Structures, functions, regulations and physiological roles of xenobiotic exporters

• Project/Area Number: 19109002
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Biological pharmacy
• Research Institution: Osaka University
• Principal Investigator: YAMAGUCHI Akihito 大阪大学, 産業科学研究所, 教授 (60114336)
• Co-Investigator(Kenkyū-buntansha): NAKASHIMA Ryosuke 大阪大学, 産業科学研究所, 助教 (20379100) ; 西野 邦彦 大阪大学, 産業科学研究所, 助教 (30432438)
• Co-Investigator(Renkei-kenkyūsha): NISHINO Kunihiko 大阪大学, 産業科学研究所, 准教授 (30432438)
• Project Period (FY): 2007 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥109,720,000 (Direct Cost: ¥84,400,000、Indirect Cost: ¥25,320,000); Fiscal Year 2011: ¥21,580,000 (Direct Cost: ¥16,600,000、Indirect Cost: ¥4,980,000); Fiscal Year 2010: ¥21,580,000 (Direct Cost: ¥16,600,000、Indirect Cost: ¥4,980,000); Fiscal Year 2009: ¥21,580,000 (Direct Cost: ¥16,600,000、Indirect Cost: ¥4,980,000); Fiscal Year 2008: ¥21,580,000 (Direct Cost: ¥16,600,000、Indirect Cost: ¥4,980,000); Fiscal Year 2007: ¥23,400,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥5,400,000)
• Keywords: 異物排出タンパク / 多剤排出タンパク / AcrB / X線結晶構造解析 / 膜タンパク質結晶構造 / ペリスタポンプ機構 / マルチサイト結合 / 環境センシング / 異物排出トランスポーター / 発現制御 / インドール / 構造解析 / 多剤耐性 / 機能的回転機構 / ペリスタルティック機構 / 構造生物学 / マイクロアレイ / 薬剤耐性 / 異物排出 / サルモネラ / 発現誘導機構 / 膜蛋白質結晶構造 / AcrAB

Research Abstract

We found out the new proximal multisite drug-binding pocket in AcrB and proposed the periplasmic pumping mechanism of drugs by AcrB. We analyzed the expression regulation of multidrug transporters by indole-mediated sensing between different bacterial species in detail and found the roles of RamA and RamR in Salmonella. In addition, we developed the micro-devices for rapid detection of drug resistant bacteria.

Research Products

• [Journal Article] Antibacterial and antifungal activities of new acylated derivatives of epigallocatechin gallate (2012)
  • Author(s): Matsumoto Y, Kaihatsu K, Nishino K, Ogawa M, Kato N, Yamaguchi A
  • Journal Title: frontiers in MICROBIOLOGY Volume: 3(in press)
  • DOI: 10.3389/fmicb.2012.00053
  • Peer Reviewed
• [Journal Article] A microfluidic device for simple and rapid evaluation of multidrug efflux pump inhibitors (2012)
  • Author(s): Iino R, Nishino K, Noji H, Yamaguchi A, Matsumoto Y
  • Journal Title: frontiers in MICROBIOLOGY Volume: 3(in press)
  • DOI: 10.3389/fmicb.2012.00040
  • Peer Reviewed
• [Journal Article] 多剤耐性細菌の異物排出タンパク質のしくみを解明 (2012)
  • Author(s): 山口明人、中島良介
  • Journal Title: 月刊化学 Volume: 2 Pages: 74-74
• [Journal Article] Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket (2011)
  • Author(s): Nakashima R., Sakurai K., Yamasaki S., Nishino K., Yamaguchi A.
  • Journal Title: Nature Volume: vol.480 Pages: 565-569
  • Peer Reviewed
• [Journal Article] Effect of overexpression of small non-coding DsrA RNA on multidrug efflux in Escherichia coli (2011)
  • Author(s): Nishino K., Yamasaki S., Hayashi-Nishino M., Yamaguchi A.
  • Journal Title: J. Antimicrob. Chemother. Volume: vol.66 Pages: 291-6
  • Peer Reviewed
• [Journal Article] The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720 (2011)
  • Author(s): Hisano Y., Kobayashi N., Kawahara A., Yamaguchi A., Nishi T.
  • Journal Title: J. Biol. Chem. Volume: vol.286 Pages: 1758-1766
  • Peer Reviewed
• [Journal Article] Roles of Salmonella multidrug efflux pumps in tigecycline resistance (2011)
  • Author(s): Horiyama T., Nikaid E., Yamaguchi A., Nishino K.
  • Journal Title: J. Antimicrob. Chemother. Volume: vol.66 Pages: 105-10
  • Peer Reviewed
• [Journal Article] The Multidrug Efflux Pump MdtEF Protects against Nitrosative Damage during the Anaerobic Respiration in Escherichia coli (2011)
  • Author(s): Zhang Y, Xiao M, Horiyama T, Zhang Y, Li X, Nishino K, Yan A
  • Journal Title: The Journal of Biological Chemistry Volume: 286 Issue: 30 Pages: 26576-26584
  • DOI: 10.1074/jbc.m111.243261
  • Peer Reviewed
• [Journal Article] Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket (2011)
  • Author(s): Nakashima R, Sakurai K, Yamasaki S, Nishino K, Yamaguchi A
  • Journal Title: Nature Volume: 480 Issue: 7378 Pages: 565-569
  • DOI: 10.1038/nature10641
  • Peer Reviewed
• [Journal Article] AcrA dependency of the AcrD efflux pump in Salmonella enterica serovar Typhimurium (2011)
  • Author(s): Yamasaki S, Nagasawa S, Hayashi-Nishino M, Yamaguchi A, Nishino K
  • Journal Title: The Journal of Antibiotics Volume: 64 Issue: 6 Pages: 433-437
  • DOI: 10.1038/ja.2011.28
  • NAID: 10030639300
  • Peer Reviewed
• [Journal Article] Evaluation of multidrug efflux pump inhibitors by a new method using microfluidic channels (2011)
  • Author(s): Matsumoto Y, Hayama K, Sakakihara S, Nishino K, Noji H, Iino R, Yamaguchi A
  • Journal Title: PLoS One Volume: 6 Issue: 4 Pages: e18547-e18547
  • DOI: 10.1371/journal.pone.0018547
  • Peer Reviewed
• [Journal Article] Regulation of AcrAB multidrug efflux pump in Salmonella enterica serovar Typhimurium in response to indole and paraquat (2011)
  • Author(s): E.Nikaido, I.Shirosaka, A.Yamaguchi, K.Nishino
  • Journal Title: Microbiology Volume: 158 Pages: 648-655
  • Peer Reviewed
• [Journal Article] Effect of overexpression of small non-coding DsrA RNA on multidrug efflux in Escherichia coli (2011)
  • Author(s): K.Nishino, S.Yamasaki, M.Hayashi-Nishino, A.Yamaguchi
  • Journal Title: The Journal of Antimicrobial Chemotherapy Volume: 66 Pages: 291-296
  • Peer Reviewed
• [Journal Article] Roles of Salmonella multidrug efflux pumps in tigecycline resistance (2011)
  • Author(s): T.Horiyama, E.Nikaido, A.Yamaguchi, K.Nishino
  • Journal Title: The Journal of Antimicrobial Chemotherapy Volume: 66 Pages: 105-110
  • Peer Reviewed
• [Journal Article] Small RNAによる多剤耐性制御 (2011)
  • Author(s): 西野邦彦、山崎聖司、西野-林美都子、山口明人
  • Journal Title: 日本化学療法学会雑誌 Volume: 59 Pages: 1-7
  • NAID: 10027817029
• [Journal Article] TolC dependency of multidrug efflux systems in Salmonella enterica serovar Typhimurium (2010)
  • Author(s): Horiyama T., Yamaguchi A., Nishino K.
  • Journal Title: J. Antimicrob. Chemother. Volume: vol.65 Pages: 1372-6
  • Peer Reviewed
• [Journal Article] Effect of NlpE overproduction on multidrug resistance in Escherichia coli (2010)
  • Author(s): Nishino K., Yamasaki Y., Hayashi-Nishino M., Yamaguchi A.
  • Journal Title: Antimicrob. Agents Chemother. Volume: vol.54 Pages: 2239-2243
  • Peer Reviewed
• [Journal Article] Impact of RNA chaperone Hfq on multidrug resistance in Escherichia coli (2010)
  • Author(s): Yamada J., Yamasaki S., Hirakawa H., Hayashi-Nishino M., Yamaguchi A., Nishino K.
  • Journal Title: J. Antimicrob. Chemother. Volume: vol.65 Pages: 853-858
  • Peer Reviewed
• [Journal Article] The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720 (2010)
  • Author(s): Y.Hisano, N.Kobayashi, A.Kawahara, A.Yamaguchi, T.Nishi
  • Journal Title: The Journal of Biological Chemistry Volume: 286 Pages: 1758-1766
  • Peer Reviewed
• [Journal Article] Indole enhances acid resistance in Escherichia coli (2010)
  • Author(s): H.Hirakawa, M.Hayashi-Nishino, A.Yamaguchi, K Nishino
  • Journal Title: Microbial Pathogenesis Volume: 49 Pages: 90-94
  • Peer Reviewed
• [Journal Article] TolC dependency of multidrug efflux systems in Salmonella enterica serovar Typhimurium (2010)
  • Author(s): T.Horiyama, A.Yamaguchi, K Nishino
  • Journal Title: Journal of Antimicrobial Chemotherapy Volume: 65 Pages: 1372-1376
  • Peer Reviewed
• [Journal Article] Macrophage ABCA5 deficiency influences cellular cholesterol efflux and increases susceptibility to atherosclerosis in female LDLr knockout mice (2010)
  • Author(s): Ye D, Meurs I, Ohigashi M, Calpe-Berdiel L, Habets KL, Zhao Y, Kubo Y, Yamaguchi A, Van Berkel TJ, Nishi T, Van Eck M
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 395 Pages: 387-394
  • Peer Reviewed
• [Journal Article] Effect of NlpE overproduction on multidrug resistance in Escherichia coli (2010)
  • Author(s): K.Nishino, S.Yamasaki, M.Hayashi-Nishino, A.Yamaguchi
  • Journal Title: Antimicrobial Agents and Chemotherapy Volume: 54 Pages: 2239-2243
  • Peer Reviewed
• [Journal Article] Impact of RNA chaperone Hfq on multidrug resistance in Escherichia coli (2010)
  • Author(s): J.Yamada, S.Yamasaki, H.Hirakawa, M.Hayashi-Nishino, A.Yamaguchi, K.Nishino
  • Journal Title: Journal of Antimicrobial Chemotherapy Volume: 65 Pages: 853-858
  • Peer Reviewed
• [Journal Article] A subdomain of the endoplasmic reticulum forms a cradle for autophago someformation (2010)
  • Author(s): Hayashi-Nishino M., Fujita N., Noda T., Yamaguchi A., Yoshimori T., Yamamoto A.
