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Structures, functions, regulations and physiological roles of xenobiotic exporters

Research Project

Project/Area Number 19109002
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionOsaka University

Principal Investigator

YAMAGUCHI Akihito  大阪大学, 産業科学研究所, 教授 (60114336)

Co-Investigator(Kenkyū-buntansha) NAKASHIMA Ryosuke  大阪大学, 産業科学研究所, 助教 (20379100)
西野 邦彦  大阪大学, 産業科学研究所, 助教 (30432438)
Co-Investigator(Renkei-kenkyūsha) NISHINO Kunihiko  大阪大学, 産業科学研究所, 准教授 (30432438)
Project Period (FY) 2007 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥109,720,000 (Direct Cost: ¥84,400,000、Indirect Cost: ¥25,320,000)
Fiscal Year 2011: ¥21,580,000 (Direct Cost: ¥16,600,000、Indirect Cost: ¥4,980,000)
Fiscal Year 2010: ¥21,580,000 (Direct Cost: ¥16,600,000、Indirect Cost: ¥4,980,000)
Fiscal Year 2009: ¥21,580,000 (Direct Cost: ¥16,600,000、Indirect Cost: ¥4,980,000)
Fiscal Year 2008: ¥21,580,000 (Direct Cost: ¥16,600,000、Indirect Cost: ¥4,980,000)
Fiscal Year 2007: ¥23,400,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥5,400,000)
Keywords異物排出タンパク / 多剤排出タンパク / AcrB / X線結晶構造解析 / 膜タンパク質結晶構造 / ペリスタポンプ機構 / マルチサイト結合 / 環境センシング / 異物排出トランスポーター / 発現制御 / インドール / 構造解析 / 多剤耐性 / 機能的回転機構 / ペリスタルティック機構 / 構造生物学 / マイクロアレイ / 薬剤耐性 / 異物排出 / サルモネラ / 発現誘導機構 / 膜蛋白質結晶構造 / AcrAB
Research Abstract

We found out the new proximal multisite drug-binding pocket in AcrB and proposed the periplasmic pumping mechanism of drugs by AcrB. We analyzed the expression regulation of multidrug transporters by indole-mediated sensing between different bacterial species in detail and found the roles of RamA and RamR in Salmonella. In addition, we developed the micro-devices for rapid detection of drug resistant bacteria.

Report

(7 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report   Self-evaluation Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (271 results)

All 2012 2011 2010 2009 2008 2007 Other

All Journal Article (59 results) (of which Peer Reviewed: 48 results) Presentation (189 results) Book (3 results) Remarks (17 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] Antibacterial and antifungal activities of new acylated derivatives of epigallocatechin gallate2012

    • Author(s)
      Matsumoto Y, Kaihatsu K, Nishino K, Ogawa M, Kato N, Yamaguchi A
    • Journal Title

      frontiers in MICROBIOLOGY

      Volume: 3(in press)

    • DOI

      10.3389/fmicb.2012.00053

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A microfluidic device for simple and rapid evaluation of multidrug efflux pump inhibitors2012

    • Author(s)
      Iino R, Nishino K, Noji H, Yamaguchi A, Matsumoto Y
    • Journal Title

      frontiers in MICROBIOLOGY

      Volume: 3(in press)

    • DOI

      10.3389/fmicb.2012.00040

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 多剤耐性細菌の異物排出タンパク質のしくみを解明2012

    • Author(s)
      山口明人、中島良介
    • Journal Title

      月刊化学

      Volume: 2 Pages: 74-74

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket2011

    • Author(s)
      Nakashima R., Sakurai K., Yamasaki S., Nishino K., Yamaguchi A.
    • Journal Title

      Nature

      Volume: vol.480 Pages: 565-569

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of overexpression of small non-coding DsrA RNA on multidrug efflux in Escherichia coli2011

    • Author(s)
      Nishino K., Yamasaki S., Hayashi-Nishino M., Yamaguchi A.
    • Journal Title

      J. Antimicrob. Chemother.

      Volume: vol.66 Pages: 291-6

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY7202011

    • Author(s)
      Hisano Y., Kobayashi N., Kawahara A., Yamaguchi A., Nishi T.
    • Journal Title

      J. Biol. Chem.

      Volume: vol.286 Pages: 1758-1766

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of Salmonella multidrug efflux pumps in tigecycline resistance2011

    • Author(s)
      Horiyama T., Nikaid E., Yamaguchi A., Nishino K.
    • Journal Title

      J. Antimicrob. Chemother.

      Volume: vol.66 Pages: 105-10

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Multidrug Efflux Pump MdtEF Protects against Nitrosative Damage during the Anaerobic Respiration in Escherichia coli2011

    • Author(s)
      Zhang Y, Xiao M, Horiyama T, Zhang Y, Li X, Nishino K, Yan A
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 286 Issue: 30 Pages: 26576-26584

    • DOI

      10.1074/jbc.m111.243261

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket2011

    • Author(s)
      Nakashima R, Sakurai K, Yamasaki S, Nishino K, Yamaguchi A
    • Journal Title

      Nature

      Volume: 480 Issue: 7378 Pages: 565-569

    • DOI

      10.1038/nature10641

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] AcrA dependency of the AcrD efflux pump in Salmonella enterica serovar Typhimurium2011

    • Author(s)
      Yamasaki S, Nagasawa S, Hayashi-Nishino M, Yamaguchi A, Nishino K
    • Journal Title

      The Journal of Antibiotics

      Volume: 64 Issue: 6 Pages: 433-437

    • DOI

      10.1038/ja.2011.28

    • NAID

      10030639300

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of multidrug efflux pump inhibitors by a new method using microfluidic channels2011

    • Author(s)
      Matsumoto Y, Hayama K, Sakakihara S, Nishino K, Noji H, Iino R, Yamaguchi A
    • Journal Title

      PLoS One

      Volume: 6 Issue: 4 Pages: e18547-e18547

    • DOI

      10.1371/journal.pone.0018547

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of AcrAB multidrug efflux pump in Salmonella enterica serovar Typhimurium in response to indole and paraquat2011

    • Author(s)
      E.Nikaido, I.Shirosaka, A.Yamaguchi, K.Nishino
    • Journal Title

      Microbiology

      Volume: 158 Pages: 648-655

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of overexpression of small non-coding DsrA RNA on multidrug efflux in Escherichia coli2011

    • Author(s)
      K.Nishino, S.Yamasaki, M.Hayashi-Nishino, A.Yamaguchi
    • Journal Title

      The Journal of Antimicrobial Chemotherapy

      Volume: 66 Pages: 291-296

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of Salmonella multidrug efflux pumps in tigecycline resistance2011

    • Author(s)
      T.Horiyama, E.Nikaido, A.Yamaguchi, K.Nishino
    • Journal Title

      The Journal of Antimicrobial Chemotherapy

      Volume: 66 Pages: 105-110

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Small RNAによる多剤耐性制御2011

    • Author(s)
      西野邦彦、山崎聖司、西野-林美都子、山口明人
    • Journal Title

      日本化学療法学会雑誌

      Volume: 59 Pages: 1-7

    • NAID

      10027817029

    • Related Report
      2010 Annual Research Report
  • [Journal Article] TolC dependency of multidrug efflux systems in Salmonella enterica serovar Typhimurium2010

    • Author(s)
      Horiyama T., Yamaguchi A., Nishino K.
    • Journal Title

      J. Antimicrob. Chemother.

      Volume: vol.65 Pages: 1372-6

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of NlpE overproduction on multidrug resistance in Escherichia coli2010

    • Author(s)
      Nishino K., Yamasaki Y., Hayashi-Nishino M., Yamaguchi A.
    • Journal Title

      Antimicrob. Agents Chemother.

      Volume: vol.54 Pages: 2239-2243

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of RNA chaperone Hfq on multidrug resistance in Escherichia coli2010

    • Author(s)
      Yamada J., Yamasaki S., Hirakawa H., Hayashi-Nishino M., Yamaguchi A., Nishino K.
    • Journal Title

      J. Antimicrob. Chemother.

      Volume: vol.65 Pages: 853-858

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY7202010

    • Author(s)
      Y.Hisano, N.Kobayashi, A.Kawahara, A.Yamaguchi, T.Nishi
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 286 Pages: 1758-1766

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Indole enhances acid resistance in Escherichia coli2010

    • Author(s)
      H.Hirakawa, M.Hayashi-Nishino, A.Yamaguchi, K Nishino
    • Journal Title

      Microbial Pathogenesis

      Volume: 49 Pages: 90-94

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TolC dependency of multidrug efflux systems in Salmonella enterica serovar Typhimurium2010

    • Author(s)
      T.Horiyama, A.Yamaguchi, K Nishino
    • Journal Title

      Journal of Antimicrobial Chemotherapy

      Volume: 65 Pages: 1372-1376

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Macrophage ABCA5 deficiency influences cellular cholesterol efflux and increases susceptibility to atherosclerosis in female LDLr knockout mice2010

    • Author(s)
      Ye D, Meurs I, Ohigashi M, Calpe-Berdiel L, Habets KL, Zhao Y, Kubo Y, Yamaguchi A, Van Berkel TJ, Nishi T, Van Eck M
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 395 Pages: 387-394

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of NlpE overproduction on multidrug resistance in Escherichia coli2010

    • Author(s)
      K.Nishino, S.Yamasaki, M.Hayashi-Nishino, A.Yamaguchi
    • Journal Title

      Antimicrobial Agents and Chemotherapy

      Volume: 54 Pages: 2239-2243

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of RNA chaperone Hfq on multidrug resistance in Escherichia coli2010

    • Author(s)
      J.Yamada, S.Yamasaki, H.Hirakawa, M.Hayashi-Nishino, A.Yamaguchi, K.Nishino
    • Journal Title

      Journal of Antimicrobial Chemotherapy

      Volume: 65 Pages: 853-858

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A subdomain of the endoplasmic reticulum forms a cradle for autophago someformation2010

    • Author(s)
      Hayashi-Nishino M., Fujita N., Noda T., Yamaguchi A., Yoshimori T., Yamamoto A.
    • Journal Title

      Nature cell Biology 11

      Pages: 1433-1437

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] H-NS modulates multidrug resistance of Salmonella enterica serovar Typhimurium by repressing multidrug efflux genes acrEF2009

    • Author(s)
      Nishino K., Hayashi-Nishino M., Yamaguchi A.
    • Journal Title

      Antimicrob Agents Chemother.

