| Budget Amount *help |
¥109,720,000 (Direct Cost: ¥84,400,000、Indirect Cost: ¥25,320,000)
Fiscal Year 2011: ¥21,580,000 (Direct Cost: ¥16,600,000、Indirect Cost: ¥4,980,000)
Fiscal Year 2010: ¥21,580,000 (Direct Cost: ¥16,600,000、Indirect Cost: ¥4,980,000)
Fiscal Year 2009: ¥21,580,000 (Direct Cost: ¥16,600,000、Indirect Cost: ¥4,980,000)
Fiscal Year 2008: ¥21,580,000 (Direct Cost: ¥16,600,000、Indirect Cost: ¥4,980,000)
Fiscal Year 2007: ¥23,400,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥5,400,000)
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| Research Abstract |
In the present study, we successfully identified several proteins which ubiquitinized in cells and have enhancing or reducing effects against methylmercury toxicity. We also found many new facts which had not been known until now by experiments examining both mechanisms of action of these proteins and the regulation mechanisms of decomposition of these proteins by ubiquitin proteasome system. From these results, it was suggested that methylmercury toxicity is determined by the mechanism intricately related to many factors within the cells.
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