• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The integrated study for molecular backgrounds and therapeutic targets of osteoarthritis : The ROAD project.

Research Project

Project/Area Number 19109007
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research Institution国立障害者リハビリテーションセンター(研究所) (2011)
The University of Tokyo (2007-2010)

Principal Investigator

NAKAMURA Kozo  国立障害者リハビリテーションセンター(研究所), 自立支援局, 自立支援局長(研究所併任) (60126133)

Co-Investigator(Kenkyū-buntansha) KAWAGUCHI Hiroshi  東京大学, 医学部・附属病院, 准教授 (40282660)
TANAKA Sakae  東京大学, 医学部・附属病院, 教授 (50282661)
AKUNE Toru  東京大学, 医学部・附属病院, 特任准教授 (60282662)
OKA Hiroyuki  東京大学, 医学部・附属病院, 特任助教 (60401064)
SAITO Taku  東京大学, 医学部・附属病院, 特任准教授 (30456107)
HIROTA Jinso  東京大学, 医学部・附属病院, 助教 (30570733)
IKEDA Toshiyuki  東京大学, 医学部・附属病院, 助教 (80322759)
ONISHI Isao  東京大学, 医学部・附属病院, 講師 (70311628)
TEI Yuichi  東京大学, 工学系・研究科, 教授 (30345053)
MABUCHI Akihiko  東京大学, 医学部・附属病院, 客員准教授 (80312312)
Co-Investigator(Renkei-kenkyūsha) ONISHI Isao  東京大学, 医学部・附属病院, 講師 (70311628)
TEI Yuichi  東京大学, 工学系・研究科, 教授 (30345053)
MABUCHI Akihiko  東京大学, 医学部・附属病院, 客員准教授 (80312312)
Project Period (FY) 2007 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥110,890,000 (Direct Cost: ¥85,300,000、Indirect Cost: ¥25,590,000)
Fiscal Year 2011: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2010: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2009: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2008: ¥27,300,000 (Direct Cost: ¥21,000,000、Indirect Cost: ¥6,300,000)
Fiscal Year 2007: ¥40,170,000 (Direct Cost: ¥30,900,000、Indirect Cost: ¥9,270,000)
Keywords変形性関節症 / 軟骨代謝 / 遺伝子 / 画像解析 / 疫学 / ゲノム
Research Abstract

Social needs for prevention and treatment of osteoarthritis(OA) is increasing. We have established the ROAD project as a comprehensive study of OA for elucidation of the etiology and identification of the molecular target of treatment. Here we performed 1) cloning of regulatory molecules of cartilage degradation and elucidation of the underlying mechanism, 2) Development of measurement of the OA severity, 3) Comprehensive and systemic search for the genetic and environmental factors.

Report

(7 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report   Self-evaluation Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (290 results)

All 2012 2011 2010 2009 2008 2007 Other

All Journal Article (123 results) (of which Peer Reviewed: 73 results) Presentation (130 results) Book (28 results) Remarks (3 results) Patent(Industrial Property Rights) (6 results)

  • [Journal Article] Lack of a chondroprotective effect of cyclooxygenase 2 inhibition in a surgically induced model of osteoarthritis in mice2012

    • Author(s)
      Fukai A, Kamekura S, Chikazu D, Nakagawa T, Hirata M, Saito T, Hosaka Y, Ikeda T, Nakamura K, Chung UI, and Kawaguchi H
    • Journal Title

      Arthritis Rheum-US

      Volume: 64 Pages: 198-203

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] C/EBP-βand RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2αas the inducer in chondrocytes2012

    • Author(s)
      Hirata M, Kugimiya F, Fukai A, Saito T, Yano F, Ikeda T, Mabuchi A, Sapkota BR, Akune T, Nishida N, Yoshimura N, Nakagawa T, Tokunaga K, Nakamura K, Chung UI, and Kawaguchi H
    • Journal Title

      Hum Mol Genet

      Volume: 21 Pages: 1111-1123

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of knee osteoarthritis with the accumulation of metabolic risk factors such as overweight, hypertension, dyslipidemia, and impaired glucose tolerance in Japanese men and women : the ROAD study2011

    • Author(s)
      Yoshimura N, et al
    • Journal Title

      J Rheumatol

      Volume: 38 Issue: 5 Pages: 2011-2011

    • DOI

      10.3899/jrheum.100569

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of occupational activity with joint space narrowing and osteophytosis in the medial compartment of the knee : The ROAD study2011

    • Author(s)
      Muraki S, et al
    • Journal Title

      Osteoarthr Cartilage

      Volume: 19 Issue: 7 Pages: 840-846

    • DOI

      10.1016/j.joca.2011.03.008

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Health-related quality of life in subjects with low back pain and knee pain in a population-based cohort study of Japanese men : the ROAD study2011

    • Author(s)
      Muraki S, et al
    • Journal Title

      Spine

      Volume: 36 Issue: 16 Pages: 1312-1319

    • DOI

      10.1097/brs.0b013e3181fa60d1

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in serum levels of biochemical markers of bone turnover during 10 years among Japanese men and women : associated factors and birth-cohort effect : The Taiji Study2011

    • Author(s)
      Yoshimura N, et al
    • Journal Title

      J Bone Miner Metab

      Volume: 29 Issue: 6 Pages: 699-708

    • DOI

      10.1007/s00774-011-0266-8

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of falls and the association with knee osteoarthritis and lumbar spondylosis as well as knee and lower back pain in Japanese men and women2011

    • Author(s)
      Muraki S, et al
    • Journal Title

      Arthrit Care Res

      Volume: 63 Issue: 10 Pages: 1425-1431

    • DOI

      10.1002/acr.20562

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Independent association of joint space narrowing and osteophyte formation at the knee with health-related quality of life in Japan2011

    • Author(s)
      Muraki S, et al
    • Journal Title

      Arthritis Rheum-US

      Volume: 63 Issue: 12 Pages: 3859-3864

    • DOI

      10.1002/art.30641

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reference values for hand grip strength, muscle mass, walking time, and one-leg standing time as indices for locomotive syndrome and associated disability : The second survey of the ROAD study2011

    • Author(s)
      Yoshimura N, et al
    • Journal Title

      J Orthop Sci

      Volume: 16 Issue: 6 Pages: 768-777

    • DOI

      10.1007/s00776-011-0160-1

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human genetic studies on osteoarthritis from clinicians' viewpoints2011

    • Author(s)
      Akune T, et al
    • Journal Title

      Osteoarthr Cartilage

      Volume: 19 Issue: 3 Pages: 251-253

    • DOI

      10.1016/j.joca.2010.12.008

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q222011

    • Author(s)
      Evangelou E, et al
    • Journal Title

      Ann Rheum Dis

      Volume: 70 Issue: 2 Pages: 349-355

    • DOI

      10.1136/ard.2010.132787

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis : The TREAT-OA Consortium2011

    • Author(s)
      Kerkhof HJ, et al
    • Journal Title

      Osteoarthr Cartilage

      Volume: 19 Issue: 3 Pages: 254-264

    • DOI

      10.1016/j.joca.2010.10.027

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptional regulation of endochondral ossification by HIF-2αduring skeletal growth and osteoarthritis development2010

    • Author(s)
      Saito T, Fukai A, Mabuchi A, Ikeda T, Yano F, Ohba S, Nishida N, Akune T, Yoshimura N, Nakagawa T, Nakamura K, Tokunaga K, Chung UI, and Kawaguchi H
    • Journal Title

      Nat Med

      Volume: 16 Pages: 678-686

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cohort profile : Research on Osteoarthritis/Osteoporosis Against Disability study2010

    • Author(s)
      Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, and Akune T
    • Journal Title

      Int J Epidemiol

      Volume: 39 Pages: 988-995

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Akt1 in murine chondrocytes controls cartilage calcification during endochondral ossification under physiologic and pathologic conditions2010

    • Author(s)
      Fukai A, Kawamura N, Saito T, Oshima Y, Ikeda T, Kugimiya F, Higashikawa H, Yano F, Ogata N, Nakamura K, Chung UI, and Kawaguchi H
    • Journal Title

      Arthritis Rheum

      Volume: 62 Pages: 826-836

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development.2010

    • Author(s)
      Saito T, et al.
    • Journal Title

      Nature Med

      Volume: 16 Pages: 678-686

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Akt1 in murine chondrocytes controls cartilage calcification during endochondral ossification under physiologic and pathologic conditions.2010

    • Author(s)
      Fukai A, et al.
    • Journal Title

      Arthritis Rheum

      Volume: 62 Pages: 826-836

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of radiographic and symptomatic knee osteoarthritis with health-related quality of life in a population-based cohort study in Japan : The ROAD study.2010

    • Author(s)
      Muraki S, et al.
    • Journal Title

      Osteoarthritis Cartilage

      Volume: 18 Pages: 1227-1234

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cohort profile : Research on Osteoarthritis/Osteoporosis Against Disability study.2010

    • Author(s)
      Yoshimura N, et al.
    • Journal Title

      Int J Epidemiol

      Volume: 39 Pages: 988-995

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of knee and low back pain on health-related quality of life in Japanese women : the Research on Osteoarthritis Against Disability(ROAD).2010

    • Author(s)
      Muraki S, et al.
    • Journal Title

      Mod Rheumatol

      Volume: 20 Pages: 444-451

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Normal and threshold values of radiographic parameters for knee osteoarthritis using a computer-assisted measuring system (KOACAD) : the ROAD study.2010

    • Author(s)
      Oka H, et al.
    • Journal Title

      J Orthop Sci

      Volume: 15 Pages: 781-789

    • NAID

      10027872613

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HIF-2α as a possible therapeutic target of osteoarthritis.2010

    • Author(s)
      Saito T, et al.
    • Journal Title

      Osteoarthritis Cartilage

      Volume: 18 Pages: 1552-1556

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Akt1 in murine chondrocytes controls cartilage calcification during endochondral ossification under physiologic and pathologic conditions2010

    • Author(s)
      Fukai A, Kawamura N, Saito T, Oshima Y, Ikeda T, Kugimiya F, Higashikawa H, Yano F, Ogata N, Nakamura K, Chung UI, Kawaguchi H
    • Journal Title

