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Analysis of proliferation and differentiation of human embryonic stem cells and research for clinical application

Research Project

Project/Area Number 19109006
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionKyoto University

Principal Investigator

NAKAHATA Tatsutoshi  Kyoto University, 物質-細胞統合システム拠点, 特定拠点教授 (20110744)

Co-Investigator(Kenkyū-buntansha) 平家 俊男  京都大学, 医学研究科, 准教授 (90190173)
梅田 雄嗣  京都大学, 医学研究科, 助教 (80397538)
Co-Investigator(Renkei-kenkyūsha) HEIKE Toshio  京都大学, 医学研究科, 教授 (90190173)
UMEDA Katsutsugu  京都大学, 医学研究科, 助手 (80397538)
SAITOH Megumu  京都大学, 物質-細胞統合システム拠点, 特定拠点助教 (90535486)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥109,200,000 (Direct Cost: ¥84,000,000、Indirect Cost: ¥25,200,000)
Fiscal Year 2009: ¥25,350,000 (Direct Cost: ¥19,500,000、Indirect Cost: ¥5,850,000)
Fiscal Year 2008: ¥32,890,000 (Direct Cost: ¥25,300,000、Indirect Cost: ¥7,590,000)
Fiscal Year 2007: ¥50,960,000 (Direct Cost: ¥39,200,000、Indirect Cost: ¥11,760,000)
KeywordsES細胞 / ヒト / 再生医療 / 幹細胞 / NOGマウス
Research Abstract

We attempt to discover the culture system for generation of desired lineage-specific stem cells from human ES cells and succeeded in generating progenitor cells for hematopoietic cells, endothelial cells, skeletal muscle, cardiomyocytes and neural cells.
VEGFR-2(+)CD34(+) cells are identified as a candidate of primate hemangioblasts. We established a novel protocol to derive myogenic precursors from murine ES/iPS cells with a monoclonal antibody SM/C-2.6 that recognizes quiescent satellite cells. SM/C-2.6-positive cells are highly myogenic and efficiently differentiate into myofibers both in vitro and in vivo. We recently developed culture system for skeletal muscle cells from human ES cells.
Recently, we developed an excellent humanized model mouse, NOG mouse, in which successful engraftment was achieved even if small number of CD34^+ cells were transplanted into the mice. In this study we confirmed that NOG mouse was useful for evaluation of ES/iPS cell-derived tissue specific stem cells.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (223 results)

All 2010 2009 2008 2007 Other

All Journal Article (141 results) (of which Peer Reviewed: 101 results) Presentation (78 results) Book (1 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Successful treatment of refractory donor lymphocyte infusion-induced immune-mediated pancytopenia by Rituximab.2010

    • Author(s)
      Kato I., Nakahata T., (他13名、14番目)
    • Journal Title

      Pediatr Blood Cancer. 54

      Pages: 329-331

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of early-onset sarcoidosis with a six-base deletion in the NOD2 gene.2010

    • Author(s)
      Sakai H, Nakahata T., (他8名、10番目)
    • Journal Title

      Rheumatology (Oxford) (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Circulating CD4+T cells Specific for H5 Hemagglutinin in Healthy Subjects.2010

    • Author(s)
      Ueno H, Nakahata T., (他8名、10番目)
    • Journal Title

      J.Infectious Diseases (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation of skeletal muscle stem/progenitor cells from murine induced pluripotent stem cells.2010

    • Author(s)
      Mizuno Y., Nakahata T., (他9名、10番目)
    • Journal Title

      FASEB J. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow engraftment but limited expansion of hematopoietic cells from multipotent germline stem cells derived from neonatal mouse testis.2010

    • Author(s)
      Yoshimoto M, Nakahata T., (他7名、9番目)
    • Journal Title

      Exp.Hematol. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Muse cells-unique multipotent cells in human mesenchymal cell populations.2010

    • Author(s)
      Kuroda Y., Nakahata T., (他13名、12番目)
    • Journal Title

      Proc.Natl.Adad.Sci.USA (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term survival after non-intenslve chemotherapy in some juvenile myelomonocytic leukemia patients with CBL mutations, and the possible presence of normal individuals with the mutstions.2010

    • Author(s)
      Matsuda K., Nakahata T., (他11名、12番目)
    • Journal Title

      Blood (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of the NOD2 genotype in the clinical phenotype of Blau syndrome and early-onset sarcoidosis.2009

    • Author(s)
      Okafuji I, Nishikomori R, Kanazawa N, Kambe N, Fujisawa A, Yamazaki S, Saito M, Yoshioka T, Kawai T, Sakai H, Tanizaki H, Heike T, Miyachi Y, Nakahata T.
    • Journal Title

      Arthritis Rheum. 60

      Pages: 242-50

    • Related Report
      2009 Final Research Report
  • [Journal Article] Generation of transplantable, functional satellite-like cells from mouse embryonic stem cells.2009

    • Author(s)
      Chang H, Yoshimoto M, Umeda K, Iwasa T, Mizuno Y, Fukada SI, Yamamoto H, Motohashi N, Suzuki YM, Takeda S, Heike T, Nakahata T.
    • Journal Title

      FASEB J. 23

      Pages: 1907-1919

    • Related Report
      2009 Final Research Report
  • [Journal Article] AKR-501 (YM477) a novel orally-active thrombopoietin receptor agonist.2009

    • Author(s)
      Fukushima-Shintani M, Suzuki KI, Iwatsuki Y, Abe M, Sugasawa K, Hirayama F, Kawasaki T, Nakahata T.
    • Journal Title

      Eur J Haematol. 82

      Pages: 247-254

    • Related Report
      2009 Final Research Report
  • [Journal Article] Direct hematological toxicity and illegitimate chromosomal recombination caused by the systemic activation of CreERT2。.2009

    • Author(s)
      Higashi A.Y., Ikawa T, Muramatsu M, Economides A.N., Niwa A, Okuda T, Murphy AJ., Rojas J, Heike T, Nakahata T, Kawamoto H, Kita T, Yanagita M.
    • Journal Title

      J Immunol. 182

      Pages: 5633-5640

    • Related Report
      2009 Final Research Report
  • [Journal Article] The effects of cardioactive drugs on cardiomyocytes derived from human induced pluripotent stem cells.2009

    • Author(s)
      Yokoo N., Baba S., Kaichi S., Niwa A., Mima T., Doi H., Yamanaka S., Nakahata T., Heike T.
    • Journal Title

      Biochem. Biophys. Res. Com. 387

      Pages: 482-488

    • Related Report
      2009 Final Research Report
  • [Journal Article] Selective infection of CD(4)+ effector memory T lymphocytes leads to preferential depletion of memory T lymphocytes in R5 HIV-infected humanized NOD/SCID/IL-2Rγnull mice.2009

    • Author(s)
      Nie C, Sato K, Misawa N, Kitayama H, Fujino H, Hiramatsu H, Heike T, Nakahata T, Tanaka Y, Ito M, Koyanagi Y
    • Journal Title

      Virology 394

      Pages: 64-72

    • Related Report
      2009 Final Research Report
  • [Journal Article] Frequent inactivation of A20 in B-cell lymphomas.2009

    • Author(s)
      Kato M, Sanada M, Kato I, Sato Y, Takita J, Takeuchi K, Niwa A, Chen Y, Nakazaki K, Nomoto J, Asakura Y, Muto S, Tamura A, Iio M, Akatsuka Y, Hayashi Y, Mori H, Igarashi T, Kurokawa M, Chiba S, Mori S, Ishikawa Y, Okamoto K, Tobinai K, Nakagama H, NakahatKato M, Sanada M, Kato I, Sato Y, Ta
    • Journal Title

      Nature 459

      Pages: 712-716

    • Related Report
      2009 Final Research Report
  • [Journal Article] Orderly Hematopoietic Development of Induced Pluripotent Stem Cells via Flk-1+ Hemoangiogenic Progenitors.2009

    • Author(s)
      Niwa A., Umeda K., Chang H., Saito M., Okita K., Takahashi K., Nakagawa M., Yamanaka S., Nakahata T., Heike T
    • Journal Title

      J. Cell. Physiol. 221

      Pages: 367-377

    • Related Report
      2009 Final Research Report
  • [Journal Article] Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor.2009

    • Author(s)
      Miyara M., Yoshioka Y., Kitoh A., Shima T., Wing K., Niwa A., Perizot C., Taflin C., Heike T., Valeyre D., Mathian A., Nakahata T., Yamaguchi T., Nomura T., Ono M., Amoura Z., Gorochov G., Sakaguchi S.
    • Journal Title

      Immunity 30

      Pages: 899-911

    • Related Report
      2009 Final Research Report
  • [Journal Article] I. 造血幹細胞1. iPS細胞からの造血分化.2009

    • Author(s)
      丹羽明、中畑龍俊
    • Journal Title

      Annual Review血液2009 40551

      Pages: 1-1

    • Related Report
      2009 Final Research Report
  • [Journal Article] 対外増幅造血細胞移植.2009

