Spatiotemporal regulation of antigen recognition and activation of T cells

• Project/Area Number: 19109005
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: SAITO Takashi 独立行政法人理化学研究所, 免疫シグナル研究グループ, グループディレクター (50205655)
• Co-Investigator(Kenkyū-buntansha): YOKOSUKA Tadashi 独立行政法人理化学研究所, 免疫シグナル研究グループ, 上級研究員 (10359599)
• Project Period (FY): 2007 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥109,720,000 (Direct Cost: ¥84,400,000、Indirect Cost: ¥25,320,000); Fiscal Year 2011: ¥21,580,000 (Direct Cost: ¥16,600,000、Indirect Cost: ¥4,980,000); Fiscal Year 2010: ¥21,580,000 (Direct Cost: ¥16,600,000、Indirect Cost: ¥4,980,000); Fiscal Year 2009: ¥21,580,000 (Direct Cost: ¥16,600,000、Indirect Cost: ¥4,980,000); Fiscal Year 2008: ¥21,580,000 (Direct Cost: ¥16,600,000、Indirect Cost: ¥4,980,000); Fiscal Year 2007: ¥23,400,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥5,400,000)
• Keywords: 免疫シナプス / ミクロクラスター / シグナル伝達 / 抗原認識 / T細胞 / 細胞活性化 / 副刺激 / 活性化シグナル / PD-i / ダイニン / 細胞骨格 / ミクロチューブル / イメージング解析 / TCR複合体 / 獲得免疫 / T細胞活性化 / 免疫学 / イメージング

Research Abstract

T cell activation is induced by TCR-microcluster(MC). We clarified the molecules accumulated within MCs, and the relationship with costimulation signals and lipid raft. Lipid raft does not function as the platform and protein interaction within MCs induce activation. CD28-mediated costimulation recruits PKCθ-Carma1 to cSMAC, whereas the inhibitory costimulation receptor CTLA-4 inhibits by accumulating in cSMAC and kicking off CD28-PKCθfrom the cSMAC. TCR-MCs associate with the dynein complex and translocate along microtubules to form cSMAC.

Research Products

• [Journal Article] A motif in the V3 domain of the kinase PKC-θdetermines its localization in the immunological synapse and functions in T cells via association with CD28 (2011)
  • Author(s): Kong K-F, et al,(6人中5番目)
  • Journal Title: Nat. Immunol Volume: 12 Pages: 1105-12
  • Peer Reviewed
• [Journal Article] Nanocluster formation : More with memory (2011)
  • Author(s): Saito T.
  • Journal Title: Immunity Volume: 35 Pages: 318-320
• [Journal Article] CIN85 regulates the canonical NF-κB pathway and subsequent B cell responses (2011)
  • Author(s): Kometani K, Yamada T, Sasaki Y, Yokosuka T, Saito T, Rajewsky K, Ishiai M, Hikida M, Kurosaki T.
  • Journal Title: J. Exp. Med Volume: 208 Pages: 1447-1457
  • Peer Reviewed
• [Journal Article] Dynein-driven transport of T cell receptor microclusters regulates immune synapse formation and T cell activation (2011)
  • Author(s): Hashimoto-Tane A, Yokosuka T, Sakata-Sogawa K, Sakuma M, Ishihara C, Tokunaga M, Saito T.
  • Journal Title: Immunity Volume: 34 Pages: 919-931
  • Peer Reviewed
• [Journal Article] Induction of colonic regulatory T cells by indigenous clostridium species (2011)
  • Author(s): Atarashi K, et al,(17人中9番目)
  • Journal Title: Science Volume: 331 Pages: 337-341
  • Peer Reviewed
• [Journal Article] A motif in the V3 domain of the kinase PKC-θ determines its localization in the immunological synapse and functions in T cells via association with CD28 (2011)
  • Author(s): Kong, K-F., Yokosuka, T., Canonigo-Balancio, A.J., et al
  • Journal Title: Nat.Immunol. Volume: 12 Issue: 11 Pages: 1105-1112
  • DOI: 10.1038/ni.2120
  • Peer Reviewed
• [Journal Article] CIN85 regulates the canonical NF-κB pathway and subsequent B cell responses (2011)
  • Author(s): Kometani K., Yamada, T., Sasaki, Y., et al
  • Journal Title: J.Exp.Med. Volume: 208 Pages: 1447-1457
  • Peer Reviewed
• [Journal Article] A heat-stable extract from mucuna stimulates the differentiation of bone marrow cells into dendritic cells and induces apoptosis in cancer cells (2011)
  • Author(s): Kurokawa, K., Ishii, T., et al
  • Journal Title: Nutr.Cancer Volume: 63 Pages: 100-108
  • Peer Reviewed
• [Journal Article] IL-23-dependent and -independent enhancement pathways of IL-17A production by lactic acid (2011)
  • Author(s): Yabu, M., Shime, H., et al
  • Journal Title: Int.Immunol. Volume: 23 Pages: 29-41
  • Peer Reviewed
• [Journal Article] IL-23-dependent and -independent enhancement pathways of IL-17A production by lactic acid (2011)
  • Author(s): Masahiko Yabu
  • Journal Title: International Immunology Volume: 23 Pages: 4865-4871
  • Peer Reviewed
• [Journal Article] A heat-stable extract from mucuna stimulates the differentiation of bone marrow cells into dendritic cells and induces apoptosis in cancer cells. (2011)
  • Author(s): Kazuhiko Kurokawa
  • Journal Title: Nutrition and Cancer Volume: 63 Pages: 100-108
  • Peer Reviewed
• [Journal Article] Induction of colonic regulatory T cells by indigenous clostridium species. (2011)
  • Author(s): Koji Atarashi
  • Journal Title: Science Volume: 331 Pages: 337-341
  • Peer Reviewed
• [Journal Article] Dynamic regulation of T cell activation and co-stimulation through TCR-microclusters (2010)
  • Author(s): Saito T, Yokosuka T, Hashimoto-Tane A.
  • Journal Title: FEBS Lett Volume: 584 Pages: 4865-4871
  • Peer Reviewed
• [Journal Article] Germ-line elimination of electric charge on pre-T-cell receptor(TCR) impairs autonomous signaling for beta-selection and TCR repertoire formation (2010)
  • Author(s): Ishikawa E, et al,(5人中4番目)
  • Journal Title: Proc Natl Acad Sci USA Volume: 107 Pages: 19979-19984
  • Peer Reviewed
• [Journal Article] Spatiotemporal basis of CTLA-4 costimulatory molecule-mediated negative regulation of T cell activation (2010)
  • Author(s): Yokosuka T, Kobayashi W, Takamatsu M, Sakata-Sogawa K, Zeng H, Hashimoto-Tane A, Yagita H, Tokunaga M, Saito T
  • Journal Title: Immunity Volume: 33 Pages: 326-339
  • Peer Reviewed
• [Journal Article] T cell receptor-microclusters critical for T-cell activation are formed independently of lipid raft clustering (2010)
  • Author(s): Hashimoto-Tane A, Yokosuka T, Ishihara C, Sakuma M, Kobayashi W and Saito T.