  • Journal Title: Nature cell Biology 11 Pages: 1433-1437
  • Peer Reviewed
• [Journal Article] H-NS modulates multidrug resistance of Salmonella enterica serovar Typhimurium by repressing multidrug efflux genes acrEF (2009)
  • Author(s): Nishino K., Hayashi-Nishino M., Yamaguchi A.
  • Journal Title: Antimicrob Agents Chemother. Volume: vol.53 Pages: 3541-3543
  • Peer Reviewed
• [Journal Article] The Sphingolipid Transporter Spns2 Functions in Migration of Zebrafish Myocardial Precursors (2009)
  • Author(s): Kawahara A., Nishi T., Hisano Y., Fukui H., Yamaguchi A., Mochizuki N.
  • Journal Title: scuence Volume: vol.323 Pages: 524-527
  • Peer Reviewed
• [Journal Article] H-NS modulates multidrug resistance of Salmonella enterica serovar Typhimurium by repressing multidrug efflux genes acrEF (2009)
  • Author(s): Nishino K., Hayashi-Nishino M., Yamaguchi A.
  • Journal Title: Antimicrob. Agents Chemother 53 Pages: 3541-3543
  • Peer Reviewed
• [Journal Article] Characterization of the ATP-dependent sphingosine-1-phosphate transporter in rat erythrocytes, Kobayashi (2009)
  • Author(s): N., Kobayashi N., Yamaguchi A., Nishi T.
  • Journal Title: J.Biol.Chem. 284 Pages: 21192-21200
  • Peer Reviewed
• [Journal Article] The Sphingolipid Transporter Spns2 Functions in Migration of Zebrafish Myocardial Precursors (2009)
  • Author(s): Kawahara A., Nishi T., Hisano Y., Fukui H., Yamaguchi A., Mochizuki N.
  • Journal Title: Science 323 Pages: 524-527
  • Peer Reviewed
• [Journal Article] H-NS modulates multidrug resistance of Salmonella enterica serovar Typhimurium by repressing multidrug efflux genes acrEF (2009)
  • Author(s): Nishino K., Hayashi-Nishino M., Yamaguchi A.
  • Journal Title: Antimicrob Agents Chemother. 53 Pages: 3541-3543
  • Peer Reviewed
• [Journal Article] Characterization of the ATP-dependent sphingosine-1-phosphate transporter in rat erythrocytes (2009)
  • Author(s): Kobayashi N., Kobayashi N., Yamaguchi A., Tsuyoshi N.
  • Journal Title: J.Biol.Chem. 284 Pages: 21192-21200
  • Peer Reviewed
• [Journal Article] スフィンゴシン-1-リン酸の輸送体Spns2は心臓前駆細胞の移動を制御よる (2009)
  • Author(s): 川原敦雄、西毅、山口明人、望月直樹
  • Journal Title: 細胞工学 28 Pages: 390-391
• [Journal Article] Role of the AraC/XylS family regulator YdeO in multidrug resistance of Escherichia coli (2009)
  • Author(s): Nishino K., Senda Y., Hayashi-Nishino M., Yamaguchi A.
  • Journal Title: J.Antibiot. 62 Pages: 251-257
  • NAID: 10030635180
  • Peer Reviewed
• [Journal Article] Regulation and physiological function of multidrug efflux pumps in Escherichia coli and Salmonella (2009)
  • Author(s): Nishino K., Nikaido E., Yamaguchi A.
  • Journal Title: Biochim.Biophys.Acta-Proteins and Proteomics 1794 Pages: 834-843
  • Peer Reviewed
• [Journal Article] The Sphingolipid Transporter Spns2 Functions in Migration of Zebrafish Myocardial Precursors (2009)
  • Author(s): A. Kawahara, T. Nishi, Y. Hisano, H. F., A. Yamaguchi, N. Mochizuki
  • Journal Title: Science 323 Pages: 524-527
  • Peer Reviewed
• [Journal Article] トランスポーターによる多剤認識の構造的基礎 (2009)
  • Author(s): 山口明人, 中島良介
  • Journal Title: 遺伝子医学MOOK12創薬研究者必見! 最新トランスポーター研究2009 12 Pages: 61-66
• [Journal Article] Secreted indole serves as a signal for expression of type III secretion system translocators in enterohaemorrhagic Escherichia coli O157 : H7 (2009)
  • Author(s): H. Hirakawa, T. Kodama, A. Takumi-Kobayashi, T. Honda, A. Yamaguchi
  • Journal Title: Microbiology 155 Pages: 541-550
  • Peer Reviewed
• [Journal Article] AcrAB Multidrug Efflux Pump Regulationin Salmonella enterica serovar Typhimurium by RamA in Response to Environmental Signals (2008)
  • Author(s): Nikaido E., Yamaguchi A., Nishino K.
  • Journal Title: J. Biol. Chem. Volume: vol.283 Pages: 24245-24253
  • Peer Reviewed
• [Journal Article] AcrAB Multidrug Efflux Pump Regulation in Salmonella enterica serovar Typhimurium by RamA in Response to Environmental Signals (2008)
  • Author(s): Nikaido E., Yamaguchi A., Nishino K.
  • Journal Title: J.Biol.Chem. 283 Pages: 24245-24253
  • Peer Reviewed
• [Journal Article] Physiological functions of drug efflux systems in Gram-negative bacteria : Their roles in bacterial drug resistance and virulence (2008)
  • Author(s): K. Nishino, A. Yamaguchi
  • Journal Title: Jaoanese Jouanal Chemotherapy 56 Pages: 443-452
  • NAID: 10022594782
  • Peer Reviewed
• [Journal Article] Virulence and Drug Resistance Roles of Multidrug Efflux Pumps in Escherichia coli and Salmonella (2008)
  • Author(s): K. Nishino, A. Yamaguchi
  • Journal Title: Bioscience and Microflora 27 Pages: 75-85
  • NAID: 10021956022
  • Peer Reviewed
• [Journal Article] AcrS/EnvR Represses the Expression of the acrAB Multidrug Efflux Genes in Escherichia coli (2008)
  • Author(s): H. Hirakawa, A. Takumi-Kobayashi, U. Theisen, T. Hirata, K. Nishino, A. Yamaguchi
  • Journal Title: Journal of Bacteriology 190 Pages: 6276-6279
  • Peer Reviewed
• [Journal Article] AcrAB Multidrug Efflux Pump Regulation in Salmonella enterica serovar Typhimurium by RamA in Response to Environmental Signals (2008)
  • Author(s): E. Nikaido, A. Yamaguchi, K. Nishino
  • Journal Title: The Journal of Biological Chemistry 283 Pages: 24245-24253
  • Peer Reviewed
• [Journal Article] 細菌の異物排出タンパク (2008)
  • Author(s): 山口明人
  • Journal Title: 日本細菌学雑誌 63 Pages: 437-446
• [Journal Article] シナプス終末の内膜系を3Dで見る (2008)
  • Author(s): 西野一林美都子, 山口明人
  • Journal Title: 細胞工学 別冊 電子顕微鏡で読み解く生命のなぞ Pages: 107-113
• [Journal Article] Role of Xenobiotic Transporters in Bacterial Drug Resistance and Virulence (Review) (2008)
  • Author(s): Kunihiko Nishino and Akihito Yamaguchi
  • Journal Title: IUBMB Life (in press)
  • Peer Reviewed
• [Journal Article] CRP regulator modulates multidrug resistance of Escherichia coli by repressing expression of the mdtEF multidrug efflux genes (2008)
  • Author(s): Kunihiko Nishino, Yasuko Senda and Akihito Yamaguchi
  • Journal Title: The Journal of Antibiotics (in press)
• [Journal Article] The AraC-family regulator GadX enhances multidrug resistance of Escherichia coli by activating expression of the mdtEF multidrug efflux genes (2008)
  • Author(s): Kunihiko Nishino, Yasuko Senda and Akihito Yamaguchi
  • Journal Title: Journal of Infection and chemotherapy 14 Pages: 23-29
  • NAID: 10021193134
  • Peer Reviewed
• [Journal Article] Identification of a spermidine excretion protein complex (MdtJI) in Esch erichia coli (2008)
  • Author(s): Kyohei Higashi, Hiroyuki Ishigure, Risa Demizu, Takeshi Uemura, Kunihiko Nishino, Akihito Yamaguchi, Keiko Kashiwagi and Kazuei Igarashi
  • Journal Title: Journal of Bacteriology 190 Pages: 872-878
  • Peer Reviewed
• [Journal Article] Tissue specific expression of the splice variants of the mouse vacuolar proton-translocating ATPase a4 subunit (2008)
  • Author(s): Kawasaki-Nishi Shoko, Yamaguchi Akihito, Forgac Michael and Nishi Tsuyoshi
  • Journal Title: Biochemical and Biophysical Research Communications 364 Pages: 1032-1036
  • Peer Reviewed
• [Journal Article] Regulation mechanism of Salmonella AcrAB-TolC xenobiotic transport system in response to bacterial metabolites (2008)
  • Author(s): Eiji Nikaido, Kunihiko Nishino and Akihito Yamaguchi
  • Journal Title: Journal of the Pharmaceutical Society of Japan 128 Pages: 27-28
• [Journal Article] Rapid detection of drug efflux from single bacterial cell enclosed in femtoliter chamber array (2008)
  • Author(s): Ryota Iino, Kunihiko Nishino, Masayoshi Nakata, Eiji Nikaido, Yoshimi Matsumoto, Syoichi Sakakihara, Syoji Takeuchi, Akihito Yamaguchi and Hiroyuki Noji
  • Journal Title: Micro Total Analysis Systems 1 Pages: 757-759
• [Journal Article] Regulation of multidrug efflux systems involved in multidrug and metal resistance of Salmonella enterica serovar Typhimurium (2008)
  • Author(s): Kunihiko Nishino, Eiji Nikaido and Akihito Yamaguchi
  • Journal Title: Journal of Bacteriology 189 Pages: 9066-9075
  • Peer Reviewed
• [Journal Article] 異物排出タンパクのメカニズム (2008)
  • Author(s): 山口 明人
  • Journal Title: 感染・炎症・免疫 37 Pages: 106-115
• [Journal Article] 大腸菌の異物排出トランスポーターAcrBの構造と異物認識機構 (2008)
  • Author(s): 村上 聡、山口 明人
  • Journal Title: 生化学 79 Pages: 542-549
• [Journal Article] Regulation of multidrug efflux systems involved in multidrug and metal resistance of Salmonella enterica serovar Typhimurium (2007)
  • Author(s): Nishino K., Nikaido E., Yamaguchi A.