    • Author(s)
      伊藤仁也, 中畑龍俊
    • Journal Title

      医学のあゆみ 229(9)

      Pages: 786-792

    • Related Report
      2009 Final Research Report
  • [Journal Article] 疾患特異的iPS細胞.2009

    • Author(s)
      中畑龍俊
    • Journal Title

      学術の動向 14(9)

      Pages: 78-83

    • NAID

      130000450684

    • Related Report
      2009 Final Research Report
  • [Journal Article] to preferential depletion of memory T lymphocytes in R5 HIV-infected humanized NOD/SCID/IL-2Rγnull mice.2009

    • Author(s)
      KamitsujiY, Kuroda J, Kimura S, Toyokuni S, Watanabe K, Ashihara E, Tanaka H, Yui Y
    • Journal Title

      Virology 394

      Pages: 64-72

    • Related Report
      2009 Final Research Report
  • [Journal Article] Generation of transplantable, functional satellite-like cells from mouse embryonic stem cells.2009

    • Author(s)
      Chang H, Nakahata T., (他10名、12番目)
    • Journal Title

      FASEB J. 23

      Pages: 1907-1919

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of autophagy in malignant rhabdoid tumor cells by the histone deacetylase inhibitor FK228 through AIF translocation.2009

    • Author(s)
      Watanbe M, Nakahata T., (他12名、14番目)
    • Journal Title

      Int.J.Caner 124

      Pages: 55-67

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of extracellular slgnal-regulated kinase activation in human osteosarcoma cell resistance to the histone deacetylase inhibitor FK228[(1S. 4S. 7Z. 10S. 16E. 21R)-7-ethylidene-4. 21-bis(propan-2-yl)-2-oxa-12, 13-dithia-5. 8. 20. 23-tetraazabicycol[8. 7. 6]tricos-16-ene-3, 6, 9. 19. 22-pentone].2009

    • Author(s)
      Matsubara H, Nakahata T., (他10名、11番目)
    • Journal Title

      J.Pharmacol Exp.Ther. 328

      Pages: 839-848

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of the NOD2 genotype in the clinical phenotype of Blau syndrome and early-onset sarcoidosis.2009

    • Author(s)
      Okafuji I, Nakahata T., (他12名、14番目)
    • Journal Title

      Arthritis Rheum. 60

      Pages: 242-250

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Successful autolngous peripheral blood stem cell transplantation with a double-conditioning regimen for recurrent hepatoblastoma after liver transplantation.2009

    • Author(s)
      Niwa A, Nakahata T., (他9名、11番目)
    • Journal Title

      Pediatr. Transplant. 13

      Pages: 259-262

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Granulocyte colony-stimulating factor protects cardiac mitochondria in the early phase of cardiac injury.2009

    • Author(s)
      Hiraumi Y, Nakahata T., (他11名、12番目)
    • Journal Title

      Am.J.Physiol.Heart Circ.Physiol. 296

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] AKR-501 (YM477) a novel orally-active thrombopoietin receptor agonist.2009

    • Author(s)
      Fukushima-Shintani M, Nakahata T., (他6名、8番目)
    • Journal Title

      Eur.J.Haematol. 82

      Pages: 247-254

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct hematological toxieity and illegitimate chromosomal recombination caused by the systemic activation of CreER^<12>.2009

    • Author(s)
      Higashi A.Y., Nakahata T., (他11名、10番目)
    • Journal Title

      J.Immunol. 182

      Pages: 5633-5640

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Treatment of Childhood MDS Study Group Trial (MDS99).2009

    • Author(s)
      Hasegawa D., Nakahata T., (他8名、10番目)
    • Journal Title

      Pediatr.Blood Cancer 53

      Pages: 1011-1015

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effects of cardioactive drugs on cardiomyocytes derived from human induced pluripotent stem cells.2009

    • Author(s)
      Yokoo N., Nakahata T., (他7名、8番目)
    • Journal Title

      Biophys.Res.Com 387

      Pages: 482-488

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changing Prevalence and Severity of Childhood Allergic Diseases in Kyoto, Japan, from 1996 to 2006.2009

    • Author(s)
      Kusunoki T, Nakahata T., (他5名、7番目)
    • Journal Title

      Allergol.Int. 58

      Pages: 543-548

    • NAID

      10027165583

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Allergic status of schoolchildren with food allergy to eggs, milk or wheat in infancy.2009

    • Author(s)
      Kusunoki T, Nakahata T., (他4名、6番目)
    • Journal Title

      Pediatr.Allergy.Immunol. 20

      Pages: 642-647

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective infection of CD(4)+effector memory T lymphocytes leads to preferential depletion of memory T lymphocytes in R5 HIV-infected humanized NOD/SCID/IL-2Rγ^<null> mice.2009

    • Author(s)
      Nie C, Nakahata T., (他9名、8番目)
    • Journal Title

      Virology 394

      Pages: 64-72

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Frequent inactivation of A20 in B-cell lymphomas.2009

    • Author(s)
      Kato M, Nakahata T., (他27名、26番目)
    • Journal Title

      Nature 459

      Pages: 712-716

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Orderly Hematopoictic Development of Induced Pluripotent Stem Cells via F1K-1-+Hemoangiogenic Progenitors.2009

    • Author(s)
      Niwa A., Nakahata T., (他8名、9番目)
    • Journal Title

      J.Cell.Physiol. 221

      Pages: 367-377

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional delineation and differentialion dynamics of human CD4+ Tcells expressing the FoxP3 transcription factor.2009

    • Author(s)
      Miyara M., Nakahata T., (他16名、12番目)
    • Journal Title

      Immunity 30

      Pages: 899-911

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Outcome of childhood acute lymhpoblastic leukemia with induction failure treated by the Japan Association of Childhood Leudemia Study (JACLS) ALL F-protocol.2009

    • Author(s)
      Suzuki N, Nakahata T., (他17名、18番目)
    • Journal Title

      Pediatric Blood Cancer. 54

      Pages: 71-78

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 小児がんに対するWT1ペプチドによるワクチン療法.2009

    • Author(s)
      澤田明久、中畑龍俊, (他38名、31番目)
    • Journal Title

      日本小児がん学会雑誌 46

      Pages: 6-16

    • NAID

      110007171798

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 感染性心内膜炎合併後に安全に非血縁臍帶血移植を施行し得た乳児白血病の1例.2009

    • Author(s)
      深尾大輔、中畑龍俊, (他12名、11番目)
    • Journal Title

      日本血液学会雑誌 23

      Pages: 126-130

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] プロトロンビン時間を重視した早期新生児のDIC診断基準.2009

    • Author(s)
      河井昌彦、中畑龍俊
    • Journal Title

      日本産婦人科・新生児血液学会誌 18

      Pages: 85-90

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 集学的アプローチにより腫瘍核出術をしえた局所型先天性高インスリン血症.2009

    • Author(s)
      長井静世、中畑龍俊(13名、15番目)
    • Journal Title

      日本小児科学会雑誌 113

      Pages: 838-842

    • NAID

      10024843519

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 対外増幅造血細胞移植.2009

    • Author(s)
      伊藤仁也、中畑龍俊
    • Journal Title

      医学のあゆみ 229

      Pages: 786-792

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 京大病院にて治療行なった6歳以下発症の骨肉腫4例の検討.2009

    • Author(s)
      徳舛麻友、中畑龍俊, (他10名、12番目)
    • Journal Title

      小児がん 46

      Pages: 195-200

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] わが国の小児造血器腫瘍診療施設の実態.2009

    • Author(s)
      堀部敬三、中畑龍俊, (他2名、4番目)
    • Journal Title

      日本小児科学会雑誌 113

      Pages: 105-111

    • NAID

      10025168606

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 小児T細胞急性リンパ性白血病に合併したgroove膵炎1例.2009

    • Author(s)
      瓜生久美子、中畑龍俊, (他7名、9番目)
    • Journal Title

      日本小児血液学会誌 23

      Pages: 209-212

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 疾患特異的iPS細胞.2009

    • Author(s)
      中畑龍俊
    • Journal Title

      学術の動向 14

      Pages: 78-83

    • NAID

      130000450684

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 疾患特異的iPS細胞.2009

    • Author(s)
      中畑龍俊
    • Journal Title

      MSDメディカル・サイエンス・ダイジェスト(10月臨時増刊号) 35

      Pages: 9-12

    • NAID

      130000450684

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 疾患特異的iPS細胞の医療応用.2009

    • Author(s)
      中畑龍俊
    • Journal Title

      再生医療 8

      Pages: 7-7

    • Related Report
      2009 Annual Research Report
  • [Journal Article] SGA児のメタボリック・シンドロームのリスクについての検討-SGA児の高血圧は幼児期から始まる?-2009