  • Journal Title: Mol. Cel. Biol Volume: 30 Pages: 3421-3429
  • Peer Reviewed
• [Journal Article] Dectin-2 recognition ofτ-mannans and induction of Th17 cell dfferentiation is essential for host defense against Candida albicans (2010)
  • Author(s): Saijo S, et al,(21人中19番目)
  • Journal Title: Immunity Volume: 32 Pages: 681-691
  • Peer Reviewed
• [Journal Article] Dendritic cell differentiation and tumor cell apoptosis induced by components of a poly-phenylpropanoid polysaccharide complex (2010)
  • Author(s): An Wei-Wei
  • Journal Title: Anticancer Research Volume: 30 Pages: 613-622
  • Peer Reviewed
• [Journal Article] Activation-induced accumulation of B and T lymphocyte attenuator at the immunological synapse in CD4+ T cells. (2010)
  • Author(s): Takayoshi Owada
  • Journal Title: Journal of Leukocyte Biology Volume: 87 Pages: 425-432
  • Peer Reviewed
• [Journal Article] Dectin-2 recognition of α-mannans and induction of Th17 cell dfferentiation is essential for host defense against Candida albicans. (2010)
  • Author(s): Shinobu Saijo
  • Journal Title: Immunity Volume: 32 Pages: 681-691
  • Peer Reviewed
• [Journal Article] T cell receptor-microclusters critical for T-cell activation are formed independently of lipid raft clustering. (2010)
  • Author(s): Akiko Hashimoto-Tane
  • Journal Title: Molecular and Cellular Biology Volume: 30 Pages: 3421-3429
  • Peer Reviewed
• [Journal Article] Spatiotemporal basis of CTLA-4 costimulatory molecule-mediated negative regulation of T cell activation. (2010)
  • Author(s): Tadashi Yokosuka
  • Journal Title: Immunity Volume: 33 Pages: 326-339
  • Peer Reviewed
• [Journal Article] Germ-line elimination of electric charge on pre-T-cell receptor (TCR) impairs autonomous signaling for beta-selection and TCR repertoire formation. (2010)
  • Author(s): Eri Ishikawa
  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 107 Pages: 19979-19984
  • Peer Reviewed
• [Journal Article] Dynamic regulation of T cell activation and co-stimulation through TCR-microclusters. (2010)
  • Author(s): Takashi Saito
  • Journal Title: FEBS Letters Volume: 584 Pages: 4865-4871
  • Peer Reviewed
• [Journal Article] (2010)
  • Author(s): Tadashi Yokosuka
  • Journal Title: Immunological Synapse (Current Topics in Microbiology and Immunology)(Springer-Verlag Berlin Heidelberg) Pages: 81-107
• [Journal Article] CRTAM confers late-stage activation of CD8+T cells to regulate retention within lymph node (2009)
  • Author(s): Takeuchi A, Itoh Y, Takumi A, Ishihara C, Arase N, Yokosuka T, Koseki H, Yamasaki S, Takai Y, Miyoshi J, Ogasawara K, and Saito T.
  • Journal Title: J. Immunol Volume: 183 Pages: 4220-4228
  • Peer Reviewed
• [Journal Article] Dynamic regulation of T-cell costimulation through TCR-CD28 microclusters (2009)
  • Author(s): Yokosuka T and Saito T
  • Journal Title: Immunol. Rev Volume: 229 Pages: 27-40
  • Peer Reviewed
• [Journal Article] CARD9 versus CARMA1 in innate and adaptive immunity (2009)
  • Author(s): Hara H and Saito T.
  • Journal Title: Trends Immunol Volume: 30 Pages: 234-242
  • Peer Reviewed
• [Journal Article] Naturally occurring regulatory dendritic cells regulate murine cutaneous chronic graft-versus-host disease (2009)
  • Author(s): Sato K, et al,(14人中13番目)
  • Journal Title: Blood Volume: 113 Pages: 4780-4789
  • Peer Reviewed
• [Journal Article] C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia (2009)
  • Author(s): Yamasaki S, Matsumoto M, Takeuchi O, Matsuzawa T, Ishikawa E, Sakuma M, Tateno H, Uno J, Hirabayashi J, Mikami Y, Takeda K, Akira S, Saito T.
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 10 Pages: 1897-1902
  • Peer Reviewed
• [Journal Article] Fc receptorγ-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils (2009)
  • Author(s): Hida S, et al,(10人中9番目)
  • Journal Title: Nat Immunol Volume: 10 Pages: 214-222
  • Peer Reviewed
• [Journal Article] Costimulation signals mediated by CD28-microclusters (2009)
  • Author(s): Yokosuka, T., Saito, T.
  • Journal Title: Immunol.Rev. 229 Pages: 27-40
  • Peer Reviewed
• [Journal Article] Differential trafficking of Src, Lyn, Yes and Fyn is specified by the state of palmitoylation in the SH4 domain (2009)
  • Author(s): Izumi Sato
  • Journal Title: Journal of Cell Science 122 Pages: 965-975
  • Peer Reviewed
• [Journal Article] Regulation of NF-κB-dependent T cell activation development by MEKK3 (2009)
  • Author(s): Hisaaki Shinohara
  • Journal Title: International Immunology 21 Pages: 393-401
  • Peer Reviewed
• [Journal Article] Naturally occurring regulatory dendritic cells regulate murine cutaneou chronic graft-versus-host disease (2009)
  • Author(s): Katsuaki Sato
  • Journal Title: Blood 113 Pages: 4780-4789
  • Peer Reviewed
• [Journal Article] Nuclear localization of Src-family tyrosine kinases is required for growth factor-induced euchromatinization (2009)
  • Author(s): Akinori Takahashi
  • Journal Title: Experimental Cell Research 315 Pages: 1117-1141
  • Peer Reviewed
• [Journal Article] CARD9 versus CARMA1 in innate and adaptive immunity (2009)
  • Author(s): Hiromitsu Hara
  • Journal Title: Trends in Immunology 30 Pages: 234-242
  • Peer Reviewed
• [Journal Article] The global thymus network : past, present future (2009)
  • Author(s): Yousuke Takahama
  • Journal Title: Trends in Immunology 30 Pages: 191-192
  • Peer Reviewed
• [Journal Article] Dynamic regulation of T-cell costimulation through TCR-CD28 microclusters (2009)
  • Author(s): Tadashi Yokosuka
  • Journal Title: Immunological Reviews 229 Pages: 27-40
  • Peer Reviewed
• [Journal Article] Involvement of Rap-1 activation early termination of immune synapse in CTLA-4-mediated negative signal (2009)
  • Author(s): Satoru Hara
  • Journal Title: Hematology 14 Pages: 150-158
  • Peer Reviewed
• [Journal Article] CRTAM confers late-stage activation of CD8+ T cells to regulate retention within lymph node (2009)
  • Author(s): Arata Takeuchi
  • Journal Title: Journal of Immunology 183 Pages: 4220-4228
  • Peer Reviewed
• [Journal Article] Fc receptor c-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils (2009)
  • Author(s): Hida, S.