  • Journal Title: J.Bacteriol. 189 Pages: 9066-9075
  • Peer Reviewed
• [Journal Article] Effect of NlpE overproduction on multidrug resistance in Escherichia coli
  • Author(s): Nishino K., Yamasaki S., Hayashi-Nishino M., Yamaguchi A.
  • Journal Title: Antimicrob.Agents Chemother. (in press)
  • Peer Reviewed
• [Journal Article] Impact of RNA chaperone Hfq on Multidrug resistance in Escherichia coli
  • Author(s): Yamada J., Yamasaki S., Hirakawa H., Hayashi-Nishino M., Yamaguchi A., Nishino K.
  • Journal Title: J.Antimicrob.Chemother. (in press)
  • Peer Reviewed
• [Presentation] Regulation of the AcrAB xenobiotic transport system in response to environmental signals (2012)
  • Author(s): Kunihiko Nishino, Eiji Nikaido, Ikue Shirosaka, Seiji Yamasaki
  • Organizer: 第85回日本細菌学会総会
  • Place of Presentation: 長崎
  • Year and Date: 2012-03-29
• [Presentation] Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket (2012)
  • Author(s): Seiji Yamasaki, Ryosuke Nakashima, Keisuke Sakurai, Kunihiko Nishino, Akihito Yamaguchi
  • Organizer: 第85回日本細菌学会総会
  • Place of Presentation: 長崎
  • Year and Date: 2012-03-29
• [Presentation] Immuno-Electron Tomography for Elucidation of Localization of the Mutidrug Efflux Pump in Salmonella (2012)
  • Author(s): Mitsuko Hayashi-Nishino, Akihito Yamaguchi, Kunihiko Nishino
  • Organizer: 第85回日本細菌学会総会
  • Place of Presentation: 長崎
  • Year and Date: 2012-03-29
• [Presentation] Outer Membrane Permeabilizing Effects of Phe-Arg-β-Naphthylamide on Pseudomonas aeruginosa (2012)
  • Author(s): Yoshimi Matsumoto, Kunihiko Nishino, Akihito Yamaguchi
  • Organizer: 第85回日本細菌学会総会
  • Place of Presentation: 長崎
  • Year and Date: 2012-03-27
• [Presentation] 外膜透過性亢進薬としてのPhe-Arg-β-naphtylamide (PAN) (2012)
  • Author(s): 松本佳巳, 西野邦彦, 山口明人
  • Organizer: 第46回緑膿菌感染症研究会
  • Place of Presentation: 東京
  • Year and Date: 2012-02-17
• [Presentation] Electron/Immuno-electron Tomography of Autophagosomal Membranes and Bacterial Multidrug Efflux Systems (2012)
  • Author(s): Mitsuko Hayashi-Nishino
  • Organizer: The 15th SANKEN International Symposium 2012, The 10th SANKEN Nanotechnology Symposium
  • Place of Presentation: 大阪
  • Year and Date: 2012-01-13
• [Presentation] Mechanism of multidrug recognition by the RamR regulatory protein required for the induction of the AcrAB multidrug efflux pump (2012)
  • Author(s): S.Yamasaki, E.Nikaido, K.Sakurai, R.Nakashima, A.Yamaguchi, K.Nishino
  • Organizer: The 15th SANKEN International Symposium 2012, The 10th SANKEN Nanotechnology Symposium
  • Place of Presentation: 大阪
  • Year and Date: 2012-01-12
• [Presentation] 生物による異物認識の原点:異物排出タンパクの構造に見る異物認識原理 (2011)
  • Author(s): 山口明人
  • Organizer: 第3回知の拠点セミナー
  • Place of Presentation: 東京(招待)
  • Year and Date: 2011-12-16
• [Presentation] マイクロデバイスを用いた簡易迅速多剤耐性緑膿菌検出法 (2011)
  • Author(s): 松本佳巳
  • Organizer: 第40回薬剤耐性菌研究会
  • Place of Presentation: 群馬
  • Year and Date: 2011-12-01
• [Presentation] マイクロデバイスを用いた簡易迅速多剤耐性緑膿菌(MDRP)検出法 (2011)
  • Author(s): 葉山浩平、松本佳巳、西野邦彦、山口明人
  • Organizer: 第59回日本化学療法学会西日本支部総会/第54回日本感染症学会中日本地方会学術集会
  • Place of Presentation: 奈良
  • Year and Date: 2011-11-25
• [Presentation] 排出タンパクによる異物認識機構-最新の知見 (2011)
  • Author(s): 山口明人
  • Organizer: 第33回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 岡山(招待)
  • Year and Date: 2011-11-24
• [Presentation] サルモネラ薬物排出トランスポーターの生理機能解析 (2011)
  • Author(s): 大野愛子、尾島学、西野美都子、山口明人、西野邦彦
  • Organizer: 第33回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 岡山
  • Year and Date: 2011-11-24
• [Presentation] 細菌異物排出トランスポーターの機能解析 (2011)
  • Author(s): 山崎聖司、中島良介、櫻井啓介、西野邦彦、山口明人
  • Organizer: 第33回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 岡山
  • Year and Date: 2011-11-24
• [Presentation] 生物はいかにして異物を認識するか (2011)
  • Author(s): 山口明人
  • Organizer: 産業科学研究第67回学術講演会
  • Place of Presentation: 大阪
  • Year and Date: 2011-11-22
• [Presentation] 多剤耐性サルモネラ異物排出トランスポーターAcrB発現制御機構の解析 (2011)
  • Author(s): 山崎優、二階堂英司、城阪郁江、櫻井啓介、中島良介、山口明人、西野邦彦
  • Organizer: 産業科学研究第67回学術講演会
  • Place of Presentation: 大阪
  • Year and Date: 2011-11-22
• [Presentation] 新たな共結晶構造から明らかになった多剤排出タンパクAcrBの多剤認識機構 (2011)
  • Author(s): 山崎聖司, 中島良介, 櫻井啓介, 西野邦彦, 山口明人
  • Organizer: 第64回日本細菌学会関酉支部総会
  • Place of Presentation: 大阪
  • Year and Date: 2011-11-19
• [Presentation] Immuno-electron tomography for elucidation of localization of the mutidrug efflux pumps in Salmonella (2011)
  • Author(s): Mitsuko Hayashi-Nishino, Akihito Yamaguchi, Kunihiko Nishino
  • Organizer: 7th Handai Nanoscience and Nanotechnology International Symposium
  • Place of Presentation: 大阪
  • Year and Date: 2011-11-11
• [Presentation] Peristaltic Mechanism of Multidrug Efflux Transporter AcrB Revealed by the Crystal Structure of AcrB with High-Molecular-Weight Drugs (2011)
  • Author(s): Nakashima R., Sakurai K., Yamasaki S., Nishino K., Yamaguchi A.
  • Organizer: 7th Handai Nanoscience and Nanotechnology International Symposium
  • Place of Presentation: 大阪
  • Year and Date: 2011-11-10
• [Presentation] マイクロデバイスを用いた迅速多剤耐性緑膿菌(MDRP)検出法 (2011)
  • Author(s): 葉山浩平、松本佳巳、西野邦彦、山口明人
  • Organizer: 第58回日本化学療法学会東日本支部総会/第60回日本感染症学会東日本地方学術集会合同学会
  • Place of Presentation: 山形
  • Year and Date: 2011-10-27
• [Presentation] Deveropment of novel therapeutic strategies to tackle multidrug-resistant pathogens (2011)
  • Author(s): Mitsuko Hayashi-Nishino, Ryosuke Nakashima, Keisuke Sakurai, Akihito Yamaguchi, Kunihiko Nishino
  • Organizer: FRANCE-JAPAN WORKSHOP, Bio-inspired approaches : Micro-& Nano-Architectures, Materials & Imaging
  • Place of Presentation: France
  • Year and Date: 2011-10-11
• [Presentation] Peristaltic mechanism of multidrug efflux transport (2011)
  • Author(s): Akihito Yamaguchi, Ryosuke Nakashima, Keisuke Sakurai, Seiji Yamasaki, Kunihiko Nishino
  • Organizer: FRANCE-JAPAN WORKSHOP, Bio-inspired approaches : Micro-& Nano-Architectures, Materials & Imaging
  • Place of Presentation: France
  • Year and Date: 2011-10-11
• [Presentation] Small RNAによる細菌多剤耐性化メカニズムの解明 (2011)
  • Author(s): 山崎聖司、西野-林美都子、山口明人、西野邦彦
  • Organizer: 第84回日本生化学大会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-24
• [Presentation] サルモネラ異物排出トランスポーターAcrB発現制御ネットワーク解析 (2011)
  • Author(s): 山崎優, 二階堂英司, 城阪郁江, 櫻井啓介, 中島良介, 山口明人, 西野邦彦
  • Organizer: 第84回日本生化学大会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-24
• [Presentation] Antibiotic Augmenting Activities of Phe-Arg-β-Naphthylamide Based on its Membrane Permeabilizing Effects (2011)
  • Author(s): Y.Matsumoto, K.Nishino, A.Yamaguchi
  • Organizer: 51st Interscience Conference on Antimicrobial Agents and Chemotherapy(ICAAC)
  • Place of Presentation: U.S.A.
  • Year and Date: 2011-09-18
• [Presentation] Effect of efflux pump inhibition versus outer membrane permeabilization to antimicrobial activities of ciprofloxacin and erythromycin against Pseudomonas aeruginosa (2011)
  • Author(s): Y.MATSUMOTO, K.NISHINO, A.YAMAGUCHI
  • Organizer: 国際微生物学連盟2011(IUMS 2011)会議/第84回日本細菌学会総会
  • Place of Presentation: 北海道
  • Year and Date: 2011-09-10
• [Presentation] AcrA dependency of the AcrD efflux pump in Salmonella enterica serovar typhimurium (2011)
  • Author(s): Seiji Yamasaki, Saya Nagasawa, Mitsuko Hayashi-Nishino, Akihito Yamaguchi, Kunihiko Nishino
  • Organizer: 国際微生物学連盟2011(IUMS 2011)会議/第84回日本細菌学会総会
  • Place of Presentation: 北海道
  • Year and Date: 2011-09-10
• [Presentation] 多剤耐性サルモネラ異物排出トランスポーターAcrB発現制御因子RamRと基質との相互作用解析 (2011)
  • Author(s): 山崎優, 二階堂英司, 櫻井啓介, 中島良介, 山口明人, 西野邦彦
  • Organizer: 第5回細菌学若手コロッセウム
  • Place of Presentation: 高知
  • Year and Date: 2011-08-10
• [Presentation] マルチコンポーネント型薬剤排出蛋白質の機能解明 (2011)
  • Author(s): 西野邦彦、中島良介、西野美都子
  • Organizer: 新学術領域研究「過渡的複合体」公開シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2011-07-11
• [Presentation] The Reguration of the AcrAB multidrug efflux pump in Salmonella (2011)
  • Author(s): Suguru Yamasaki, nikaido eiji, Keisuke Sakurai, Ryousuke Nakashima, Akihito Yamaguchi, Kunihiko Nishino
  • Organizer: France 4th Symposium on Antimicrobial Resistance in Animals and the Environment
  • Place of Presentation: France
  • Year and Date: 2011-06-28
• [Presentation] 排出ポンプ阻害薬と外膜透過性亢進薬の有用性 (2011)
  • Author(s): 松本佳巳、西野邦彦、山口明人
  • Organizer: 第59回日本化学療法学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2011-06-25
• [Presentation] Structural basis of multidrug efflux (2011)
  • Author(s): Yamaguchi A.