    • Author(s)
      河井昌彦、中畑龍俊, (他6名、8番目)
    • Journal Title

      日本周産期・新生児医学会雑誌 45

      Pages: 1274-1275

    • NAID

      10029091108

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] I.総論インフォームド・コンセント2-システムとしての対応.2009

    • Author(s)
      中畑龍俊
    • Journal Title

      小児科診療 72

      Pages: 1793-1800

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] さまざまな幹細胞を用いた今後の再生医療2009

    • Author(s)
      中畑龍俊
    • Journal Title

      血液フロンティア 19

      Pages: 17-18

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of autophagy in malignant rhabdoid tumor cells by the histone deacetylase inhibitor FK228 through AIF translocation.2009

    • Author(s)
      Watanabe M., Nakahata, T., 他12名, 14番目
    • Journal Title

      Int. J. Cancer 124

      Pages: 55-67

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of extracellular signal-regulated kinase activation in human osteosarcoma cell resistance to the histone deacetylase inhibitor FK228 [(1S. 4S, 7Z, 10S, 16E, 21R) -7-ethylidene-4, 21-bis (propan-2-yl)- 2-oxa-12, 13-dithia-5, 8, 20, 23-tetraazabicyclo [8. 7. 6] tricos-16-ene-3. 6, 9, 19, 22-pentone].2009

    • Author(s)
      Matsubara H., Nakahata, T., 他10名, 11番目
    • Journal Title

      J. Pharmacol. Exp. Ther. 328

      Pages: 839-848

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of the N0D2 genotype in the clinical phenotype of Blau syndrome and early-onset sarcoidosis.2009

    • Author(s)
      Okafuji I., Nakahata, T., 他12名, 14番目
    • Journal Title

      Arthritis Rheum. 60

      Pages: 242-250

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Successful autologous peripheral blood stem cell transplantation with a double-conditioning regimen for recurrent hepatoblastoma after liver transplantation.2009

    • Author(s)
      Niwa A., Nakahata, T., 他9名, 11番目
    • Journal Title

      Pediatr. Transplant. 13

      Pages: 259-262

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] AKR-501 (YM477) a novel orally-active thrombopoietin receptor agonist.2009

    • Author(s)
      Fukushima-Shintani M., Nakahata, T., 他6名, 8番目
    • Journal Title

      Eur. J. Haematol. 82

      Pages: 247-254

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Granulocyte colony-stimulating factor protects cardiac mitochondria in the early phase of cardiac injury.2009

    • Author(s)
      Hiraumi Y., Nakahata, T., 他11名, 12番目
    • Journal Title

      Am. J. Physiol. Heart Circ. Physiol. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation of transplantable, functional satellite-like cells from mouse embryonic stem cells.2009

    • Author(s)
      Chang H., Nakahata, T., 他10名, 12番目
    • Journal Title

      FASEB J. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct hematological toxicity and illegitimate chromosomal recombination caused by the systemic acactivation of CreER_<T2>. .2009

    • Author(s)
      Higashi A. Y., Nakahata, T., 他11名, 10番目
    • Journal Title

      J. Immunol. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Circulating CD4+ T cells Specific for H5 Hemagglutinin in Healthy Subjects.2009

    • Author(s)
      Ueno H., Nakahata, T., 他13名, 10番目
    • Journal Title

      J. Infectious Diseases (inpress)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Frequent inactivation of A20 in B-cell lymphomas.2009

    • Author(s)
      Kato M., Nakahata, T., 他13名, 10番目
    • Journal Title

      Nature (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] I. 造血幹細胞 (1. iPS細胞からの造血分化)2009

    • Author(s)
      丹羽明, 中畑龍俊
    • Journal Title

      Annual Review 血液

      Pages: 1-8

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct development of functionary mature tryptase/ chymase double-positive connective tissue-type mast cells from primate embryonic stem cells.2008

    • Author(s)
      Ma F, Kambe N, Dan W, Shinoda G, Fujino H, Umeda K, Fujisawa A, Ma L, Suemori H, Nakatsuji N, Miyachi Y, Torii R, Tsuji K, Heike T, Nakahata T
    • Journal Title

      Stem Cells 26

      Pages: 706-714

    • Related Report
      2009 Final Research Report
  • [Journal Article] NOD/Shi-scid IL2rγnull (NOG)Mice More Appropriate for Humanized Mouse Models.2008

    • Author(s)
      Ito M, Kobayashi K, Nakahata T
    • Journal Title

      Curr. Top. Microbiol. Immunol. 324

      Pages: 54-76

    • Related Report
      2009 Final Research Report
  • [Journal Article] Generatuion of functional erythrocytes from human embryonic stem cell-derived definitive hematopoiesis.2008

    • Author(s)
      Ma F, Ebihara Y, Umeda K, Sakai H, Hanada S, Hong Z, Zaike Y, Tsuchida E, Nakahata T, Nakauchi H, Tsuji K
    • Journal Title

      PNAS 105(35)

      Pages: 13087-13092

    • Related Report
      2009 Final Research Report
  • [Journal Article] Side population cells contribute to the genesis of human endometrium.2008

    • Author(s)
      Tsuji S, Yoshimoto M, Takahashi K, Noda Y, Nakahata T, Heike T
    • Journal Title

      Fertility and Sterility 90

      Pages: 1528-1537

    • Related Report
      2009 Final Research Report
  • [Journal Article] Sca-1+ endothelial cells (SPECs) reside in the portal area of the liver and contribute to rapid recovery from acute liver disease.2008

    • Author(s)
      Tsuchiya A., Heike T., Baba S., Fujino H., Umeda K., Matsuda Y., Nomoto M., Ichida T., Aoyagi Y., Nakahata T.
    • Journal Title

      Biochem. Biophys. Res. Com. 365

      Pages: 595-601

    • Related Report
      2009 Final Research Report
  • [Journal Article] Disease-associated CIAS1 mutations induce monocyte death, revealing low-level mosaicism in mutation-negative cryopyrin-associated periodic syndrome patients.2008

    • Author(s)
      Saito M., Nishikomori R., Kambe N., Fujisawa A., Tanizaki H., Takeichi K., Imagawa T., Iehara T., Takada H., Matsubayashi T., TanakaH., Kawashima K., Kagami S., Kawai T., Okafuji I., Yoshioka T., Adachi S., Heike T., Miyachi Y., Nakahata T.
    • Journal Title

      Blood 111

      Pages: 2132-2141

    • Related Report
      2009 Final Research Report
  • [Journal Article] Loss of Borealin/DasraB leads to defective cell proliferation, p53 accumulation and early embryonic lethality.2008

    • Author(s)
      Yamanaka Y., Kumada T., Heike T., Shibata M., Takaoka Y., Kitano A., Shiraishi K., Kato T., Nagato M., Okawa K., Furushima K., Nakao K., Aizawa S., Nakamura Y., Taketo M.M. Nakahata T.
    • Journal Title

      Mech. Develop. 125

      Pages: 4441-450

    • Related Report
      2009 Final Research Report
  • [Journal Article] 幹細胞の臨床応用とその課題.2008

    • Author(s)
      中畑龍俊
    • Journal Title

      日本臨床 66(5)

      Pages: 831-840

    • Related Report
      2009 Final Research Report
  • [Journal Article] 造血幹細胞. 進みつづける細胞移植治療の実際上巻ー再生医療の実現に向けた科学・技術と周辺要素の理解ー2008

    • Author(s)
      中畑龍俊
    • Journal Title

      遺伝子医学MOOK別冊メディカルドゥ 60-66

    • Related Report
      2009 Final Research Report
  • [Journal Article] Direct development of functionally mature tryptase/chymase double positive connective tissue-type mast cells from primate ES cells.2008

    • Author(s)
      Ma F., Nakahata, T., 他13名, 15番目
    • Journal Title

      stem Cells 26

      Pages: 706-714

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutation analysis of AML1 gene in pediatric primary myelodysplastic syndrome and juvenile myelomonocytic leukemia.2008

    • Author(s)
      Masunaga A., Nakahata, T., 他7名, 9番目
    • Journal Title

      Leuk Res. 32

      Pages: 995-997

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NOD/Shi-scid IL2rγull (NOG) Mice More Appropriate for Humanized Mouse Models. Current Topics in Microbiology and Immunology2008

    • Author(s)
      Ito M., Kobayashi K, Nakahata, T.
    • Journal Title

      Current Topics in Microbiology and Immunology 324

      Pages: 54-76

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generatuion of functional erythrocytes from human embryonic stem cell-derived definitive hematopoiesis.2008

    • Author(s)
      Ma F., Nakahata, T., 他9名, 9番目
    • Journal Title

      Proc. Natl. Acad. Sci. USA 105

      Pages: 13087-13092

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Bcr-Abl kinase inhibitor INNO-406 induces autophagyand different modes of cell death execution in Bcr-Abl-positive luekemias.2008