      Volume: vol.53 Pages: 3541-3543

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Sphingolipid Transporter Spns2 Functions in Migration of Zebrafish Myocardial Precursors2009

    • Author(s)
      Kawahara A., Nishi T., Hisano Y., Fukui H., Yamaguchi A., Mochizuki N.
    • Journal Title

      scuence

      Volume: vol.323 Pages: 524-527

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] H-NS modulates multidrug resistance of Salmonella enterica serovar Typhimurium by repressing multidrug efflux genes acrEF2009

    • Author(s)
      Nishino K., Hayashi-Nishino M., Yamaguchi A.
    • Journal Title

      Antimicrob. Agents Chemother 53

      Pages: 3541-3543

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Characterization of the ATP-dependent sphingosine-1-phosphate transporter in rat erythrocytes, Kobayashi2009

    • Author(s)
      N., Kobayashi N., Yamaguchi A., Nishi T.
    • Journal Title

      J.Biol.Chem. 284

      Pages: 21192-21200

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] The Sphingolipid Transporter Spns2 Functions in Migration of Zebrafish Myocardial Precursors2009

    • Author(s)
      Kawahara A., Nishi T., Hisano Y., Fukui H., Yamaguchi A., Mochizuki N.
    • Journal Title

      Science 323

      Pages: 524-527

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] H-NS modulates multidrug resistance of Salmonella enterica serovar Typhimurium by repressing multidrug efflux genes acrEF2009

    • Author(s)
      Nishino K., Hayashi-Nishino M., Yamaguchi A.
    • Journal Title

      Antimicrob Agents Chemother. 53

      Pages: 3541-3543

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of the ATP-dependent sphingosine-1-phosphate transporter in rat erythrocytes2009

    • Author(s)
      Kobayashi N., Kobayashi N., Yamaguchi A., Tsuyoshi N.
    • Journal Title

      J.Biol.Chem. 284

      Pages: 21192-21200

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] スフィンゴシン-1-リン酸の輸送体Spns2は心臓前駆細胞の移動を制御よる2009

    • Author(s)
      川原敦雄、西毅、山口明人、望月直樹
    • Journal Title

      細胞工学 28

      Pages: 390-391

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Role of the AraC/XylS family regulator YdeO in multidrug resistance of Escherichia coli2009

    • Author(s)
      Nishino K., Senda Y., Hayashi-Nishino M., Yamaguchi A.
    • Journal Title

      J.Antibiot. 62

      Pages: 251-257

    • NAID

      10030635180

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation and physiological function of multidrug efflux pumps in Escherichia coli and Salmonella2009

    • Author(s)
      Nishino K., Nikaido E., Yamaguchi A.
    • Journal Title

      Biochim.Biophys.Acta-Proteins and Proteomics 1794

      Pages: 834-843

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Sphingolipid Transporter Spns2 Functions in Migration of Zebrafish Myocardial Precursors2009

    • Author(s)
      A. Kawahara, T. Nishi, Y. Hisano, H. F., A. Yamaguchi, N. Mochizuki
    • Journal Title

      Science 323

      Pages: 524-527

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] トランスポーターによる多剤認識の構造的基礎2009

    • Author(s)
      山口明人, 中島良介
    • Journal Title

      遺伝子医学MOOK12創薬研究者必見! 最新トランスポーター研究2009 12

      Pages: 61-66

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Secreted indole serves as a signal for expression of type III secretion system translocators in enterohaemorrhagic Escherichia coli O157 : H72009

    • Author(s)
      H. Hirakawa, T. Kodama, A. Takumi-Kobayashi, T. Honda, A. Yamaguchi
    • Journal Title

      Microbiology 155

      Pages: 541-550

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] AcrAB Multidrug Efflux Pump Regulationin Salmonella enterica serovar Typhimurium by RamA in Response to Environmental Signals2008

    • Author(s)
      Nikaido E., Yamaguchi A., Nishino K.
    • Journal Title

      J. Biol. Chem.

      Volume: vol.283 Pages: 24245-24253

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] AcrAB Multidrug Efflux Pump Regulation in Salmonella enterica serovar Typhimurium by RamA in Response to Environmental Signals2008

    • Author(s)
      Nikaido E., Yamaguchi A., Nishino K.
    • Journal Title

      J.Biol.Chem. 283

      Pages: 24245-24253

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Physiological functions of drug efflux systems in Gram-negative bacteria : Their roles in bacterial drug resistance and virulence2008

    • Author(s)
      K. Nishino, A. Yamaguchi
    • Journal Title

      Jaoanese Jouanal Chemotherapy 56

      Pages: 443-452

    • NAID

      10022594782

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Virulence and Drug Resistance Roles of Multidrug Efflux Pumps in Escherichia coli and Salmonella2008

    • Author(s)
      K. Nishino, A. Yamaguchi
    • Journal Title

      Bioscience and Microflora 27

      Pages: 75-85

    • NAID

      10021956022

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] AcrS/EnvR Represses the Expression of the acrAB Multidrug Efflux Genes in Escherichia coli2008

    • Author(s)
      H. Hirakawa, A. Takumi-Kobayashi, U. Theisen, T. Hirata, K. Nishino, A. Yamaguchi
    • Journal Title

      Journal of Bacteriology 190

      Pages: 6276-6279

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] AcrAB Multidrug Efflux Pump Regulation in Salmonella enterica serovar Typhimurium by RamA in Response to Environmental Signals2008

    • Author(s)
      E. Nikaido, A. Yamaguchi, K. Nishino
    • Journal Title

      The Journal of Biological Chemistry 283

      Pages: 24245-24253

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 細菌の異物排出タンパク2008

    • Author(s)
      山口明人
    • Journal Title

      日本細菌学雑誌 63

      Pages: 437-446

    • Related Report
      2008 Annual Research Report
  • [Journal Article] シナプス終末の内膜系を3Dで見る2008

    • Author(s)
      西野一林美都子, 山口明人
    • Journal Title

      細胞工学 別冊 電子顕微鏡で読み解く生命のなぞ

      Pages: 107-113

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Role of Xenobiotic Transporters in Bacterial Drug Resistance and Virulence (Review)2008

    • Author(s)
      Kunihiko Nishino and Akihito Yamaguchi
    • Journal Title

      IUBMB Life (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CRP regulator modulates multidrug resistance of Escherichia coli by repressing expression of the mdtEF multidrug efflux genes2008

    • Author(s)
      Kunihiko Nishino, Yasuko Senda and Akihito Yamaguchi
    • Journal Title

      The Journal of Antibiotics (in press)

    • Related Report
      2007 Annual Research Report
  • [Journal Article] The AraC-family regulator GadX enhances multidrug resistance of Escherichia coli by activating expression of the mdtEF multidrug efflux genes2008

    • Author(s)
      Kunihiko Nishino, Yasuko Senda and Akihito Yamaguchi
    • Journal Title

      Journal of Infection and chemotherapy 14

      Pages: 23-29

    • NAID

      10021193134

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a spermidine excretion protein complex (MdtJI) in Esch erichia coli2008

    • Author(s)
      Kyohei Higashi, Hiroyuki Ishigure, Risa Demizu, Takeshi Uemura, Kunihiko Nishino, Akihito Yamaguchi, Keiko Kashiwagi and Kazuei Igarashi
    • Journal Title

      Journal of Bacteriology 190

      Pages: 872-878

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tissue specific expression of the splice variants of the mouse vacuolar proton-translocating ATPase a4 subunit2008

    • Author(s)
      Kawasaki-Nishi Shoko, Yamaguchi Akihito, Forgac Michael and Nishi Tsuyoshi
    • Journal Title

      Biochemical and Biophysical Research Communications 364

      Pages: 1032-1036

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation mechanism of Salmonella AcrAB-TolC xenobiotic transport system in response to bacterial metabolites2008

    • Author(s)
      Eiji Nikaido, Kunihiko Nishino and Akihito Yamaguchi
    • Journal Title

      Journal of the Pharmaceutical Society of Japan 128

      Pages: 27-28

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Rapid detection of drug efflux from single bacterial cell enclosed in femtoliter chamber array2008

    • Author(s)
      Ryota Iino, Kunihiko Nishino, Masayoshi Nakata, Eiji Nikaido, Yoshimi Matsumoto, Syoichi Sakakihara, Syoji Takeuchi, Akihito Yamaguchi and Hiroyuki Noji
    • Journal Title

      Micro Total Analysis Systems 1

      Pages: 757-759

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Regulation of multidrug efflux systems involved in multidrug and metal resistance of Salmonella enterica serovar Typhimurium2008

    • Author(s)
      Kunihiko Nishino, Eiji Nikaido and Akihito Yamaguchi
    • Journal Title

      Journal of Bacteriology 189

      Pages: 9066-9075

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 異物排出タンパクのメカニズム2008

    • Author(s)
      山口 明人
    • Journal Title

      感染・炎症・免疫 37

      Pages: 106-115

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 大腸菌の異物排出トランスポーターAcrBの構造と異物認識機構2008

    • Author(s)
      村上 聡、山口 明人
    • Journal Title

      生化学 79

      Pages: 542-549

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Regulation of multidrug efflux systems involved in multidrug and metal resistance of Salmonella enterica serovar Typhimurium2007

    • Author(s)
      Nishino K., Nikaido E., Yamaguchi A.
    • Journal Title

      J.Bacteriol. 189

      Pages: 9066-9075

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Effect of NlpE overproduction on multidrug resistance in Escherichia coli