  • Organizer: The 80th Anniversary Commemoration of Osaka University International Symposium Series
  • Place of Presentation: Hampshire Hotel-Plaza(Groningen, The Netherlands)(招待講演)
  • Year and Date: 2011-06-22
• [Presentation] Structural basis of multidrug efflux (2011)
  • Author(s): Akihito Yamaguchi
  • Organizer: The 80th Anniversary Commemoration of Osaka University International Symposium Series
  • Place of Presentation: Netherlands(招待)
  • Year and Date: 2011-06-22
• [Presentation] Development of novel therapeutic strategies to tackle multidrug-resistant pathogens (2011)
  • Author(s): Nishino, K., S.Yamasaki, M.Hayashi-Nishino, A.Yamaguchi
  • Organizer: The American Association for the Advancement of Science (AAAS) 2011 Annual Meeting
  • Place of Presentation: Washington, DC, U.S.A.
  • Year and Date: 2011-02-20
• [Presentation] 排出ポンプ阻害剤Phe-Arg-ss-naphtylamide (PAN)の作用メカニズム (2011)
  • Author(s): 松本佳巳、葉山浩平、飯野亮太、西野邦彦、野地博行、山口明人
  • Organizer: 第45回緑膿菌感染症研究会
  • Place of Presentation: 仙台、宮城
  • Year and Date: 2011-02-04
• [Presentation] Streptococcus pneumoniaeの自然免疫回避におけるPfbAの役割 (2011)
  • Author(s): 山口雅也、寺尾豊、西野邦彦、山口明人、浜田茂幸、川端重忠
  • Organizer: 第3回口腔環境制御研究カテゴリー集会
  • Place of Presentation: 長崎
  • Year and Date: 2011-02-04
• [Presentation] Function of mammalian sphingosin 1-phosphate transporter (2011)
  • Author(s): Nishi, T., Hisano, Y., Kawasaki-Nishi, S., Yamaguchi, A.
  • Organizer: The 14^<th> SANKEN international symposium
  • Place of Presentation: ロイヤルオークホテル、大津
  • Year and Date: 2011-01-25
• [Presentation] Functional network of multi-component drug efflux systems in Salmonella enterica serovar typhimurium (2011)
  • Author(s): Yamasaki, S., S.Nagasawa, M.Hayashi-Nishino, A.Yamaguchi, K.Nishino
  • Organizer: The 14^<th> SANKEN international symposium
  • Place of Presentation: ロイヤルオークホテル、大津
  • Year and Date: 2011-01-25
• [Presentation] 異物排出タンパクAcrBに存在する基質結合マルチサイトの解明 (2011)
  • Author(s): 櫻井啓介、中島良介、山崎聖司、西野邦彦、山口明人
  • Organizer: 平成23年度日本結晶学会年会
  • Place of Presentation: 北海道
• [Presentation] スフィンゴシン1リン酸輸送体の同定と機能解析 (2010)
  • Author(s): 西毅、小林直木、久野悠、川原敦雄、山口明人
  • Organizer: 日本生体エネルギー研究会第35回討論会
  • Place of Presentation: 北海道
  • Year and Date: 2010-12-19
• [Presentation] Functional analysis of a novel S1P transporter, SPNS2 (2010)
  • Author(s): Y.Hisano, A.Yamaguchi, T.Nishi
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 兵庫
  • Year and Date: 2010-12-09
• [Presentation] TolC dependency of multidrug efflux systems in Salmonella enterica serovar Typhimurium (2010)
  • Author(s): T.Horiyama, A.Yamaguchi, K.Nishino
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 兵庫
  • Year and Date: 2010-12-09
• [Presentation] サルモネラ異物排出トランスポーターAcrABの発現制御に関与するRamRの解析 (2010)
  • Author(s): 二階堂英司、櫻井啓介、中島良介、城阪郁江、山口明人、西野邦彦
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 兵庫
  • Year and Date: 2010-12-09
• [Presentation] RNA chaperone regulates the multidrug transporter AcrB in Escherichia coli (2010)
  • Author(s): S.Yamasaki, J.Yamada, H.Hirakawa, M.Hayashi-Nishino, A.Yamaguchi, K.Nishino
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 兵庫
  • Year and Date: 2010-12-09
• [Presentation] Streptococcus pneumoniaeは赤血球に侵入し好中球免疫を回避する (2010)
  • Author(s): 山口雅也、寺尾豊、八木哲也、西野邦彦, 山口明人、川端重忠
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 兵庫
  • Year and Date: 2010-12-07
• [Presentation] サルモネラ異物排出トランスポーターAcrAB発現制御因子RamRの構造機能解析 (2010)
  • Author(s): 二階堂英司、櫻井啓介、中島良介、城阪郁江、山口明人、西野邦彦
  • Organizer: 平成22年度日本結晶学会年会
  • Place of Presentation: 大阪大学コンベンションセンター
  • Year and Date: 2010-12-03
• [Presentation] Role of the RNA chaperon Hfq in multidrug resistance of Escherichia coli (2010)
  • Author(s): Nishino, K., S.Yamasaki, M.Hayashi-Nishino, A.Yamaguchi
  • Organizer: Joint meeting of the NZ Microbiological Society and NZ Society for Biochemistry & Molecular Biology
  • Place of Presentation: The Univ.Auckland, New Zealand
  • Year and Date: 2010-12-01
• [Presentation] 免疫抑制剤FTY720の作用機序におけるS1P輸送体SPNS2の役割 (2010)
  • Author(s): 久野悠、山口明人、西毅
  • Organizer: 第32回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 富山
  • Year and Date: 2010-11-29
• [Presentation] S1P輸送体SPNS2の生理機能の解析 (2010)
  • Author(s): 西毅、久野悠、山口明人
  • Organizer: 第36回日本生体エネルギー研究会
  • Place of Presentation: 大阪大学銀杏会館
  • Year and Date: 2010-11-19
• [Presentation] 排出ポンプ阻害剤Phe-Arg-ss-naphtylamide (PAN)の外膜障害作用 (2010)
  • Author(s): 松本佳巳、葉山浩平、飯野亮太、西野邦彦、野地博行、山口明人
  • Organizer: 第39回薬剤耐性菌研究会
  • Place of Presentation: 伊香保、群馬
  • Year and Date: 2010-11-12
• [Presentation] サルモネラ異物排出トランスポーターAcrAB発現制御因子RamRのX線結晶構造解析 (2010)
  • Author(s): 二階堂英司、櫻井啓介、西野邦彦、山口明人、中島良介
  • Organizer: 第48回日本生物物理学会
  • Place of Presentation: 東北大、宮城
  • Year and Date: 2010-09-21
• [Presentation] TolC dependency of multidrug efflux systems in Salmonella enterica serovar Typhimurium (2010)
  • Author(s): T.Horiyama, A.Yamaguchi, K.Nishino
  • Organizer: The 10th Awaji International Forum on Infection and Immunity
  • Place of Presentation: Awaji, Hyogo
  • Year and Date: 2010-09-09
• [Presentation] Impact of Hfq on multidrug resistance in Escherichia coli (2010)
  • Author(s): S.Yamasaki, J.Yamada, H.Hirakawa, M.Hayashi-Nishino, A.Yamaguchi, K.Nishino
  • Organizer: The 10th Awaji International Forum on Infection and Immunity
  • Place of Presentation: Awaji, Hyogo
  • Year and Date: 2010-09-09
• [Presentation] The analysis of sphingosine 1-phosphate secretion from cells expressing Spns2 (2010)
  • Author(s): Hisano, Y., Yamaguchi, A., Nish, T.
  • Organizer: 51st International conference on the Bioscience of Lipids
  • Place of Presentation: Alhondiga Conference Center, Bilbao, Spain
  • Year and Date: 2010-09-07
• [Presentation] サルモネラ異物排出トランスポーターAcrAB発現制御メカニズムの解析 (2010)
  • Author(s): 二階堂英司、櫻井啓介、中島良介、城阪郁江、山口明人、西野邦彦
  • Organizer: 第22回微生物シンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-04
• [Presentation] 大腸菌多剤耐性化におけるRNAシャペロンHfqの役割 (2010)
  • Author(s): 山崎聖司、山田純子、平川秀忠、西野美都子、山口明人、西野邦彦
  • Organizer: 第22回微生物シンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-04
• [Presentation] Structural basis of multidrug recognition (2010)
  • Author(s): Yamaguchi A.
  • Organizer: Nanofair 2010-8th International Nanotechnology Symposium
  • Place of Presentation: International Congress Center(Dresden, Germany)(招待講演)
  • Year and Date: 2010-07-06
• [Presentation] Structural basis of multidrug recognition (2010)
  • Author(s): Akihito Yamaguchi
  • Organizer: Nanofair 2010 8th International Nanotechnology Symposium
  • Place of Presentation: International Congress Center Dresden, Germany(招待講演)
  • Year and Date: 2010-07-06
• [Presentation] Sphingoshine 1-Phosphate Efflux Transporter (2010)
  • Author(s): Akihito Yamaguchi
  • Organizer: The 27th Naito Conference, Membrane Dynamics and Lipid Biology[I]
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2010-07-01
• [Presentation] Analysis of the mammalian sphingosine 1-phosphate transporters (2010)
  • Author(s): Nishi T., Hisano Y., Kobayashi N., Yamaguchi A.
  • Organizer: The 27th Naito Conference, Membrane Dynamics and Lipid Biology[I]
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2010-07-01
• [Presentation] Functional analysis of novel S1P transporter, Spns2 (2010)
  • Author(s): Hisano, Y., Yamaguchi, A., Nishi T.
