| Co-Investigator(Kenkyū-buntansha) |
NAKAI Naoya 大阪大学, 医学系・研究科, 准教授 (90324508)
KAWANO Fuminori 大阪大学, 医学系・研究科, 助教 (90346156)
NISHIMOTO Norihiro 和歌山県立医科大学, 医学部, 教授 (80273663)
SAKODA Saburou 大阪大学, 医学系・研究科, 教授 (00178625)
OHMI Shinobu 東京大学, 医科学研究所, 准教授 (20160046)
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| Budget Amount *help |
¥116,350,000 (Direct Cost: ¥89,500,000、Indirect Cost: ¥26,850,000)
Fiscal Year 2011: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2010: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2009: ¥27,560,000 (Direct Cost: ¥21,200,000、Indirect Cost: ¥6,360,000)
Fiscal Year 2008: ¥23,270,000 (Direct Cost: ¥17,900,000、Indirect Cost: ¥5,370,000)
Fiscal Year 2007: ¥27,300,000 (Direct Cost: ¥21,000,000、Indirect Cost: ¥6,300,000)
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| Research Abstract |
Effects of antigravity muscle activity on the function and/ or protein expression in rat brain were studied. Since the muscle injury inhibits the physical activity, the study was also performed to investigate the suitable methods for promotion of regeneration of injured muscle. As the results, inhibition of hindlimb muscle activity by gravitational unloading caused detrimental effects on the normal growth and development of brain in new-born rats. Further, application of heat stress to injured muscles promoted the regeneration. In these muscles, cells expressing heat shock protein 72(HSP72) were observed in capillary vessels, not in muscle fibers. These cells were either bone marrow cells or neutrophils. The data indicated that HSP72 plays some indirect roles for stimulation of muscle regeneration. Heat-stress-specific changes in gene and protein expression were also observed.
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