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
• [Presentation] Dominant negative mutation in STAT3 results in defective osteoblast and osteoclast function in hyper-IgE syndrome (2009)
  • Author(s): 峯岸克行
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
• [Presentation] Establishment of diphtheria toxin based in vivo deletion system of basophils and mast cells (2009)
  • Author(s): Sawaguchi, M.
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
• [Presentation] Basophils play an important role in the acquisition of resistance to infections with nematodes (2009)
  • Author(s): Obata, K.
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
• [Presentation] The role for basophils in the development of resistance to external parasites (2009)
  • Author(s): Wada, T.
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
• [Presentation] The generation of induced Treg(iTreg)but not naturally occurring Treg(nTreg)is impaired in the hyper IgE syndrome (2009)
  • Author(s): Saito, M.
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
• [Presentation] Importance of the subclass and oligoclonality of IgG for efficient induction of systemic anaphylaxis (2009)
  • Author(s): Ishikawa, R.
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
• [Presentation] A novel mechanism for the autonomous termination of pre-B cell receptor expression through BLINK-mediated induction of LAPTM5 (2009)
  • Author(s): Kawano, Y.
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
• [Presentation] Basophils regulate macrophage functions through Th2 cytokines in all eraic inflammation (2009)
  • Author(s): Karasuyama, H
  • Organizer: Keystone Symposia 'Allergy and Asthma
  • Place of Presentation: Keystone, USA
• [Presentation] 見逃されていた好塩基球の重要性 (2008)
  • Author(s): 烏山一
  • Organizer: 第36回日本臨床免疫学会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-18
• [Presentation] 高IgE症候群の分子基盤 (2008)
  • Author(s): 峯岸克行
  • Organizer: 第36回日本臨床免疫学会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-18
• [Presentation] アトピー性皮膚炎を伴うユニークな免疫不全症「高IgE症候群」の責任遺伝子と病態の解明 (2008)
  • Author(s): 烏山一
  • Organizer: 生体機能と創薬シンポジウム2008
  • Place of Presentation: 東京
  • Year and Date: 2008-08-05
• [Presentation] 好塩基球の21世紀ルネサンス〜好塩基球の生体内でのユニークな役割の解明〜 (2008)
  • Author(s): 烏山一
  • Organizer: 四国免疫フォーラム
  • Place of Presentation: 高知
  • Year and Date: 2008-06-21
• [Presentation] Basophils play a pivotal role in IgG- but not IgE-mediated systemic anaphylaxis in contrast to mast cells (2008)
  • Author(s): Karasuyama, H
  • Organizer: LIAI Allergy Symposium
  • Place of Presentation: La Jolla, USA
  • Year and Date: 2008-04-04
• [Presentation] Basophils play a pivotal role in IgG- but not IgE-mediated systemic anaphylaxis in contrast to mast cells (2008)
  • Author(s): Karasuyama, H
  • Organizer: Experimental Biology 2008
  • Place of Presentation: San Diego, USA
• [Presentation] Basophils and mast cells play distinct roles in acute and chronic alleigic reactions (2008)
  • Author(s): Karasuyama, H
  • Organizer: 27^<th> Symposium of the Collegium International Allergologicum
  • Place of Presentation: Curacao
• [Presentation] Chronic cutaneous allergic inflammation - responsible cells and causative genes (2008)
  • Author(s): Karasuyama, H
  • Organizer: International Investigative Dermatology 2008
  • Place of Presentation: Kyoto
• [Presentation] Roles of mast cells and basophils in the development of allergic diseases (2008)
  • Author(s): Karasuyama, H
  • Organizer: Frontiers in Allergy and Autoimmunity
  • Place of Presentation: Mainz, Germany
• [Presentation] Basophils and mast cells play distinct roles in acute and chronic allergic responses (2008)