  • Organizer: The 27th Naito Conference, Membrane Dynamics and Lipid Biology[I]
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2010-06-29
• [Presentation] サルモネラ異物排出トランスポーターAcrABの発現制御機構解析 (2010)
  • Author(s): 二階堂英司、城阪郁江、中島良介、櫻井啓介、山口明人、西野邦彦
  • Organizer: 第10回日本蛋白質科学会年会
  • Place of Presentation: 札幌
  • Year and Date: 2010-06-16
• [Presentation] スフィンゴシン1リン酸輸送体の同定と生理機能の解析 (2010)
  • Author(s): 西毅、久野悠、山口明人
  • Organizer: 第52回日本脂質生化学会
  • Place of Presentation: 伊香保・森秋旅館
  • Year and Date: 2010-06-14
• [Presentation] Overexpressed Lipoprotein Increases Multidrug Resistance by Induction of Multidrug Transporters in E.coli (2010)
  • Author(s): S.Yamasaki, M.Hayashi-Nishino, A.Yamaguchi, K.Nishino
  • Organizer: American Society for Microbiology 110th General Meeting
  • Place of Presentation: San Diego, U.S.A.
  • Year and Date: 2010-05-25
• [Presentation] Electron Tomography Revealed the Endoplasmic Reticulum as a Source of Autophagosomal Membranes (2010)
  • Author(s): M.Hayashi-Nishino, N.Fujita, T.Noda, A.Yamaguchi, K.Nishino, T.Yoshimori, A.Yamamoto
  • Organizer: American Society for Microbiology 110th General Meeting
  • Place of Presentation: San Diego, U.S.A.
  • Year and Date: 2010-05-24
• [Presentation] 大腸菌マクロライド排出蛋白質の膜局在 (2010)
  • Author(s): 平田隆弘、北村昭夫、西野邦彦、山口明人
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-28
• [Presentation] 大腸菌薬剤排出ポンプ制御におけるNlpEの役割 (2010)
  • Author(s): 山崎聖司、西野美都子、山口明人、西野邦彦
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-28
• [Presentation] S1P輸送体Spns2のヒトオルソログの機能解析 (2010)
  • Author(s): 久野悠、川原敦雄、山口明人、西毅
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-28
• [Presentation] サルモネラ異物排出トランスポーターAcrABの発現制御ネットワーク解析 (2010)
  • Author(s): 二階堂英司、城阪郁江、中島良介、山口明人、西野邦彦
  • Organizer: 第83回日本細菌学会総会
  • Place of Presentation: 神奈川
  • Year and Date: 2010-03-27
• [Presentation] Effects of pyridopyrimidine(PP)and Phe-Arg-β-naphthylamide(PAN)on MexB & MexY in Escherichia coli (2010)
  • Author(s): Matsumoto Y., Hayama K., Iino R., Nishino K., Noji H., Yamaguchi A.
  • Organizer: 第83回日本細菌学会総会
  • Place of Presentation: 神奈川
  • Year and Date: 2010-03-27
• [Presentation] 大腸菌を用いた緑膿菌のRND型排出ポンプMexABおよびMexXYの活性測定 (2010)
  • Author(s): 松本佳巳、葉山浩平、飯野亮太、西野邦彦、野地博行、山口明人
  • Organizer: 第42回緑膿菌感染症研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-02-12
• [Presentation] Effects of NlpE overproduction on the induction of xenobiotic transporters involved in multidrug resistance in Escherichia coli (2010)
  • Author(s): Yamasaki S., Nishino-Hayashi M., Yamaguchi A., Nishino K.
  • Organizer: The 13th SANKEN International Symposium
  • Place of Presentation: 大阪
  • Year and Date: 2010-01-18
• [Presentation] 新規S1P輸送体Spns2の機能解析 (2009)
  • Author(s): 久野悠、川原敦雄、山口明人、西毅
  • Organizer: 日本生体エネルギー研究会第35回討論会
  • Place of Presentation: 北海道
  • Year and Date: 2009-12-19
• [Presentation] Functional analysis of human spinster-like protein 3 ; a homologue of sphingosine 1-phosphate transporter, spns2 (2009)
  • Author(s): Murata M., Hisano Y., Yamaguchi A., Nishi T.
  • Organizer: 第31回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-01
• [Presentation] Electron tomography revealed a subdomain of the endoplasmic reticulum as a cradle for autophagosome formation (2009)
  • Author(s): Hayashi-Nishino M., Fujita N., Noda T., Yamaguchi A., Nishino K., Yoshimori T., Yamamoto A.
  • Organizer: 第31回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-01
• [Presentation] Characterization of the sphingoshin-1-phosphate transporter (2009)
  • Author(s): Nishi N., Kobayashi N., Hisano Y., Yamaguchi A.
  • Organizer: 第31回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2009-11-30
• [Presentation] The localization study of a bacterial efflux transporter (2009)
  • Author(s): Hirata T., Kitamura A., Nishino K., Yamaguchi A.
  • Organizer: 第31回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2009-11-30
• [Presentation] Regulation mechanism of Salmonella AcrAB Multidrug Efflux Pump in Response to Extracellular Signals (2009)
  • Author(s): Nikaido E., Shirosaka I., Nakashima R., Yamaguchi A., Nishino K.
  • Organizer: 第31回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2009-11-30
• [Presentation] サルモネラ多剤排出トランスポーターの生理機能解明 (2009)
  • Author(s): 西野邦彦、二階堂英司、松本佳巳、山口明人
  • Organizer: 第57回日本化学療法学会西日本支部総会
  • Place of Presentation: 愛知
  • Year and Date: 2009-11-28
• [Presentation] スフィンゴシン1-リン酸(S1P)輸送体Spns2による心臓発生の制御機構 (2009)
  • Author(s): 久野悠、川原敦雄、山口明人、西毅、望月直樹
  • Organizer: 第19回日本循環薬理学会
  • Place of Presentation: 京都
  • Year and Date: 2009-11-27
• [Presentation] Fluorescein di-β-D-galactopyranoside(FDG)を用いた排出ポンプ阻害剤の評価 (2009)
  • Author(s): 松本佳巳、葉山浩平、飯野亮太、西野邦彦、野地博行、山口明人
  • Organizer: 第38回薬剤耐性菌研究会
  • Place of Presentation: 群馬
  • Year and Date: 2009-11-19
• [Presentation] Sphingosine 1-phosphate Exporter Spins2 Identification of the transporter that export sphingosine 1-phosphate from the cells (2009)
  • Author(s): Yamaguchi A.
  • Organizer: 11th International Conference
  • Place of Presentation: Cancun, Mexico
  • Year and Date: 2009-10-27
• [Presentation] 外部シグナルによるサルモネラ異物排出トランスポーターAcrAB発現制御メカニズム解析 (2009)
  • Author(s): 二階堂英司、城阪郁江、中島良介、山口明人、西野邦彦
  • Organizer: 第3回細菌学・若手コロッセウム
  • Place of Presentation: 宮崎
  • Year and Date: 2009-10-26
• [Presentation] Salmonella gene regulation mechanism by RamA in response to signals(口頭) (2009)
  • Author(s): Nikaido E., Shirosaka I, Nakashima R., Yamaguchi A., Nishino K.
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 兵庫
  • Year and Date: 2009-10-24
• [Presentation] Salmonella gene regulation mechanism by RamA in response to signals(ポスター) (2009)
  • Author(s): Nikaido E., Shirosaka I, Nakashima R., Yamaguchi A., Nishino K.
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 兵庫
  • Year and Date: 2009-10-24
• [Presentation] Spns2はスフィンゴシン-1-リン酸(S1P)の細胞外への放出を制御する (2009)
  • Author(s): 川原敦雄、西毅、久野悠、山口明人、望月直樹
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 兵庫
  • Year and Date: 2009-10-23
• [Presentation] スフィンゴシン1-リン酸(S1P)の光反応性アナログを用いたS1P輸送体の探索 (2009)
  • Author(s): 小林直木、西毅、山口明人
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 兵庫
  • Year and Date: 2009-10-22
• [Presentation] 血小板モデル細胞を用いたS1P輸送体の探索 (2009)
  • Author(s): 久野悠、山口明人、西毅
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 兵庫
  • Year and Date: 2009-10-22
• [Presentation] Roles of xenobiotic transporters in bacterial drug resistance and virulence (2009)
  • Author(s): Nishino K., Yamaguchi A.
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 兵庫
  • Year and Date: 2009-10-22
• [Presentation] Effects of lipoprotein overproduction on the induction of xenobiotic transporters involved in multidrug resistance in Salmonella enterica (2009)
  • Author(s): Shirosaka I., Nikaido E., Yamaguchi A., Nishino K.
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 兵庫
  • Year and Date: 2009-10-22
• [Presentation] Roles of bacterial xenobiotic transporters in immune evasion (2009)
  • Author(s): Ueda T., Hayashi-Nishino M., Yamaguchi A., Nishino K.
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 兵庫
  • Year and Date: 2009-10-22
• [Presentation] Autophagy and the Endoplasmic Reticulum (2009)
  • Author(s): Hayashi-Nishino M., Fujita N., Noda T., Yamaguchi A., Yoshimori T., Yamamoto A.
  • Organizer: 5th International Symposium on Autophagy
  • Place of Presentation: 滋賀
  • Year and Date: 2009-09-25
• [Presentation] Membrane-damaging activity of Phe-Arg-β-Naphthylamide in Escherichiacol (2009)
  • Author(s): Matsumoto Y., Hayama K., Iino R., Nishino K., Noji H., Yamaguchi A.
  • Organizer: 49years ICAAC, Interscience Conference on Antimicrobial Agents and Chemotherapy
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2009-09-14
• [Presentation] Roles of xenobiotic transporters in bacterial drug resistance and virulence (2009)
  • Author(s): Nishino, K., Yamaguchi A.
  • Organizer: The Awaji International Forum on Infection and Immunity
  • Place of Presentation: 兵庫
  • Year and Date: 2009-09-08
• [Presentation] 大腸菌RND型薬剤排出ポンプの進化 (2009)
  • Author(s): 田中真奈美、川下理日人、高木達也、安永照雄、山口明人、西野邦彦
  • Organizer: 第11回日本進化学会大会
  • Place of Presentation: 北海道
  • Year and Date: 2009-09-03
• [Presentation] 排出ポンプ阻害活性と膜障害作用の分離評価 (2009)
  • Author(s): 松本佳巳、西野邦彦、飯野亮太、野地博行、山口明人
  • Organizer: 第57回日本化学療法学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-06-03
• [Presentation] Electron Tomography Revealed a Subdomain of the Endoplasmic Reticulum as a Cradle for Autophagosome Formation (2009)
  • Author(s): Hayashi-Nishlino M., Fujita N., Noda T., Yamaguchi A., Yoshimori T., Yamamoto A.