      Arthritis Rheum 62

      Pages: 826-836

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Mechanisms underlying catabolic and anabolic functions of parathyroid hormone on bone by combination of culture systems of mouse cells2010

    • Author(s)
      Shinoda Y, Kawaguchi H, Higashikawa A, Hirata M, Miura T, Saito T, Nakamura K, Chung UI, Ogata N
    • Journal Title

      J Cell Biochem 109

      Pages: 755-763

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Regulation of osteoarthritis development by Wnt-β-catenin signaling through the endochondral ossification process2009

    • Author(s)
      Kawaguchi H
    • Journal Title

      J Bone Miner Res

      Volume: 24 Pages: 8-11

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of the core element responsive to runt-related transcription factor 2 in the promoter of human type x collagen gene2009

    • Author(s)
      Higashikawa A, Saito T, Ikeda T, Kamekura S, Kawamura N, Kan A, Oshima Y, Ohba S, Ogata N, Takeshita K, Nakamura K, Chung UI, and Kawaguchi H
    • Journal Title

      Arthritis Rheum

      Volume: 60 Pages: 166-178

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] C/EBPβpromotes transition from proliferation to hypertrophic differentiation of chondrocytes through transactivation of p57^<Kip2>2009

    • Author(s)
      Hirata M, Kugimiya F, Fukai A, Ohba S, Kawamura N, Ogasawara T, Kawasaki Y, Saito T, Yano F, Ikeda T, Nakamura K, Chung UI, and Kawaguchi H
    • Journal Title

      PLoS ONE

      Volume: 4

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of occupational activity with radiographic knee osteoarthritis and lumbar spondylosis in elderly patients of population-based cohorts : A large-scale population-based study2009

    • Author(s)
      Muraki S, Akune T, Oka H, Mabuchi A, En-yo Y, Yoshida M, Saika A, Nakamura K, Kawaguchi H, and Yoshimura N
    • Journal Title

      Arthritis Rheum

      Volume: 61 Pages: 779-786

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of radiographic lumbar spondylosis and its association with low back pain in the elderly of population-based cohorts : the ROAD study2009

    • Author(s)
      Muraki S, Oka H, Mabuchi A, Akune T, En-yo Y, Yoshida M, Saika A, Suzuki T, Yoshida H, Ishibashi H, Yamamoto S, Nakamura K, Kawaguchi H, and Yoshimura N
    • Journal Title

      Ann Rheum Dis

      Volume: 68 Pages: 1401-1406

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Locomotive syndrome : disability-free life expectancy and locomotive organ health in a "super-aged" society2009

    • Author(s)
      Nakamura K
    • Journal Title

      J Orthop Sci 14

      Pages: 1-2

    • NAID

      10025353371

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Regulation of osteoarthritis development by Wnt-β-catenin signaling through the endochondral ossification process2009

    • Author(s)
      Kawaguchi H
    • Journal Title

      J Bone Miner Res 24

      Pages: 8-11

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Identification of the core element responsive to runt-related transcription factor 2 in the promoter of human type x collagen gene2009

    • Author(s)
      Higashikawa A, Saito T, Ikeda T, Kamekura S, Kawamura N, Kan A, Oshima Y, Ohba S, Ogata N, Takeshita K, Nakamura K, Chung UI, Kawaguchi H
    • Journal Title

      Arthritis Rheum 60

      Pages: 166-178

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] C/EBPβ promotes transition from proliferation to hypertrophic differentiation of chondrocytes through transactivation of p57^<Kip2>2009

    • Author(s)
      Hirata M, Kugimiya F, Fukai A, Ohba S, Kawamura N, Ogasawara T, Kawasaki Y, Saito T, Yano F, Ikeda T, Nakamura K, Chung UI, Kawaguchi H
    • Journal Title

      PLoS ONE 4

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Association of occupational activity with radiographic knee osteoarthritis and lumbar spondylosis in elderly patients of population-based cohorts : A large-scale population-based study2009

    • Author(s)
      Muraki S, Akune T, Oka H, Mabuchi A, En-yo Y, Yoshida M, Saika A, Nakamura K, Kawaguchi H, Yoshimura N
    • Journal Title

      Arthritis Rheum 61

      Pages: 779-786

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Epidemiology of lumbar osteoporosis and osteoarthritis and their causal relationship-Is osteoarthritis a predictor for osteoporosis or vice versa?: The Miyama study2009

    • Author(s)
      Yoshimura N, Muraki S, Oka H, Kinoshita H, Yoshida M, Mabuchi A, Kawaguchi H, Nakamura K, Akune T
    • Journal Title

      Osteoporosis Int 20

      Pages: 999-1008

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Transcriptional induction of SOX9 by NF-κB family member RelA in chondrogenic cells2009

    • Author(s)
      Ushita M, Saito T, Ikeda T, Yano F, Higashikawa A, Ogata N, Chung UI, Nakamura K, Kawaguchi H
    • Journal Title

      Osteoarthritis Cartilage 17

      Pages: 1065-1075

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Prevalence of radiographic lumbar spondylosis and its association with low back pain in the elderly of population-based cohorts : the ROAD study2009

    • Author(s)
      Muraki S, Oka H, Mabuchi A, Akune T, En-yo Y, Yoshida M, Saika A, Suzuki T, Yoshida H, Ishibashi H, Yamamoto S, Nakamura K, Kawaguchi H, Yoshimura N
    • Journal Title

      Ann Rheum Dis 68

      Pages: 1401-1406

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Prevalence of knee osteoarthritis, lumbar spondylosis, and osteoporosis in Japanese men and women : the research on osteoarthritis/osteoporosis against disability study2009

    • Author(s)
      Yoshimura N, Muraki S, Oka H, Mabuchi A, En-Yo Y, Yoshida M, Saika A, Yoshida H, Suzuki T, Yamamoto S, Ishibashi H, Kawaguchi H, Nakamura K, Akune T
    • Journal Title

      J Bone Miner Metab 27

      Pages: 620-628

    • NAID

      10027205889

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Prevalence of radiographic knee osteoarthritis and its association with knee pain in the elderly of Japanese population-based cohorts : The ROAD study2009

    • Author(s)
      Muraki S, Oka H, Akune T, Mabuchi A, En-yo Y, Yoshida M, Saika A, Suzuki T, Yoshida H, Ishibashi H, Yamamoto S, Nakamura K, Kawaguchi H, Yoshimura N
    • Journal Title

      Osteoarthritis Cartilage 17

      Pages: 1137-1143

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Screening of chondrogenic factors by a real-time fluorescence monitoring cell line ATDC5-C2ER : Identification of sorting nexin 19 as a novel factor2009

    • Author(s)
      Kan A, Ikeda T, Saito T, Yano F, Fukai A, Ogata N, Nakamura K, Chung UI, Kawaguchi H
    • Journal Title

      Arthritis Rheum 60

      Pages: 3314-3323

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Low dietary vitamin K intake is associated with radiographic knee osteoarthritis in the Japanese elderly : Dietary survey in a population-based cohort of the ROAD study2009

    • Author(s)
      Oka H, Akune T, Muraki S, Mabuchi A, En-yo Y, Yoshida M, Saika A, Sasaki S, Nakamura K, Kawaguchi H, Yoshimura N
    • Journal Title

      J Orthop Sci 14

      Pages: 687-692

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Selection of highly osteogenic and chondrogenic cells from bone marrow stromal cells in biocompatible polymer-coated plates2009

    • Author(s)
      Liu G, Iwata K, Ogasawara T, Watanabe J, Fukazawa K, Ishihara K, Asawa Y, Fujihara Y, Chung UI, Moro T, Takatori Y, Takato T, Nakamura K, Kawaguchi H, Hoshi K
    • Journal Title

      J Biomed Mater Res A 92

      Pages: 1273-1282

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Assessment of vertebral fracture risk and therapeutic effects of alendronate in postmenopausal women using a quantitative computed tomography-based nonlinear finite element method2009

    • Author(s)
      Imai K, Ohnishi I, Matsumoto T, Yamamoto S, Nakamura K
    • Journal Title

      Osteoporos Int 20

      Pages: 801-810

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Prediction of vertebral strength under loading conditions occurring in activities of daily living using a computed tomography-based nonlinear finite element method2009

    • Author(s)
      Matsumoto T, Ohnishi I, Bessho M, Imai K, Ohashi S, Nakamura K
    • Journal Title

      Spine 34

      Pages: 1464-1469

    • NAID

      10027244266

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Prediction of proximal femur strength using a CT-based nonlinear finite element method : differences in predicted fracture load and site with changing load and boundary conditions2009

    • Author(s)
      Bessho M, Ohnishi I, Matsumoto T, Ohashi S, Matsuyama J, Tobita K, Kaneko M, Nakamura K
    • Journal Title

      Bone 45

      Pages: 226-231

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] The efficacy of prostaglandin E1 derivative in patients with lumbar spinal stenosis2009

    • Author(s)
      Matsudaira K, Seichi A, Kunogi J, Yamazaki T, Kobayashi A, Anamizu Y, Kishimoto J, Hoshi K, Takeshita K, Nakamura K
    • Journal Title

      Spine 34

      Pages: 115-120

    • NAID

      10027237572

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Modified fenestration with restorative spinoplasty for lumbar spinal stenosis2009

    • Author(s)
      Matsudaira K, Yamazaki T, Seichi A, Hoshi K, Hara N, Ogiwara S, Terayama S, Chikuda H, Takeshita K, Nakamura K
    • Journal Title

      J Neurosurg Spine 10

      Pages: 587-594

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Locomotive syndrome : disability-free life expectancy and locomotive organ health in a"super-aged"society.2009

    • Author(s)
      Nakamura K
    • Journal Title

      J Orthop Sci 14

      Pages: 1-2

    • NAID

      10025353371

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of osteoarthritis development by wnt-β-catenin signaling through the endochondral ossification process.2009

    • Author(s)
      Kawaguchi H
    • Journal Title

      J Bone Miner Res 24

      Pages: 8-11

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of the core element responsive to runt-related transcription factor 2 in the promoter of human type x collagen gene.2009

    • Author(s)
      Higashikawa A
    • Journal Title

      Arthritis Rheum 60

      Pages: 166-178

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C/EBP β promotes transition from proliferation to hypertrophic differentiation of chondrocytes through transactivation of p57^<Kip2>.2009