    • Author(s)
      Nishino K., Yamasaki S., Hayashi-Nishino M., Yamaguchi A.
    • Journal Title

      Antimicrob.Agents Chemother. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of RNA chaperone Hfq on Multidrug resistance in Escherichia coli

    • Author(s)
      Yamada J., Yamasaki S., Hirakawa H., Hayashi-Nishino M., Yamaguchi A., Nishino K.
    • Journal Title

      J.Antimicrob.Chemother. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Regulation of the AcrAB xenobiotic transport system in response to environmental signals2012

    • Author(s)
      Kunihiko Nishino, Eiji Nikaido, Ikue Shirosaka, Seiji Yamasaki
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket2012

    • Author(s)
      Seiji Yamasaki, Ryosuke Nakashima, Keisuke Sakurai, Kunihiko Nishino, Akihito Yamaguchi
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Immuno-Electron Tomography for Elucidation of Localization of the Mutidrug Efflux Pump in Salmonella2012

    • Author(s)
      Mitsuko Hayashi-Nishino, Akihito Yamaguchi, Kunihiko Nishino
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Outer Membrane Permeabilizing Effects of Phe-Arg-β-Naphthylamide on Pseudomonas aeruginosa2012

    • Author(s)
      Yoshimi Matsumoto, Kunihiko Nishino, Akihito Yamaguchi
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎
    • Year and Date
      2012-03-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] 外膜透過性亢進薬としてのPhe-Arg-β-naphtylamide (PAN)2012

    • Author(s)
      松本佳巳, 西野邦彦, 山口明人
    • Organizer
      第46回緑膿菌感染症研究会
    • Place of Presentation
      東京
    • Year and Date
      2012-02-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Electron/Immuno-electron Tomography of Autophagosomal Membranes and Bacterial Multidrug Efflux Systems2012

    • Author(s)
      Mitsuko Hayashi-Nishino
    • Organizer
      The 15th SANKEN International Symposium 2012, The 10th SANKEN Nanotechnology Symposium
    • Place of Presentation
      大阪
    • Year and Date
      2012-01-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mechanism of multidrug recognition by the RamR regulatory protein required for the induction of the AcrAB multidrug efflux pump2012

    • Author(s)
      S.Yamasaki, E.Nikaido, K.Sakurai, R.Nakashima, A.Yamaguchi, K.Nishino
    • Organizer
      The 15th SANKEN International Symposium 2012, The 10th SANKEN Nanotechnology Symposium
    • Place of Presentation
      大阪
    • Year and Date
      2012-01-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] 生物による異物認識の原点:異物排出タンパクの構造に見る異物認識原理2011

    • Author(s)
      山口明人
    • Organizer
      第3回知の拠点セミナー
    • Place of Presentation
      東京(招待)
    • Year and Date
      2011-12-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] マイクロデバイスを用いた簡易迅速多剤耐性緑膿菌検出法2011

    • Author(s)
      松本佳巳
    • Organizer
      第40回薬剤耐性菌研究会
    • Place of Presentation
      群馬
    • Year and Date
      2011-12-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] マイクロデバイスを用いた簡易迅速多剤耐性緑膿菌(MDRP)検出法2011

    • Author(s)
      葉山浩平、松本佳巳、西野邦彦、山口明人
    • Organizer
      第59回日本化学療法学会西日本支部総会/第54回日本感染症学会中日本地方会学術集会
    • Place of Presentation
      奈良
    • Year and Date
      2011-11-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] 排出タンパクによる異物認識機構-最新の知見2011

    • Author(s)
      山口明人
    • Organizer
      第33回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      岡山(招待)
    • Year and Date
      2011-11-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] サルモネラ薬物排出トランスポーターの生理機能解析2011

    • Author(s)
      大野愛子、尾島学、西野美都子、山口明人、西野邦彦
    • Organizer
      第33回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      岡山
    • Year and Date
      2011-11-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 細菌異物排出トランスポーターの機能解析2011

    • Author(s)
      山崎聖司、中島良介、櫻井啓介、西野邦彦、山口明人
    • Organizer
      第33回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      岡山
    • Year and Date
      2011-11-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 生物はいかにして異物を認識するか2011

    • Author(s)
      山口明人
    • Organizer
      産業科学研究第67回学術講演会
    • Place of Presentation
      大阪
    • Year and Date
      2011-11-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 多剤耐性サルモネラ異物排出トランスポーターAcrB発現制御機構の解析2011

    • Author(s)
      山崎優、二階堂英司、城阪郁江、櫻井啓介、中島良介、山口明人、西野邦彦
    • Organizer
      産業科学研究第67回学術講演会
    • Place of Presentation
      大阪
    • Year and Date
      2011-11-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新たな共結晶構造から明らかになった多剤排出タンパクAcrBの多剤認識機構2011

    • Author(s)
      山崎聖司, 中島良介, 櫻井啓介, 西野邦彦, 山口明人
    • Organizer
      第64回日本細菌学会関酉支部総会
    • Place of Presentation
      大阪
    • Year and Date
      2011-11-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] Immuno-electron tomography for elucidation of localization of the mutidrug efflux pumps in Salmonella2011

    • Author(s)
      Mitsuko Hayashi-Nishino, Akihito Yamaguchi, Kunihiko Nishino
    • Organizer
      7th Handai Nanoscience and Nanotechnology International Symposium
    • Place of Presentation
      大阪
    • Year and Date
      2011-11-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] Peristaltic Mechanism of Multidrug Efflux Transporter AcrB Revealed by the Crystal Structure of AcrB with High-Molecular-Weight Drugs2011

    • Author(s)
      Nakashima R., Sakurai K., Yamasaki S., Nishino K., Yamaguchi A.
    • Organizer
      7th Handai Nanoscience and Nanotechnology International Symposium
    • Place of Presentation
      大阪
    • Year and Date
      2011-11-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] マイクロデバイスを用いた迅速多剤耐性緑膿菌(MDRP)検出法2011

    • Author(s)
      葉山浩平、松本佳巳、西野邦彦、山口明人
    • Organizer
      第58回日本化学療法学会東日本支部総会/第60回日本感染症学会東日本地方学術集会合同学会
    • Place of Presentation
      山形
    • Year and Date
      2011-10-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Deveropment of novel therapeutic strategies to tackle multidrug-resistant pathogens2011

    • Author(s)
      Mitsuko Hayashi-Nishino, Ryosuke Nakashima, Keisuke Sakurai, Akihito Yamaguchi, Kunihiko Nishino
    • Organizer
      FRANCE-JAPAN WORKSHOP, Bio-inspired approaches : Micro-& Nano-Architectures, Materials & Imaging
    • Place of Presentation
      France
    • Year and Date
      2011-10-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] Peristaltic mechanism of multidrug efflux transport2011

    • Author(s)
      Akihito Yamaguchi, Ryosuke Nakashima, Keisuke Sakurai, Seiji Yamasaki, Kunihiko Nishino
    • Organizer
      FRANCE-JAPAN WORKSHOP, Bio-inspired approaches : Micro-& Nano-Architectures, Materials & Imaging
    • Place of Presentation
      France
    • Year and Date
      2011-10-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] Small RNAによる細菌多剤耐性化メカニズムの解明2011

    • Author(s)
      山崎聖司、西野-林美都子、山口明人、西野邦彦
    • Organizer
      第84回日本生化学大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] サルモネラ異物排出トランスポーターAcrB発現制御ネットワーク解析2011

    • Author(s)
      山崎優, 二階堂英司, 城阪郁江, 櫻井啓介, 中島良介, 山口明人, 西野邦彦
    • Organizer
      第84回日本生化学大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] Antibiotic Augmenting Activities of Phe-Arg-β-Naphthylamide Based on its Membrane Permeabilizing Effects2011

    • Author(s)
      Y.Matsumoto, K.Nishino, A.Yamaguchi
    • Organizer
      51st Interscience Conference on Antimicrobial Agents and Chemotherapy(ICAAC)
    • Place of Presentation
      U.S.A.
    • Year and Date
      2011-09-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effect of efflux pump inhibition versus outer membrane permeabilization to antimicrobial activities of ciprofloxacin and erythromycin against Pseudomonas aeruginosa2011

    • Author(s)
      Y.MATSUMOTO, K.NISHINO, A.YAMAGUCHI
    • Organizer
      国際微生物学連盟2011(IUMS 2011)会議/第84回日本細菌学会総会
    • Place of Presentation
      北海道
    • Year and Date
      2011-09-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] AcrA dependency of the AcrD efflux pump in Salmonella enterica serovar typhimurium2011

    • Author(s)
      Seiji Yamasaki, Saya Nagasawa, Mitsuko Hayashi-Nishino, Akihito Yamaguchi, Kunihiko Nishino
    • Organizer
      国際微生物学連盟2011(IUMS 2011)会議/第84回日本細菌学会総会
    • Place of Presentation
      北海道
    • Year and Date
      2011-09-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] 多剤耐性サルモネラ異物排出トランスポーターAcrB発現制御因子RamRと基質との相互作用解析2011

    • Author(s)
      山崎優, 二階堂英司, 櫻井啓介, 中島良介, 山口明人, 西野邦彦
    • Organizer
      第5回細菌学若手コロッセウム
    • Place of Presentation
      高知
    • Year and Date
      2011-08-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] マルチコンポーネント型薬剤排出蛋白質の機能解明2011

    • Author(s)
      西野邦彦、中島良介、西野美都子
    • Organizer
      新学術領域研究「過渡的複合体」公開シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2011-07-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] The Reguration of the AcrAB multidrug efflux pump in Salmonella2011

    • Author(s)
      Suguru Yamasaki, nikaido eiji, Keisuke Sakurai, Ryousuke Nakashima, Akihito Yamaguchi, Kunihiko Nishino
    • Organizer
      France 4th Symposium on Antimicrobial Resistance in Animals and the Environment
    • Place of Presentation
      France
    • Year and Date
      2011-06-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 排出ポンプ阻害薬と外膜透過性亢進薬の有用性2011