    • Author(s)
      Kamitsuji Y., Nakahata, T., 他15名, 16番目
    • Journal Title

      Cell Death and Differ. 15

      Pages: 1712-1722

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Side population cells contribute to the genesis of human endometrium.2008

    • Author(s)
      Tsuji S., Nakahata, T., 他4名, 5番目
    • Journal Title

      Fertility and Sterility 90

      Pages: 1528-1537

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel conditioning regimen consisting of busulfan, fludarabine and melphalan for allogeneic stem cell transplantation in children with juvenile myelomonocytic leukemia.2008

    • Author(s)
      Yabe M., Nakahata, T., 他15名, 17番目
    • Journal Title

      Pediatr. Transplant. 12

      Pages: 862-867

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sca-1+ endothelial cells (SPECs) reside in the portal area of the liver and contribute to rapid recovery from acute liver disease.2008

    • Author(s)
      Tsuchiya A., Nakahata, T., 他8名, 10番目
    • Journal Title

      Biochem. Biophys. Res. Com 365

      Pages: 595-601

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Disease-associated CIAS1 mutations induce monocyte death, revealing low-level mosaicism in mutation-negative cryopyrin-associated periodic syndrome patients.2008

    • Author(s)
      Saito M., Nakahata, T., 他18名, 20番目
    • Journal Title

      Blood 111

      Pages: 2132-2141

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prospective multicenter trial comparing repeated immunosuppressive therapy with stem cell transplantation from an alternative donor as second-line treatment for children with severe and very severe aplastic anemia.2008

    • Author(s)
      Kosaka Y., Nakahata, T., 他14名, 14番目
    • Journal Title

      Blood 111

      Pages: 1054-1059

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A CIAS1 mutation in a Japanese girl with familial cold autoinflammatory syndrome.2008

    • Author(s)
      Kanegane H., Nakahata, T., 他7名, 8番目
    • Journal Title

      Eur. J. Pediatr. 167

      Pages: 245-247

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinicopathological characteristics of erythroblast-rich RAEB and AML M6a in children.2008

    • Author(s)
      Honda Y., Nakahata, T., 他8名, 10番目
    • Journal Title

      Int J Hematol 88

      Pages: 524-529

    • NAID

      10023971232

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow-derived cells expressing Ibal are constitutively present as resident tissue macrophages in the mouse cochlea.2008

    • Author(s)
      Okano T., Nakahata, T., 他5名, 6番目
    • Journal Title

      J. Neurosci. Res. 86

      Pages: 1758-1767

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Loss of Borealin/DasraB leads to defective cell proliferation, p53 accumulation and early embryonic lethality.2008

    • Author(s)
      Yamanaka Y., Nakahata, T., 他14名, 16番目
    • Journal Title

      Mech. Develop. 125

      Pages: 441-450

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Delivery route in bone marrow cell transplantation should be optimized according to the etiology of heart disease.2008

    • Author(s)
      Nakajima H., Nakahata, T., 他11名, 12番目
    • Journal Title

      Circ. J. 72

      Pages: 1528-1535

    • NAID

      110006894393

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression profile analysis of aorta-gonad-mesonephros region-derived stromal cells reveals genes that regulate hematopoiesis.2008

    • Author(s)
      Nagao K., Nakahata, T., 他10名, 10番目
    • Journal Title

      Biochem. Biophys. Res. Commun. 377

      Pages: 205-209

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Successful treatment of a patient with Klinefelter's syndrome complicated by Mediastinal germ cell tumor and AML (M7).2008

    • Author(s)
      Hiramatsu H., Nakahata, T., 他7名, 8番目
    • Journal Title

      Bone Marrow Transplant. 41

      Pages: 907-908

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 幹細胞の臨床応用とその課題2008

    • Author(s)
      中畑龍俊
    • Journal Title

      日本臨床 66

      Pages: 831-840

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 造血幹細胞. 進みつづける細胞移植治療の実際上巻-再生医療の実現に向けた科学・技術と周辺要素の理解-2008

    • Author(s)
      中畑龍俊
    • Journal Title

      遺伝子医学MOOK別冊 メディカルドゥ 別冊

      Pages: 60-66

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 骨髄移植俊に生じたサイトメガロウイルス(CMV)肛門周囲腫瘍2008

    • Author(s)
      松永裕美, 松村由美, 宮地良樹, 三富陽子, 真鍋俊明, 河野文彦, 安部大輔, 梅田雄嗣, 足立壮一, 中畑龍俊
    • Journal Title

      臨床皮膚科 62

      Pages: 847-849

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 小児同種造血幹細胞移植症例に伴う腎障害の検討2008

    • Author(s)
      加藤格, 梅田雄嗣, 松原央, 平松英文, 渡邊健一郎, 足立壮一, 中畑龍俊
    • Journal Title

      臨床血液 49

      Pages: 1530-1535

    • NAID

      10024455211

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A CIASI mutation in a Japanese girl with familial coldautoinflammatory syndrome.2008

    • Author(s)
      Kanegane H., Nakahata, T.(他7名, 8番目)
    • Journal Title

      Eur J Pediatr. 167

      Pages: 245-247

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Disease-associated CIAS1 mutations induce monocyte death, revealing low-level mosaicism inmutation-negative cryopyrin-associated periodic syndrome patients.2008

    • Author(s)
      Saito M., Nakahata, T.(他18名, 20番目)
    • Journal Title

      Blood 111

      Pages: 2132-2141

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prospective multicenter trial comparing repeated immunosuppressive therapy with stem cell transplantation from an alternative donor as second-line treatment for children with severe and verysevere aplastic anemia.2008

    • Author(s)
      Kosaka Y., Nakahata, T.(他14名, 14番目)
    • Journal Title

      Blood 111

      Pages: 1054-1059

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sca-1+ endothelial cells(SPECs)reside in the portal area of the liver and contribute to rapid recovery from acute liver disease.2008

    • Author(s)
      Tsuchiya A., Nakahata, T.(他8名, 10番目)
    • Journal Title

      Biochem. Biophys. Res. Com. 365

      Pages: 595-601

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct development of functionally mature tryptase/chymase double positiveconnective tissue-type mast cells from primate ES cells.2008

    • Author(s)
      Ma. F., Nakahata, T.(他13名, 15番目)
    • Journal Title

      Stem Cells 26

      Pages: 706-714

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutation analysis of AML1 gene in pediatric primary myelodysplasticsyndrome and juvenile myelomonocytic leukemia.2008

    • Author(s)
      Masunaga A., Nakahata, T.(他7名, 9番目)
    • Journal Title

      Leuk. Res. 32

      Pages: 995-997

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel conditioning regimen consisting of busulfan, fludarabine and melphalan for allogeneic stem cell transplantation in children with juvenile myelomonocytic leukemia.2008

    • Author(s)
      Yabe M., Nakahata, T.(他15名, 17番目)
    • Journal Title

      Pediatr. Transplant. (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Obesity and prevalence of allergic diseases in schoolchildren.2008

    • Author(s)
      Kusunoki T., Nakahata, T.(他5名, 7番目)
    • Journal Title

      Pediatr Allergy Immunol. (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Loss of Borealin/DasraB leads to defective cell proliferation, p53accumulation and early embryonic lethality.2008

    • Author(s)
      Yamanaka Y., Nakahata, T.(他14名, 16番目)
    • Journal Title

      Mech. Develop. (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isolation and characterization of bone marrow-derived mesenchymal progenitor cells with myogenic and neuronal properties.2007

    • Author(s)
      Shiota M, Heike T, Haruyama M, Baba S, Tsuchiya A, Fujino H, Kobayashi H, Umeda K, Yoshimoto M, Nakahata T
    • Journal Title

      Exp Cell Res. 313(5)

      Pages: 1008-1023

    • Related Report
      2009 Final Research Report
  • [Journal Article] α4-Integrin+ endothelium deriverd from primate embryonic stem cells generates primitive and definitive hematopoietic cells.2007

    • Author(s)
      Shinoda G, Umeda K, Heike T, Arai M, Niwa A, Ma F, Suemori H, Luo HY, Chui DH, Torii R, Shibuya M, Nakatsuji N, Nakahata T
    • Journal Title

      Blood 109(6)

      Pages: 2406-2415

    • Related Report
      2009 Final Research Report
  • [Journal Article] Generation of Cardiac and Endothelial Cells from Neonatal Mouse Testis-Derived Multipotent Germline Stem Cells.2007

    • Author(s)
      Baba S, Heike T, Umeda K, Iwasa T, Kaichi S, Hiraumi T, Doi H, Yoshimoto M, Kanatsu-Shinohata M, Shinohara T, Nakahata T
    • Journal Title

      Stem Cells 25

      Pages: 1375-1383

    • Related Report
      2009 Final Research Report
  • [Journal Article] Disease-associated mutations in CIAS1 induce cathepsin B-dependent rapid cell death of human THP-1 monocytic cells.2007