    • Author(s)
      Hirata M
    • Journal Title

      PLoS ONE 4

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of occupational activity with radiographic knee osteoarthritis and lumbar spondylosis in elderly patients of population-based cohorts : A large-scale population-based study.2009

    • Author(s)
      Muraki S
    • Journal Title

      Arthritis Rheum 61

      Pages: 779-786

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epidemiology of lumbar osteoporosis and osteoarthritis and their causal relationship-Is osteoarthritis a predictor for osteoporosis or vice versa? : The Miyama study.2009

    • Author(s)
      Yoshimura N
    • Journal Title

      Osteoporosis Int 20

      Pages: 999-1008

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptional induction of SOX9 by NF-κB family member RelA in chondrogenic cells.2009

    • Author(s)
      Ushita M
    • Journal Title

      Osteoarthritis Cartilage 17

      Pages: 1065-1075

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of radiographic lumbar spondylosis and its association with low back pain in the elderly of population-based cohorts : the POAD study.2009

    • Author(s)
      Muraki S
    • Journal Title

      Ann Rheum Dis 68

      Pages: 1401-1406

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of knee osteoarthritis, lumbar spondylosis, and osteoporosis in Japanese men and women : the research on osteoarthritis/osteoporosis against disability study.2009

    • Author(s)
      Yoshimura N
    • Journal Title

      J Bone Miner Metab 27

      Pages: 620-628

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of radiographic knee osteoarthritis and its association with knee pain in the elderly of Japanese population-based cohorts : The ROAD study.2009

    • Author(s)
      Muraki S
    • Journal Title

      Osteoarthritis Cartilage 17

      Pages: 1137-1143

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Screening of chondrogenic factors by a real-time fluorescence monitoring cell line ATDC5-C2ER : Identification of sorting nexin 19 as a novel factor.2009

    • Author(s)
      Kan A
    • Journal Title

      Arthritis Rheum 60

      Pages: 3314-3323

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low dietary vitamin K intake is associated with radiographic knee osteoarthritis in the Japanese elderly : Dietary survey in a population-based cohort of the ROAD study.2009

    • Author(s)
      Oka H
    • Journal Title

      J Orthop Sci 14

      Pages: 687-692

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endochondral ossification signals in cartilage degradation during osteoarthritis progression in experimental mouse models2008

    • Author(s)
      Kawaguchi H
    • Journal Title

      Mol Cells

      Volume: 25 Pages: 1-6

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A "super-aged" society and the "locomotive syndrome"2008

    • Author(s)
      Nakamura K
    • Journal Title

      J Orthop Sci 13

      Pages: 1-2

    • NAID

      10024138811

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Endochondral ossification signals in cartilage degradation during osteoarthritis progression in experimental mouse models2008

    • Author(s)
      Kawaguchi H
    • Journal Title

      Mol Cells 25

      Pages: 1-6

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Analysis of the Runx2 promoter in osseous and non-osseous cells and identification of HIF2A as a potent transcriptional activator2008

    • Author(s)
      Tamiya H, Ikeda T, Jung JH, Saito T, Jung YK, Kawaguchi H, Ohba S, Chung UI, Choi JY
    • Journal Title

      Gene 416

      Pages: 53-60

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Association of microsomal prostaglandin E synthase 1 deficiency with impaired fracture healing, but not with bone loss or osteoarthritis, in mouse models of skeletal disorders2008

    • Author(s)
      Yamakawa K, Kamekura S, Kawamura N, Saegusa M, Kamei D, Murakami M, Kudo I, Uematsu S, Akira S, Chung UI, Nakamura K, Kawaguchi H
    • Journal Title

      Arthritis Rheum 58

      Pages: 172-183

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity2008

    • Author(s)
      Ohba S, Kawaguchi H, Kugimiya F, Ogasawara T, Kawamura N, Saito T, Ikeda T, Fujii K, Miyajima T, Kuramochi A, Miyashita T, Oda H, Nakamura K, Takato T, Chung UI
    • Journal Title

      Dev Cell 14

      Pages: 689-699

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Phosphorylation of GSK-3β by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes2008

    • Author(s)
      Kawasaki Y, Kugimiya F, Chikuda H, Kamekura S, Ikeda T, Kawamura N, Saito T, Shinoda Y, Higashikawa A, Yano F, Ogasawara T, Ogata N, Hoshi K, Hofmann F, Woodgett JR, Nakamura K, Chung UI, Kawaguchi H
    • Journal Title

      J Clin Invest 118

      Pages: 2506-2515

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] The Distinct role of the Runx proteins in chondrocyte differentiation and intervertebral disc degeneration : Findings in murine models and in human disease2008

    • Author(s)
      Sato S, Kimura A, Ozdemir J, Asou Y, Miyazaki M, Jinno T, Ae K, Liu X, Osaki M, Takeuchi Y, Fukumoto S, Kawaguchi H, Haro H, Shinomiya K, Karsenty G, Takeda S
    • Journal Title

      Arthritis Rheum 58

      Pages: 2764-2775

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Kruppel-like factor 5 causes cartilage degradation through transactivation of matrix metalloproteinase 92008

    • Author(s)
      Shinoda Y, Ogata N, Higashikawa A, Manabe I, Shindo T, Yamada T, Kugimiya F, Ikeda T, Kawamura N, Kawasaki Y, Tsushima K, Takeda N, Nagai R, Hoshi K, Nakamura K, Chung UI, Kawaguchi H
    • Journal Title

      J Biol Chem 283

      Pages: 24682-24689

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Pivotal role of Bcl-2 family proteins in the regulation of chondrocyte apoptosis2008

    • Author(s)
      Oshima Y, Akiyama T, Hikita A, Iwasawa M, Nagase Y, Nakamura M, Wakeyama H, Kawamura N, Ikeda T, Chung UI, Hennighausen L, Kawaguchi H, Nakamura K, Tanaka S
    • Journal Title

      J Biol Chem 283

      Pages: 26499-26508

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Fully automatic quantification of knee osteoarthritis severity on plain radiographs2008

    • Author(s)
      Oka H, Muraki S, Akune T, Mabuchi A, Suzuki T, Yoshida H, Yamamoto S, Nakamura K, Yoshimura N, Kawaguchi H
    • Journal Title

      Osteoarthritis Cartilage 16

      Pages: 1300-1306

    • NAID

      40020243882

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] In vivo assessment of lumbar vertebral strength in elderly women using computed tomography-based nonlinear finite element model2008

    • Author(s)
      Imai K, Ohnishi I, Yamamoto S, Nakamura K
    • Journal Title

      Spine 33

      Pages: 27-32

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] A new method for evaluation of fracture healing by echo tracking2008

    • Author(s)
      Matsuyama J, Ohnishi I, Sakai R, Bessho M, Matsumoto T, Miyasaka K, Harada A, Ohashi S, Nakamura K
    • Journal Title

      Ultrasound Med Biol 34

      Pages: 775-783

    • NAID

      40015625301

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Control of fracture reduction robot using force/torque measurement2008

    • Author(s)
      Douke T, Nakajima Y, Mori Y, Onogi S, Sugita N, Mitsuishi M, Bessho M, Ohhashi S, Tobita K, Ohnishi I, Sakuma I, Dohi T, Maeda Y, Koyama T, Sugano N, Yonenobu K, Matsumoto Y, Nakamura K
    • Journal Title

      Conf Proc IEEE Eng Med Biol Soc 2008

      Pages: 3265-3268

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Early functional improvement after a modified ligament reconstruction tendon interposition arthroplasty for thumb basal joint arthritis2008

    • Author(s)
      Miura T, Osuka K, Itoh S, Nakagawa T, Kawano H, Nakamura K
    • Journal Title

      Hand Surg 13

      Pages: 153-158

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Tumor necrosis factor-alpha inhibits chondrogenic differentiation of synovial fibroblasts through p38 mitogen activating protein kinase pathways2008

    • Author(s)
      Okuma-Yoshioka C, Seto H, Kadono Y, Hikita A, Oshima Y, Kurosawa H, Nakamura K, Tanaka S
    • Journal Title

      Mod Rheumatol 18

      Pages: 366-378

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Analysis of the Runx2 promoter in osseous and non-osseous cells and identification of HIF2A as a potent transcriptional activator.2008

    • Author(s)
      Hiroyuki Tamiya, et al.
    • Journal Title

      Gene 416

      Pages: 53-60

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity.2008

    • Author(s)
      Shinsuke Ohba, et al.
    • Journal Title

      Dev Cell 14

      Pages: 689-699

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation of GSK-3β by cGMP-dependent protein kinase ll promotes hypertrophic differentiation of murine chondrocytes.2008

    • Author(s)
      Yosuke Kawasaki, et al.
    • Journal Title

      J Clin Invest 118

      Pages: 2506-2515

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of 2-methacryloyloxyethyl phosphorylcholine concentration on photo-induced graft polymerization of polyethylene in reducing the wear of orthopaedic bearing surface.2008

    • Author(s)
      Masayuki Kyomoto, et al.
    • Journal Title

      J Biomed Mater Res A 86

      Pages: 439-47

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The distinct role of the Runx proteins in chondrocyte differentiation and intervertebral disc degeneration: Findings in murine models and in human disease.2008

    • Author(s)
      Shingo Sato, et al.
    • Journal Title

      Artyritis Rheum 58

      Pages: 2764-2775

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Kruppel-like factor 5causes cartilage degradation through transactivation of matrix metalloproteinase 9.2008

    • Author(s)
      Yusuke Shimoda, et al.
    • Journal Title

      J Biol Chem 283

      Pages: 24682-24689

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pivotal role of Bcl-2 family proteins in the regulation of chondrocyte apoptosis.2008

    • Author(s)
      Ysushi Oshima, et al.
    • Journal Title

      J Biol Chem 283

      Pages: 26499-26508

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fully automatic quantification of knee osteoarthritis severity on plain radiographs.2008

    • Author(s)
      Hiroyuki Oka, et al.
    • Journal Title

      Osteoarthritis Cartilage 16

      Pages: 1300-1306

    • NAID

      40020243882

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dnm3os, a non-coding RNA, is required for normal growth and skeletal development in mice2008

    • Author(s)
      Tokumitsu Watanabe, et al.
    • Journal Title

      Dev Dynam 237

      Pages: 3738-3748

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of the core element responsive to runt-related transcription factor 2 in the promoter of human type x collagen gene.2008