    • Author(s)
      松本佳巳、西野邦彦、山口明人
    • Organizer
      第59回日本化学療法学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2011-06-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] Structural basis of multidrug efflux2011

    • Author(s)
      Yamaguchi A.
    • Organizer
      The 80th Anniversary Commemoration of Osaka University International Symposium Series
    • Place of Presentation
      Hampshire Hotel-Plaza(Groningen, The Netherlands)(招待講演)
    • Year and Date
      2011-06-22
    • Related Report
      2011 Final Research Report
  • [Presentation] Structural basis of multidrug efflux2011

    • Author(s)
      Akihito Yamaguchi
    • Organizer
      The 80th Anniversary Commemoration of Osaka University International Symposium Series
    • Place of Presentation
      Netherlands(招待)
    • Year and Date
      2011-06-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] Development of novel therapeutic strategies to tackle multidrug-resistant pathogens2011

    • Author(s)
      Nishino, K., S.Yamasaki, M.Hayashi-Nishino, A.Yamaguchi
    • Organizer
      The American Association for the Advancement of Science (AAAS) 2011 Annual Meeting
    • Place of Presentation
      Washington, DC, U.S.A.
    • Year and Date
      2011-02-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 排出ポンプ阻害剤Phe-Arg-ss-naphtylamide (PAN)の作用メカニズム2011

    • Author(s)
      松本佳巳、葉山浩平、飯野亮太、西野邦彦、野地博行、山口明人
    • Organizer
      第45回緑膿菌感染症研究会
    • Place of Presentation
      仙台、宮城
    • Year and Date
      2011-02-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Streptococcus pneumoniaeの自然免疫回避におけるPfbAの役割2011

    • Author(s)
      山口雅也、寺尾豊、西野邦彦、山口明人、浜田茂幸、川端重忠
    • Organizer
      第3回口腔環境制御研究カテゴリー集会
    • Place of Presentation
      長崎
    • Year and Date
      2011-02-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Function of mammalian sphingosin 1-phosphate transporter2011

    • Author(s)
      Nishi, T., Hisano, Y., Kawasaki-Nishi, S., Yamaguchi, A.
    • Organizer
      The 14^<th> SANKEN international symposium
    • Place of Presentation
      ロイヤルオークホテル、大津
    • Year and Date
      2011-01-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Functional network of multi-component drug efflux systems in Salmonella enterica serovar typhimurium2011

    • Author(s)
      Yamasaki, S., S.Nagasawa, M.Hayashi-Nishino, A.Yamaguchi, K.Nishino
    • Organizer
      The 14^<th> SANKEN international symposium
    • Place of Presentation
      ロイヤルオークホテル、大津
    • Year and Date
      2011-01-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 異物排出タンパクAcrBに存在する基質結合マルチサイトの解明2011

    • Author(s)
      櫻井啓介、中島良介、山崎聖司、西野邦彦、山口明人
    • Organizer
      平成23年度日本結晶学会年会
    • Place of Presentation
      北海道
    • Related Report
      2011 Annual Research Report
  • [Presentation] スフィンゴシン1リン酸輸送体の同定と機能解析2010

    • Author(s)
      西毅、小林直木、久野悠、川原敦雄、山口明人
    • Organizer
      日本生体エネルギー研究会第35回討論会
    • Place of Presentation
      北海道
    • Year and Date
      2010-12-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] Functional analysis of a novel S1P transporter, SPNS22010

    • Author(s)
      Y.Hisano, A.Yamaguchi, T.Nishi
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      兵庫
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] TolC dependency of multidrug efflux systems in Salmonella enterica serovar Typhimurium2010

    • Author(s)
      T.Horiyama, A.Yamaguchi, K.Nishino
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      兵庫
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] サルモネラ異物排出トランスポーターAcrABの発現制御に関与するRamRの解析2010

    • Author(s)
      二階堂英司、櫻井啓介、中島良介、城阪郁江、山口明人、西野邦彦
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      兵庫
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] RNA chaperone regulates the multidrug transporter AcrB in Escherichia coli2010

    • Author(s)
      S.Yamasaki, J.Yamada, H.Hirakawa, M.Hayashi-Nishino, A.Yamaguchi, K.Nishino
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      兵庫
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Streptococcus pneumoniaeは赤血球に侵入し好中球免疫を回避する2010

    • Author(s)
      山口雅也、寺尾豊、八木哲也、西野邦彦, 山口明人、川端重忠
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      兵庫
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] サルモネラ異物排出トランスポーターAcrAB発現制御因子RamRの構造機能解析2010

    • Author(s)
      二階堂英司、櫻井啓介、中島良介、城阪郁江、山口明人、西野邦彦
    • Organizer
      平成22年度日本結晶学会年会
    • Place of Presentation
      大阪大学コンベンションセンター
    • Year and Date
      2010-12-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Role of the RNA chaperon Hfq in multidrug resistance of Escherichia coli2010

    • Author(s)
      Nishino, K., S.Yamasaki, M.Hayashi-Nishino, A.Yamaguchi
    • Organizer
      Joint meeting of the NZ Microbiological Society and NZ Society for Biochemistry & Molecular Biology
    • Place of Presentation
      The Univ.Auckland, New Zealand
    • Year and Date
      2010-12-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 免疫抑制剤FTY720の作用機序におけるS1P輸送体SPNS2の役割2010

    • Author(s)
      久野悠、山口明人、西毅
    • Organizer
      第32回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      富山
    • Year and Date
      2010-11-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] S1P輸送体SPNS2の生理機能の解析2010

    • Author(s)
      西毅、久野悠、山口明人
    • Organizer
      第36回日本生体エネルギー研究会
    • Place of Presentation
      大阪大学銀杏会館
    • Year and Date
      2010-11-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] 排出ポンプ阻害剤Phe-Arg-ss-naphtylamide (PAN)の外膜障害作用2010

    • Author(s)
      松本佳巳、葉山浩平、飯野亮太、西野邦彦、野地博行、山口明人
    • Organizer
      第39回薬剤耐性菌研究会
    • Place of Presentation
      伊香保、群馬
    • Year and Date
      2010-11-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] サルモネラ異物排出トランスポーターAcrAB発現制御因子RamRのX線結晶構造解析2010

    • Author(s)
      二階堂英司、櫻井啓介、西野邦彦、山口明人、中島良介
    • Organizer
      第48回日本生物物理学会
    • Place of Presentation
      東北大、宮城
    • Year and Date
      2010-09-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] TolC dependency of multidrug efflux systems in Salmonella enterica serovar Typhimurium2010

    • Author(s)
      T.Horiyama, A.Yamaguchi, K.Nishino
    • Organizer
      The 10th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Awaji, Hyogo
    • Year and Date
      2010-09-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Impact of Hfq on multidrug resistance in Escherichia coli2010

    • Author(s)
      S.Yamasaki, J.Yamada, H.Hirakawa, M.Hayashi-Nishino, A.Yamaguchi, K.Nishino
    • Organizer
      The 10th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Awaji, Hyogo
    • Year and Date
      2010-09-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] The analysis of sphingosine 1-phosphate secretion from cells expressing Spns22010

    • Author(s)
      Hisano, Y., Yamaguchi, A., Nish, T.
    • Organizer
      51st International conference on the Bioscience of Lipids
    • Place of Presentation
      Alhondiga Conference Center, Bilbao, Spain
    • Year and Date
      2010-09-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] サルモネラ異物排出トランスポーターAcrAB発現制御メカニズムの解析2010

    • Author(s)
      二階堂英司、櫻井啓介、中島良介、城阪郁江、山口明人、西野邦彦
    • Organizer
      第22回微生物シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 大腸菌多剤耐性化におけるRNAシャペロンHfqの役割2010

    • Author(s)
      山崎聖司、山田純子、平川秀忠、西野美都子、山口明人、西野邦彦
    • Organizer
      第22回微生物シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Structural basis of multidrug recognition2010

    • Author(s)
      Yamaguchi A.
    • Organizer
      Nanofair 2010-8th International Nanotechnology Symposium
    • Place of Presentation
      International Congress Center(Dresden, Germany)(招待講演)
    • Year and Date
      2010-07-06
    • Related Report
      2011 Final Research Report
  • [Presentation] Structural basis of multidrug recognition2010

    • Author(s)
      Akihito Yamaguchi
    • Organizer
      Nanofair 2010 8th International Nanotechnology Symposium
    • Place of Presentation
      International Congress Center Dresden, Germany(招待講演)
    • Year and Date
      2010-07-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] Sphingoshine 1-Phosphate Efflux Transporter2010

    • Author(s)
      Akihito Yamaguchi
    • Organizer
      The 27th Naito Conference, Membrane Dynamics and Lipid Biology[I]
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      2010-07-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Analysis of the mammalian sphingosine 1-phosphate transporters2010

    • Author(s)
      Nishi T., Hisano Y., Kobayashi N., Yamaguchi A.
    • Organizer
      The 27th Naito Conference, Membrane Dynamics and Lipid Biology[I]
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      2010-07-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Functional analysis of novel S1P transporter, Spns22010

    • Author(s)
      Hisano, Y., Yamaguchi, A., Nishi T.
    • Organizer
      The 27th Naito Conference, Membrane Dynamics and Lipid Biology[I]
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      2010-06-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] サルモネラ異物排出トランスポーターAcrABの発現制御機構解析2010

    • Author(s)
      二階堂英司、城阪郁江、中島良介、櫻井啓介、山口明人、西野邦彦
    • Organizer
      第10回日本蛋白質科学会年会
    • Place of Presentation
      札幌
    • Year and Date
      2010-06-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] スフィンゴシン1リン酸輸送体の同定と生理機能の解析2010

    • Author(s)
      西毅、久野悠、山口明人
    • Organizer
      第52回日本脂質生化学会
    • Place of Presentation
      伊香保・森秋旅館
    • Year and Date
      2010-06-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] Overexpressed Lipoprotein Increases Multidrug Resistance by Induction of Multidrug Transporters in E.coli2010