  • Journal Title: Nat. Immunol. 10 Pages: 214-222
  • Peer Reviewed
• [Journal Article] C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia (2009)
  • Author(s): Yamasaki, S.
  • Journal Title: Proc. Natl. Acad. Sci. USA
  • Peer Reviewed
• [Journal Article] Differential trafficking of c-Src, Lyn, c-Yes, and Fyn is specified by the state of palmitoylation in the SH4 domain (2009)
  • Author(s): Sato, I.
  • Journal Title: J. Cell Sci.
  • Peer Reviewed
• [Journal Article] Regulation of NF-kappa B-dependent T cell activation and development by MEKK3 (2009)
  • Author(s): Shinohara, H.
  • Journal Title: Int. Immunol.
  • Peer Reviewed
• [Journal Article] Naturally occurring regulatory dendritic cells regulate murine cutaneous chronic graft-versus-host disease (2009)
  • Author(s): Sato, K.
  • Journal Title: Blood
  • Peer Reviewed
• [Journal Article] Nuclear localization of Src-family tyrosine kinases is required for growth factor-induced euchromatinization (2009)
  • Author(s): Takahashi, A.
  • Journal Title: Exp. Cell Res.
  • Peer Reviewed
• [Journal Article] Essential role of Rap signal in pre-TCR。Vmediatedυ-selection checkpoint inτυT cell development (2008)
  • Author(s): Kometani K, et al,(9人中7番目)
  • Journal Title: Blood Volume: 112 Pages: 4565-4573
  • Peer Reviewed
• [Journal Article] Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters through protein kinase Cθtranslocation (2008)
  • Author(s): Yokosuka T, Kobayashi W, Sakata-Sogawa, K, Takamatsu M, Hashimoto-Tane A, Dustin ML, Tokunaga M, Saito T.
  • Journal Title: Immunity Volume: 29 Pages: 589-601
  • Peer Reviewed
• [Journal Article] Mincle is an ITAM-coupled activating receptor that senses damaged cells (2008)
  • Author(s): Yamasaki S, Ishikawa E, Sakuma M, Hara H, Ogata K, Saito T.
  • Journal Title: Nat. Immunol Volume: 9 Pages: 1179-1188
  • Peer Reviewed
• [Journal Article] Cell type-specific regulation of ITAM-mediated NF-κB activation by the adaptors, CARMA1 and CARD9 (2008)
  • Author(s): Hara H, Ishihara C, Takeuchi A, Xue L, Morris SW, Penninger JM, Yoshida H, Saito T.
  • Journal Title: J. Immunol Volume: 181 Pages: 918-930
  • Peer Reviewed
• [Journal Article] Thymic selection determinesγδT cell effector fate : antigen-naive cells make interleukin-17 and antigen-experienced cells make interferonγ. (2008)
  • Author(s): Jensen KD, et al,(12人中8番目)
  • Journal Title: Immunity Volume: 29 Pages: 90-100
  • Peer Reviewed
• [Journal Article] A lysosomal protein negatively regulate surface T cell antigen receptor expression by promoting CD3ζ-chain degradation (2008)
  • Author(s): Ouchida R, et al,(15人中13番目)
  • Journal Title: Immunity Volume: 29 Pages: 33-43
  • Peer Reviewed
• [Journal Article] Differential contribution of three activating IgG Fc receptors(FcγRI, FcγRIII and FcγRIV) to IgG2a-and IgG2b-induced autoimmune hemolytic anemia in mice (2008)
  • Author(s): Baudino L, et al,(9人中5番目)
  • Journal Title: J. Immunol Volume: 180 Pages: 1948-1953
  • Peer Reviewed
• [Journal Article] Mincle is an ITAM-coupled activating receptor that senses damaged cells (2008)
  • Author(s): Yamasaki S, Ishikawa E, Sakuma M, Hara H, Ogata K, Saito T
  • Journal Title: Nat.Immunol. 9 Pages: 1179-1188
  • Peer Reviewed
• [Journal Article] Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters through protein kinase C θ translocation (2008)
  • Author(s): Yokosuka T, Kobayashi W, Sakata-Sogawa K, Takamatsu M, Hashimoto-Tane A, Dustin ML, Tokunaga M, Saito T
  • Journal Title: Immunity 29 Pages: 589-601
  • Peer Reviewed
• [Journal Article] A lysosomal protein negatively regulate surface T cell antigen receptor expression by promoting CD3ζ degradation (2008)
  • Author(s): Ouchida, R.
  • Journal Title: Immunity 29 Pages: 33-43
  • Peer Reviewed
• [Journal Article] Thymic selection determines γ δ T cell effector fate : antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon γ (2008)
  • Author(s): Jensen, K. D.
  • Journal Title: Immunity 29 Pages: 90-100
  • Peer Reviewed
• [Journal Article] Cell type-specific regulation of ITAM-mediated NF-κB activation by the adaptors, CARMA1 and CARD9 (2008)
  • Author(s): Hara, H.
  • Journal Title: J. Immunol. 181 Pages: 918-930
  • Peer Reviewed
• [Journal Article] LFA-1 decreases the antigen dose for T cell activation in vivo (2008)
  • Author(s): Wang, Y.
  • Journal Title: Int. Immunol. 20 Pages: 1119-1127
  • Peer Reviewed
• [Journal Article] Genetic analysis reveals an intrinsic property of the germinal center B cells to generate A : T mutations (2008)
  • Author(s): Ouchida, R.
  • Journal Title: DNA Repair (Amst) 7 Pages: 1392-1398
  • Peer Reviewed
• [Journal Article] Selective impairment of FcεRI-mediated allergic reaction in Gadsdeficient mice (2008)
  • Author(s): Yamasaki, S.