    • Author(s)
      Akiro Higashikawa, et al.
    • Journal Title

      Arthritis Rheum 60

      Pages: 166-178

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Radiographic analysis of the cervical spine in patients with retro-odontoid pseudotumors.2008

    • Author(s)
      Hirotaka Chikuda, et al.
    • Journal Title

      Spine 34

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C/EBPβ promotes transition from proliferation to hypertrophic nsactivation of differentiation of chondrocytes through trap57^<kip2>2008

    • Author(s)
      Makoto Hirata, et al.
    • Journal Title

      PLoS ONE 4

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Continuous activation of Gαq in osteoblasts results in osteopenia through impaired osteoblast differentiation2008

    • Author(s)
      Naoshi Ogata, et. al.
    • Journal Title

      J Biol Chem 282

      Pages: 35757-64

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of microsomal prostaglandin E synthase 1 deficiency with impaired fracture healing,but not with bone loss osteoarthrltis, in mouse models of skeletal disorders2008

    • Author(s)
      Kiyofumi Yamakawa, et. al.
    • Journal Title

      Arthrltis Rheum 58

      Pages: 172-183

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between height loss and bone loss,cumulative incidence of vertebral fractures and future quality of life:The Miyama Study2008

    • Author(s)
      Noriko Yoshimura, et. al.
    • Journal Title

      Osteoporosis lnt 19

      Pages: 21-8

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced wear resistance of orthopaedic bearing due to the cross-linking of poly (MPC) graft chains induced by gamma-rayirradiation2008

    • Author(s)
      Masayuki Kyomoto, et. al.
    • Journal Title

      J Biomed Mater Res B 84

      Pages: 320-327

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] S100A1 and B, transcriptional targets of SOX trio, inhibit terminal differentiation of chondrocytes2007

    • Author(s)
      Saito T, Ikeda T, Nakamura K, Chung UI, Kawaguchi H
    • Journal Title

      EMBO Rep 8

      Pages: 504-509

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Identification of a potent combination of osteogenic genes for bone regeneration using embryonic stem (ES) cell-based sensor2007

    • Author(s)
      Ohba S, Ikeda T, Kugimiya F, Yano F, Lichtler AC, Nakamura K, Takato T, Kawaguchi H, Chung UI
    • Journal Title

      FASEB J 21

      Pages: 1777-1787

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] A novel osteogenic helioxanthin-derivative acts in a BMP-dependent manner2007

    • Author(s)
      Ohba S, Nakajima K, Komiyama Y, Kugimiya F, Igawa K, Itaka K, Moro T, Nakamura K, Kawaguchi H, Takato T, Chung UI
    • Journal Title

      Biochem Biophys Res Commun 357

      Pages: 854-860

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Identification and characterization of the human SOX6 promoter2007

    • Author(s)
      Ikeda T, Saito T, Ushita M, Yano F, Kan A, Itaka K, Moro T, Nakamura K, Kawaguchi H, Chung UI
    • Journal Title

      Biochem Biophys Res Commun 357

      Pages: 383-390

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Optimal combination of soluble factors for tissue engineering of permanent cartilage from cultured human chondrocytes2007

    • Author(s)
      Liu G, Kawaguchi H, Ogasawara T, Asawa Y, Kishimoto JI, Takahashi T, Chung UI, Yamaoka H, Asato H, Nakamura K, Takato T, Hoshi K
    • Journal Title

      J Biol Chem 282

      Pages: 20407-20415

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Diet and lifestyle associated with increased bone mineral density : cross-sectional study of Japanese elderly women at an osteoporosis outpatient clinic2007

    • Author(s)
      Muraki S, Yamamoto S, Ishibashi H, Oka H, Yoshimura N, Kawaguchi H, Nakamura K
    • Journal Title

      J Orthop Sci 12

      Pages: 317-320

    • NAID

      10019816110

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] GSK-3β controls osteogenesis through regulating Runx2 activity2007

    • Author(s)
      Kugimiya F, Kawaguchi H, Ohba S, Kawamura N, Hirata M, Chikuda H, Azuma Y, Woodgett JR, Nakamura K, Chung UI
    • Journal Title

      PLoS ONE 2

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Prevention of cartilage destruction with intraarticular osteoclastogenesis inhibitory factor/osteoprotegerin in a murine model of osteoarthritis2007

    • Author(s)
      Shimizu S, Asou Y, Itoh S, Cung UI, Kawaguchi H, Shinomiya K, Muneta T
    • Journal Title

      Arthritis Rheum 56

      Pages: 3358-3365

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Continuous activation of Gαq in osteoblasts results in osteopenia through impaired osteoblast differentiation2007

    • Author(s)
      Ogata N, Kawaguchi H, Chung UI, Roth SI, Segre GV
    • Journal Title

      J Biol Chem 282

      Pages: 35757-64

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Prediction of strength and strain of the proximal femur by a CT-based finite element method2007

    • Author(s)
      Bessho M, Ohnishi I, Matsuyama J, Matsumoto T, Imai K, Nakamura K
    • Journal Title

      J Biomech 40

      Pages: 1745-1753

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Redifferentiation of dedifferentiated bovine articular chondrocytes enhanced by cyclic hydrostatic pressure under a gas-controlled system2007

    • Author(s)
      Kawanishi M, Oura A, Furukawa K, Fukubayashi T, Nakamura K, Tateishi T, Ushida T
    • Journal Title

      Tissue Eng 13

      Pages: 957-964

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Erk pathways negatively regulate matrix mineralization2007

    • Author(s)
      Shin-jiro Kono, et. al.
    • Journal Title

      Bone 23

      Pages: 68-74

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impaired bone fracture healing in matrix metalloproteinase-13 deficient mice2007

    • Author(s)
      Naoto Kosaki, et. al.
    • Journal Title

      Biochem Biophys Res Commun 354

      Pages: 846-51

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Local application of recombinant human fibrobalst growth factor-2 on bone repair: a dose-escalation prospective trial on patients with osteotomy2007

    • Author(s)
      Hiroshi Kawaguchi, et. al.
    • Journal Title

      J Orthop Res 25

      Pages: 480-487

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High lubricious surface of cobalt-chromium-molybdenum alloy prepared by grafting poly(2-methacryloyloxyethylphosphorylcholine)2007

    • Author(s)
      Masayuki Kyomoto, et. al.
    • Journal Title

      Biomaterials 28

      Pages: 3121-3130

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] S100A1 and B, transcripitional targets of SOX trio, inhibit terminal differentiation of chondrocytes2007

    • Author(s)
      Taku Saito, et. al.
    • Journal Title

      EMBO Rep 8

      Pages: 504-509

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced wear resistance of modified cross-linked polyethylene by grafting with poly(2-methcryloyloxyethylphosphorylcholine)2007

    • Author(s)
      Masayuki Kyomoto, et. al.
    • Journal Title

      J Biomed Mater Res A 82

      Pages: 10-17

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a potent combination of osteogenic genes for bone regeneration using embryonic stem (ES) cell-based sensor2007

    • Author(s)
      Shinsuke Ohba, et. al.
    • Journal Title

      FASEB J 21

      Pages: 1777-1787

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel osteogenic helioxanthin-derivative acts in a BMP-dependent manner2007

    • Author(s)
      Shinsuke Ohba, et. al.
    • Journal Title

      Biochem Biophys Res Commun 357

      Pages: 854-860

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ldentification and characterization of the human SOX6 promoter2007

    • Author(s)
      Toshiyuki lkeda, et. al.
    • Journal Title

      Biochem Biophys Res Commun 357

      Pages: 383-390

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Runx2 determines bone maturity and turnover rate in postnatalbone development and is involved in bone loss in estrogen deflciency2007

    • Author(s)
      Zenjiro Maruyama, et. al.
    • Journal Title

      Dev Dynam 236

      Pages: 1876-1890

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optimal combinatlorl of soluble factors for tissue engineering of permanent cartilage from cultured human chorldrocytes2007

    • Author(s)
      Guangyao Liu, et. al.
    • Journal Title

      J Biol Chem 282

      Pages: 20407-20415

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diet and lifestyle associated with increased bone mineral density:cross-sectional study of Japanese elderly women at an osteoporosis outpatient clinic2007

    • Author(s)
      Shigeyuki Muraki, et. al.
    • Journal Title

      J Orthop Sci 12

      Pages: 317-320

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of photo-induced graft polymerlzation of 2-methacryloyloxyethyl phosphorylcholine on physical properties of cross-linked polyethylene in artificial hipjoints2007

    • Author(s)
      Masayuki Kyomoto, et. al.
    • Journal Title

      J Mater Sci Mater M 18

      Pages: 1809-1815

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GSK-3β controls osteogenesis through regulating Runx2 activity2007

    • Author(s)
      Fumitaka Kugimiya, et. al.
    • Journal Title

      PLoS ONE 2

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone regeneration by regulated in vivo gene transfer using biocompatible polyplex nanomicelles2007

    • Author(s)
      Keiji ltaka, et. al.
    • Journal Title

      Mol Ther 15

      Pages: 1655-1662

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevention of cartilage destruction with intraarticular osteoclastogenesis inhibitory factor/osteoprotegerin in amurine model of osteoarethritis2007

    • Author(s)
      Sadanori Shimizu, et. al.
    • Journal Title

      Arthritis Rheum 56

      Pages: 3358-3365

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Akt1 in osteoblasts and osteoclasts controls bone remodeling2007

    • Author(s)
      Naohiro Kawamura, et. al.
    • Journal Title

      PLoS ONE 2

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptional regulation of endochondral ossification by HIF2A during skeletal growth and osteoarthritis development

    • Author(s)
      Saito T, Fukai A, Mabuchi A, Ikeda T, Yano F, Ohba S, Nishida N, Akune T, Yoshimura N, Nakagawa T, Nakamura K, Tokunaga K, Chung UI, Kawaguchi H
    • Journal Title

      Nature Med (in press)

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Health-related quality of life with vertebral fracture, lumbar spondylosis and knee osteoarthritis in Japanese men : the ROAD study