    • Author(s)
      Fujisawa A, Kambe N, Saito M, Nishikomori R, Tanizaki H, Kanazawa N, Adachi S, Heike T, Sagara J, Suda T, Nakahata T, Miyachi Y
    • Journal Title

      Blood 109(7)

      Pages: 2903-2911

    • Related Report
      2009 Final Research Report
  • [Journal Article] Long-term culture of postnatal mouse hepatic stem/ progenitor cells and their relative development hierarchy.2007

    • Author(s)
      Tsuchiya A, Heike T, Baba S, Fujino H, Umeda K, Matsuda Y, Nomoto M, Ichida T, AoyagiY, Nakahata T
    • Journal Title

      Stem Cells 25

      Pages: 895-902

    • Related Report
      2009 Final Research Report
  • [Journal Article] Flk1+ cardiac stem/progenitor cells derived from embryonic stem cells improve cardiac function in a dilated cardiomyopathy mouse model.2007

    • Author(s)
      Baba S, Heike T, Yoshimoto M, Umeda K, Doi H, Iwasa T, Lin X, Matsuoka S, Komeda M, Nakahata T
    • Journal Title

      Cardiiovascular Res. 76

      Pages: 119-131

    • Related Report
      2009 Final Research Report
  • [Journal Article] Characterization of side-population cells in human normal endometrium.2007

    • Author(s)
      Kato K, Yoshimoto M, Kato K, Adachi S, Yamayoshi A, ArimaT, Asanoma K, Kyo S, Nakahata T, Wake N
    • Journal Title

      Human Reproduction 22(5)

      Pages: 1214-1223

    • Related Report
      2009 Final Research Report
  • [Journal Article] Notch ligand Delta-1 differentially modulates the effects of gp130 activation on interleukin-6 receptorα-positive and-negative human hematopoietic progenitors.2007

    • Author(s)
      Yamamura K, Ohishi K, Katayama N, Kato K, Shibasaki T, Sugimoto Y, Miyata E, Shiku H, Masuya M, Nishioka J, Nobori T, Nishikawa M, Yoshimasa I, Hiramatsu H, Nakahata T
    • Journal Title

      Cancer Sci 98(10)

      Pages: 1597-1603

    • NAID

      10019997575

    • Related Report
      2009 Final Research Report
  • [Journal Article] Human cord blood CD34+ cells develop into hepatocytes in the livers of NOD/SCID/gcnull mice through cell fusion.2007

    • Author(s)
      Fujino H, Hiramatsu H, Tsuchiya A, Niwa A, Noma H, Shiota M, Umeda K, Yoshimoto M, Ito M, Heike T, Nakahata T.
    • Journal Title

      FASEB J. 21

      Pages: 3499-3510

    • Related Report
      2009 Final Research Report
  • [Journal Article] Novel method for efficient production of multipotential hematopoietic progenitors from human embryonic stem cells.2007

    • Author(s)
      Ma F., Wang D., Hanada S., Ebihara Y., Kawasaki H., Zaike Y., Heike T., Nakahata T., Tsuji K.
    • Journal Title

      Int. Hematol. 85

      Pages: 371-379

    • Related Report
      2009 Final Research Report
  • [Journal Article] Efficient Assay for Evaluating human thrombopoiesis using NOD/SCID mice transplanted with cord blood CD34+ cells.2007

    • Author(s)
      Suzuki K, Hiramatsu H, Fukushima-Shintani M, Heike T, Nakahata T.
    • Journal Title

      Eur J Haematol 78

      Pages: 123-130

    • Related Report
      2009 Final Research Report
  • [Journal Article] B cell potetial can be obtained from pre-circulatory yolk sac, but with low frequency.2007

    • Author(s)
      Sugiyama D, Ogawa M, Nakao K, Osumi N, Nishikawa S, Nishikawa S, Arai K, Nakahata T, Tsuji K
    • Journal Title

      Dev. Biol. 301

      Pages: 53-61

    • Related Report
      2009 Final Research Report
  • [Journal Article] 血球系の再生医療.2007

    • Author(s)
      中畑龍俊, 梅田雄嗣
    • Journal Title

      Medical Science Digest 33(14)

      Pages: 20-24

    • Related Report
      2009 Final Research Report
  • [Journal Article] ヒトes細胞を用いた造血幹細胞や神経幹細胞への分化誘導.2007

    • Author(s)
      平家俊男, 梅田雄嗣, 加藤竹雄, 中畑龍俊
    • Journal Title

      医学のあゆみ 220(2)

      Pages: 186-190

    • Related Report
      2009 Final Research Report
  • [Journal Article] α4-integrin+ endothelium derived from primate embryonic stem cells generates primitive and definitive hematopoietic cells.2007

    • Author(s)
      Shinoda, G., Nakahat, T.(他10名, 12番目)
    • Journal Title

      Blood 109

      Pages: 2406-2415

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Disease-associated mutations in CIAS1 induce cathepsin B-dependent rapid cell death of human THP-1 monocytic cells.2007

    • Author(s)
      Fujisawa A., Nakahata, T.(他10名, 11番目)
    • Journal Title

      Blood 109

      Pages: 2903-2911

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human cord blood CD34+ cells develop into hepatocytes in the livers of NOD/SCID/gcnull mice through cell fusion.2007

    • Author(s)
      Fujino H, Nakahata, T.(他9名, 11番目)
    • Journal Title

      FASEB J. 21

      Pages: 3499-3510

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fibrillin I gene polymorphism is associated with tall stature of normal individuals.2007

    • Author(s)
      Mamada M., Nakahata, T.(他4名, 6番目)
    • Journal Title

      Hum. Genet. 120

      Pages: 733-735

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel method for efficient production of multipotential hematopoietic progenitors from human embryonic stem cells.2007

    • Author(s)
      Ma F., Nakahata, T.(他7名, 8番目)
    • Journal Title

      Int. Hematol. 85

      Pages: 371-379

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficient Assay for Evaluating Human Thrombopoiesis Using NOD/SCID Mice Transplanted with Cord Blood CD34+ Cells.2007

    • Author(s)
      Suzuki K, Nakahata, T.(他3名, 5番目)
    • Journal Title

      Eur J Haematol 78

      Pages: 123-130

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sequential analysis of α-and β-globin gene expressions during erythropoietic differentiation from primate embryonic stem cells.2007

    • Author(s)
      Umeda, K., Nakahata, T.(他11名, 13番目)
    • Journal Title

      Stem Cells 24

      Pages: 2627-2636

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term culture of postnatal mouse hepatic stem/progenitor cells and their relative developmental hierarchy.2007

    • Author(s)
      Tsuchiya A., Nakahata, T.(他8名, 10番目)
    • Journal Title

      Stem Cells 25

      Pages: 895-902

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation of cardiac and endothelial cells from neonatal mouse testis-derived multipotent germline stem cells.2007

    • Author(s)
      Baba S., Nakahata, T.(他9名, 11番目)
    • Journal Title

      Stem Cells 25

      Pages: 1375-1383

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Flk1+ Cardiac Stem/Progenitor Cells Derived from ES Cells Improve the Cardiac Function of Dilated Cardiomyopathy Mice.2007

    • Author(s)
      Baba S., Nakahata, T.(他8名, 10番目)
    • Journal Title

      Cardiovascular Res. 76

      Pages: 119-131

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A pediatric case of transfusion-related acute lung injury following bone marrow infusion.2007

    • Author(s)
      Yui Y., Nakahata, T.(他7名, 9番目)
    • Journal Title

      Pediatr Transplant. 11

      Pages: 543-546

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Notch ligand Delta-1 differentially modulates the effects of gp130 activation on interleukin-6 receptor α-positive and-negative human hematopoietic progenitors.2007

    • Author(s)
      Yamamura K., Nakahata, T.(他13名, 15番目)
    • Journal Title

      Cancer Sci. 98

      Pages: 1597-1603

    • NAID

      10019997575

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Outcome of risk-based therapy for infant acute lymphoblastic leukemia with or without an MLL gene rearrangement, with emphasis on late effects: A final report of two consecutive studies, MLL96 and MLL98, of the Japan Infant Leukemia Study Group.2007

    • Author(s)
      Tomizawa D., Nakahata, T.(他13名, 13番目)
    • Journal Title

      Leukemia 21

      Pages: 2258-2263

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isolation and characterization of bone marrow-derived mesenchymal progenitor cells with myogenic and neuronal properties.2007

    • Author(s)
      Shiota M., Nakahata, T.(他9名, 11番目)
    • Journal Title

      Exp. Cell Res. 313

      Pages: 1008-1023

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Noninvasive ventilation for pediatric patients under 1 year of age after cardiac surgery.2007

    • Author(s)
      Chin K., Nakahata, T.(他10名, 9番目)
    • Journal Title

      J Thorac Cardiovasc Surg. 134

      Pages: 260-261

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diabetes mellitus after stem cell transplantation in a patient with acute lymphoblastic leukemia: possible association with tacrolimus.2007