    • Author(s)
      S.Yamasaki, M.Hayashi-Nishino, A.Yamaguchi, K.Nishino
    • Organizer
      American Society for Microbiology 110th General Meeting
    • Place of Presentation
      San Diego, U.S.A.
    • Year and Date
      2010-05-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Electron Tomography Revealed the Endoplasmic Reticulum as a Source of Autophagosomal Membranes2010

    • Author(s)
      M.Hayashi-Nishino, N.Fujita, T.Noda, A.Yamaguchi, K.Nishino, T.Yoshimori, A.Yamamoto
    • Organizer
      American Society for Microbiology 110th General Meeting
    • Place of Presentation
      San Diego, U.S.A.
    • Year and Date
      2010-05-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 大腸菌マクロライド排出蛋白質の膜局在2010

    • Author(s)
      平田隆弘、北村昭夫、西野邦彦、山口明人
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 大腸菌薬剤排出ポンプ制御におけるNlpEの役割2010

    • Author(s)
      山崎聖司、西野美都子、山口明人、西野邦彦
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] S1P輸送体Spns2のヒトオルソログの機能解析2010

    • Author(s)
      久野悠、川原敦雄、山口明人、西毅
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] サルモネラ異物排出トランスポーターAcrABの発現制御ネットワーク解析2010

    • Author(s)
      二階堂英司、城阪郁江、中島良介、山口明人、西野邦彦
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      神奈川
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effects of pyridopyrimidine(PP)and Phe-Arg-β-naphthylamide(PAN)on MexB & MexY in Escherichia coli2010

    • Author(s)
      Matsumoto Y., Hayama K., Iino R., Nishino K., Noji H., Yamaguchi A.
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      神奈川
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 大腸菌を用いた緑膿菌のRND型排出ポンプMexABおよびMexXYの活性測定2010

    • Author(s)
      松本佳巳、葉山浩平、飯野亮太、西野邦彦、野地博行、山口明人
    • Organizer
      第42回緑膿菌感染症研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-02-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effects of NlpE overproduction on the induction of xenobiotic transporters involved in multidrug resistance in Escherichia coli2010

    • Author(s)
      Yamasaki S., Nishino-Hayashi M., Yamaguchi A., Nishino K.
    • Organizer
      The 13th SANKEN International Symposium
    • Place of Presentation
      大阪
    • Year and Date
      2010-01-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新規S1P輸送体Spns2の機能解析2009

    • Author(s)
      久野悠、川原敦雄、山口明人、西毅
    • Organizer
      日本生体エネルギー研究会第35回討論会
    • Place of Presentation
      北海道
    • Year and Date
      2009-12-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] Functional analysis of human spinster-like protein 3 ; a homologue of sphingosine 1-phosphate transporter, spns22009

    • Author(s)
      Murata M., Hisano Y., Yamaguchi A., Nishi T.
    • Organizer
      第31回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Electron tomography revealed a subdomain of the endoplasmic reticulum as a cradle for autophagosome formation2009

    • Author(s)
      Hayashi-Nishino M., Fujita N., Noda T., Yamaguchi A., Nishino K., Yoshimori T., Yamamoto A.
    • Organizer
      第31回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Characterization of the sphingoshin-1-phosphate transporter2009

    • Author(s)
      Nishi N., Kobayashi N., Hisano Y., Yamaguchi A.
    • Organizer
      第31回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2009-11-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] The localization study of a bacterial efflux transporter2009

    • Author(s)
      Hirata T., Kitamura A., Nishino K., Yamaguchi A.
    • Organizer
      第31回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2009-11-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Regulation mechanism of Salmonella AcrAB Multidrug Efflux Pump in Response to Extracellular Signals2009

    • Author(s)
      Nikaido E., Shirosaka I., Nakashima R., Yamaguchi A., Nishino K.
    • Organizer
      第31回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2009-11-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] サルモネラ多剤排出トランスポーターの生理機能解明2009

    • Author(s)
      西野邦彦、二階堂英司、松本佳巳、山口明人
    • Organizer
      第57回日本化学療法学会西日本支部総会
    • Place of Presentation
      愛知
    • Year and Date
      2009-11-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] スフィンゴシン1-リン酸(S1P)輸送体Spns2による心臓発生の制御機構2009

    • Author(s)
      久野悠、川原敦雄、山口明人、西毅、望月直樹
    • Organizer
      第19回日本循環薬理学会
    • Place of Presentation
      京都
    • Year and Date
      2009-11-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Fluorescein di-β-D-galactopyranoside(FDG)を用いた排出ポンプ阻害剤の評価2009

    • Author(s)
      松本佳巳、葉山浩平、飯野亮太、西野邦彦、野地博行、山口明人
    • Organizer
      第38回薬剤耐性菌研究会
    • Place of Presentation
      群馬
    • Year and Date
      2009-11-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] Sphingosine 1-phosphate Exporter Spins2 Identification of the transporter that export sphingosine 1-phosphate from the cells2009

    • Author(s)
      Yamaguchi A.
    • Organizer
      11th International Conference
    • Place of Presentation
      Cancun, Mexico
    • Year and Date
      2009-10-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 外部シグナルによるサルモネラ異物排出トランスポーターAcrAB発現制御メカニズム解析2009

    • Author(s)
      二階堂英司、城阪郁江、中島良介、山口明人、西野邦彦
    • Organizer
      第3回細菌学・若手コロッセウム
    • Place of Presentation
      宮崎
    • Year and Date
      2009-10-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] Salmonella gene regulation mechanism by RamA in response to signals(口頭)2009

    • Author(s)
      Nikaido E., Shirosaka I, Nakashima R., Yamaguchi A., Nishino K.
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      兵庫
    • Year and Date
      2009-10-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] Salmonella gene regulation mechanism by RamA in response to signals(ポスター)2009

    • Author(s)
      Nikaido E., Shirosaka I, Nakashima R., Yamaguchi A., Nishino K.
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      兵庫
    • Year and Date
      2009-10-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] Spns2はスフィンゴシン-1-リン酸(S1P)の細胞外への放出を制御する2009

    • Author(s)
      川原敦雄、西毅、久野悠、山口明人、望月直樹
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      兵庫
    • Year and Date
      2009-10-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] スフィンゴシン1-リン酸(S1P)の光反応性アナログを用いたS1P輸送体の探索2009

    • Author(s)
      小林直木、西毅、山口明人
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      兵庫
    • Year and Date
      2009-10-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 血小板モデル細胞を用いたS1P輸送体の探索2009

    • Author(s)
      久野悠、山口明人、西毅
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      兵庫
    • Year and Date
      2009-10-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] Roles of xenobiotic transporters in bacterial drug resistance and virulence2009

    • Author(s)
      Nishino K., Yamaguchi A.
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      兵庫
    • Year and Date
      2009-10-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effects of lipoprotein overproduction on the induction of xenobiotic transporters involved in multidrug resistance in Salmonella enterica2009

    • Author(s)
      Shirosaka I., Nikaido E., Yamaguchi A., Nishino K.
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      兵庫
    • Year and Date
      2009-10-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] Roles of bacterial xenobiotic transporters in immune evasion2009

    • Author(s)
      Ueda T., Hayashi-Nishino M., Yamaguchi A., Nishino K.
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      兵庫
    • Year and Date
      2009-10-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] Autophagy and the Endoplasmic Reticulum2009

    • Author(s)
      Hayashi-Nishino M., Fujita N., Noda T., Yamaguchi A., Yoshimori T., Yamamoto A.
    • Organizer
      5th International Symposium on Autophagy
    • Place of Presentation
      滋賀
    • Year and Date
      2009-09-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Membrane-damaging activity of Phe-Arg-β-Naphthylamide in Escherichiacol2009

    • Author(s)
      Matsumoto Y., Hayama K., Iino R., Nishino K., Noji H., Yamaguchi A.
    • Organizer
      49years ICAAC, Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2009-09-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] Roles of xenobiotic transporters in bacterial drug resistance and virulence2009

    • Author(s)
      Nishino, K., Yamaguchi A.
    • Organizer
      The Awaji International Forum on Infection and Immunity
    • Place of Presentation
      兵庫
    • Year and Date
      2009-09-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] 大腸菌RND型薬剤排出ポンプの進化2009

    • Author(s)
      田中真奈美、川下理日人、高木達也、安永照雄、山口明人、西野邦彦
    • Organizer
      第11回日本進化学会大会
    • Place of Presentation
      北海道
    • Year and Date
      2009-09-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 排出ポンプ阻害活性と膜障害作用の分離評価2009

    • Author(s)
      松本佳巳、西野邦彦、飯野亮太、野地博行、山口明人
    • Organizer
      第57回日本化学療法学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-06-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Electron Tomography Revealed a Subdomain of the Endoplasmic Reticulum as a Cradle for Autophagosome Formation2009

    • Author(s)
      Hayashi-Nishlino M., Fujita N., Noda T., Yamaguchi A., Yoshimori T., Yamamoto A.
    • Organizer
      第61回日本細胞生物学会大会
    • Place of Presentation
      愛知
    • Year and Date
      2009-06-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] ラット赤血球におけるATP依存的スフィンゴシン1リン酸輸送体の解析2009

    • Author(s)
      小林直木、小林伸好、西毅、山口明人
    • Organizer
      第4回トランスポーター研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-05-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 血小板様分子を産生するMEG-01細胞を用いたS1P輸送体の探索2009

    • Author(s)
      久野悠、西毅、山口明人
    • Organizer
      第4回トランスポーター研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-05-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] サルモネラ異物排出トランスポーターAcrAB誘導に関与するRamAおよびRamRの解析2009

    • Author(s)
      城阪郁江、二階堂英司、中島良介、山口明人
    • Organizer
      第9回日本蛋白質科学会年会
    • Place of Presentation
      熊本
    • Year and Date
      2009-05-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] Sphingosine-1-phosphate (S1P) Release From Erythrocytes Mediated By ATP-dependent Transporter2009