    • Author(s)
      Muraki S, Akune T, Oka H, En-yo Y, Saika A, Suzuki T, Yoshida H, Ishibashi H, Tokimura F, Yamamoto S, Nakamura K, Kawaguchi H, Yoshimura N
    • Journal Title

      Arch Osteoporos (in press)

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Cohort profile : Research on Osteoarthritis/Osteoporosis Against Disability study

    • Author(s)
      Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T
    • Journal Title

      Int J Epidemiol (in press)

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Title : Identification of oxytetracycline as a chondrogenic compound using a cell-based screening system

    • Author(s)
      Hojo H, Yano F, Ohba S, Igawa K, Nakajima K, Komiyama Y, Kan A, Ikeda T, Yonezawa T, Woo JT, Takato T, Nakamura K, Kawaguchi H, Chung UI
    • Journal Title

      J Bone Miner Metab (in press)

    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Incidence of multiple falls and risk factors in a longitudinal population-based cohort study in Japan : The ROAD study2011

    • Author(s)
      Muraki S
    • Organizer
      33th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
    • Place of Presentation
      San Diego, California, USA
    • Year and Date
      2011-09-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] Functional redundancy of GSK-α and GSK-β to control chondrocyte differentiation through phosphorylation of RelA/NF-kB p652011

    • Author(s)
      Itoh S
    • Organizer
      33th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
    • Place of Presentation
      San Diego, California, USA
    • Year and Date
      2011-09-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] C/EBP-β and RUNX2 cooperatively control cartilage degradation with MMP-13 as the target and HIF-α as the inducer in chondrocytes2011

    • Author(s)
      Hirata M
    • Organizer
      33th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
    • Place of Presentation
      San Diego, California, USA
    • Year and Date
      2011-09-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] Notch/Rbpj/Hes1 signal in chondrocytes modulates the terminal stage of endochondral ossification during skeletal growth and osteoarthritis development2011

    • Author(s)
      Hosaka Y
    • Organizer
      33th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
    • Place of Presentation
      San Diego, California, USA
    • Year and Date
      2011-09-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Risk factors for the incidence and progression of radiographic knee osteoarthritis in Japanese men and women : The ROAD study2011

    • Author(s)
      Muraki S
    • Organizer
      2011 World Congress on Osteoarthritis (OARSI)
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2011-09-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Incidence of risk factors for radiographic lumbar spondylosis : The ROAD study2011

    • Author(s)
      Muraki S
    • Organizer
      2011 World Congress on Osteoarthritis (OARSI)
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Notch/Rbpj/Hes1 signal in chondrocytes modulates terminal stage of endochondral ossification during skeletal growth and osteoarthritis development2011

    • Author(s)
      Hosaka Y
    • Organizer
      2011 World Congress on Osteoarthritis (OARSI)
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] GSK-α and GSK-β modulate early stage of chondrocyte differentiation through phosphorylation of RelA/NF-kB p652011

    • Author(s)
      Itoh S
    • Organizer
      2011 World Congress on Osteoarthritis (OARSI)
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Overview of molecular backgrounds of osteoarthritis2011

    • Author(s)
      Kawaguchi H
    • Organizer
      The 3rd International Cartilage and Osteoar thritis Symposium(ICOA 2011)
    • Place of Presentation
      Suwon, Korea
    • Year and Date
      2011-07-05
    • Related Report
      2011 Final Research Report
  • [Presentation] Overview of molecular backgrounds of osteoarthritis2011

    • Author(s)
      Kawaguchi H
    • Organizer
      The 3rd International Cartilage and Osteoarthritis Symposium (ICOA 2011)
    • Place of Presentation
      Suwon, Korea(招待講演)
    • Year and Date
      2011-07-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] Endochondral ossification signals as potential therapeutic targets for osteoarthritis(Invited Lecture)2011

    • Author(s)
      Kawaguchi H
    • Organizer
      2011 Gordon Research Conference : Cartilage Biology & Pathology
    • Place of Presentation
      Ventura, CA, USA
    • Year and Date
      2011-03-08
    • Related Report
      2011 Final Research Report
  • [Presentation] Transcriptional induction of ADAMTS5 by NF-kΒfamily member RelA/p65 in chondrocytes during osteoarthritis development2011

    • Author(s)
      Kobayashi H
    • Organizer
      2011 Gordon Research Conference : Cartilage Biology & Pathology
    • Place of Presentation
      Ventura, CA, USA
    • Year and Date
      2011-03-08
    • Related Report
      2011 Final Research Report
  • [Presentation] C/EBP-βand RUNX2 in chondrocytes control cartilage degradation2011

    • Author(s)
      Hirata M
    • Organizer
      2011 Gordon Research Conference : Cartilage Biology & Pathology
    • Place of Presentation
      Ventura, CA, USA
    • Year and Date
      2011-03-07
    • Related Report
      2011 Final Research Report
  • [Presentation] Notch/Rbpj/Hes1 signaling in chondrocytes controls terminal stage of endochondral ossification in skeletal growth and osteoarthritis development2011

    • Author(s)
      Sugita S
    • Organizer
      2011 Gordon Research Conference : Cartilage Biology & Pathology
    • Place of Presentation
      Ventura, CA, USA
    • Year and Date
      2011-03-06
    • Related Report
      2011 Final Research Report
  • [Presentation] Molecular backgrounds of cartilage degradation during osteoarthritis progression (Invited Lecture)2010

    • Author(s)
      Kawaguchi H
    • Organizer
      2010 Anti-aging and Well-being International Symposium
    • Place of Presentation
      Daegu, Korea
    • Year and Date
      2010-02-19
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Therapeutic target molecules for cartilage degradation in osteoarthritis progression (Invited Lecture)2010

    • Author(s)
      Kawaguchi H
    • Organizer
      System Biology and Drug Discovery
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2010-02-09
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Endochondral ossification signal : A potential therapeutic target for osteoarthritis (invited lecture).2010

    • Author(s)
      Kawaguchi H
    • Organizer
      2010 World Congress on Osteoarthritis (OARSI)
    • Place of Presentation
      Brussels, Belgium
    • Related Report
      2010 Annual Research Report
  • [Presentation] HIF2A/NF-kappa B signal in chondrocytes controls extensive steps of osteoarthritis development in mice and humans2010

    • Author(s)
      Fukai A, et al.
    • Organizer
      2010 World Congress on Osteoarthritis (OARSI)
    • Place of Presentation
      Brussels, Belgium
    • Related Report
      2010 Annual Research Report
  • [Presentation] Molecular network on the C/EBP-beta axis including Runx2, MMP13, and HIF2A controls osteoarthritis development2010

    • Author(s)
      Hirata M, et al.
    • Organizer
      2010 World Congress on Osteoarthritis (OARSI)
    • Place of Presentation
      Brussels, Belgium
    • Related Report
      2010 Annual Research Report
  • [Presentation] Association of occupational activity with joint space narrowing and osteoahytosis at the knee : The ROAD study.2010

    • Author(s)
      Akune T, et al.
    • Organizer
      2010 World Congress on Osteoarthritis (OARSI)
    • Place of Presentation
      Brussels, Belgium
    • Related Report
      2010 Annual Research Report
  • [Presentation] A Transcription factor p63 controls extensive steps of endochondral ossification through distinct functions of the isoforms2010

    • Author(s)
      Taniguchi Y, et al.
    • Organizer
      32th annua Imeeting of the American Society for Bone and Mineral Research (ASBMR)
    • Place of Presentation
      Toronto, Canada
    • Related Report
      2010 Annual Research Report
  • [Presentation] Association of changes in serum levels of intact parathyroid hormone with changes in biochemical markers of bone turnover and bone mineral density ; A 10-year follow-Up of the Taiji Cohort.2010

    • Author(s)
      Yoshimura N, et al.
    • Organizer
      32th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
    • Place of Presentation
      Toronto, Canada
    • Related Report
      2010 Annual Research Report
  • [Presentation] Gentler differences in factors associated with falls in a population-based cohort study in Japan : The ROAD study.2010

    • Author(s)
      Muraki S, et al.
    • Organizer
      32th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
    • Place of Presentation
      Toronto, Canada
    • Related Report
      2010 Annual Research Report
  • [Presentation] Molecular backgrounds of cartilage degeneration during osteoarthritis progression (Special Lecture : OARSI-KORS Co-sponsored Symposium)2009

    • Author(s)
      Kawaguchi H
    • Organizer
      The 35th Annual Meeting of the Korean Orthopaedic Research Society
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2009-10-14
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Molecular backgrounds of cartilage degeneration during osteoarthritis progression(Special Lecture : OARSI-KORS Co-sponsored Symposium).2009

    • Author(s)
      Kawaguchi H
    • Organizer
      The 35th Annual Meeting of the Korean Orthopaedic Research Society.
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2009-10-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] Transcriptional regulation of cartilage degeneration during osteoarthritis progression2009

    • Author(s)
      Kawaguchi H
    • Organizer
      The 2nd International Cartilage and Osteoarthritis Symposium (Plenary Lecture)
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2009-10-10
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Transcriptional regulation of cartilage degeneration during osteoarthritis progression.2009

    • Author(s)
      Kawaguchi H
    • Organizer
      The 2nd International Cartilage and Osteoarthrit is Symposium(Plenary Lecture).
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2009-10-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mouse genetics studies on molecular mechanisms underlying bone and cartilage disorders (Kappa Delta Award Paper Presentation)2009

    • Author(s)
      Kawaguchi H, Akune T, Yamada T, Ogata N
    • Organizer
      55th Annual Meeting of the Orthopaedic Research Society (ORS)
    • Place of Presentation
      Las Vegas, Nevada, USA
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] A novel thienoindazole-derivative small compound induces chondrogenic differentiation without promoting hypertrophy through Runx1 (Young Investigator Award)2009

    • Author(s)
      Yano F, Ikeda T, Saito T, Ogata N, Hojo H, Kimura A, Takeda S, Takato T, Nakamura K, Kawaguchi H, Chung UI
    • Organizer
      31th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
    • Place of Presentation
      Denver, Colorado, USA
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Comprehensive control of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis progression2009

    • Author(s)
      Saito T, Fukai A, Ikeda T, Yano F, Hirata M, Kan A, Nakamura K, Chung UI, Kawaguchi H
    • Organizer
      31th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
    • Place of Presentation
      Denver, Colorado, USA
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Notch/RBPJk/Hes1 signaling controls terminal differentiation of chondrocytes during endochondral ossification2009