    • Author(s)
      Niwa A., Nakahata, T.(他10名, 12番目)
    • Journal Title

      Pediatr Int. 49

      Pages: 530-532

    • NAID

      10019815020

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correction of immunodeficiency associated with NEMO mutation by umbilical cord bloodtransplantetion using a reduced-intensity conditioning regimen.2007

    • Author(s)
      Tono C., Nakahata, T.(他13名, 12番目)
    • Journal Title

      Bone Marrow Transplant 39

      Pages: 801-804

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] B cell potential can be obtained from pre-circulatory yolksac, but with low frequency.2007

    • Author(s)
      Sugiyama D., Nakahata, T.(他8名, 7番目)
    • Journal Title

      Dev. Biol. 301

      Pages: 53-61

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preferential Selection of human T-cell leukemia virus type-1 Provirus Lacking the 5' long terminal repeat during oncogenesis.2007

    • Author(s)
      Miyazaki M., Nakahata, T.(他4名, 5番目)
    • Journal Title

      J. Virol. 81

      Pages: 5714-5723

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of side-population cells(SP cells)in humannormal endometrium.2007

    • Author(s)
      Kato K., Nakahata, T.(他8名, 9番目)
    • Journal Title

      Human Reproduction 22

      Pages: 1214-1223

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute myeloid leukemia with multilineage dysplasia in children.2007

    • Author(s)
      Adachi S., Nakahata, T.(他7名, 9番目)
    • Journal Title

      Int. J. Hematol. 86

      Pages: 358-363

    • NAID

      10019990289

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Retrospective nationwide survey of Japanese patients withtransfusion-dependent MDS and aplastic anaemia highlights the negative impact of iron overload on morbidity/mortality.2007

    • Author(s)
      Takatoku M., Nakahata, T.(他9名, 8番目)
    • Journal Title

      Eur. J. Hematol. 78

      Pages: 487-494

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 臍帯血/骨髄造血幹細胞の増幅2007

    • Author(s)
      中畑龍俊
    • Journal Title

      第6節 バイオ医薬品の開発と品質・安全性確保

      Pages: 530-536

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ex vivo増幅造血幹/前駆細胞の臍帯血移植への応用2007

    • Author(s)
      田中宏和、伊藤仁也、丸山京子、中畑龍俊
    • Journal Title

      再生医療11月号 6

      Pages: 61-66

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 血球系の再生医療2007

    • Author(s)
      中畑龍俊、梅田雄嗣
    • Journal Title

      Medical Science Digest 33

      Pages: 20-24

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation of skeletal muscle stem/progenitor cells from murine induced pluripotent stem cells.

    • Author(s)
      Mizuno Y., Chang H., Umeda K., Niwa A., IwasaT., Awaya T., Fukada S., Hiroshi Yamamoto H., Yamanaka S., Nakahata T., Heike T.
    • Journal Title

      FASEB J. (in press)

    • Related Report
      2009 Final Research Report
  • [Presentation] iPS細胞を用いたこれからの医療.2009

    • Author(s)
      中畑龍俊
    • Organizer
      大阪大学医学部附属病院iPS細胞臨床研究センター開設記念シンポジウム
    • Place of Presentation
      大阪大学
    • Year and Date
      2009-12-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 外来経過観察中の小児癌経験者の疲労度のアンケートによる調査-肥満度や生活習慣との関連.2009

    • Author(s)
      久保田優、中畑龍俊, 他8名
    • Organizer
      第51回日本小児血液学会・第25回日本小児がん学会
    • Place of Presentation
      東京ベイホテル東急
    • Year and Date
      2009-11-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 胆道原発横紋筋肉腫の1例.2009

    • Author(s)
      河田紗耶架、中畑龍俊, 他10名
    • Organizer
      第25回日本小児がん学会
    • Place of Presentation
      東京ベイホテル東急
    • Year and Date
      2009-11-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Frequent inactivation of A20 through gene mutation in B-cell lymphomas.2009

    • Author(s)
      Motohiro Kato, Tatsutoshi Nakahata, 他23名
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2009-10-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 白血病細胞と髄外微小環境の解析.2009

    • Author(s)
      加藤格、中畑龍俊, 他5名
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2009-10-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] iPS細胞由来赤芽球系分化の経時的解析と成熟血球の機能評価.2009

    • Author(s)
      丹羽明、中畑龍俊, 他5名
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2009-10-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高リスク急性リンパ性白血球(ALL)に対する臍帶血移植の経験.2009

    • Author(s)
      才田聡、中畑龍俊, 他5名
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2009-10-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] iPS細胞産業化の課題に関する論点整理.2009

    • Author(s)
      中畑龍俊
    • Organizer
      Biojapan 2009~World Business Forum~
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-10-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] iPS細胞を用いた今後の医療.2009

    • Author(s)
      中畑龍俊
    • Organizer
      第19回日本小児リウマチ学会総会・学術集会
    • Place of Presentation
      京都リサーチパーク
    • Year and Date
      2009-10-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] 再生医療研究の現状と将来.2009

    • Author(s)
      中畑龍俊
    • Organizer
      第14回静岡健康・長寿学術フォーラム
    • Place of Presentation
      静岡県コンベンションアーツセンター
    • Year and Date
      2009-10-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] B細胞性悪性リンパ腫に対する綱羅的ゲノム解析によるがん抑制遺伝子A20の同定.2009

    • Author(s)
      加藤元博、中畑龍俊, 他11名
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Future of regenerative medicine with various stem cell.2009

    • Author(s)
      中畑龍俊
    • Organizer
      Plenary Leclure, The 3rd International Symposium of Lysosomal Storage Diseases.
    • Place of Presentation
      名古屋能楽堂
    • Year and Date
      2009-09-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 左室縮小術術後6年で再増悪した心不全に対し、除細動器付両心室ペースメーカー(CRT-D)植え込みを施行し症状の改善を得た、小児期発症二次性拡張型心筋症の1例.2009

    • Author(s)
      横尾憲孝、中畑龍俊, 他5名
    • Organizer
      第45回日本小児循環器学会総会・学術集会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2009-07-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] 生体部分肝移植後、epoprostenol持続静注から離脱し得た門脈肺高血圧(PPHTN)の2例.2009

    • Author(s)
      鷄内伸二、中畑龍俊, 他6名
    • Organizer
      第45回日本小児循環器学会総会・学術集会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2009-07-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] SGA児とメタボリックシンドロームのリスクについての検討.第45回日本周産期・新生児医学会総会および学術集会2009

    • Author(s)
      河井昌彦、中畑龍俊, 他3名
    • Organizer
      第45回日本周産期・新生児医学会総会/学術集会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2009-07-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新生児における簡易PT測定装置の有用性と重症出血傾向スクリーニングに関する検討.2009

    • Author(s)
      松倉崇、中畑龍俊, 他3名
    • Organizer
      第45回日本周産期・新生児医学会総会/学術集会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2009-07-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] 早期新生児期のDICパラメターの出生体重・日齢に伴う変化についての検討.2009

    • Author(s)
      河井昌彦、中畑龍俊, 他2名
    • Organizer
      第19回日本産婦人科・新生児血液学会
    • Place of Presentation
      北海道大学学術交流会館
    • Year and Date
      2009-06-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新生児管理における簡易PT測定装置(CoaguChek XS)の有用性に関する検討.2009

    • Author(s)
      松倉崇、中畑龍俊, 他2名
    • Organizer
      第19回日本産婦人科・新生児血液学会
    • Place of Presentation
      北海道大学学術交流会館
    • Year and Date
      2009-06-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] iPS細胞などの幹細胞を用いたこれからの小児医療の可能性.2009

    • Author(s)
      中畑龍俊
    • Organizer
      第1回日本小児科学会長野地方会
    • Place of Presentation
      信州大学医学部附属病院
    • Year and Date
      2009-06-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] Future of regenerative medicine with various stem cell.2009

    • Author(s)
      中畑龍俊
    • Organizer
      The 9th World Congress on Inflammation
    • Place of Presentation
      Keio Plaza Hotel, Tokyo
    • Year and Date
      2009-06-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] Clinical applications of various stem cells.2009

    • Author(s)
      中畑龍俊
    • Organizer
      The Fourth iCeMS International Symposium
    • Place of Presentation
      Hotel Fujita Kyoto
    • Year and Date
      2009-05-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 胆道原発横紋筋肉腫の1例.2009

    • Author(s)
      才田聡、中畑龍俊, 他6名
    • Organizer
      第441回日本小児科学会京都地方会学術集会
    • Place of Presentation
      京都府立医科大学
    • Year and Date
      2009-05-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 低毒性骨髄破壞的処置を用いて臍帶血移植を施行した進行期副腎白質ジストロフィーの2例.2009