  • Author(s): Karasuyama, H
  • Organizer: FOCIS (Federation of Clinical Immunology Societies) 2008
  • Place of Presentation: Boston, USA
• [Presentation] Hyper-IgEs yndrome is a compound primary immunodeficiency caused by the signalopathy of multiple cytokines (2008)
  • Author(s): Minegishi,Y
  • Organizer: RCAI-JSI Intemational Symposium
  • Place of Presentation: Ybkahama
• [Presentation] 生体防御ならびにアレルギー疾患における好塩基球のユニークな役割 (2008)
  • Author(s): 烏山一
  • Organizer: 第32回阿蘇シンポジウム
  • Place of Presentation: 熊本
• [Presentation] The role for basophils in the protection against external parasites (2008)
  • Author(s): Karasuyama, H
  • Organizer: The 8^<th> Awaji International Forum on Infection and Immunity
  • Place of Presentation: Awali
• [Presentation] 特別講演「好塩基球の21世紀ルネサンス〜急性ならびに慢性アレルギーにおける好塩基球の新たな役割」 (2008)
  • Author(s): 烏山一
  • Organizer: 第58回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
• [Presentation] 高IgE症候群の責任遺伝子の同定と病態解析 (2007)
  • Author(s): 烏山 一
  • Organizer: 第1回千葉基礎・臨床免疫セミナー
  • Place of Presentation: 千葉
  • Year and Date: 2007-10-29
• [Presentation] 即時型ならびに慢性アレルギーにおける好塩基球の重要性 (2007)
  • Author(s): 烏山 一
  • Organizer: 第21回難病治療研究会
  • Place of Presentation: 東京
  • Year and Date: 2007-10-24
• [Presentation] 高IgE症候群の原因遺伝子 (2007)
  • Author(s): 峯岸克行、齋藤雅子、烏山 一
  • Organizer: 信州免疫アレルギー懇話会
  • Place of Presentation: 松本
  • Year and Date: 2007-10-05
• [Presentation] 「アレルギー疾患と免疫」 (2007)
  • Author(s): 烏山 一
  • Organizer: 姫路内科医会
  • Place of Presentation: 姫路
  • Year and Date: 2007-09-08
• [Presentation] 好塩基球が主役を演じる新たな慢性アレルギー炎症. (2007)
  • Author(s): 烏山 一
  • Organizer: 第10回 No side GI conference.
  • Place of Presentation: 大阪
  • Year and Date: 2007-07-21
• [Presentation] Basophils function as initiators rather than effectors in IgE-mediated chronic allergic inflammation, independently of T cells and mast cells. (2007)
  • Author(s): Karasuyama H, Mukai K, Obata K, Ishiwata K, Watanabe N, Kawano Y, Minegishi Y.
  • Organizer: The 94th annual meeting of the American Association of Immunologists.
  • Place of Presentation: Miami.
• [Presentation] Hyper-IgE syndrome. IUIS 2007:. (2007)
  • Author(s): Karasuyama H. and Minegishi Y.
  • Organizer: Symposium on Primary Immunodeficiency Diseases.
  • Place of Presentation: Jackson Hole.
• [Presentation] The traffic of basophils in allergic responses. (2007)
  • Author(s): Karasuyama H.
  • Organizer: The 28th Congress of the European Academy of Allergology and Clinical Immunology.
  • Place of Presentation: Goteborg
• [Presentation] Basophils functions as initiators rather than effectors in a novel type of chronicallergic inflammation. (2007)
  • Author(s): Karasuyama H.
  • Organizer: The 13th International Congress of Immunology.
  • Place of Presentation: Rio de Janeiro
• [Presentation] Vovel mechanism of chronic allergic inflammation; pivotal role of basophils. (2007)
  • Author(s): Karasuyama H.
  • Organizer: World Allergy Congress 2007.
  • Place of Presentation: Bangkok
• [Presentation] 慢性アレルギー性炎症における好塩基球の役割. (2007)
  • Author(s): 烏山 一
  • Organizer: 第17回国際喘息学会日本北アジア部会
  • Place of Presentation: 東京
• [Presentation] 即時型ならびに慢性アレルギー反応における好塩基球の新たな役割 (2007)
  • Author(s): 烏山 一
  • Organizer: 生体機能と創薬シンポジウム2007
  • Place of Presentation: 金沢
• [Presentation] 教育講演「自己免疫現象と疾患発症」 (2007)
  • Author(s): 烏山 一
  • Organizer: 第17回日本小児リウマチ学会
  • Place of Presentation: 横浜
• [Presentation] Basophils function as an initiator of chronic allergic inflammation. (2007)
  • Author(s): Karasuyama H, Mukai K, Obata K, Tsujimura Y, Kawano Y, Ishiwata K, Watanabe N, and Minegishi Y.