  • Journal Title: Int. Immunol. 20 Pages: 1289-1297
  • Peer Reviewed
• [Journal Article] Mincle is an ITAM-coupled activating receptor that senses damaged cells (2008)
  • Author(s): Yamasaki, S.
  • Journal Title: Nat. Immunol. 9 Pages: 1179-1188
  • Peer Reviewed
• [Journal Article] Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C θ translocation (2008)
  • Author(s): Yokosuka, T.
  • Journal Title: Immunity 29 Pages: 589-601
  • Peer Reviewed
• [Journal Article] Essential role of Rap signal in pre-TCR-mediated β-selection checkpoint in αβ T cell development (2008)
  • Author(s): Kometani, K.
  • Journal Title: Blood 112 Pages: 4565-4573
  • Peer Reviewed
• [Journal Article] Early development of human hematopoietic and acquired immune systems in new born NOD/Scid/Jak3null mice intrahepatic engrafted with cord blood-derived CD34+ cells (2008)
  • Author(s): Okada, S.
  • Journal Title: Int. J. Hematol. 88 Pages: 476-482
  • Peer Reviewed
• [Journal Article] Differential contribution of three activating IgG Fc receptors (FcγRI, Fcγ RIII and FcγRIV) to IgG2a-and IgG2b-induced autoimmune hemolytic anemia in mice. (2008)
  • Author(s): Baudino, L.
  • Journal Title: J. Immunol. 180 Pages: 1948-1953
  • Peer Reviewed
• [Journal Article] Cloning of B cell-specific membrane tetraspanning molecule BTS possessing B cell proliferation-inhibitory function (2007)
  • Author(s): Suenaga T, Arase H, Yamasaki S, Kohno M, Yokosuka T, Takeuchi A, Hattori T, Saito T.
  • Journal Title: Eur. J. Immunol Volume: 37 Pages: 3197-3207
  • Peer Reviewed
• [Journal Article] Diverging signaling events control the pathway of GPVI down-regulation in vivo (2007)
  • Author(s): Rabie T., et al,(8人中6番目)
  • Journal Title: Blood Volume: 110 Pages: 529-535
  • Peer Reviewed
• [Journal Article] TLR2 directly triggers Th1 effector functions (2007)
  • Author(s): Imanishi T, Hara H, Suzuki S, Suzuki N, Akira S, Saito T.
  • Journal Title: J. Immunol Volume: 178 Pages: 6715-6719
  • Peer Reviewed
• [Journal Article] The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors (2007)
  • Author(s): Hara H, et al,(16人中16番目)
  • Journal Title: Nat. Immunol Volume: 8 Pages: 619-629
  • Peer Reviewed
• [Journal Article] LAT and NTAL mediate immunoglobulin E-induced sustained extracellular signal-regulated kinase activation critical for mast cell survival (2007)
  • Author(s): Yamasaki S, Ishikawa E, Sakuma M, Kanagawa O, Cheng AM, Malissen B, Saito T.
  • Journal Title: Mol. Cell. Biol Volume: 27 Pages: 4406-4415
  • Peer Reviewed
• [Journal Article] Molecular basis for pre-TCR-mediated autonomous signaling (2007)
  • Author(s): Yamasaki S, Saito T.
  • Journal Title: Trends. Immunol Volume: 28 Pages: 39-43
  • Peer Reviewed
• [Journal Article] The actin cloud induced by LFA-1.mediated outside-in signals lowers the threshold for T-cell activation (2007)
  • Author(s): Suzuki J-I, Yamasaki S, Wu J, Koretzky GA, Saito T.
  • Journal Title: Blood Volume: 109 Pages: 168-175
  • Peer Reviewed
• [Journal Article] The actin cloud induced by LFA-1-mediated outside-in signals lowers the threshold for T-cell activation. (2007)
  • Author(s): Suzuki, J-I.
  • Journal Title: Blood 109 Pages: 168-175
  • Peer Reviewed
• [Journal Article] Molecular basis for pre-TCR-mediated autonomous signaling. (2007)
  • Author(s): Yamasaki, S.
  • Journal Title: Trends. Immunol. 28 Pages: 39-43
• [Journal Article] LAT and NTAL mediate immunoglobulin E-induced sustained extracellular signal-regulated kinase activation critical for mast cell survival. (2007)
  • Author(s): Yamasaki, S.
  • Journal Title: Mol. Cel. Biol. 27 Pages: 4406-4415
  • Peer Reviewed
• [Journal Article] The adaptor protein CARD9 is essential for activation of myeloid cells through ITAM-associated and Tbl-like receptors. (2007)
  • Author(s): Hara, H.
  • Journal Title: Nature Immunol. 8 Pages: 619-629
  • Peer Reviewed
• [Journal Article] TLR2 directly triggers Th1 effector functions. (2007)
  • Author(s): Imanishi T.
  • Journal Title: J. Immunol. 178 Pages: 6715-6719
  • Peer Reviewed
• [Journal Article] Diverging signaling events control the pathway of GPVI downregulation in vivo. (2007)
  • Author(s): Rabie, T.
  • Journal Title: Blood 110 Pages: 529-535
  • Peer Reviewed
• [Journal Article] Construction of an open-access database that integrates cross-reference information from the transcriptome and proteome of immune cells. (2007)
  • Author(s): Hijikata, A.
  • Journal Title: Bioinformatics 23 Pages: 2934-2941
  • Peer Reviewed
• [Journal Article] Cloning of B-cell-specific membrane tetraspanning molecule BTS possess ing B cell proliferation-inhibitory function. (2007)
  • Author(s): Suenaga, T.
  • Journal Title: Eur. J. Immunol. 37 Pages: 3197-3207
  • Peer Reviewed
• [Journal Article] Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2
  • Author(s): Yokosuka T, Takamatsu M, Kobayashi-Imanishi W, Hashimoto-Tane A, Azuma M, Saito T.
  • Journal Title: J. Exp. Med Volume: (in press)
  • Peer Reviewed
• [Presentation] Negative regulation of TCR signaling by PD-1 microcluster (2012)
  • Author(s): Yokosuka, T. and Saito, T
  • Organizer: Keystone Symposia-Regulation of Lymphocyte Signaling
  • Place of Presentation: Keystone, CO. USA
  • Year and Date: 2012-03-15
• [Presentation] Negative regulation of TCR signaling by PD-1 microcluster (2012)
  • Author(s): Yokosuka, T., Saito, T.