    • Author(s)
      才田聡、中畑龍俊, 他5名
    • Organizer
      第17回近畿臍帶血幹細胞移植研究会
    • Place of Presentation
      ホテルグランビア大阪
    • Year and Date
      2009-05-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新規MVK変異による高IgD症候群が疑われる1の家系~周期熱の鑑別におけるIgDの役割.2009

    • Author(s)
      酒井秀政、中畑龍俊, 他6名
    • Organizer
      第53回日本リウマチ学会総会・学術集会
    • Place of Presentation
      グランドプリンスホテル新高輪
    • Year and Date
      2009-04-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] iPS細胞を用いた今後の医療の可能性.2009

    • Author(s)
      中畑龍俊
    • Organizer
      第112回日本小児科学会学術集会
    • Place of Presentation
      奈良文化会館
    • Year and Date
      2009-04-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 先天性高インスリン血症の遺伝子解析2009

    • Author(s)
      依藤亨、中畑龍俊, 他5名
    • Organizer
      第112回日本小児科学会学術集会
    • Place of Presentation
      奈良文化会館
    • Year and Date
      2009-04-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 副腎白質ジストロフィーに骨髄非破壞的処置を用いて臍帶血移植を施行した2例.2009

    • Author(s)
      才田聡、中畑龍俊, 他8名
    • Organizer
      第112回日本小児科学会学術集会
    • Place of Presentation
      奈良文化会館
    • Year and Date
      2009-04-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新規MVK変異による高IgD症候群が疑われる1家系~周期熱の鑑別におけるIgDの役割.2009

    • Author(s)
      酒井秀政、中畑龍俊, 他7名
    • Organizer
      第112回日本小児科学会学術集会
    • Place of Presentation
      奈良文化会館
    • Year and Date
      2009-04-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 骨髄移植後に合併した特発性器質化肺炎(BOOP)にRSV感染の関与が推定されたDown症の1例.2009

    • Author(s)
      浅井浩一、中畑龍俊, 他8名
    • Organizer
      第112回日本小児科学会学術集会
    • Place of Presentation
      奈良文化会館
    • Year and Date
      2009-04-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] NOD 2遺伝子に6塩基欠失の変異を認めた若年性サルコイドーシスの一例.2009

    • Author(s)
      酒井秀政、中畑龍俊, 他7名
    • Organizer
      第112回日本小児科学会学術集会
    • Place of Presentation
      奈良文化会館
    • Year and Date
      2009-04-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 低身長精査で偶然発見されたダノン病の一男児例.2009

    • Author(s)
      粟屋美絵、中畑龍俊, 他8名
    • Organizer
      第112回日本小児科学会学術集会
    • Place of Presentation
      奈良文化会館
    • Year and Date
      2009-04-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Future of regenerative medicine with various stem cells.2009

    • Author(s)
      Tatsutoshi Nakahata
    • Organizer
      The 3rd International Symposium of Lysosomal Storage Deseases
    • Place of Presentation
      名古屋能楽堂名古屋市
    • Related Report
      2009 Final Research Report
  • [Presentation] 造血幹細胞を用いた再生医療2009

    • Author(s)
      中畑龍俊
    • Organizer
      第27回日本医学会総会
    • Place of Presentation
      大阪
    • Related Report
      2009 Final Research Report
  • [Presentation] Aberration of Genes Regulating NF Kappa B Pathway in B-Cell Malignant Lymphoma.2009

    • Author(s)
      Kato M., Nakahata T., 他24名
    • Organizer
      51st Annual Meeting of the AMERICAN SOCIETY of HEMATOLOGY
    • Place of Presentation
      New Orleans(米)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Blockage of SDF-1-CXCR4 Axis by AMD 3100 Can Be a Novel Therapy for Acute Lymphoblastic Leukemia by Targeting the Extramedullary Sites of Leukemia Cells.2009

    • Author(s)
      Kato I., Nakahata T., 他7名
    • Organizer
      51st Annual Meeting of the AMERICAN SOCIETY of HEMATOLOGY
    • Place of Presentation
      New Orleans(米)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Hypoxia-Adapted CML Cells Are More Primitive Population and Are Eradicated by Glyoxalase-1 Inhibitors.2009

    • Author(s)
      Takeuchi M., Nakahata T., 他14名
    • Organizer
      51st Annual Meeting of the AMERICAN SOCIETY of HEMATOLOGY
    • Place of Presentation
      New Orleans(米)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Analyzing the Stepwise Developmental Pathway Form ES/IPS Cells to Functional Mature Erythrocytes.2009

    • Author(s)
      Niwa A., Nakahata T., 他8名
    • Organizer
      51st Annual Meeting of the AMERICAN SOCIETY of HEMATOLOGY
    • Place of Presentation
      New Orleans(米)
    • Related Report
      2009 Annual Research Report
  • [Presentation] マスト細胞研究の過去・現在・未来2008

    • Author(s)
      中畑龍俊
    • Organizer
      第45回日本小児アレルギー学会
    • Place of Presentation
      シフィコ横浜会議センター
    • Year and Date
      2008-12-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] A novel hypomorphic NEMO mutation caused atypical incontientia pigmenti (IP) whose skins manifestations triggered by viral infections.2008

    • Author(s)
      Kawai T, Nakahata T, 他4名
    • Organizer
      日本免疫学会総会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2008-12-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] 生体肝移植後PTLD(post-transplant lymphoproliferative disorder)を発症した4症例2008

    • Author(s)
      加藤格, 中畑龍俊, 他14名
    • Organizer
      第50回日本小児血液学会・第24回日本小児がん学会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2008-11-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] 生後14日で発症し4ヶ月で臍帯血移植を施行した家族性血球貪食性リンパ組織球症(FHL3)の一例2008

    • Author(s)
      矢野潤. 中畑龍俊, 他4名
    • Organizer
      第50回日本小児血液学会・第24回日本小児がん学会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2008-11-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] 再移植後早期に血球貪食症候群(HPS)の再燃を認めたRI-CBTの1例2008

    • Author(s)
      納富誠司郎, 中畑龍俊, 他9名
    • Organizer
      第50回日本小児血液学会・第24回日本小児がん学会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2008-11-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] トポイソメラーゼ阻害剤による骨肉腫肺転移抑制効果の検討2008

    • Author(s)
      由井理洋, 中畑龍俊, 他7名
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] iPS細胞などの幹細胞を用いた今後の医療の可能性2008

    • Author(s)
      中畑龍俊
    • Organizer
      第56回日本ウイルス学会学術集会
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2008-10-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] マウスiPS細胞から試験管内造血誘導における、文化過程の経時的解析とベマンジオブラストの同定2008

    • Author(s)
      丹羽明, 中畑龍俊, 他13名
    • Organizer
      第70回日本血液学会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2008-10-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] iPS細胞などの幹細胞を用いた今後の医療2008

    • Author(s)
      中畑龍俊
    • Organizer
      第14回未熟児新生児医療研究会
    • Place of Presentation
      京都テルサ
    • Year and Date
      2008-10-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] iPS細胞などの幹細胞を用いた医療の将来2008

    • Author(s)
      中畑龍俊
    • Organizer
      第30回信州血液懇話会
    • Place of Presentation
      ホテルメトロポリタン長野
    • Year and Date
      2008-09-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] iPS細胞を用いた今後の医療の可能性2008

    • Author(s)
      中畑龍俊
    • Organizer
      第15回八幡平造血セミナー
    • Place of Presentation
      盛岡グランドホテル
    • Year and Date
      2008-09-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] iPS細胞を用いた一次造血・二次造血の試験管内分化誘導2008

    • Author(s)
      丹羽明, 中畑龍俊, 他9名
    • Organizer
      第29回日本炎症・再生医学会
    • Place of Presentation
      都市センターホテル(東京)
    • Year and Date
      2008-07-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Doxorubicinによる心筋ミトコンドリア障害とG-CSFの保護効果2008

    • Author(s)
      平海良美, 中畑龍俊, 他7名
    • Organizer
      第44回日本小児循環器学会
    • Place of Presentation
      ホテルハマツ(福島県郡山市)
    • Year and Date
      2008-07-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] Proliferation and differentiation of various Stem Cells in vitro and in vivo.2008

    • Author(s)
      中畑龍俊
    • Organizer
      国際神経芽腫学会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2008-05-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] 骨髄非破壊的臍帯血により良好な経過を得ている副腎白質ジストロフィーの進行例2008

    • Author(s)
      粟屋智就, 中畑龍俊, 他7名
    • Organizer
      第111回日本小児科学会学術集会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-04-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] 全身性自己炎症症候群の病態とマネージメント2008

    • Author(s)
      西小森隆太, 中畑龍俊, 他4名
    • Organizer
      第52回日本リウマチ学会総会
    • Place of Presentation
      札幌市教育文化会館
    • Year and Date
      2008-04-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] 小児科領域における幹細胞を用いた再生医療の現状と将来2008