  • Organizer: The 20th Naito Conference
  • Place of Presentation: Kanagawa
• [Presentation] Schistosoma mansoni infection: The basophil kinetics. (2007)
  • Author(s): Anyan W. K, 熊谷 貴、下河原 理江子、小畑 一茂、和田 剛、烏山 一、太田 伸生
  • Organizer: 第48回日本熱帯医学会大会
  • Place of Presentation: 大分
• [Presentation] 高IgE症候群の原因遺伝子の検討 (2007)
  • Author(s): 峯岸克行、齋藤雅子、高田英俊、原寿郎、川村信明、有賀 正、土屋 滋、柘植郁哉、烏山 一
  • Organizer: 第57回日本アレルギー学会秋季学術大会
  • Place of Presentation: 横浜
• [Presentation] 慢性アレルギー炎症におけるイニシエーターとしての好塩基球の役割 (2007)
  • Author(s): 向井香織、峯岸克行、烏山一
  • Organizer: 第57回日本アレルギー学会秋季学術大会
  • Place of Presentation: 横浜
• [Presentation] 好塩基球に選択的に発現する顆粒酵素に対する特異抗体の樹立とその応用 (2007)
  • Author(s): 宇賀神つかさ、小島利之、小畑一茂、辻村祐佑、向井香織、河野洋平、峯岸克行、烏山一
  • Organizer: 第57回日本アレルギー学会秋季学術大会
  • Place of Presentation: 横浜
• [Presentation] 好塩基球が中心的な役割を果たすIgG依存性全身性アナフィラキシー (2007)
  • Author(s): 辻村祐佑、河野洋平、峯岸克行、烏山一
  • Organizer: 第57回日本アレルギー学会秋季学術大会
  • Place of Presentation: 横浜
• [Presentation] CD200R3は好塩基球・マスト細胞特異的な活性型受容体として機能する (2007)
  • Author(s): 小畑 一茂、小島 利之、辻村 祐佑、峯岸 克行、烏山 一
  • Organizer: 第57回日本アレルギー学会秋季学術大会
  • Place of Presentation: 横浜
• [Presentation] Basophils and mast cells play distinct roles in systemic anaphylaxis. (2007)
  • Author(s): Karasuyama H, Tsujimura Y, Obata K, Mukai K, Kojima T, Nishikado H, Kawano Y, Minegishi Y.
  • Organizer: The 37th JSI annual meeting
  • Place of Presentation: Tokyo
• [Presentation] Molecular mechanism of BASH-mediated preBCR down-regulation (2007)
  • Author(s): Kawano Y, Yamamoto M, Kitamura D. and Karasuyama H.
  • Organizer: The 37th JSI annual meeting
  • Place of Presentation: Tokyo
• [Presentation] Basophils function as initiator rather than effectors in IgE-mediated chronic allergic inflammation (2007)
  • Author(s): Mukai K, Kawano Y, Minegishi Y, Karasuyama H.
  • Organizer: The 37th JSI annual meeting
  • Place of Presentation: Tokyo
• [Presentation] A CD200-like protein CD200R3 is selectively expressed on basophils and a subset of mast cells (2007)
  • Author(s): Kojima T, Obata K, Mukai K, Sato S, Minegishi Y, Karasuyama H.
  • Organizer: The 37th JSI annual meeting
  • Place of Presentation: Tokyo
• [Presentation] Identification and characterization of murine basophil granular enzymes mMCP-8 and mMCP-11 (2007)
  • Author(s): Ugajin T, Kojima T, Obata K, Tsujimura Y, Mukai K, Kawano Y, Yokozeki H, Minegishi Y, Karasuyama H.
  • Organizer: The 37th JSI annual meeting
  • Place of Presentation: Tokyo
• [Presentation] Basophils play a piovotal role in IgG-but not IgE-mediated systemic anaphylaxis (2007)
  • Author(s): Tsujimura Y, Kawano Y, Minegishi Y, and Karasuyama H.
  • Organizer: The 37th JSI annual meeting
  • Place of Presentation: Tokyo
• [Presentation] CD200R3 functions as an activating receptor expressed exclusively on basophils and a subset of a mast cells (2007)
  • Author(s): Obata K, Kojima T, Tsujimura Y, Kawano Y, Minegishi Y. and Karasuyama H.
  • Organizer: The 37th JSI annual meeting
  • Place of Presentation: Tokyo
• [Presentation] PreBCR positively selects phosphatidylcholine-reactive V_H11-μH chains during B cell ontogeny in fetal liver (2007)
  • Author(s): Yoshikawa S, Kawano Y, Minegishi Y, and Karasuyama H.
  • Organizer: The 37th JSI annual meeting
  • Place of Presentation: Tokyo
• [Presentation] Possible functions of basophils in the protection against external parasite (2007)
  • Author(s): Onuma N, Obata K, Ishiwata K, Watanabe N, Minegishi Y. and Karasuyama H.
  • Organizer: The 37th JSI annual meeting
  • Place of Presentation: Tokyo
• [Presentation] Regulatotory dendritic cells are functionally defective in human Tyk2 deficiency (2007)
  • Author(s): Saito M, Minegishi Y, Nonoyama S, and Karasuyama H.
  • Organizer: The 37th JSI annual meeting
  • Place of Presentation: Tokyo
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