  • Organizer: 第61回日本細胞生物学会大会
  • Place of Presentation: 愛知
  • Year and Date: 2009-06-03
• [Presentation] ラット赤血球におけるATP依存的スフィンゴシン1リン酸輸送体の解析 (2009)
  • Author(s): 小林直木、小林伸好、西毅、山口明人
  • Organizer: 第4回トランスポーター研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-05-23
• [Presentation] 血小板様分子を産生するMEG-01細胞を用いたS1P輸送体の探索 (2009)
  • Author(s): 久野悠、西毅、山口明人
  • Organizer: 第4回トランスポーター研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-05-23
• [Presentation] サルモネラ異物排出トランスポーターAcrAB誘導に関与するRamAおよびRamRの解析 (2009)
  • Author(s): 城阪郁江、二階堂英司、中島良介、山口明人
  • Organizer: 第9回日本蛋白質科学会年会
  • Place of Presentation: 熊本
  • Year and Date: 2009-05-20
• [Presentation] Sphingosine-1-phosphate (S1P) Release From Erythrocytes Mediated By ATP-dependent Transporter (2009)
  • Author(s): N. Kobayashi, N. Kobayashi, T. Nishi, A. Yamaguchi
  • Organizer: 12th Sanken International Symposium/7th nanote chnology center international symposium/2nd MSTEC international symposium/1st Sanken Alliance Symposium
  • Place of Presentation: Osaka
  • Year and Date: 2009-01-22
• [Presentation] Identification of the transporter that export sphingosine 1-phosphate from the cells (2009)
  • Author(s): Yamaguchi A.
  • Organizer: 11th International Conference-Cancun
  • Place of Presentation: Mexico
• [Presentation] AcrAB multidrug efflux pump regulation in Salmonella enterica serovar Typhimurium by RamA in response to environmental signals (2008)
  • Author(s): K. Nishino, E. Nikaido, A. Yamaguchi
  • Organizer: The Awaji International Forum on Infection and Immunity
  • Place of Presentation: 兵庫
  • Year and Date: 2008-09-10
• [Presentation] サルモネラ異物排出トランスポーターAcrABの発現制御と環境応答におけるRamAの役割 (2008)
  • Author(s): 二階堂英司, 西野邦彦, 山口明人
  • Organizer: 第2回細菌学・若手コロッセウム
  • Place of Presentation: 神奈川
  • Year and Date: 2008-08-03
• [Presentation] 排出機構 -多剤耐性化と病原因子のキー・プレイヤー (2008)
  • Author(s): 西野邦彦
  • Organizer: 第82回日本感染症学会総会
  • Place of Presentation: 島根
  • Year and Date: 2008-04-17
• [Presentation] Metal Resistance Roles of Multidrug Transporters in Salmonella enterica (2008)
  • Author(s): ○西野 邦彦、二階堂 英司、山口 明人
  • Organizer: 日本薬学会第128回年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-28
• [Presentation] サルモネラ異物排出トランスポーターAcrAB制御因子の同定 (2008)
  • Author(s): ○二階堂 英司 、西野 邦彦、山口 明人
  • Organizer: 日本薬学会第128回年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-28
• [Presentation] サルモネラ異物排出トランスポーターEmrABの機能解析 (2008)
  • Author(s): ○坂田 博樹、西野 邦彦、山口 明人
  • Organizer: 日本薬学会第128回年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-28
• [Presentation] Characterization of ATP-dependent transport of the sphingosine-1-phosphate (S1P) in rat erythrocytes (2008)
  • Author(s): ○小林 直木、小林 信好、西 毅、山口 明人
  • Organizer: 日本薬学会第128回年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-28
• [Presentation] Analysis of the S1P transporter in MEG-01 cell line (2008)
  • Author(s): ○久野 悠、西 毅、山口 明人
  • Organizer: 日本薬学会第128回年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-28
• [Presentation] Analysis of the expression site and the physiological role of mouse ABC A5 (2008)
  • Author(s): ○大東 穂、西 毅、山口 明人
  • Organizer: 日本薬学会第128回年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-27
• [Presentation] Cellular localization of drug efflux transporters in Escherichia coli (2008)
  • Author(s): ○平田 隆弘、北村 昭夫、西野 邦彦、山口 明人
  • Organizer: 日本薬学会第128回年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-27
• [Presentation] 異物排出トランスポーターの構造・機能とその制御に関する研究 (2008)
  • Author(s): 山口明人
  • Organizer: 日本薬学会第128回年会
  • Place of Presentation: パシフィコ横浜(横浜)(日本薬学会賞受賞公演、招待講演)
  • Year and Date: 2008-03-26
• [Presentation] Studies on the Structure, Function and Regulation of Xenobiotic Exporters (2008)
  • Author(s): ○山口 明人
  • Organizer: 日本薬学会第128回年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-26
• [Presentation] サルモネラ異物排出トランスポーターAcrAB生理的役割と発現誘導機構の解析 (2008)
  • Author(s): ○二階堂 英司、西野 邦彦、山口 明人
  • Organizer: 第81回日本細菌学会総会
  • Place of Presentation: 京都
  • Year and Date: 2008-03-26
• [Presentation] サルモネラ異物排出トランスポーターEmrABの機能解析 (2008)
  • Author(s): ○坂田 博樹、西野 邦彦、山口 明人
  • Organizer: 第81回日本細菌学会総会
  • Place of Presentation: 京都
  • Year and Date: 2008-03-26
• [Presentation] 大腸菌薬剤排出タンパク質の細胞内局在 (2008)
  • Author(s): ○平田 隆弘、北村 昭夫、西野 邦彦、山口 明人
  • Organizer: 第81回日本細菌学会総会
  • Place of Presentation: 京都
  • Year and Date: 2008-03-26
• [Presentation] 細菌異物排出タンパクの構造・機能とその発現制御に関する研究 (2008)
  • Author(s): 山口明人
  • Organizer: 第81回日本細菌学会総会
  • Place of Presentation: 国立京都国際会館(京都)(浅川賞受賞講演、招待講演)
  • Year and Date: 2008-03-25
• [Presentation] 細菌異物排出タンパクの構造・機能とその発現制御に関する研究 (2008)
  • Author(s): ○山口 明人
  • Organizer: 第81回日本細菌学会総会
  • Place of Presentation: 京都
  • Year and Date: 2008-03-25
• [Presentation] サルモネラ菌薬剤排出ポンプの生理機能 -多剤耐性および病原性発現における役割について- (2008)
  • Author(s): ○西野 邦彦、山口 明人
  • Organizer: 第81回日本細菌学会総会
  • Place of Presentation: 京都
  • Year and Date: 2008-03-24
• [Presentation] 異物排出蛋白質発現抑制因子AcrSの機能解明とAcrAB,AcrEFの発現制御 (2008)
  • Author(s): ○平川 秀忠、西野 邦彦、平田 隆弘、山口 明人
  • Organizer: 第81回日本細菌学会総会
  • Place of Presentation: 京都
  • Year and Date: 2008-03-24
• [Presentation] Phenotypic analysis of multidrug efflux pumps-not just for multidrug resistance (2008)
  • Author(s): ○Kunihiko Nishino
  • Organizer: Florence Conference on Phenotype MicroArray Analysis of Microorganisms
  • Place of Presentation: Florence, Italy
  • Year and Date: 2008-03-19
• [Presentation] Roles of multidrug efflux pumps in antimicrobial peptide resistance of Salmonella enterica (2008)
  • Author(s): ○Tomoyuki Nakano, Kunihiko Nishino and Akihito Yamaguchi
  • Organizer: Florence Conference on Phenotype MicroArray Analysis of Microorganisms
  • Place of Presentation: Florence, Italy
  • Year and Date: 2008-03-19
• [Presentation] Regulatory network of AcrAB multidrug efflux pump in Salmonella and its role in response to metabolites (2008)
  • Author(s): ○Eiji Nikaido, Kunihiko Nishino and Akihito Yamaguchi
  • Organizer: Florence Conference on Phenotype MicroArray Analysis of Microorganisms
  • Place of Presentation: Florence, Italy
  • Year and Date: 2008-03-19
• [Presentation] Physiological functions of bacterial multidrug efflux pumps (2008)
  • Author(s): ○Kunihiko Nishino and Akihito Yamaguchi
  • Organizer: The 3rd CNU-SANKEN Joint Symposium on Advanced Materials Science
  • Place of Presentation: Chungnam National University, Korea
  • Year and Date: 2008-02-27
• [Presentation] 多剤排出トランスポーターの構造と機能発現 (2008)
  • Author(s): ○山口 明人
  • Organizer: 第2回 分子生物薬剤学セミナー「トランスポーター科学最前線」
  • Place of Presentation: 金沢大学、石川県
  • Year and Date: 2008-02-16
• [Presentation] Structural Basis of Bacterial Multidrug Export (2008)
  • Author(s): ○Akihito Yamaguchi
  • Organizer: 11th Sanken International Symposium/6th nanotechnology center international symposium/1st MSTEC international symposium
  • Place of Presentation: Hyogo
  • Year and Date: 2008-02-05
• [Presentation] Analysis of the S1P transporter in MEG-01 cell line (2008)
  • Author(s): ○Yu Hisano
  • Organizer: 11th Sanken International Symposium/6th nanotechnology center international symposium/1st MSTEC international symposium
  • Place of Presentation: Hyogo
  • Year and Date: 2008-02-04
• [Presentation] Analysis of the expression-site and the physiological role of mouse ABCA5 (2008)
  • Author(s): ○Megumi Ohigashi
  • Organizer: 11th Sanken International Symposium/6th nanotechnology center international symposium/1st MSTEC international symposium
  • Place of Presentation: Hyogo
  • Year and Date: 2008-02-04
• [Presentation] Regulatory network of AcrAB multidrug efflux pump in Salmonella and its role in response to metabolites (2008)
  • Author(s): ○Eiji Nikaido
  • Organizer: 11th Sanken International Symposium/6th nanotechnology center international symposium/1st MSTEC international symposium
  • Place of Presentation: Hyogo
  • Year and Date: 2008-02-04
• [Presentation] Structure and Mechanism of the Tripartite Multidrug Exporter (2008)
  • Author(s): Yamaguchi A.