    • Author(s)
      N. Kobayashi, N. Kobayashi, T. Nishi, A. Yamaguchi
    • Organizer
      12th Sanken International Symposium/7th nanote chnology center international symposium/2nd MSTEC international symposium/1st Sanken Alliance Symposium
    • Place of Presentation
      Osaka
    • Year and Date
      2009-01-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] Identification of the transporter that export sphingosine 1-phosphate from the cells2009

    • Author(s)
      Yamaguchi A.
    • Organizer
      11th International Conference-Cancun
    • Place of Presentation
      Mexico
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] AcrAB multidrug efflux pump regulation in Salmonella enterica serovar Typhimurium by RamA in response to environmental signals2008

    • Author(s)
      K. Nishino, E. Nikaido, A. Yamaguchi
    • Organizer
      The Awaji International Forum on Infection and Immunity
    • Place of Presentation
      兵庫
    • Year and Date
      2008-09-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] サルモネラ異物排出トランスポーターAcrABの発現制御と環境応答におけるRamAの役割2008

    • Author(s)
      二階堂英司, 西野邦彦, 山口明人
    • Organizer
      第2回細菌学・若手コロッセウム
    • Place of Presentation
      神奈川
    • Year and Date
      2008-08-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] 排出機構 -多剤耐性化と病原因子のキー・プレイヤー2008

    • Author(s)
      西野邦彦
    • Organizer
      第82回日本感染症学会総会
    • Place of Presentation
      島根
    • Year and Date
      2008-04-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] Metal Resistance Roles of Multidrug Transporters in Salmonella enterica2008

    • Author(s)
      ○西野 邦彦、二階堂 英司、山口 明人
    • Organizer
      日本薬学会第128回年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] サルモネラ異物排出トランスポーターAcrAB制御因子の同定2008

    • Author(s)
      ○二階堂 英司 、西野 邦彦、山口 明人
    • Organizer
      日本薬学会第128回年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] サルモネラ異物排出トランスポーターEmrABの機能解析2008

    • Author(s)
      ○坂田 博樹、西野 邦彦、山口 明人
    • Organizer
      日本薬学会第128回年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] Characterization of ATP-dependent transport of the sphingosine-1-phosphate (S1P) in rat erythrocytes2008

    • Author(s)
      ○小林 直木、小林 信好、西 毅、山口 明人
    • Organizer
      日本薬学会第128回年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] Analysis of the S1P transporter in MEG-01 cell line2008

    • Author(s)
      ○久野 悠、西 毅、山口 明人
    • Organizer
      日本薬学会第128回年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] Analysis of the expression site and the physiological role of mouse ABC A52008

    • Author(s)
      ○大東 穂、西 毅、山口 明人
    • Organizer
      日本薬学会第128回年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] Cellular localization of drug efflux transporters in Escherichia coli2008

    • Author(s)
      ○平田 隆弘、北村 昭夫、西野 邦彦、山口 明人
    • Organizer
      日本薬学会第128回年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] 異物排出トランスポーターの構造・機能とその制御に関する研究2008

    • Author(s)
      山口明人
    • Organizer
      日本薬学会第128回年会
    • Place of Presentation
      パシフィコ横浜(横浜)(日本薬学会賞受賞公演、招待講演)
    • Year and Date
      2008-03-26
    • Related Report
      2011 Final Research Report
  • [Presentation] Studies on the Structure, Function and Regulation of Xenobiotic Exporters2008

    • Author(s)
      ○山口 明人
    • Organizer
      日本薬学会第128回年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] サルモネラ異物排出トランスポーターAcrAB生理的役割と発現誘導機構の解析2008

    • Author(s)
      ○二階堂 英司、西野 邦彦、山口 明人
    • Organizer
      第81回日本細菌学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-03-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] サルモネラ異物排出トランスポーターEmrABの機能解析2008

    • Author(s)
      ○坂田 博樹、西野 邦彦、山口 明人
    • Organizer
      第81回日本細菌学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-03-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] 大腸菌薬剤排出タンパク質の細胞内局在2008

    • Author(s)
      ○平田 隆弘、北村 昭夫、西野 邦彦、山口 明人
    • Organizer
      第81回日本細菌学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-03-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] 細菌異物排出タンパクの構造・機能とその発現制御に関する研究2008

    • Author(s)
      山口明人
    • Organizer
      第81回日本細菌学会総会
    • Place of Presentation
      国立京都国際会館(京都)(浅川賞受賞講演、招待講演)
    • Year and Date
      2008-03-25
    • Related Report
      2011 Final Research Report
  • [Presentation] 細菌異物排出タンパクの構造・機能とその発現制御に関する研究2008

    • Author(s)
      ○山口 明人
    • Organizer
      第81回日本細菌学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-03-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] サルモネラ菌薬剤排出ポンプの生理機能 -多剤耐性および病原性発現における役割について-2008

    • Author(s)
      ○西野 邦彦、山口 明人
    • Organizer
      第81回日本細菌学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-03-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] 異物排出蛋白質発現抑制因子AcrSの機能解明とAcrAB,AcrEFの発現制御2008

    • Author(s)
      ○平川 秀忠、西野 邦彦、平田 隆弘、山口 明人
    • Organizer
      第81回日本細菌学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-03-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] Phenotypic analysis of multidrug efflux pumps-not just for multidrug resistance2008

    • Author(s)
      ○Kunihiko Nishino
    • Organizer
      Florence Conference on Phenotype MicroArray Analysis of Microorganisms
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2008-03-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] Roles of multidrug efflux pumps in antimicrobial peptide resistance of Salmonella enterica2008

    • Author(s)
      ○Tomoyuki Nakano, Kunihiko Nishino and Akihito Yamaguchi
    • Organizer
      Florence Conference on Phenotype MicroArray Analysis of Microorganisms
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2008-03-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] Regulatory network of AcrAB multidrug efflux pump in Salmonella and its role in response to metabolites2008

    • Author(s)
      ○Eiji Nikaido, Kunihiko Nishino and Akihito Yamaguchi
    • Organizer
      Florence Conference on Phenotype MicroArray Analysis of Microorganisms
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2008-03-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] Physiological functions of bacterial multidrug efflux pumps2008

    • Author(s)
      ○Kunihiko Nishino and Akihito Yamaguchi
    • Organizer
      The 3rd CNU-SANKEN Joint Symposium on Advanced Materials Science
    • Place of Presentation
      Chungnam National University, Korea
    • Year and Date
      2008-02-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] 多剤排出トランスポーターの構造と機能発現2008

    • Author(s)
      ○山口 明人
    • Organizer
      第2回 分子生物薬剤学セミナー「トランスポーター科学最前線」
    • Place of Presentation
      金沢大学、石川県
    • Year and Date
      2008-02-16
    • Related Report
      2007 Annual Research Report
  • [Presentation] Structural Basis of Bacterial Multidrug Export2008

    • Author(s)
      ○Akihito Yamaguchi
    • Organizer
      11th Sanken International Symposium/6th nanotechnology center international symposium/1st MSTEC international symposium
    • Place of Presentation
      Hyogo
    • Year and Date
      2008-02-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] Analysis of the S1P transporter in MEG-01 cell line2008

    • Author(s)
      ○Yu Hisano
    • Organizer
      11th Sanken International Symposium/6th nanotechnology center international symposium/1st MSTEC international symposium
    • Place of Presentation
      Hyogo
    • Year and Date
      2008-02-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Analysis of the expression-site and the physiological role of mouse ABCA52008

    • Author(s)
      ○Megumi Ohigashi
    • Organizer
      11th Sanken International Symposium/6th nanotechnology center international symposium/1st MSTEC international symposium
    • Place of Presentation
      Hyogo
    • Year and Date
      2008-02-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Regulatory network of AcrAB multidrug efflux pump in Salmonella and its role in response to metabolites2008

    • Author(s)
      ○Eiji Nikaido
    • Organizer
      11th Sanken International Symposium/6th nanotechnology center international symposium/1st MSTEC international symposium
    • Place of Presentation
      Hyogo
    • Year and Date
      2008-02-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Structure and Mechanism of the Tripartite Multidrug Exporter2008

    • Author(s)
      Yamaguchi A.
    • Organizer
      The Joint 4th AOHUPO(Asian Oceania Human Proteome Organisation) and 2nd PRICPS(Pacific Rim International Conference on Protein Science)
    • Place of Presentation
      Carins Convention Center, Australia
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Structure and Mechanism of the Tripartite Multidrug Exporter2008

    • Author(s)
      A. Yamaguchi, S. Murakami
    • Organizer
      The Joint 4^<th> AOHUPO (Asian Oceania Human Proteome Organization) and 2^<nd> PRICPS (Pacific Rim International Conference on Protein Science)
    • Place of Presentation
      Cairns, Australia
    • Related Report
      2008 Annual Research Report
  • [Presentation] Electron Tomography Revealed the Endoplasmic Reticulum as a Cradle for Autophagosome Formation2008

    • Author(s)
      M. Hayashi-Nishino, N. Fujita, T. Noda, A. Yamaguchi, T. Yoshimori, A. Yamamoto
    • Organizer
      The American Society for Cell Biology 48th Annual Meeting
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] Electron tomographic reconstruction of clathrin coated endocytic intermediates in nerve terminals that lack dynamin 12008

    • Author(s)
      M. Hayashi-Nishino, E. O'Toole, S. Ferguson, A. Yamaguchi, P. De Camilli
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Presentation] 輸送体を介した赤血球からのスフィンゴシン1リン酸放出機構2008

    • Author(s)
      小林直木, 小林伸好, 西毅, 山口明人
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Presentation] RamAによるサルモネラ異物排出トランスポーターAcrAB発現制御機構の解析2008

    • Author(s)
      二階堂英司, 西野邦彦, 城阪郁江, 山口明人
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Presentation] 膜傷害保護における異物排出トランスポーターの役割2008

    • Author(s)
      坂田博樹, 西野邦彦, 上田珠美, 山口明人
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Presentation] 抗菌ペプチド耐性における多剤排出ポンプの役割2008