  • Organizer: Keystone Symposia-Regulation of Lymphocyte Signaling
  • Place of Presentation: Keystone, CO, USA(招待講演)
  • Year and Date: 2012-03-15
• [Presentation] SH3-Guk domain regulating Carmal micro-cluster formation is essential for antigen receptor-induced NF-κB activation (2011)
  • Author(s): Hara, H., Yokosuka, T., et al
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-15
• [Presentation] Analysis of target genes regulated by MafK in T cells (2011)
  • Author(s): Tsukumo, S.I., Unno, M., et al
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-14
• [Presentation] Dynamic regulation of T cell activation by TCR microclusters (2011)
  • Author(s): Yokosuka, T.
  • Organizer: 2^<nd> CSI/JSI/KAI Joint Symposium on Immunology "Regulation of Immune Responses in Health and Diseases"
  • Place of Presentation: Osaka(日中韓免疫シンポジウム)(招待講演)
  • Year and Date: 2011-12-06
• [Presentation] 免疫シナプスにおけるダイニンによるT細胞受容体ミクロクラスター運搬の分子機構 (2011)
  • Author(s): 多根(橋本)彰子、横須賀忠、斉藤隆
  • Organizer: 第40回日本免疫学会総会学術集会
  • Place of Presentation: 千葉
  • Year and Date: 2011-11-29
• [Presentation] T細胞における核酸認識機構の解明 (2011)
  • Author(s): 今西貴之、竹内理、河合太郎、審良静男、斉藤隆
  • Organizer: 第40回日本免疫学会総会学術集会
  • Place of Presentation: 千葉
  • Year and Date: 2011-11-29
• [Presentation] The PD-1 microclusters : negative costimulatory signalosomes directly targeting TCR downstream (2011)
  • Author(s): Yokosuka, T., Saito, T.
  • Organizer: 第40回日本免疫学会総会学術集会
  • Place of Presentation: 千葉(招待講演)
  • Year and Date: 2011-11-28
• [Presentation] イメージング解析が拓くT細胞活性化の制御機構 (2011)
  • Author(s): 斉藤隆
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-11-12
• [Presentation] A. Spatiotemporal regulation of T cell activation and costimulation (2011)
  • Author(s): Saito, T., Yokosuka, T., Hashimoto-Tane
  • Organizer: 1^<st> POSTECH International Symposium of Bio-Imaging
  • Place of Presentation: Pohang, Korea
  • Year and Date: 2011-09-30
• [Presentation] Spatiotemporal regulation of T cell activation and costimulation (2011)
  • Author(s): Saito, T., Yokosuka, T., Tane-Hashimoto, A.
  • Organizer: 1^<st> POSTECH International Symposium of Bio-Imaging
  • Place of Presentation: Pophang, Korea(招待講演)
  • Year and Date: 2011-09-30
• [Presentation] 分子イメージングが拓くT細胞活性化の制御機構 (2011)
  • Author(s): 横須賀忠
  • Organizer: 第20回日本バイオイメージング学会学術集会
  • Place of Presentation: 千歳(招待講演)
  • Year and Date: 2011-09-02
• [Presentation] Spatiotemporal regulation of T cell co-stimulation (2011)
  • Author(s): Saito, T., Yokosuka, T., Tane-Hashimoto, A.
  • Organizer: FASEB Summer Conferences-Signal Transduction in the Immune System
  • Place of Presentation: Snowmass Village, CO
  • Year and Date: 2011-06-23
• [Presentation] Spatiotemporal regulation of T cell co-stimulation (2011)
  • Author(s): Saito, T., Yokosuka, T., Tane-Hashimoto, A.
  • Organizer: FASEB Summer Conferences-Signal Transduction in the Immune System
  • Place of Presentation: Snowmass Village, CO, USA(招待講演)
  • Year and Date: 2011-06-23
• [Presentation] Visualising the dynamics of immune synapse by TIRF (2011)
  • Author(s): Saito, T., Yokosuka, T., Tane-Hashimoto, A., Sakata-Sogawa, K., Tokunaga, M.
  • Organizer: XXVI Congress of the International Society for Advancement of Cytometry(CYTO2011)
  • Place of Presentation: Baltimore, MD, USA
  • Year and Date: 2011-05-24
• [Presentation] Visualising the dynamics of immune synapse by TIRF (2011)
  • Author(s): Saito, T., Yokosuka, T., Tane-Hashimoto, A.
  • Organizer: XXVI Congress of the International Society for Advancement of Cytometry (CYTO2011)
  • Place of Presentation: Baltimore, MD, USA(招待講演)
  • Year and Date: 2011-05-24
• [Presentation] Immune cell activation under the microscope. World Immune Regulation Meeting-V(WIRM) (2011)
  • Author(s): Saito, T
  • Organizer: Innate and Adaptive Immune Response and Role of Tissue in Immune Regulation
  • Place of Presentation: Davos, Switzerland
  • Year and Date: 2011-03-25
• [Presentation] Immune cell activation under the microscope (2011)
  • Author(s): Takashi Saito
  • Organizer: World Immune regulation Meeting-V
  • Place of Presentation: Davos(スイス)
  • Year and Date: 2011-03-25
• [Presentation] Dynamic regulation of positive/negative T cell co-stimulation (2010)
  • Author(s): Takashi Saito
  • Organizer: CSI-IFReC Joint Symposium on Immunology
  • Place of Presentation: 杭州(中国)
  • Year and Date: 2010-11-04
• [Presentation] Direct regulation of T cell activation by TLR ligands (2010)
  • Author(s): Takashi Saito
  • Organizer: 第10回あわじしま感染症・免疫フォーラム
  • Place of Presentation: 淡路
  • Year and Date: 2010-09-07
• [Presentation] Spatio-temporal regulation of T cell activation (2010)
  • Author(s): Saito, T
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: 神戸
  • Year and Date: 2010-08-25
• [Presentation] Spatio-temporal regulation of T cell activation (2010)
  • Author(s): Takashi Saito
  • Organizer: 14th International Congress of Immunology(第14回国際免疫学会議)
  • Place of Presentation: 神戸
  • Year and Date: 2010-08-25
• [Presentation] Molecular dynamics for T cell activation and costimulation. Keystone Symposia (2010)
  • Author(s): Saito, T
  • Organizer: Lymphocyte Activation and Gene Expression
  • Place of Presentation: Breckenridge, CO
  • Year and Date: 2010-03-03
• [Presentation] Molecular Dynamics for T Cell Activation and Costimulation (2010)
  • Author(s): Takashi Saito
  • Organizer: Keystone Symposia Lymphocyte Activation and Gene Expression
  • Place of Presentation: Breckenridge(USA)
  • Year and Date: 2010-03-03
• [Presentation] Dynein-mediated translocation of TCR microclusters along microtubules to form cSMAC (2010)