    • Author(s)
      Hikata T, Saito T, Takaishi H, Akiyama H, Nakamura T, Yamaguchi A, Matsumoto M, Chiba K, Toyama Y, Kawaguchi H
    • Organizer
      31th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
    • Place of Presentation
      Denver, Colorado, USA
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Regulator of G protein signaling (RGS)-2 enhances bone anabolic action of PTH through inhibition of Gαq/PKC pathway in osteoblasts2009

    • Author(s)
      Ogata N, Yano F, Chikazu D, Chung UI, Nakamura K, Kawaguchi H
    • Organizer
      31th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
    • Place of Presentation
      Denver, Colorado, USA
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Association of knee osteoarthritis, lumbar spondylosis and osteoporosis with mild cognitive impairment : The ROAD (Research on Osteoarthritis/osteoporosis Against Disability) study2009

    • Author(s)
      Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T
    • Organizer
      31th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
    • Place of Presentation
      Denver, Colorado, USA
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Health-related quality of life in subjects with vertebral fracture, knee osteoarthritis, lumbar spondylosis and other chronic diseases as well as low back pain and knee pain in a population-based cohort study in Japan : The ROAD study2009

    • Author(s)
      Muraki S, Akune T, Oka H, Nakamura K, Kawaguchi H, Yoshimura N
    • Organizer
      31th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
    • Place of Presentation
      Denver, Colorado, USA
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Identification of receptor tyrosine kinase-like orphan receptor 2 (ROR2)/WNT5B signaling as a therapeutic target against osteosarcoma2009

    • Author(s)
      Morioka K, Matsuda K, Kawano H, Nakamura K, Kawaguchi H, Nakamura Y
    • Organizer
      31th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
    • Place of Presentation
      Denver, Colorado, USA
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Requirement of Runx1 for chondrocyte lineage commitment2009

    • Author(s)
      Kimura A, Inose H, Fujita K, Yano F, Kawaguchi H, Chung UI, Shinomiya K, Takeda S
    • Organizer
      31th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
    • Place of Presentation
      Denver, Colorado, USA
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] NF-kappa B family member RelA/p65, a transcription factor of Sox9, is essential for chondrogenic differentiation and skeletal growth (Young Investigator Award)2009

    • Author(s)
      Itoh S, Saito T, Ushita M, Ikeda T, Yano F, Ogata N, Chung UI, Nakamura K, Kawaguchi H
    • Organizer
      2009 World Congress on Osteoarthritis (OARSI)
    • Place of Presentation
      Monteral, Quebec, Canada
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Distinct transcriptional control of chondrocyte hypertrophy and cartilage degeneration by C/EBP-beta and Runx2 during endochondral ossification2009

    • Author(s)
      Hirata M, Kugimiya F, Fukai A, Saito T, Kan A, Higashikawa A, Yano F, Ikeda T, Nakamura K, Chung UI, Kawaguchi H
    • Organizer
      2009 World Congress on Osteoarthritis (OARSI)
    • Place of Presentation
      Monteral, Quebec, Canada
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Akt1 in chondrocytes controls cartilage calcification during osteophyte foration in osteoarthritis2009

    • Author(s)
      Fukai A, Kawamura N, Saito T, Ikeda T, Ogata N, Nakamura K, Chung UI, Kawaguchi H
    • Organizer
      2009 World Congress on Osteoarthritis (OARSI)
    • Place of Presentation
      Monteral, Quebec, Canada
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Association of radiographic severity of lumbar spondylosis with low back pain and related disabilities : The ROAD study2009

    • Author(s)
      Akune T, Muraki S, Oka H, Nakamura K, Kawaguchi H, Yoshimura N
    • Organizer
      2009 World Congress on Osteoarthritis (OARSI)
    • Place of Presentation
      Monteral, Quebec, Canada
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Automated quantification and diagnosis of the knee on plain radiographs : The ROAD study2009

    • Author(s)
      Oka H, Akune T, Muraki S, Nakamura K, Kawaguchi H, Yoshimura N
    • Organizer
      2009 World Congress on Osteoarthritis (OARSI)
    • Place of Presentation
      Monteral, Quebec, Canada
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Cross-linked brush-like structure of surface-modified layers gives high durability to joint replacement2009

    • Author(s)
      Kyomoto M, Moro T, Miyaji F, Yamawaki N, Kawaguchi H, Takatori Y, Nakamura K, Ishihara K
    • Organizer
      22nd annual conference of the European Society for Biomaterials (ESB)
    • Place of Presentation
      Lausanne, Swiss
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Cyclic GMP-dependent protein kinase II promotes chondrocyte hypertrophy and skeletal growth2009

    • Author(s)
      Kawaguchi H, Chikuda H, Kawasaki Y, Hofmann F
    • Organizer
      4th International Conference on cGMP
    • Place of Presentation
      Rosensburg, Germany
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Osteoarthritis, osteoporosis and cognitive impairment : the research on osteoarthritis/osteoporosis against disability study2009

    • Author(s)
      Yoshimura N. Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T
    • Organizer
      36th European Symposium on Calcified Tissues (ECTS)
    • Place of Presentation
      Vienna, Austria
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Full-automatic quantification of hip geometry on plain radiographs by a novel computer-assisted system2009

    • Author(s)
      Oka H, Akune T, Muraki S, Nakamura K, Kawaguchi H, Yoshimura N
    • Organizer
      36th European Symposium on Calcified Tissues (ECTS)
    • Place of Presentation
      Vienna, Austria
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Mouse genetics studies on molecular mechanisms underlying bone and cartilage disorders.2009

    • Author(s)
      Kawaguchi H
    • Organizer
      55th Annual Meeting of the Orthopaedic Research Society(ORS).
    • Place of Presentation
      Las Vegas, Nevada, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] 大規模コホート研究による腰椎圧迫骨折、変形性膝関節症および変形性腰椎症の健康関連QOLへの影響-ROADプロジェクト-2008

    • Author(s)
      村木重之
    • Organizer
      第10回日本骨粗鬆症学会
    • Place of Presentation
      大阪
    • Year and Date
      2008-10-31
    • Related Report
      2008 Annual Research Report
  • [Presentation] Lau Edith, Kwok Anthony, Leung Ping-Chung:アジア諸国における脊椎椎体骨折有病率の比較 The Asian Vartebral Osteoporosis Study(AVOS)2008

    • Author(s)
      吉村典子
    • Organizer
      第10回日本骨粗髭症学会
    • Place of Presentation
      大阪
    • Year and Date
      2008-10-31
    • Related Report
      2008 Annual Research Report
  • [Presentation] Hypoxia-inducible factor 2α(HIF-2α)は軟骨内骨化を統合的に制御する転写因子である2008

    • Author(s)
      斎藤琢
    • Organizer
      第26回日本骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] C/EBPβ/p57^<KLp2>シグナルは軟骨細胞の細胞周期を制御して増殖から肥大化ほの移行を促進する2008

    • Author(s)
      平田真
    • Organizer
      第26回日本骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] Runx1はRunx2と協調的に軟骨分化を調節する-Runx1コンデイショナルノックアウトマウスを用いた検討-2008

    • Author(s)
      木村文子
    • Organizer
      第26回日本骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 新規低分子化合物チエノインダゾール誘導体はRunx9 trioを介して永久軟骨再生を誘導する2008

    • Author(s)
      矢野文子
    • Organizer
      第26回日本骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 関節軟骨形成遺伝子Wht9aおよびGdf5の転写制御の検討による転写因子p63の同定2008

    • Author(s)
      菅哲徳
    • Organizer
      第26回日本骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 変形性膝関節症におけるレントゲン上の外側関節裂隙狭小は膝痛増悪予測因子である-重症度自動計測システムKOACADを用いた縦断研究-2008

    • Author(s)
      岡敏之
    • Organizer
      第26回日本骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 変形性膝関節症のX線学的重症度と膝症状および下肢機能との関連:ROAD(Research on Osteoarthritis against Disabilit)プロジェクト2008

    • Author(s)
      阿久根徹
    • Organizer
      第26回日本骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 変形性膝関節症および変形性脊椎症とメタポリック症候群との関連:ROAD(Research on Osteoarthritis against Disabilit)プロジェクト2008

    • Author(s)
      吉村典子
    • Organizer
      第26回日本骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] GαqシグナルはPKCδを介してPTHの骨同化作用を抑制する2008

    • Author(s)
      緒方直史
    • Organizer
      第26回日本骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 間葉系細胞の分化多能性維持機構におけるNanogの役割2008

    • Author(s)
      小笠原徹
    • Organizer
      第26回日本骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] cDNAマイクロアレイを用いた骨肉腫の治療標的分子ROR2の同定および機能解析2008

    • Author(s)
      森岡和仁
    • Organizer
      第23回日本整形外科学会基礎学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] 再生軟骨組織移植における移植細胞と母床由来細胞との相互作用2008

    • Author(s)
      星和人
    • Organizer
      第23回日本整形外科学会基礎学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] 高齢者では腰椎椎間狭小化と腰痛との関連は女性の方が男性よりも強い-ROADプロジェクト-2008

    • Author(s)
      村木重之
    • Organizer
      第23回日本整形外科学会基礎学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] 変形性膝関節症における骨棘形成および関節裂隙狭小化の膝痛への影響-ROADプロジェクト-2008

    • Author(s)
      村木重之
    • Organizer
      第23回日本整形外科学会基礎学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] 組織癒着防止効果を有する生体内解離性MPCゲルの開発2008

    • Author(s)
      石山典幸
    • Organizer
      第23回日本整形外科学会基礎学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] Aktlは軟骨内骨化における軟骨細胞の石灰化を維持して骨格成長を制御する2008

    • Author(s)
      深井厚
    • Organizer
      第23回日本整形外科学会基礎学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] HIF-2Aは軟骨内骨化における軟骨細胞の後期分化を広く制御する転写因子である2008

    • Author(s)
      斎藤琢
    • Organizer
      第23回日本整形外科学会基礎学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] 人工股関節ライナー表面のにMPCグラフト処理による摩耗抑制効果の検討-ライナーの架橋有無および金属骨頭とアルミナ骨頭の比較2008