  • Organizer: The Joint 4th AOHUPO(Asian Oceania Human Proteome Organisation) and 2nd PRICPS(Pacific Rim International Conference on Protein Science)
  • Place of Presentation: Carins Convention Center, Australia
• [Presentation] Structure and Mechanism of the Tripartite Multidrug Exporter (2008)
  • Author(s): A. Yamaguchi, S. Murakami
  • Organizer: The Joint 4^<th> AOHUPO (Asian Oceania Human Proteome Organization) and 2^<nd> PRICPS (Pacific Rim International Conference on Protein Science)
  • Place of Presentation: Cairns, Australia
• [Presentation] Electron Tomography Revealed the Endoplasmic Reticulum as a Cradle for Autophagosome Formation (2008)
  • Author(s): M. Hayashi-Nishino, N. Fujita, T. Noda, A. Yamaguchi, T. Yoshimori, A. Yamamoto
  • Organizer: The American Society for Cell Biology 48th Annual Meeting
  • Place of Presentation: San Francisco, USA
• [Presentation] Electron tomographic reconstruction of clathrin coated endocytic intermediates in nerve terminals that lack dynamin 1 (2008)
  • Author(s): M. Hayashi-Nishino, E. O'Toole, S. Ferguson, A. Yamaguchi, P. De Camilli
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会
  • Place of Presentation: 神戸
• [Presentation] 輸送体を介した赤血球からのスフィンゴシン1リン酸放出機構 (2008)
  • Author(s): 小林直木, 小林伸好, 西毅, 山口明人
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会
  • Place of Presentation: 神戸
• [Presentation] RamAによるサルモネラ異物排出トランスポーターAcrAB発現制御機構の解析 (2008)
  • Author(s): 二階堂英司, 西野邦彦, 城阪郁江, 山口明人
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会
  • Place of Presentation: 神戸
• [Presentation] 膜傷害保護における異物排出トランスポーターの役割 (2008)
  • Author(s): 坂田博樹, 西野邦彦, 上田珠美, 山口明人
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会
  • Place of Presentation: 神戸
• [Presentation] 抗菌ペプチド耐性における多剤排出ポンプの役割 (2008)
  • Author(s): 中濃知志, 西野邦彦, 山口明人
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会
  • Place of Presentation: 神戸
• [Presentation] Regulatory network of multidrug transporters reveals their physiological role in Salmonella virulence (2008)
  • Author(s): 西野邦彦, 山口明人
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会
  • Place of Presentation: 神戸
• [Presentation] 大腸菌異物排出タンパク質AcrBの基質認識における芳香族アミノ酸の重要性 (2008)
  • Author(s): 岩田歩, 村上聡, 山口明人
  • Organizer: 第46回日本生物物理学会年会
  • Place of Presentation: 福岡
• [Presentation] 神経細胞におけるABC (ATP Binding Cassette)輸送体ABCA5の発現 (2008)
  • Author(s): 大東穂, 西毅, 山口明人
  • Organizer: 第30回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 北海道
• [Presentation] MC-7-05 MEG-01細胞からのS1P放出輸送体のsiRNAによる検索 (2008)
  • Author(s): 久野悠, 西毅, 山口明人
  • Organizer: 第30回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 北海道
• [Presentation] 脂溶性情報伝達物質の細胞外放出機構の解明 (2008)
  • Author(s): 西毅, 小林直木, 山口明人
  • Organizer: 第30回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 北海道
• [Presentation] 細菌トランスポートソームのレジストーム解析 (2008)
  • Author(s): 西野邦彦, 二階堂英司, 坂田博樹, 中濃知志, 田中真奈美, 西野-林美都子, 上田珠美, 城阪郁江, 山口明人
  • Organizer: 第30回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 北海道
• [Presentation] 電子線トモグラフィーを用いたダイナミン1KOシナプスにおけるエンドサイトーシス中間体の解析 (2008)
  • Author(s): 西野-林美都子, Eileen O'Toole, Shawn Ferguson, 西野邦彦, 山口明人, Pietro De Camilli
  • Organizer: 第30回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 北海道
• [Presentation] 膜傷害保護における異物排出トランスポーターの役割 (2008)
  • Author(s): 坂田博樹, 西野邦彦, 山口明人
  • Organizer: 第30回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 北海道
• [Presentation] Regulatory network of multidrug efflux pumps reveals their physiological role in Salmonella virulence (2008)
  • Author(s): K. Nishino, A. Yamaguchi
  • Organizer: Gordon Research Conference
  • Place of Presentation: MA, USA
• [Presentation] Molecular Design of the Carbenicillin Hyper-Resistance AcrB Multidrug Exporter in Escherichia coli (2008)
  • Author(s): A. Iwata, N. Kobayashi, S. Murakami, A. Yamaguchi
  • Organizer: 22nd Annual Symposium of The Protein Siciety
  • Place of Presentation: San Diego, California USA
• [Presentation] 大腸菌とサルモネラにおける薬剤排出ポンプ役割解明に関する研究 (2008)
  • Author(s): 西野邦彦
  • Organizer: 第12回腸内細菌学会
  • Place of Presentation: 東京
• [Presentation] Regulatory Network of Multidrug Transporters Reveals their Physiological Role in Salmonella Virulence (2008)
  • Author(s): K. Nishino, A. Yamaguchi
  • Organizer: American Society for Microbiology 108th General Meeting
  • Place of Presentation: Boston, Massachusetts
• [Presentation] Regulation of the AcrAB Multidrug Efflux Pump in Salmonella enterica by RamA in Response to Environmental Signals (2008)
  • Author(s): E. Nikaido, K. Nishino, A. Yamaguchi
  • Organizer: American Society for Microbiology 108th General Meeting
  • Place of Presentation: Boston, Massachusetts
• [Presentation] Analysis of the xenobiotic exporter EmrAB in Salmonella enterica serovar Typhimurium (2007)
  • Author(s): ○坂田 博樹、西野 邦彦、山口 明人
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-14
• [Presentation] The regulatory mechanism of the AcrAB and AcrEF multidrug exporter system by AcrS in Escherichia coli (2007)
  • Author(s): ○平川 秀忠、Ulrike Theisen、小林 あすか、平田 隆弘、西野 邦彦、山口 明人
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-14
• [Presentation] Induction mechanism of AcrAB in Salmonella enterica (2007)
  • Author(s): ○二階堂 英司、西野 邦彦、山口 明人
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-14
• [Presentation] Identification of novel gene products which play roles on biofilm formation in Escherichia coli (2007)
  • Author(s): ○王 麗媛、平田 隆弘、平川 秀忠、西野 邦彦、山口 明人
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-14
• [Presentation] 細菌薬剤耐性化と病原性発現における薬剤排出トランスポーターの役割 (2007)
  • Author(s): ○西野 邦彦
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-13
• [Presentation] Release of sphingosine 1-phosphate from platelet-like particles derived from MEG-01 cells MEG-01 (2007)
  • Author(s): ○久野 悠、西 毅、山口 明人
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-12
• [Presentation] Characterization of ATP-dependent sphingosine-1-phosphate transport in rat erythrocytes by using the inside-out membrane vesicles (2007)
  • Author(s): ○小林 直木、小林 伸好、西 毅、山口 明人
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-12
• [Presentation] Functional roles of ABCA7 in mouse platelet (2007)
  • Author(s): ○尾上 麻実子、柴田 紗貴子、西 毅、山口 明人
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-12
• [Presentation] Cellular localization of mouse ABCA5 proteins in various mouse tissues (2007)
  • Author(s): ○大東 穂、西 毅、山口 明人
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-11
• [Presentation] Tissue and subcellular localization of mouse ABCA6 transporter (2007)
  • Author(s): ○宮田 耕資、大東 穂、西 毅、山口 明人
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-11
• [Presentation] 膜輸送体作動メカニズムの結晶学的解明 (2007)
  • Author(s): ○村上 聡、中島 良介、松本 崇、近藤 洋平、津田 岳夫、小川 治夫、豊島 近
  • Organizer: 第11回 Spring8シンポジウム
  • Place of Presentation: 兵庫県
  • Year and Date: 2007-11-29
• [Presentation] Expression and cellular localization of ABCA6 in mouse liver (2007)
  • Author(s): ○宮田 耕資、大東 穂、西 毅、山口 明人
  • Organizer: 第29回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2007-11-26
• [Presentation] Identification of the sphingosine-1-phosphate export system in rat erythrocytes (2007)
  • Author(s): ○小林 直木、小林 伸好、西 毅、山口 明人
  • Organizer: 第29回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2007-11-26
• [Presentation] Identification of the function of ABCA7 in mouse platelets (2007)
  • Author(s): ○尾上 麻実子、柴田 紗貴子、西 毅、山口 明人
  • Organizer: 第29回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2007-11-26
• [Presentation] 細菌代謝物によるサルモネラ菌異物排出トランスポーターAcrAB-TolCシステム発現制御機構の解析 (2007)
  • Author(s): ○二階堂 英司、西野 邦彦、山口 明人
  • Organizer: 第29回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2007-11-26
• [Presentation] マウスABCA5の生理機能の解明 (2007)
  • Author(s): ○大東 穂、西 毅、山口 明人
  • Organizer: 日本生体エネルギー研究会 第33回討論会
  • Place of Presentation: 山口
  • Year and Date: 2007-11-17
• [Presentation] ATP依存的な輸送体を介した脂質メディエーター放出機構 (2007)
  • Author(s): ○西 毅、小林 直木、山口明人
  • Organizer: 日本生体エネルギー研究会 第33回討論会
  • Place of Presentation: 山口
  • Year and Date: 2007-11-16
• [Presentation] 環境因子によるサルモネラ菌AcrAB異物排出蛋白質発現誘導機構の解析 (2007)
  • Author(s): ○二階堂 英司
  • Organizer: 第63回 大阪大学産業科学研究所学術講演会
  • Place of Presentation: 大阪大学接合科学研究所
  • Year and Date: 2007-11-16
• [Presentation] The regulation of bacterial"needle-like"bio-nanomachinary and pathogenicity by indole in enterohaemorrhagic E. coli (2007)
  • Author(s): ○平川 秀忠
  • Organizer: 第63回 大阪大学産業科学研究所学術講演会
  • Place of Presentation: 大阪大学接合科学研究所
  • Year and Date: 2007-11-16
• [Presentation] 細菌多剤耐性化と病原性発現における薬剤排出ポンプの役割に関する研究-多剤耐性化と病原性を軽減させる新薬ターゲットの解析- (2007)
  • Author(s): ○西野 邦彦
  • Organizer: 第9回日本抗生物質学術協議会奨励賞授賞式および受賞講演
  • Place of Presentation: 東京
  • Year and Date: 2007-11-08
• [Presentation] サルモネラ菌多剤排出トランスポーターの生理機能解明 (2007)
  • Author(s): ○西野 邦彦、松本 佳巳
  • Organizer: 第55回日本化学療法学会西日本支部総会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2007-10-30
• [Presentation] フェムトリッターチャンバーを用いた薬剤排出ポンプの活性測定 (2007)
  • Author(s): ○松本 佳巳、西野 邦彦
  • Organizer: 第55回日本化学療法学会西日本支部総会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2007-10-30
• [Presentation] ライフサイエンスの新展開 (2007)
  • Author(s): ○山口 明人
  • Organizer: 平成19年度産研テクノサロン(第3回例会)
  • Place of Presentation: 大阪大学接合科学研究所
  • Year and Date: 2007-10-24
• [Presentation] Roles of indole signaling and intercellular signal transduction on type III secretion system-dependent pathogenicity in EHEC (2007)
  • Author(s): ○Hidetada Hirakawa, Toshio Kodama, Takeshi Honda and Akihito Yamaguchi
  • Organizer: 3rd ASM Conference on Cell-Cell Communication in Bacteria
  • Place of Presentation: Texas, USA
  • Year and Date: 2007-10-07
• [Presentation] Novel Aspects of Mechanisms of Antibacterial Resistance Revealed by Crystal Structure (2007)
  • Author(s): Yamaguchi A.