  • Author(s): Akiko Hashimoto-Tane
  • Organizer: Keystone Symposia Lymphocyte Activation and Gene Expression
  • Place of Presentation: Breckenridge(USA)
  • Year and Date: 2010-03-01
• [Presentation] Dynamic regulation of T-cell costimulation by TCR microclusters and the c-SMAC (2010)
  • Author(s): Tadashi Yokosuka
  • Organizer: 第13回国際細胞膜研究フォーラム/第6回iCeMS国際シンポジウム
  • Place of Presentation: 京都
  • Year and Date: 2010-01-27
• [Presentation] Dual specificity receptor for damaged cells and pathogen (2010)
  • Author(s): Takashi Saito
  • Organizer: US-Japan Joint Immunology Board & Parasitic Disease Panel Conference
  • Place of Presentation: San Diego(USA)
  • Year and Date: 2010-01-10
• [Presentation] Transcription factor Bach2 controls tissue-specific homing of naive T cells by regulating CCR4 and CCR9 gene expressions (2009)
  • Author(s): Shin-ichi Tsukumo
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-11
• [Presentation] Dynamic regulation of T-cell costimulation by TCR microclusters and the c-SMAC (2009)
  • Author(s): Tadashi Yokosuka
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-03
• [Presentation] T細胞活性化及びcSMAC形成につながる微小管モーター・ダイニンによるTCRミクロクラスターの移動/ Dynein-mediated translocation of TCR microclusters along microtubules to from cSMAC during T cell activation (2009)
  • Author(s): 橋本(多根)彰子
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-03
• [Presentation] Nucleic acid-mediated T cell costimulation is independent of TLR (2009)
  • Author(s): Takayuki Imanishi
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-03
• [Presentation] CARD9 and innate immunity (2009)
  • Author(s): Takashi Saito
  • Organizer: Center for the Study of Inflammatory Bowel Disease 19th Annual Workshop-Integrating Innate an Adaptive Immunity in Complex Human Diseases
  • Place of Presentation: Boston(USA)
  • Year and Date: 2009-11-13
• [Presentation] T細胞活性化シグナルの時空間的制御 (2009)
  • Author(s): 斉藤隆
  • Organizer: 特定領域研究「生体膜トランスポートソームの分子機構と生理機能」平成21年度第1回班会議
  • Place of Presentation: 阿蘇
  • Year and Date: 2009-08-28
• [Presentation] Dynamic regulation of T-cell costimulation by TCR microclusters (2009)
  • Author(s): Tadashi Yokosuka
  • Organizer: FASEB Summer Research Conferences-Signal Transduction in the Immune System
  • Place of Presentation: Snowmass Village(USA)
  • Year and Date: 2009-06-24
• [Presentation] Sensing self and non-self danger by ITAM-coupled innate receptor Mincle (2009)
  • Author(s): Saito, T. and Yamasaki, S
  • Organizer: FASEB Summer Research Conferences-Signal Transduction in the Immune System
  • Place of Presentation: Snowmass Village, CO
  • Year and Date: 2009-06-23
• [Presentation] Sensing self non-self danger by ITAM-coupled innate receptor Mincle (2009)
  • Author(s): Takashi Saito
  • Organizer: FASEB Summer Research Conferences-Signal Transduction in the Immune System
  • Place of Presentation: Snowmass Village(USA)
  • Year and Date: 2009-06-23
• [Presentation] Visualization of T cell activation and co-stimulation (2009)
  • Author(s): Takashi Saito
  • Organizer: The 1st Joint SIgN-iFReC Symposium- Integrating Immune Networks with Immuno-imaging
  • Place of Presentation: Singapore(Singapore)
  • Year and Date: 2009-06-18
• [Presentation] Dynamic assembly of signaling complex for positive and negative costimulation of T cell activation (2009)
  • Author(s): Takashi Saito
  • Organizer: The 5th International Workshop of Kyoto T Cell Conference 2009
  • Place of Presentation: 京都
  • Year and Date: 2009-06-02
• [Presentation] Spatiotemporal regulation of lymphocyte activation (2009)
  • Author(s): Takashi Saito
  • Organizer: The 2nd RIKEN-University of Edinburgh Joint Workshop for Computational Systems Biology
  • Place of Presentation: 東京
  • Year and Date: 2009-05-15
• [Presentation] Recognition of damaged self and non-self pathogens by ITAM-coupled C-type lectin, Mincle (2009)
  • Author(s): Yamasaki, S and Saito, T.
  • Organizer: World Immune Regulation Meeting-III
  • Place of Presentation: Davos, Switzerland
  • Year and Date: 2009-03-23
• [Presentation] C型レクチン Mincle による自己・非自己リガンドの認識とその意義 (2009)
  • Author(s): 山崎晶
  • Organizer: 第18回東京免疫フォーラム
  • Place of Presentation: 東京
  • Year and Date: 2009-03-12
• [Presentation] ITAM受容体による免疫系の形成・維持と生体防御の制御機構 (2009)
  • Author(s): 山崎晶
  • Organizer: 慶応医学会例会
  • Place of Presentation: 東京
  • Year and Date: 2009-02-18
• [Presentation] Self and non-self recognition by ITAM-coupled C-type lectin receptor, Mincle (2009)
  • Author(s): Yamasaki, S.
  • Organizer: The 2^<nd> International Symposium of WPI Immunology Frontier Research Center
  • Place of Presentation: 大阪
  • Year and Date: 2009-02-13
• [Presentation] Dynamic assembly of signaling unit for antigen recognition and activation of immune cells (2009)
  • Author(s): Saito, T.
  • Organizer: Symposium on Meso Control of the cells, by the cells, for the cells
  • Place of Presentation: 京都
  • Year and Date: 2009-01-27
• [Presentation] Dynamic regulation of T cell co-stimulation by TCR-CD28 microclusters (2009)
  • Author(s): Yokosuka, T.
  • Organizer: LIAI-RCAI Joint Workshop 2009
  • Place of Presentation: 横浜
  • Year and Date: 2009-01-07
• [Presentation] CARD9 and innate immunity (2009)
  • Author(s): Saito, T
  • Organizer: Center for the Study of Inflammatory Bowel Disease 19th Annual Workshop. Integrating Innate an Adaptive Immunity in Complex Human Diseases
  • Place of Presentation: Boston
• [Presentation] Mincle is an ITAM-coupled activating receptor that senses damaged cells (2008)
  • Author(s): Yamasaki, S.