    • Author(s)
      中濃知志, 西野邦彦, 山口明人
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Presentation] Regulatory network of multidrug transporters reveals their physiological role in Salmonella virulence2008

    • Author(s)
      西野邦彦, 山口明人
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Presentation] 大腸菌異物排出タンパク質AcrBの基質認識における芳香族アミノ酸の重要性2008

    • Author(s)
      岩田歩, 村上聡, 山口明人
    • Organizer
      第46回日本生物物理学会年会
    • Place of Presentation
      福岡
    • Related Report
      2008 Annual Research Report
  • [Presentation] 神経細胞におけるABC (ATP Binding Cassette)輸送体ABCA5の発現2008

    • Author(s)
      大東穂, 西毅, 山口明人
    • Organizer
      第30回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      北海道
    • Related Report
      2008 Annual Research Report
  • [Presentation] MC-7-05 MEG-01細胞からのS1P放出輸送体のsiRNAによる検索2008

    • Author(s)
      久野悠, 西毅, 山口明人
    • Organizer
      第30回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      北海道
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脂溶性情報伝達物質の細胞外放出機構の解明2008

    • Author(s)
      西毅, 小林直木, 山口明人
    • Organizer
      第30回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      北海道
    • Related Report
      2008 Annual Research Report
  • [Presentation] 細菌トランスポートソームのレジストーム解析2008

    • Author(s)
      西野邦彦, 二階堂英司, 坂田博樹, 中濃知志, 田中真奈美, 西野-林美都子, 上田珠美, 城阪郁江, 山口明人
    • Organizer
      第30回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      北海道
    • Related Report
      2008 Annual Research Report
  • [Presentation] 電子線トモグラフィーを用いたダイナミン1KOシナプスにおけるエンドサイトーシス中間体の解析2008

    • Author(s)
      西野-林美都子, Eileen O'Toole, Shawn Ferguson, 西野邦彦, 山口明人, Pietro De Camilli
    • Organizer
      第30回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      北海道
    • Related Report
      2008 Annual Research Report
  • [Presentation] 膜傷害保護における異物排出トランスポーターの役割2008

    • Author(s)
      坂田博樹, 西野邦彦, 山口明人
    • Organizer
      第30回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      北海道
    • Related Report
      2008 Annual Research Report
  • [Presentation] Regulatory network of multidrug efflux pumps reveals their physiological role in Salmonella virulence2008

    • Author(s)
      K. Nishino, A. Yamaguchi
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      MA, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] Molecular Design of the Carbenicillin Hyper-Resistance AcrB Multidrug Exporter in Escherichia coli2008

    • Author(s)
      A. Iwata, N. Kobayashi, S. Murakami, A. Yamaguchi
    • Organizer
      22nd Annual Symposium of The Protein Siciety
    • Place of Presentation
      San Diego, California USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] 大腸菌とサルモネラにおける薬剤排出ポンプ役割解明に関する研究2008

    • Author(s)
      西野邦彦
    • Organizer
      第12回腸内細菌学会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] Regulatory Network of Multidrug Transporters Reveals their Physiological Role in Salmonella Virulence2008

    • Author(s)
      K. Nishino, A. Yamaguchi
    • Organizer
      American Society for Microbiology 108th General Meeting
    • Place of Presentation
      Boston, Massachusetts
    • Related Report
      2008 Annual Research Report
  • [Presentation] Regulation of the AcrAB Multidrug Efflux Pump in Salmonella enterica by RamA in Response to Environmental Signals2008

    • Author(s)
      E. Nikaido, K. Nishino, A. Yamaguchi
    • Organizer
      American Society for Microbiology 108th General Meeting
    • Place of Presentation
      Boston, Massachusetts
    • Related Report
      2008 Annual Research Report
  • [Presentation] Analysis of the xenobiotic exporter EmrAB in Salmonella enterica serovar Typhimurium2007

    • Author(s)
      ○坂田 博樹、西野 邦彦、山口 明人
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] The regulatory mechanism of the AcrAB and AcrEF multidrug exporter system by AcrS in Escherichia coli2007

    • Author(s)
      ○平川 秀忠、Ulrike Theisen、小林 あすか、平田 隆弘、西野 邦彦、山口 明人
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] Induction mechanism of AcrAB in Salmonella enterica2007

    • Author(s)
      ○二階堂 英司、西野 邦彦、山口 明人
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] Identification of novel gene products which play roles on biofilm formation in Escherichia coli2007

    • Author(s)
      ○王 麗媛、平田 隆弘、平川 秀忠、西野 邦彦、山口 明人
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] 細菌薬剤耐性化と病原性発現における薬剤排出トランスポーターの役割2007

    • Author(s)
      ○西野 邦彦
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] Release of sphingosine 1-phosphate from platelet-like particles derived from MEG-01 cells MEG-012007

    • Author(s)
      ○久野 悠、西 毅、山口 明人
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] Characterization of ATP-dependent sphingosine-1-phosphate transport in rat erythrocytes by using the inside-out membrane vesicles2007

    • Author(s)
      ○小林 直木、小林 伸好、西 毅、山口 明人
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] Functional roles of ABCA7 in mouse platelet2007

    • Author(s)
      ○尾上 麻実子、柴田 紗貴子、西 毅、山口 明人
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] Cellular localization of mouse ABCA5 proteins in various mouse tissues2007

    • Author(s)
      ○大東 穂、西 毅、山口 明人
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] Tissue and subcellular localization of mouse ABCA6 transporter2007

    • Author(s)
      ○宮田 耕資、大東 穂、西 毅、山口 明人
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] 膜輸送体作動メカニズムの結晶学的解明2007

    • Author(s)
      ○村上 聡、中島 良介、松本 崇、近藤 洋平、津田 岳夫、小川 治夫、豊島 近
    • Organizer
      第11回 Spring8シンポジウム
    • Place of Presentation
      兵庫県
    • Year and Date
      2007-11-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] Expression and cellular localization of ABCA6 in mouse liver2007

    • Author(s)
      ○宮田 耕資、大東 穂、西 毅、山口 明人
    • Organizer
      第29回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2007-11-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] Identification of the sphingosine-1-phosphate export system in rat erythrocytes2007

    • Author(s)
      ○小林 直木、小林 伸好、西 毅、山口 明人
    • Organizer
      第29回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2007-11-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] Identification of the function of ABCA7 in mouse platelets2007

    • Author(s)
      ○尾上 麻実子、柴田 紗貴子、西 毅、山口 明人
    • Organizer
      第29回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2007-11-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] 細菌代謝物によるサルモネラ菌異物排出トランスポーターAcrAB-TolCシステム発現制御機構の解析2007

    • Author(s)
      ○二階堂 英司、西野 邦彦、山口 明人
    • Organizer
      第29回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2007-11-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] マウスABCA5の生理機能の解明2007

    • Author(s)
      ○大東 穂、西 毅、山口 明人
    • Organizer
      日本生体エネルギー研究会 第33回討論会
    • Place of Presentation
      山口
    • Year and Date
      2007-11-17
    • Related Report
      2007 Annual Research Report
  • [Presentation] ATP依存的な輸送体を介した脂質メディエーター放出機構2007

    • Author(s)
      ○西 毅、小林 直木、山口明人
    • Organizer
      日本生体エネルギー研究会 第33回討論会
    • Place of Presentation
      山口
    • Year and Date
      2007-11-16
    • Related Report
      2007 Annual Research Report
  • [Presentation] 環境因子によるサルモネラ菌AcrAB異物排出蛋白質発現誘導機構の解析2007

    • Author(s)
      ○二階堂 英司
    • Organizer
      第63回 大阪大学産業科学研究所学術講演会
    • Place of Presentation
      大阪大学接合科学研究所
    • Year and Date
      2007-11-16
    • Related Report
      2007 Annual Research Report
  • [Presentation] The regulation of bacterial"needle-like"bio-nanomachinary and pathogenicity by indole in enterohaemorrhagic E. coli2007

    • Author(s)
      ○平川 秀忠
    • Organizer
      第63回 大阪大学産業科学研究所学術講演会
    • Place of Presentation
      大阪大学接合科学研究所
    • Year and Date
      2007-11-16
    • Related Report
      2007 Annual Research Report
  • [Presentation] 細菌多剤耐性化と病原性発現における薬剤排出ポンプの役割に関する研究-多剤耐性化と病原性を軽減させる新薬ターゲットの解析-2007

    • Author(s)
      ○西野 邦彦
    • Organizer
      第9回日本抗生物質学術協議会奨励賞授賞式および受賞講演
    • Place of Presentation
      東京
    • Year and Date
      2007-11-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] サルモネラ菌多剤排出トランスポーターの生理機能解明2007

    • Author(s)
      ○西野 邦彦、松本 佳巳
    • Organizer
      第55回日本化学療法学会西日本支部総会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2007-10-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] フェムトリッターチャンバーを用いた薬剤排出ポンプの活性測定2007

    • Author(s)
      ○松本 佳巳、西野 邦彦
    • Organizer
      第55回日本化学療法学会西日本支部総会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2007-10-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] ライフサイエンスの新展開2007

    • Author(s)
      ○山口 明人
    • Organizer
      平成19年度産研テクノサロン(第3回例会)
    • Place of Presentation
      大阪大学接合科学研究所
    • Year and Date
      2007-10-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] Roles of indole signaling and intercellular signal transduction on type III secretion system-dependent pathogenicity in EHEC2007

    • Author(s)
      ○Hidetada Hirakawa, Toshio Kodama, Takeshi Honda and Akihito Yamaguchi
    • Organizer
      3rd ASM Conference on Cell-Cell Communication in Bacteria
    • Place of Presentation
      Texas, USA
    • Year and Date
      2007-10-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] Novel Aspects of Mechanisms of Antibacterial Resistance Revealed by Crystal Structure2007