  • Organizer: 47th Interscience Conference on Antimicrobial Agents and Chemotherapy
  • Place of Presentation: McCormick Place(Chicago, Illinois, USA)(招待講演)
  • Year and Date: 2007-09-18
• [Presentation] Visualization of Escherichia coli AcrAB-TolC efflux pump activity using ultra small chambers (2007)
  • Author(s): ○Yoshimi Matsumoto, Kunihiko Nishino, Ryota Iino, Syoichi Sakakihara, Masayoshi Nakata, Hiroyuk Nojii and Akihito Yamaguchi
  • Organizer: 47th Interscience Conference on Antimicrobial Agents and Chemotherapy
  • Place of Presentation: McCormick Place, Illinois USA
  • Year and Date: 2007-09-18
• [Presentation] フェムトリッターチャンバーを用いた薬剤排出ポンプの研究 (2007)
  • Author(s): ○松本 佳巳、西野 邦彦、飯野 亮太、榊原 秀一、仲田 昌義、野地 博行、山口 明人
  • Organizer: 第19回微生物シンポジウム
  • Place of Presentation: 東京大学
  • Year and Date: 2007-09-08
• [Presentation] 細菌代謝物によるサルモネラ菌異物排出トランスポーターAcrAB発現誘導機構の解析 (2007)
  • Author(s): ○二階堂 英司、西野 邦彦、坂田 博樹、中濃 知志、田中 真奈美、山口 明人
  • Organizer: 第19回微生物シンポジウム
  • Place of Presentation: 東京大学
  • Year and Date: 2007-09-07
• [Presentation] Analysis of the xenobiotic exporter EmrAB in Salmonella enterica serovar Typhimurium (2007)
  • Author(s): ○坂田 博樹、西野 邦彦、山口 明人
  • Organizer: 第19回微生物シンポジウム
  • Place of Presentation: 東京大学
  • Year and Date: 2007-09-07
• [Presentation] Identification of novel gene products which play roles on biofilm formation in Escherichia coli (2007)
  • Author(s): ○王 麗媛、平田 隆弘、平川 秀忠、西野 邦彦、山口 明人
  • Organizer: 第19回微生物シンポジウム
  • Place of Presentation: 東京大学
  • Year and Date: 2007-09-07
• [Presentation] Regulation mechanisms of the acrAB multidrug efflux pump in Salmonella enterica in response to bacterial metabolites (2007)
  • Author(s): ○Eiji Nikaido, Kunihiko Nishino and Akihito Yamaguchi
  • Organizer: 7th The Awaji International Forum on Infection and Immunity
  • Place of Presentation: Awaji Yumebutai International Conference Center
  • Year and Date: 2007-09-03
• [Presentation] Regulatory network of multidrug transporters reveals their physiological role in Salmonella virulence (2007)
  • Author(s): ○Kunihiko Nishino, Eiji Nikaido, Hiroki Sakata, Tomoyuki Nakano, Manami Tanaka and Akihito Yamaguchi
  • Organizer: 7th The Awaji International Forum on Infection and Immunity
  • Place of Presentation: Awaji Yumebutai International Conference Center
  • Year and Date: 2007-09-01
• [Presentation] 大腸菌異物排出蛋白質MacABの極への局在 (2007)
  • Author(s): ○平田 隆弘、北村 昭夫、西野 邦彦、山口 明人
  • Organizer: 第4回21世紀大腸菌研究会
  • Place of Presentation: 静岡
  • Year and Date: 2007-07-18
• [Presentation] 多剤耐性感染症を克服する新規治療の確立 (2007)
  • Author(s): ○西野 邦彦
  • Organizer: 第6回産学官連携推進会議
  • Place of Presentation: 京都
  • Year and Date: 2007-06-17
• [Presentation] フェムトリッター(fL)チャンバーを用いた薬剤排出ポンプ阻害薬の評価法 (2007)
  • Author(s): ○松本 佳巳、西野 邦彦、飯野 亮太、榊原 昇一、仲田 昌義、二階堂 英司、山口 明人、野地 博行、竹内 昌治
  • Organizer: 第55回 日本化学療法学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2007-06-01
• [Presentation] 細菌オーファン輸送体の生理機能解明 (2007)
  • Author(s): ○西野 邦彦、山口 明人
  • Organizer: 第55回 日本化学療法学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2007-06-01
• [Presentation] Single Cell Measurement of Bacterial Drug Efflux in Femtoliter Chamber Array (2007)
  • Author(s): ○Kunihiko Nishino, Ryota Iino, Masaaki Nakata, Yoshimi Matsumoto, Eiji Nikaido, Syoichi Sakakihara, Syoji Takeuchi, Akihito Yamaguchi and Hiroyuki Noji
  • Organizer: American Society of Microbiology, 107th General Meeting
  • Place of Presentation: Metro Toronto Convention Center, Toronto, Canada
  • Year and Date: 2007-05-22
• [Presentation] Metabolites of Escherichia coli Induce the Expression of Multidrug Efflux pumps in Salmonella enterica (2007)
  • Author(s): ○Eiji Nikaido, Kunihiko Nishino and Akihito Yamaguchi
  • Organizer: American Society of Microbiology, 107th General Meeting
  • Place of Presentation: Metro Toronto Convention Center, Toronto, Canada
  • Year and Date: 2007-05-22
• [Presentation] Novel Aspects of Mechanisms of Antibacterial Resistance Revealed by Crystal Structure (2007)
  • Author(s): Yamaguchi A.
  • Organizer: 47th Interscience Conference on Antimicrobial Agents and Chemotherapy
  • Place of Presentation: McCormick Place, Illinois USA
• [Book] 化学療法学.医療のあるべき姿を見据えて.[抗生物質最前線] (2010)
  • Author(s): 山口明人
  • Total Pages: 315
  • Publisher: 京都廣川書店
• [Book] トランスポーター科学最前線-フロンティアサイエンスへの招き- (2008)
  • Author(s): 山口明人
  • Total Pages: 384
  • Publisher: 京都廣川書店
• [Book] トランスポーター科学最前線-フロンティアサイエンスへの招き- (2008)
  • Author(s): 山口明人, 他分担執筆
  • Total Pages: 374
  • Publisher: 京都 廣川書店
• [Remarks]
  • URL: http://www.sanken.osaka-u.ac.jp/labs/cmb/
• [Remarks] 読売新聞、2011年12月5日、病原菌ポンプで抗生物質排除阪大グループ仕組み解明新聞報道
• [Remarks] 朝日新聞、2011年11月28日、多剤耐性菌構造を解明阪大グループ新聞報道
• [Remarks] 毎日新聞、2011年11月28日、多剤耐性緑膿菌治療薬に光阪大チーム抗生物質効かぬ謎解明新聞報道
• [Remarks] 産経新聞、2011年11月28日、多剤耐性菌の異物認識システム解明阪大チーム「創薬へ展望」新聞報道
• [Remarks] 日経新聞、2011年11月28日、抗生物質、細胞外へ排出阪大が仕組み解明新薬開発に可能性新聞報道
• [Remarks] 平成22年度科学技術分野の文部科学大臣表彰科学技術賞、「異物排出タンパク構造・機能・制御と生理的役割に関する研究」、山口明人受賞
• [Remarks] 平成20年度科学技術分野の文部科学大臣表彰科学技術賞(若手科学者賞)、「細菌ゲノムに潜む多剤耐性因子と制御機構の研究」、西野邦彦受賞
• [Remarks] 平成20年日本薬学会賞、「異物排出トランスポーターの構造・機能とその制御に関する研究」、山口明人受賞
• [Remarks] 平成20年日本細菌学会浅川賞、「細菌異物排出タンパクの構造・機能とその発現制御に関する研究」、山口明人受賞
• [Remarks] 研究室ホームページ
  • URL: http://www.sanken.osaka-u.ac.jp/labs/cmb/
• [Remarks] 産業科学研究所プレスリリース(阪大広報課発信)
  • URL: http://www.sanken.osaka-u.ac.jp/jp/operation/press_release.html
• [Remarks] 大型放射光施設SPring-8プレスリリース
  • URL: http://www.spring8.or.jp/ja/news_publications/press_release/2011/111128
• [Remarks]
  • URL: http://www.sanken.osaka-u.ac.jp/labs/cmb/
• [Remarks]
  • URL: http://www.sanken.osaka-u.ac.jp/labs/cmb
• [Remarks]
  • URL: http://www.sanken.osaka-u.ac.jp/labs/cmb/
• [Remarks]
  • URL: http://www.sanken.osaka-u.ac.jp/labs/cmb/
• [Patent(Industrial Property Rights)] 細菌または真菌の抗菌薬感受性の検査方法およびそれに用いるシステム (2011)
  • Inventor(s): 松本佳巳、葉山浩平、榊原昇一、西野邦彦、山口明人、野地博行、飯野亮太
  • Industrial Property Rights Holder: 国立大学法人大阪大学
  • Industrial Property Number: 2011-200036
  • Filing Date: 2011-09-13
• [Patent(Industrial Property Rights)] スフィンゴシン1-リン酸の新規トランスポーター分子 (2008)
  • Inventor(s): 望月直樹、川原敦雄、西毅、山口明人
  • Industrial Property Rights Holder: 財団法人ヒューマンサイエンス振興財団/国立大学法人大阪大学
  • Industrial Property Number: 2008-245177
  • Filing Date: 2008-09-25
• [Patent(Industrial Property Rights)] スフィンゴシン1-リン酸の新規トランスポーター分子 (2008)
  • Inventor(s): 望月直樹, 川原敦雄, 西毅, 山口明人
  • Industrial Property Rights Holder: 財団法人ヒューマンサイエンス振興財団
  • Industrial Property Number: 2008-245177
  • Filing Date: 2008-09-25