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-03
• [Presentation] C-type lectin Mincle is an ITAM-coupled activating receptor sensing damaged cells (2008)
  • Author(s): Yamasaki, S.
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-03
• [Presentation] Identification of a region in immunological synapse critical for T cell co-stimulation (2008)
  • Author(s): Yokosuka, T.
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-03
• [Presentation] CRTAM regulate CD8^+ T cell proliferation in regional lymph nodes through the interaction with CD8α^+ dendritic cell (2008)
  • Author(s): Takeuchi, A.
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-03
• [Presentation] Quantitative analysis of TCR microclusters in CD3zetaGFP knock-in T cells (2008)
  • Author(s): Hashimoto-Tane, A.
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-03
• [Presentation] pre-TCRα-chain knock-in mice lacking charged residues (2008)
  • Author(s): Ishikawa, E.
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-03
• [Presentation] Dynamic Regulation of Immunological Synapse and T cell Activation (2008)
  • Author(s): Saito, T.
  • Organizer: 17th Annual Meeting of Bioimaging Society
  • Place of Presentation: 千葉
  • Year and Date: 2008-10-31
• [Presentation] Dynamic regulation of TCR-and costimulatory signals via microclusters (2008)
  • Author(s): Saito, T
  • Organizer: Cantoblanco Workshops on Biology. Initiation of Antigen Receptor Signaling
  • Place of Presentation: Madrid, Spain
  • Year and Date: 2008-10-22
• [Presentation] Dynamic regulation of TCR- and costimulatory signals via microclusters (2008)
  • Author(s): Saito, T.
  • Organizer: Cantoblanco Workshops on Biology, Initiation of Antigen Receptor Signaling
  • Place of Presentation: Madrid, Spain
  • Year and Date: 2008-10-22
• [Presentation] Macrophage-inducible C-type lectin is an ITAM-coupled activating receptor that senses damaged cells (2008)
  • Author(s): Saito, T.
  • Organizer: 第10回国際樹状細胞シンポジウム
  • Place of Presentation: 神戸
  • Year and Date: 2008-10-08
• [Presentation] Mincle is an ITAM-coupled activating receptor that senses damaged cells (2008)
  • Author(s): Yamasaki, S., Ishikawa, E., Sakuma, M., Hara, H., Ogata, K. and Saito, T.
  • Organizer: The 10th International Symposium on Dendritic Cells
  • Place of Presentation: 神戸
  • Year and Date: 2008-10-03
• [Presentation] C-type lectin Mincle is an ITAM-coupled activating receptor sensing damaged cells (2008)
  • Author(s): Saito, T.
  • Organizer: The 8th Awaji International Forum of Infection and Immunity
  • Place of Presentation: 淡路
  • Year and Date: 2008-09-09
• [Presentation] 免疫応答の始まりと維持の分子機構-T細胞活性化のダイナミズム- (2008)
  • Author(s): 斉藤隆
  • Organizer: 日本免疫学会免疫サマースクール2008
  • Place of Presentation: 南あわじ
  • Year and Date: 2008-08-25
• [Presentation] Dynamic Regulation of T Cell Co-stimulation by TCR-CD28 Microclusters (2008)
  • Author(s): Yokosuka, T. and Saito, T
  • Organizer: RCAI-JSI International Symposium on Immunology 2008 : Regulation of Immune Homeostasis and Diseases
  • Place of Presentation: Yokohama
  • Year and Date: 2008-06-26
• [Presentation] Dynamic Regulation of T Cell Co-stimulation by TCR-CD28 Microclusters (2008)
  • Author(s): Saito, T.
  • Organizer: RCAI-JSI International Symposium on Immunology 2008
  • Place of Presentation: 横浜
  • Year and Date: 2008-06-26
• [Presentation] T細胞初期分化におけるNFκBの役割 (2008)
  • Author(s): 山崎晶
  • Organizer: 第18回 Kyoto T Cell Conference 学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-06-13
• [Presentation] Imaging of initiation of T cell activation (2008)
  • Author(s): Saito, T.
  • Organizer: Kick-off Symposium of WPI IFReC, Immunology and Imaging
  • Place of Presentation: 大阪
  • Year and Date: 2008-03-28
• [Presentation] Spatiotemporal regulation of T cell activation and co-stimulation by microclusters (2008)
  • Author(s): Saito, T.
  • Organizer: The First iCeMS International Symposium: The Eleventh Membrane Research Forum
  • Place of Presentation: 京都
  • Year and Date: 2008-02-22
• [Presentation] Differential cellular adaptors mediating innate and adaptive immunity (2008)
  • Author(s): Saito, T
  • Organizer: Hepatic Inflammation and Immunity 2008
  • Place of Presentation: Galveston, TX, USA
  • Year and Date: 2008-01-25
• [Presentation] Differential cellular adaptors mediating innate and adaptive immunity (2008)
  • Author(s): Saito, T.
  • Organizer: Hepatic Inflammation and Immunity2008
  • Place of Presentation: Galveston,USA
  • Year and Date: 2008-01-25
• [Presentation] CRTAM regulates retention of T cells within lymph node and delivery to effecter tissues (2008)
  • Author(s): Saito, T
  • Organizer: Keystone Symposia/Novel Modulators of Leukocyte Traffic
  • Place of Presentation: Keystone, CO. USA
  • Year and Date: 2008-01-16
• [Presentation] CRTAM regulates retention of T cells within lymph node and delivery to effecter tissues (2008)
  • Author(s): Saito, T.
  • Organizer: Keystone Symposia
  • Place of Presentation: Keystone,USA
  • Year and Date: 2008-01-16
• [Presentation] C-type lectin Mincle is an ITAM-coupled activating receptor sensing damaged cells (2008)
  • Author(s): Yamasaki, S.
  • Organizer: FASEB Summer Research Conferences
  • Place of Presentation: New Haven, CT、USA
• [Presentation] TCRミクロクラスターによる抗原認識と活性化の動的制御 (2007)
  • Author(s): 斉藤 隆
  • Organizer: BMB2007第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-13
• [Presentation] T cell recognition and activation through TCR microclusters (2007)
  • Author(s): Saito, T.
  • Organizer: 第37回日本免疫学会総会・学術集会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-21
• [Presentation] TCR-CD28マイクロクラスターとc-SMACによるT細胞活性化の時空間的制御 (2007)
  • Author(s): 横須賀 忠
  • Organizer: 第37回日本免疫学会総会・学術集会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-21
• [Presentation] CARD 9-mediated innate signaling in myeloid cells (2007)
  • Author(s): Saito, T.