    • Author(s)
      Yamaguchi A.
    • Organizer
      47th Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Place of Presentation
      McCormick Place(Chicago, Illinois, USA)(招待講演)
    • Year and Date
      2007-09-18
    • Related Report
      2011 Final Research Report
  • [Presentation] Visualization of Escherichia coli AcrAB-TolC efflux pump activity using ultra small chambers2007

    • Author(s)
      ○Yoshimi Matsumoto, Kunihiko Nishino, Ryota Iino, Syoichi Sakakihara, Masayoshi Nakata, Hiroyuk Nojii and Akihito Yamaguchi
    • Organizer
      47th Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Place of Presentation
      McCormick Place, Illinois USA
    • Year and Date
      2007-09-18
    • Related Report
      2007 Annual Research Report
  • [Presentation] フェムトリッターチャンバーを用いた薬剤排出ポンプの研究2007

    • Author(s)
      ○松本 佳巳、西野 邦彦、飯野 亮太、榊原 秀一、仲田 昌義、野地 博行、山口 明人
    • Organizer
      第19回微生物シンポジウム
    • Place of Presentation
      東京大学
    • Year and Date
      2007-09-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] 細菌代謝物によるサルモネラ菌異物排出トランスポーターAcrAB発現誘導機構の解析2007

    • Author(s)
      ○二階堂 英司、西野 邦彦、坂田 博樹、中濃 知志、田中 真奈美、山口 明人
    • Organizer
      第19回微生物シンポジウム
    • Place of Presentation
      東京大学
    • Year and Date
      2007-09-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] Analysis of the xenobiotic exporter EmrAB in Salmonella enterica serovar Typhimurium2007

    • Author(s)
      ○坂田 博樹、西野 邦彦、山口 明人
    • Organizer
      第19回微生物シンポジウム
    • Place of Presentation
      東京大学
    • Year and Date
      2007-09-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] Identification of novel gene products which play roles on biofilm formation in Escherichia coli2007

    • Author(s)
      ○王 麗媛、平田 隆弘、平川 秀忠、西野 邦彦、山口 明人
    • Organizer
      第19回微生物シンポジウム
    • Place of Presentation
      東京大学
    • Year and Date
      2007-09-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] Regulation mechanisms of the acrAB multidrug efflux pump in Salmonella enterica in response to bacterial metabolites2007

    • Author(s)
      ○Eiji Nikaido, Kunihiko Nishino and Akihito Yamaguchi
    • Organizer
      7th The Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Awaji Yumebutai International Conference Center
    • Year and Date
      2007-09-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] Regulatory network of multidrug transporters reveals their physiological role in Salmonella virulence2007

    • Author(s)
      ○Kunihiko Nishino, Eiji Nikaido, Hiroki Sakata, Tomoyuki Nakano, Manami Tanaka and Akihito Yamaguchi
    • Organizer
      7th The Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Awaji Yumebutai International Conference Center
    • Year and Date
      2007-09-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] 大腸菌異物排出蛋白質MacABの極への局在2007

    • Author(s)
      ○平田 隆弘、北村 昭夫、西野 邦彦、山口 明人
    • Organizer
      第4回21世紀大腸菌研究会
    • Place of Presentation
      静岡
    • Year and Date
      2007-07-18
    • Related Report
      2007 Annual Research Report
  • [Presentation] 多剤耐性感染症を克服する新規治療の確立2007

    • Author(s)
      ○西野 邦彦
    • Organizer
      第6回産学官連携推進会議
    • Place of Presentation
      京都
    • Year and Date
      2007-06-17
    • Related Report
      2007 Annual Research Report
  • [Presentation] フェムトリッター(fL)チャンバーを用いた薬剤排出ポンプ阻害薬の評価法2007

    • Author(s)
      ○松本 佳巳、西野 邦彦、飯野 亮太、榊原 昇一、仲田 昌義、二階堂 英司、山口 明人、野地 博行、竹内 昌治
    • Organizer
      第55回 日本化学療法学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2007-06-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] 細菌オーファン輸送体の生理機能解明2007

    • Author(s)
      ○西野 邦彦、山口 明人
    • Organizer
      第55回 日本化学療法学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2007-06-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] Single Cell Measurement of Bacterial Drug Efflux in Femtoliter Chamber Array2007

    • Author(s)
      ○Kunihiko Nishino, Ryota Iino, Masaaki Nakata, Yoshimi Matsumoto, Eiji Nikaido, Syoichi Sakakihara, Syoji Takeuchi, Akihito Yamaguchi and Hiroyuki Noji
    • Organizer
      American Society of Microbiology, 107th General Meeting
    • Place of Presentation
      Metro Toronto Convention Center, Toronto, Canada
    • Year and Date
      2007-05-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] Metabolites of Escherichia coli Induce the Expression of Multidrug Efflux pumps in Salmonella enterica2007

    • Author(s)
      ○Eiji Nikaido, Kunihiko Nishino and Akihito Yamaguchi
    • Organizer
      American Society of Microbiology, 107th General Meeting
    • Place of Presentation
      Metro Toronto Convention Center, Toronto, Canada
    • Year and Date
      2007-05-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] Novel Aspects of Mechanisms of Antibacterial Resistance Revealed by Crystal Structure2007

    • Author(s)
      Yamaguchi A.
    • Organizer
      47th Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Place of Presentation
      McCormick Place, Illinois USA
    • Related Report
      2009 Self-evaluation Report 2007 Annual Research Report
  • [Book] 化学療法学.医療のあるべき姿を見据えて.[抗生物質最前線]2010

    • Author(s)
      山口明人
    • Total Pages
      315
    • Publisher
      京都廣川書店
    • Related Report
      2011 Final Research Report
  • [Book] トランスポーター科学最前線-フロンティアサイエンスへの招き-2008

    • Author(s)
      山口明人
    • Total Pages
      384
    • Publisher
      京都廣川書店
    • Related Report
      2011 Final Research Report
  • [Book] トランスポーター科学最前線-フロンティアサイエンスへの招き-2008

    • Author(s)
      山口明人, 他分担執筆
    • Total Pages
      374
    • Publisher
      京都 廣川書店
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.sanken.osaka-u.ac.jp/labs/cmb/

    • Related Report
      2011 Final Research Report
  • [Remarks] 読売新聞、2011年12月5日、病原菌ポンプで抗生物質排除阪大グループ仕組み解明新聞報道

    • Related Report
      2011 Final Research Report
  • [Remarks] 朝日新聞、2011年11月28日、多剤耐性菌構造を解明阪大グループ新聞報道

    • Related Report
      2011 Final Research Report
  • [Remarks] 毎日新聞、2011年11月28日、多剤耐性緑膿菌治療薬に光阪大チーム抗生物質効かぬ謎解明新聞報道

    • Related Report
      2011 Final Research Report
  • [Remarks] 産経新聞、2011年11月28日、多剤耐性菌の異物認識システム解明阪大チーム「創薬へ展望」新聞報道

    • Related Report
      2011 Final Research Report
  • [Remarks] 日経新聞、2011年11月28日、抗生物質、細胞外へ排出阪大が仕組み解明新薬開発に可能性新聞報道

    • Related Report
      2011 Final Research Report
  • [Remarks] 平成22年度科学技術分野の文部科学大臣表彰科学技術賞、「異物排出タンパク構造・機能・制御と生理的役割に関する研究」、山口明人受賞

    • Related Report
      2011 Final Research Report
  • [Remarks] 平成20年度科学技術分野の文部科学大臣表彰科学技術賞(若手科学者賞)、「細菌ゲノムに潜む多剤耐性因子と制御機構の研究」、西野邦彦受賞

    • Related Report
      2011 Final Research Report
  • [Remarks] 平成20年日本薬学会賞、「異物排出トランスポーターの構造・機能とその制御に関する研究」、山口明人受賞

    • Related Report
      2011 Final Research Report
  • [Remarks] 平成20年日本細菌学会浅川賞、「細菌異物排出タンパクの構造・機能とその発現制御に関する研究」、山口明人受賞

    • Related Report
      2011 Final Research Report
  • [Remarks] 研究室ホームページ

    • URL

      http://www.sanken.osaka-u.ac.jp/labs/cmb/

    • Related Report
      2011 Annual Research Report
  • [Remarks] 産業科学研究所プレスリリース(阪大広報課発信)

    • URL

      http://www.sanken.osaka-u.ac.jp/jp/operation/press_release.html

    • Related Report
      2011 Annual Research Report
  • [Remarks] 大型放射光施設SPring-8プレスリリース

    • URL

      http://www.spring8.or.jp/ja/news_publications/press_release/2011/111128

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.sanken.osaka-u.ac.jp/labs/cmb/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.sanken.osaka-u.ac.jp/labs/cmb

    • Related Report
      2009 Self-evaluation Report
  • [Remarks]

    • URL

      http://www.sanken.osaka-u.ac.jp/labs/cmb/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.sanken.osaka-u.ac.jp/labs/cmb/

    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 細菌または真菌の抗菌薬感受性の検査方法およびそれに用いるシステム2011

    • Inventor(s)
      松本佳巳、葉山浩平、榊原昇一、西野邦彦、山口明人、野地博行、飯野亮太
    • Industrial Property Rights Holder
      国立大学法人大阪大学
    • Industrial Property Number
      2011-200036
    • Filing Date
      2011-09-13
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Patent(Industrial Property Rights)] スフィンゴシン1-リン酸の新規トランスポーター分子2008

    • Inventor(s)
      望月直樹、川原敦雄、西毅、山口明人
    • Industrial Property Rights Holder
      財団法人ヒューマンサイエンス振興財団/国立大学法人大阪大学
    • Industrial Property Number
      2008-245177
    • Filing Date
      2008-09-25
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] スフィンゴシン1-リン酸の新規トランスポーター分子2008

    • Inventor(s)
      望月直樹, 川原敦雄, 西毅, 山口明人
    • Industrial Property Rights Holder
      財団法人ヒューマンサイエンス振興財団
    • Industrial Property Number
      2008-245177
    • Filing Date
      2008-09-25
    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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