    • Author(s)
      茂呂徹
    • Organizer
      第23回日本整形外科学会基礎学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] βカテニンは副甲状腺ホルモン(PTH)受容体の細胞内ドメインに直接結合しそのシグナルを制御する2008

    • Author(s)
      緒方直史
    • Organizer
      第23回日本整形外科学会基礎学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] シュワン細胞マーカーSIOOBの転写制御機構の解析2008

    • Author(s)
      藤原清香
    • Organizer
      第23回日本整形外科学会基礎学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] Transcriptional regulation of osteoarthritis progression (Symposium: Update on Osteoarthritis: from Bench to Beside - APLAR-OARSI Co-Sponsored Symposium).2008

    • Author(s)
      Kawaguchi H
    • Organizer
      The 13th Cohgress of the Asia Pacific League of Associations for Rheumitology(APLAR 2008)
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-09-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] C/EBP-beta promotes hypertrophic differentiation of chondrocytes through transactivation of p57^<kip2> during endochonderal ossification (Young Investigator Award)2008

    • Author(s)
      Kugimiya F
    • Organizer
      2008 World Congress on Osteoarthritis(OARSI)
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2008-09-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] Aktl contributes to chondrocyte calcification during endochondral ossification.2008

    • Author(s)
      Fukai A
    • Organizer
      2008 World Congress on Osteoarthritis(OARSI)
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2008-09-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] Association of radiographic severity of knee osteoarthritis with symptomatic parameters: The ROAD study.2008

    • Author(s)
      Akume T
    • Organizer
      2008 World Congress on Osteoarthritis(OARSI)
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2008-09-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] Lateral joint space narrowing on radiographs predicts pain progression in knee osteoarthritis patients: Application of fully automatic KOACAD system to OAI public data.2008

    • Author(s)
      Oka H
    • Organizer
      2008 World Congress on Osteoarthritis(OARSI)
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2008-09-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] β-Catenin directly binds to aspecifc intracellular domain of PTH/PTHrP receptor and regulates the signaling inchondrocytes during endochondral ossification. (President's Award)2008

    • Author(s)
      Yano F
    • Organizer
      30^<th>ASBMR Annual Meeting
    • Place of Presentation
      Montrial. Quebec. Canada
    • Year and Date
      2008-09-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] C/EBPβ / p57^<kip2> signaling maintains transition from proliferation to hypertrophic differerntiation of chondrocytes during skeletal growth.2008

    • Author(s)
      Hirata M
    • Organizer
      30^<th>ASBMR Annual Meeting
    • Place of Presentation
      Montrial. Quebec. Canada
    • Year and Date
      2008-09-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] Inhibitory role of Gαq / PKCδ signal in the bone anabolic action of PTH.2008

    • Author(s)
      Ogata N
    • Organizer
      30^<th>ASBMR Annual Meeting
    • Place of Presentation
      Montrial. Quebec. Canada
    • Year and Date
      2008-09-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] Identification of a transcription factor p63 for transactivation of Wnt9a and Gdf5 causing joint cartilage formation. 30th annual meeting of the American Society for Bone and Mineral Research.2008

    • Author(s)
      Kan A
    • Organizer
      30^<th>ASBMR Annual Meeting
    • Place of Presentation
      Montrial. Quebec. Canada
    • Year and Date
      2008-09-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] Predictive capacity of biochemical markers of bone turnover and endogenous hormones for osteoporosis in men: ten-year follow-up of a Japanese cohort.2008

    • Author(s)
      Yoshimura N
    • Organizer
      30^<th>ASBMR Annual Meeting
    • Place of Presentation
      Montrial. Quebec. Canada
    • Year and Date
      2008-09-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] Hypoxia-inducible factor 2A (HIF2A) controls sequential steps in the late stage of endochondarl ossification (Young Investigator Award)2008

    • Author(s)
      Saito T
    • Organizer
      30^<th>ASBMR Annual Meeting
    • Place of Presentation
      Montrial. Quebec. Canada
    • Year and Date
      2008-09-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 変形性関節症up-to-date:診断と治療の最前線2008

    • Author(s)
      川口浩
    • Organizer
      第1回TCOA(東京都臨床整形外科医会)up-to-dateセミナ一
    • Place of Presentation
      東京
    • Year and Date
      2008-08-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] 変形性関節症研究の現状と問題点(シンポジウム:プロテオーム解析技術の新展開:創薬ターゲット/臨床マーカー発見を目指して)2008

    • Author(s)
      川口浩
    • Organizer
      日本ヒトプロテオーム機構第6回大会
    • Place of Presentation
      大阪
    • Year and Date
      2008-07-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 糖代謝・脂質代謝シグナルによる骨代謝制御2008

    • Author(s)
      川口浩
    • Organizer
      第18回中図・四国骨代謝研究会
    • Place of Presentation
      岡山
    • Year and Date
      2008-07-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 研究・診療の現状と問題点(シンポジウム:骨粗鬆症と変形性関節症:研究と診療の最前線)2008

    • Author(s)
      川口浩
    • Organizer
      第50回日本考年医学会学術集会・総会
    • Place of Presentation
      千葉
    • Year and Date
      2008-06-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] 変形性関節症:その病態解明・診断・治療の最前線2008

    • Author(s)
      川口浩
    • Organizer
      福岡県臨床整形外科医会
    • Place of Presentation
      福岡
    • Year and Date
      2008-06-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] 変形性関節症の疫学研究の現状と問題点:ROAD(Research on Osteoarthritis against Disabilit)プロジェクト(シンポジウム:変形性膝関節症のマネージメント- 最新の臨床エビデンスとエキスパートオピニオン-)2008

    • Author(s)
      川口浩
    • Organizer
      第81回日本整形外科学会学術総会
    • Place of Presentation
      北海道
    • Year and Date
      2008-05-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] 変形性関節症の大規模臨床統合データベースの構築と、これを用いた観察疫学・ゲノム疫学研究(シンポジウム:学術プロジェクト課題の研究成果報告)2008

    • Author(s)
      川口浩
    • Organizer
      第81回日本整形外科学会学術総会
    • Place of Presentation
      北海道
    • Year and Date
      2008-05-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] 頸椎症における高位別有病率と頚部痛との関係-Research on Osteoarthritis against Disabilit (ROAD) プロジェクト-2008

    • Author(s)
      延與良夫
    • Organizer
      第81回日本整形外科学会学術総会
    • Place of Presentation
      北海道
    • Year and Date
      2008-05-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] 腰椎における加齢変化の縦断的検討-山村地域住民における15年のコホート追跡結果より-2008

    • Author(s)
      延與良夫
    • Organizer
      第37回日本脊椎脊髄病学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-04-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] 頚髄症での錐体路徴候の感度および運動機能との関連:Babinski徴候は麻痺の重症度を反映するか?2008

    • Author(s)
      築田博隆
    • Organizer
      第37回日本脊椎脊髄病学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-04-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] 変形性関節症研究の現状と問題点(シンポジウム:変形性関節症研究の基礎と臨床)2008

    • Author(s)
      川口浩
    • Organizer
      第52回日本リウマチ学会総会・学術集会
    • Place of Presentation
      北海道
    • Year and Date
      2008-04-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] 変形性関節症研究の現状(ランチョンセミナー)2008

    • Author(s)
      川口浩
    • Organizer
      第52回日本リウマチ学会総会・学術集会
    • Place of Presentation
      北海道
    • Year and Date
      2008-04-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] 変形性膝関節症:その課題とアプローチの現状(プレナリーレクチャー)2008

    • Author(s)
      中村耕三
    • Organizer
      第52回日本リウマチ学会総会・学術集会
    • Place of Presentation
      北海道
    • Year and Date
      2008-04-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] 変形性関節症研究の疫学研究:ROAD(Research on Osteoarthritia Against Disability)プロジェクト(シンポジジウム:変形性関節症研究の基礎と臨床)2008

    • Author(s)
      吉村典子
    • Organizer
      第52回日本リウマチ学会総会・学術集会
    • Place of Presentation
      北海道
    • Year and Date
      2008-04-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] 変形性膝関節症 : その課題とアプローチの現状 (プレナリーレクチャー)2008

    • Author(s)
      中村耕三, 川口浩, 吉村典子, 阿久根徹, 岡敬之, 村木重之, 馬淵昭彦
    • Organizer
      第52回日本リウマチ学会総会・学術集会
    • Place of Presentation
      北海道厚生年金会館、北海道
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] C/EBP-beta promotes hypertrophic differentiation of chondrocytes through transactivation of p57^<Kip2> during endochonderal ossification (Young Investigator Award)2008

    • Author(s)
      Kugimiya F, Hirata M, Ohba S, Kawamura K, Ogasawara T, Kawasaki Y, Ikeda T, Nakamura K, Chung UI, Kawaguchi H
    • Organizer
      2008 World Congress on Osteoarthritis (OARSI)
    • Place of Presentation
      Rome, Italy
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] A Novel small thienoindazole-derivative compound promotes chondrogenic differentiation without inducing hypertrophy through production of Runx1 (Young Investigator Award)2008

    • Author(s)
      Yano F, Ikeda T, Saito T, Ogata N, Nakamura K, Takato T, Kawaguchi H, Chung UI
    • Organizer
      2008 World Congress on Osteoarthritis (OARSI)
    • Place of Presentation
      Rome, Italy
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Akt1 contributes to chondrocyte calcification during endochondral ossification2008

    • Author(s)
      Fukai A, Kawamura N, Nakamura K, Chung UI, Kawaguchi H
    • Organizer
      2008 World Congress on Osteoarthritis (OARSI)
    • Place of Presentation
      Rome, Italy
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Association of radiographic severity of knee osteoarthritis with symptomatic parameters : The ROAD study2008

    • Author(s)
      Akune T, Muraki S, Oka H, Nakamura K, Kawaguchi H, Yoshimura N
    • Organizer
      2008 World Congress on Osteoarthritis (OARSI)
    • Place of Presentation
      Rome, Italy
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Lateral joint space narrowing on radiographs predicts pain progression in knee osteoarthritis patients : Application of fully automatic KOACAD system to OAI public data2008

    • Author(s)
      Oka H, Akune T, Muraki S, Nakamura K, Yoshimura N, Kawaguchi H
    • Organizer
      2008 World Congress on Osteoarthritis (OARSI)
    • Place of Presentation
      Rome, Italy
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Biocompatible phospholipid polymer grafting on liner surface of artificial hip joints enhances the wear resistance independently of liner cross-link or femoral head material2008