  • Organizer: The 20^<th> Naito Conference-Innate Immunity in Medicine and Biology[III]
  • Place of Presentation: 葉山
  • Year and Date: 2007-10-10
• [Presentation] Dynamic regulation of T cell activation through TCR micloclusters (2007)
  • Author(s): Saito, T.
  • Organizer: 13^<th> International Congress of Immunology
  • Place of Presentation: Rio de Janeiro, Brazil
  • Year and Date: 2007-08-24
• [Presentation] Dynamic regulation of T cell activation through TCR micloclusters (2007)
  • Author(s): Saito, T.
  • Organizer: 13^<th> International Congress of Immunology
  • Place of Presentation: Rio de Janeiro,Brazil
  • Year and Date: 2007-08-24
• [Presentation] Spatiotemporal regulation of T cell activation by TCR-CD28-microclusters (2007)
  • Author(s): Yokosuka, T.
  • Organizer: 13^<th> International Congress of Immunology
  • Place of Presentation: Rio de Janeiro,Brazil
  • Year and Date: 2007-08-21
• [Presentation] TCR-CD28マイクロクラスターによるT細胞活性化の時空間的制御 (2007)
  • Author(s): 横須賀 忠
  • Organizer: 第17回Kyoto T Cell Coference(KTCC)学術集会
  • Place of Presentation: 京都
  • Year and Date: 2007-06-15
• [Presentation] Initiation and sustenance of T cell activation by TCR microclusters (2007)
  • Author(s): Saito, T.
  • Organizer: 4th International Leukocyte Signal Transduction Workshop : Clinical implications of signaling pathways
  • Place of Presentation: Rhodes, Greece
  • Year and Date: 2007-06-04
• [Presentation] Initiation and sustenance of T cell activation by TCR microclusters (2007)
  • Author(s): Saito, T.
  • Organizer: 4th International Leukocyte Signal Transduction Workshop
  • Place of Presentation: Rhodes,Greece
  • Year and Date: 2007-06-04
• [Presentation] TCR microclusters and co-stimulation for T cell activation (2007)
  • Author(s): Saito, T.
  • Organizer: EMBO Conference Series on "Signaling in the immune system" Lymphocyte antigen receptor and coreceptor signaling
  • Place of Presentation: Siena, Italy
  • Year and Date: 2007-05-26
• [Presentation] TCR microclusters and co-stimulation for T cell activation (2007)
  • Author(s): Saito, T.
  • Organizer: EMBO Conference Series on"Signaling in the immune system"
  • Place of Presentation: Siena,Italy
  • Year and Date: 2007-05-26
• [Presentation] Spatiotemporal regulation of T cell activation by TCR-CD28-microclusters (2007)
  • Author(s): Yokosuka, T.
  • Organizer: 第7回日本蛋白質科学会年会
  • Place of Presentation: 仙台
  • Year and Date: 2007-05-25
• [Presentation] Spatiotemporal regulation of lymphocyte activation : Signalsome (2007)
  • Author(s): Yokosuka, T
  • Organizer: TCR-microcluster. National Academy of Engineering 2007 Japan-America Frontiers of Engineering Symposium
  • Place of Presentation: Palo Alto, CA
• [Presentation] Spatiotemporal regulation of T cell activation by TCR-CD28-microclusters (2007)
  • Author(s): Yokosuka, T.
  • Organizer: FASEB Summer Research Conferences-Signal Transduction in the Immune System
  • Place of Presentation: Snowmass,USA
• [Presentation] Spatiotemporal regulation of lymphocyte activation-Signalsome,TCR-microcluster- (2007)
  • Author(s): Yokosuka, T.
  • Organizer: 2007Japan-America Frontiers of Engineering Symposium
  • Place of Presentation: Palo Alto,USA
• [Book] The immunological synapse, TCR microclusters, and T cell activation (2010)
  • Author(s): Yokosuka T and Saito T.
  • Publisher: Springer-Verlag Berlin Heidelberg
• [Book] Curr.Top.Microbiol.Immunol. (T. Saito and F. D. Batista (eds.), The immunological synapse, TCR microclusters, and T cell activation.) (2010)
  • Author(s): Yokosuka T, Saito T.
  • Publisher: Springer-Verlag
• [Remarks]
  • URL: http://www.rcai.riken.go.jp/group/signaling/index.html
• [Remarks] 細胞骨格によるT細胞活性化制御の成果に関して
  • URL: http://www.riken.go.jp/r-world/info/release/press/2011/110624_2/index.html
• [Remarks] HP
  • URL: http://www.rcai.riken.jp/group/signaling/index.html
• [Patent(Industrial Property Rights)] 糖鎖認識受容体の新規用途 (2008)
  • Inventor(s): 斉藤隆、山崎晶
  • Industrial Property Rights Holder: 理化学研究所
  • Industrial Property Number: 2008-186570
  • Filing Date: 2008-07-17
• [Patent(Industrial Property Rights)] 糖鎖認識受容体の新規用途 (2008)
  • Inventor(s): 斉藤隆、山崎晶
  • Industrial Property Rights Holder: 理化学研究所
  • Industrial Property Number: 2008-285948
  • Filing Date: 2008-11-06
• [Patent(Industrial Property Rights)] 糖鎖認識受容体の新規用途 (2008)
  • Inventor(s): 山崎晶, 斉藤隆
  • Industrial Property Rights Holder: (独)理化学研究所
  • Industrial Property Number: 2008-186570
  • Filing Date: 2008-07-17
• [Patent(Industrial Property Rights)] 糖鎖認識受容体の新規用途 (2008)
  • Inventor(s): 山崎晶, 斉藤隆
  • Industrial Property Rights Holder: (独)理化学研究所
  • Industrial Property Number: 2008-285948
  • Filing Date: 2008-11-06
• [Patent(Industrial Property Rights)] 糖鎖認識受容体の新規用途 (2008)
  • Inventor(s): 斉藤隆, 山崎晶
  • Industrial Property Rights Holder: 理化学研究所
  • Industrial Property Number: 2008-186570
  • Filing Date: 2008-07-17
• [Patent(Industrial Property Rights)] 糖鎖認識受容体の新規用途 (2008)
  • Inventor(s): 斉藤隆, 山崎晶, 他
  • Industrial Property Rights Holder: 理化学研究所,千葉大学
  • Industrial Property Number: 2008-285948
  • Filing Date: 2008-11-06
• [Patent(Industrial Property Rights)] T細胞分化調節剤(および細胞表面タンパク質間の細胞外領域における相互作用の検出システム) (2007)
  • Inventor(s): 斉藤隆、山崎晶
  • Industrial Property Rights Holder: 理化学研究所
  • Industrial Property Number: 2007-539809
  • Filing Date: 2007-03-04