    • Author(s)
      中畑龍俊
    • Organizer
      第54回広島県小児科医会総会
    • Place of Presentation
      広島グランドインテリジェントホテル
    • Year and Date
      2008-01-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] Special lecture: Proliferation and Differentiation of Various Stem Cells in vitro and in vivo.2008

    • Author(s)
      Tatsutoshi Nakahata
    • Organizer
      Advances in Neuroblastoma Research 2008国際神経芽腫学会
    • Place of Presentation
      Makuhari Messe International Conference Hall Chiba
    • Related Report
      2009 Final Research Report
  • [Presentation] Wnt/β-Catenin Pathway Affects the Cell-Fate Decisions of Hematopoietic Stem/Progenitor Cells Modulating the Epigenetic states of Various Essential Transcription Factors.2008

    • Author(s)
      Tanaka H, Nakahata T, 他4名
    • Organizer
      50 th Annual Meeting of the AMERICAN SOCIETYof HEMATOLOGY
    • Place of Presentation
      Moscone Center(San Francisco, USA)
    • Related Report
      2008 Annual Research Report
  • [Presentation] Myelodysplastic Syndrome(MDS)and Myeloproliferative Disease (MPD) in Children : A Prospective Registration of 222 Cases.2008

    • Author(s)
      Hirabayashi S, Nakahata T, 他11名
    • Organizer
      50 th Annual Meeting of the AMERICAN SOCIETYof HEMATOLOGY
    • Place of Presentation
      Moscone Center(San Francisco, USA)
    • Related Report
      2008 Annual Research Report
  • [Presentation] Fujiyama Y, Maekawa T : Glyoxalase-I Inhibition Eliminates Hypoxia-Adapted CML Cells Resistant to2008

    • Author(s)
      Takeuchi M, Nakahata T, 他10名
    • Organizer
      50 th Annual Meeting of the AMERICAN SOCIETYof HEMATOLOGY
    • Place of Presentation
      Moscone Center (San Francisco, USA)
    • Related Report
      2008 Annual Research Report
  • [Presentation] ダウン症合併AML再発に対して同胞からの骨髄移植を施行し無病生存を得ている1例2007

    • Author(s)
      大封智雄、中畑龍俊, 他10名
    • Organizer
      第49回日本小児血液学会・第23回日本小児がん学会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2007-12-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] NOGマウスを用いたヒト造血幹細胞の測定2007

    • Author(s)
      中畑龍俊
    • Organizer
      シンポジウム:ゲノム解析からin vivo解析への回帰
    • Place of Presentation
      つくば国際会議場
    • Year and Date
      2007-11-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] 再生不良性貧血に対するHLA一致同胞間移植前処置;CY+ATGとFlu+Cy+TAI/TLIの比較2007

    • Author(s)
      矢部普正、中畑龍俊, 他8名
    • Organizer
      第69回日本血液学会 第49回日本臨床血液学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-10-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] 霊長類ES細胞からのへマンギオブラストの分化誘導におけるVEGF関連因子の作用の検討2007

    • Author(s)
      梅田雄嗣、中畑龍俊, 他10名
    • Organizer
      第69回日本血液学会 第49回日本臨床血液学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-10-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] ヒトES細胞から血液細胞への分化誘導2007

    • Author(s)
      馬峰、中畑龍俊, 他3名
    • Organizer
      第69回日本血液学会 第49回日本臨床血液学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-10-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] Mechanisms of INNO-406-mediated cell death in Bcr-Abl leukemic cells.2007

    • Author(s)
      Kimura S, Nakahata T 他5名
    • Organizer
      66th Annual Meeting of the Japanese Canser Assosiation
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-10-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Topoisomerase I inhibitors suppress metastasis of osteosarcoma cell lines by reducing migration.2007

    • Author(s)
      Yui Y, Nakahata T 他6名
    • Organizer
      66th Annual Meeting of the Japanese Canser Assosiation
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-10-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] ヒトES細胞から肥満細胞への分化誘導2007

    • Author(s)
      馬峰、中畑龍俊, 他4名
    • Organizer
      第28回日本炎症・再生医学会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2007-08-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] マウエES細胞由来骨格筋前駆・幹細胞の効率的分化方法の確立2007

    • Author(s)
      張璽、 中畑龍俊, 他3名
    • Organizer
      第28回日本炎症・再生医学会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2007-08-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] 霊長類ES細胞由来血管内皮細胞からの造血発生2007

    • Author(s)
      梅田雄嗣、中畑龍俊, 他7名
    • Organizer
      第11回京都分子血液フォーラム
    • Place of Presentation
      京都国際ホテル
    • Year and Date
      2007-06-23
    • Related Report
      2007 Annual Research Report
  • [Presentation] 小児造血幹細胞移植症例に伴う腎障害の検討2007

    • Author(s)
      加藤格、中畑龍俊, 他4名
    • Organizer
      第87回近畿血液学地方会
    • Place of Presentation
      大阪テイジンホール
    • Year and Date
      2007-06-16
    • Related Report
      2007 Annual Research Report
  • [Presentation] 幹細胞を用いた再生医療の現状と将来2007

    • Author(s)
      中畑龍俊
    • Organizer
      第5回北東北血液研究会
    • Place of Presentation
      秋田キャッスルホテル
    • Year and Date
      2007-05-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] これからの小児医療:再生医療を中心として2007

    • Author(s)
      中畑龍俊
    • Organizer
      第145回日本小児科学会青森地方会
    • Place of Presentation
      弘前大学
    • Year and Date
      2007-04-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] 基調講演:造血幹細胞を用いた再生医療2007

    • Author(s)
      中畑龍俊
    • Organizer
      第27回日本医学会総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2007-04-06
    • Related Report
      2007 Annual Research Report
  • [Presentation] Proliferation and differentiation of human hematopoietic stem cells in a novel mouse model.2007

    • Author(s)
      中畑龍俊
    • Organizer
      21st century COE symposium
    • Place of Presentation
      芝蘭会館(京都)
    • Related Report
      2007 Annual Research Report
  • [Presentation] Primitive and Definitive Hematopoietisis from Primate ES Cell-derived Hemogenic Endothelium.2007

    • Author(s)
      Shinoda G, Makahata T 他10名
    • Organizer
      21st century COE symposium
    • Place of Presentation
      芝蘭会館(京都)
    • Related Report
      2007 Annual Research Report
  • [Presentation] Decreased Incidence of Clonal Evolution to Myelodysplastic Syndorome/Acute Myeloid Leukemia with Monosomy 7 in Children with Aplastic Anemia Following Reduced Use of G-CSF.2007

    • Author(s)
      Takahashi Y, Nakahata T 他10名
    • Organizer
      46th Annual Meeting of the AMERICAN SOCIETY of HEMATOLOGY
    • Place of Presentation
      Georgia World Congress Center
    • Related Report
      2007 Annual Research Report
  • [Presentation] Clonal Analysis of Progressive Maturation of Erythroid Cells from Human Embryonic Stem Cell-Derived Definitive Hematopoiesis.2007

    • Author(s)
      Ma F, Nakahata T 他8名
    • Organizer
      46th Annual Meeting of the AMERICAN SOCIETY of HEMATOLOGY
    • Place of Presentation
      Georgia World Congress Center
    • Related Report
      2007 Annual Research Report
  • [Presentation] The Bcr-Abl Kinase Inhibitor INNO-406 Induces Autophagy and Different Modes of Cell Death Execution in Bcr-Abl Positive Leukemias.2007

    • Author(s)
      Kamitsuji Y, Nakahata T 他13名
    • Organizer
      46th Annual Meeting of the AMERICAN SOCIETY of HEMATOLOGY
    • Place of Presentation
      Georgia World Congress Center
    • Related Report
      2007 Annual Research Report
  • [Presentation] Temporal, Quantitative and Functional Characteristics of Single-KIR Positive Alloreactive NK Cell Recovery Account For Impaired Graft Versus Leukemia Activity after Haploidentical HSCT.2007

    • Author(s)
      Kato S, Nakahata T 他14名
    • Organizer
      46th Annual Meeting of the AMERICAN SOCIETY of HEMATOLOGY
    • Place of Presentation
      Georgia World Congress Center
    • Related Report
      2007 Annual Research Report
  • [Book] 日本さい帶血バンクネットワーク設立10周年記念『そして明日から』2009

    • Author(s)
      中畑龍俊, 他
    • Total Pages
      174
    • Publisher
      日本さい帶血バンクネットワーク
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.cira.kyoto-u.ac.jp/j/research/nakahata-summary.html

    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 多能性幹細胞からの肥満細胞の製造方法2009

    • Inventor(s)
      Tatsutoshi Nakahata, Kohichiro Tsuji, Feng MA
    • Industrial Property Rights Holder
      Kyoto University
    • Filing Date
      2009-09-08
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 多能性幹細胞から中胚葉細胞の分化誘導法

    • Inventor(s)
      丹羽明, 中畑龍俊
    • Industrial Property Rights Holder
      Kyoto University
    • Related Report
      2009 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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