| Budget Amount *help |
¥113,490,000 (Direct Cost: ¥87,300,000、Indirect Cost: ¥26,190,000)
Fiscal Year 2011: ¥21,190,000 (Direct Cost: ¥16,300,000、Indirect Cost: ¥4,890,000)
Fiscal Year 2010: ¥21,710,000 (Direct Cost: ¥16,700,000、Indirect Cost: ¥5,010,000)
Fiscal Year 2009: ¥22,880,000 (Direct Cost: ¥17,600,000、Indirect Cost: ¥5,280,000)
Fiscal Year 2008: ¥22,880,000 (Direct Cost: ¥17,600,000、Indirect Cost: ¥5,280,000)
Fiscal Year 2007: ¥24,830,000 (Direct Cost: ¥19,100,000、Indirect Cost: ¥5,730,000)
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| Research Abstract |
To examine molecular mechanism for generating neuronal diversity and for building neural network formation in the brain, we focused to diverse CNR/protocadherin molecules which express in the brain. In this study, we identified the several cis-elements, and revealed that DNA methylation and CTCF are essential to regulate expression of CNR/protocadherin genes in each neuron. And also we demonstrated that CNR/protocadherin- α molecules are essential to correct neural networkformation in the brain.
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