    • Author(s)
      Moro T, Takatori Y, Kyomoto M, Ishihara K, Nakamura K, Kawaguchi H
    • Organizer
      2008 World Congress on Osteoarthritis (OARSI)
    • Place of Presentation
      Rome, Italy
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Evaluation of the usefulness of biomarkers in knee osteoarthritis or lumbar spondylosis in mass cohort study of Japan2008

    • Author(s)
      Morita M, Yamada H, Yoshimura N, Date H, Oka H, Muraki S, Akune T, Ichinose H, Kawaguchi H, Nakamura K
    • Organizer
      2008 World Congress on Osteoarthritis (OARSI)
    • Place of Presentation
      Rome, Italy
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Hypoxia-inducible factor 2A (HIF2A) controls sequential steps in the late stage of endochondral ossification (Young Investigator Award)2008

    • Author(s)
      Saito T, Ikeda T, Kan A, Hirata M, Fukai A, Yano F, Nakamura K, Chung UI, Kawaguchi H
    • Organizer
      2008 World Congress on Osteoarthritis (OARSI)
    • Place of Presentation
      Rome, Italy
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] β-catenin directly binds to a specifc intracellular domain of PTH/PTHrP receptor and regulates the signaling in chondrocytes during endochondral ossification. (President's Award)2008

    • Author(s)
      Yano F, Chung UI, Ikeda T, Kawasaki Y, Kawaguchi H, Tawfeek HAW, Mahon MJ, Segre GV, Ogata N
    • Organizer
      30th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
    • Place of Presentation
      Montreal, Quebec, Canada
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] C/EBPβ/p57^<Kip2> signaling maintains transition from proliferation to hypertrophic differentiation of chondrocytes during skeletal growth2008

    • Author(s)
      Hirata M, Kugimiya F, Ohba S, Kawamura N, Ogasawara T, Kawasaki Y, Ikeda T, Nakamura K, Chung UI, Kawaguchi H
    • Organizer
      30th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
    • Place of Presentation
      Montreal, Quebec, Canada
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Identification of a transcription factor p63 for transactivation of Wnt9a and Gdf5 causing joint cartilage formation2008

    • Author(s)
      Kan A, Ikeda T, Saito T, Nakamura K, Chung UI, Kawaguchi H
    • Organizer
      30th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
    • Place of Presentation
      Montreal, Quebec, Canada
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Predictive capacity of biochemical markers of bone turnover and endogenous hormones for osteoporosis in men : ten-year follow-up of a Japanese cohort2008

    • Author(s)
      Yoshimura N, Oka H, Muraki S, Akune T, Kawaguchi H, Nakamura K
    • Organizer
      30th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
    • Place of Presentation
      Montreal, Quebec, Canada
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Development of high-throughput screening system for osteogenic drugs using cell-based sensor2008

    • Author(s)
      Hojo H, Igawa K, Ohba S, Yano F, Nakajima K, Komiyama K, Yonezawa T, Woo JT, Lichtler AC, Rowe DW, Ikeda T, Nakamura K, Kawaguchi H, Chung UI
    • Organizer
      30th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
    • Place of Presentation
      Montreal, Quebec, Canada
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Prevalence and risk factors for radiographic osteoarthritis of the knee and lumbar spine in Japan : The Research on Osteoarthritis Against Disability (ROAD) Study2008

    • Author(s)
      Yoshimura N, Muraki S, Oka H, Akune T, Mabuchi A, En-yo Y, Yoshida M, Suzuki T, Yoshida H, Kawaguchi H, Nakamura K
    • Organizer
      35th European Symposium on Calcified Tissues (ECTS)
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] マウスジェネティクスを用いた変形性関節症の分子メカニズムの解明 (シンポジウム : 骨・軟骨疾患の分子生物学)2007

    • Author(s)
      川口浩
    • Organizer
      第30回日本分子生物学会・第80回日本生化学学会 合同大会 (BMB2007)
    • Place of Presentation
      パシフィコ横浜、神奈川
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Transcriptional regulation of cartilage degeneration from a mouse OA model (invited lecture)2007

    • Author(s)
      Kawaguchi H
    • Organizer
      2007 World Congress on Osteoarthritis (OARSI)
    • Place of Presentation
      Ft. Lauderdale, Florida, USA
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Local application of recombinant human fibroblast growth factor-2 on bone repair2007

    • Author(s)
      Kawaguchi H
    • Organizer
      The 6th Combined Meeting of the Orthopaedic Research Societies
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Cartilage differentiation and osteoarthritis2007

    • Author(s)
      Kawaguchi H
    • Organizer
      19th Annual Meeting of the Korean Society for Molecular Cell Biology (Symposium : Cartilage and Bone)
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Insulin/IRS/Akt signaling for maintainance of bone mass and turnover. (Symposia : Mediators of PTH action)2007

    • Author(s)
      Kawaguchi H
    • Organizer
      The Endocrine Society's 89th Annual Meeting (ENDO 07)
    • Place of Presentation
      Toronto, Canada
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Transcriptional induction of type X collagen expression and hypertrophic differentiation of chondrocytes by Runx2 during osteoarthritis progression (Young Investigator Award)2007

    • Author(s)
      Higashikawa A, Saito T, Kamekura S, Ohba S, Ikeda T, Nakamura K, Chung UI, Kawaguchi H
    • Organizer
      2007 World Congress on Osteoarthritis (OARSI)
    • Place of Presentation
      Ft. Lauderdale, Florida, USA
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Risk factors for radiographic knee osteoarthritis and lumbar spomdylosis : the ROAD study (Young Investigator Award)2007

    • Author(s)
      Muraki S, Oka H, Mabuchi A, En-yo Y, Yoshida M, Saiga A, Nakamura K, Kawaguchi H, Yoshimura N
    • Organizer
      2007 World Congress on Osteoarthritis (OARSI)
    • Place of Presentation
      Ft. Lauderdale, Florida, USA
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Fully automatic quantification of knee osteoarthritis severity on standard radiographs by a novel computer-assisted system2007

    • Author(s)
      Oka H, Yoshimura N, Muraki S, Mabuchi A, Nakamura K, Kawaguchi H
    • Organizer
      2007 World Congress on Osteoarthritis (OARSI)
    • Place of Presentation
      Ft. Lauderdale, Florida, USA
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Identification of sorting nexin 19 as a novel chondrogenic factor by a real-time fluorescence monitoring cell line ATDC5-S2RD5 (Young Investigator Award)2007

    • Author(s)
      Kan A, Ikeda T, Saito T, Ushita M, Nakamura K, Chung UI, Kawaguchi H
    • Organizer
      2007 World Congress on Osteoarthritis (OARSI)
    • Place of Presentation
      Ft. Lauderdale, Florida, USA
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] GSK-3β inhibits osteoblastic bone formation through suppression of Runx2 transcriptional activity by the phosphorylation at a specific site (Young Investigator Award)2007

    • Author(s)
      Hirata M, Kugimiya F, Kawamura N, Ohba S, Nakamura K, Kawaguchi H, Chung UI
    • Organizer
      29th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Hypoxia-inducible factor 2α induces type X collagen and promotes hypertrophic differentiation of chondrocytes2007

    • Author(s)
      Saito T, Ikeda T, Higashikawa A, Kawasaki Y, Kan A, Ushita M, Ohba S, Yano F, Nakamura K, Chung UI, Kawaguchi H
    • Organizer
      29th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Identification of a novel chondrogenic factor Sorting Nexin 19 using a real-time fluorescence monitoring cell line ATDC5-S2RD52007

    • Author(s)
      Kan A, Ikeda T, Saito T, Chung UI, Kawaguchi H
    • Organizer
      29th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Transcriptional induction of SOX9 by NF-κB subunit p65 during chondrogenesis2007

    • Author(s)
      Ushita M, Ikeda T, Saito T, Kan A, Nakamura K, Chung UI, Kawaguchi H
    • Organizer
      29th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Transcriptional regulation of type X collagen by Runx2 : Molecular network underlying chondrocyte hypertrophy causing osteoarthritis2007

    • Author(s)
      Higashikawa A, Saito T, Kamekura S, Ohba S, Ikeda T, Nakamura K, Chung UI, Kawaguchi H
    • Organizer
      29th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Runx1, co-activator of Sox5, Sox6 and Sox9 (the Sox trio) regulates chondrogenic differentiation2007

    • Author(s)
      Yano F, Ikeda T, Saito T, Ogata N, Takeda S, Kimura A, Ohba S, Kugimiya F, Nakamura K, Takato T, Kawaguchi H, Chung UI
    • Organizer
      29th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] p63 plays a central role in cartilage development by directly regulating key genes for chondrogenesis2007

    • Author(s)
      Ikeda T, Kawaguchi H, Saito T, Kan A, Yano F, Ushita M, Kawasaki Y, Nakamura K, Chung UI
    • Organizer
      29th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Is osteoporosis related to future incidence of osteoarthritis over 10 years, or vice-versa?2007

    • Author(s)
      Yoshimura N, Muraki S, Oka H, Mabuchi A, Kawaguchi H, Nakamura K
    • Organizer
      29th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Prevalence of radiographic osteoarthritis of knee and lumbar spine and its association with pain : The Research on Osteoarthritis Against Disability (ROAD) study2007

    • Author(s)
      Muraki S, Yoshimura N, Oka H, Mabuchi A, En-yo Y, Yoshida M, Suzuki T, Yoshida H, Ishibashi H, Yamamoto S, Kawaguchi H, Nakamura K
    • Organizer
      29th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Full-automatic measurement of knee osteoarthritis parameters by a novel computer-assisted system on standard radiographs2007

    • Author(s)
      Oka H, Yoshimura N, Muraki S, Mabuchi A, Nakamura K, Kawaguchi H
    • Organizer
      1st Workshops on Imaging-Based Measures of Osteoarthritis
    • Place of Presentation
      Salzburg & Ainring, Germany
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Association of radiographic osteoarthritis of knee and lumbar spine with pain. The Research on Osteoarthritis Against Disability (ROAD) study2007

    • Author(s)
      Muraki S, Yoshimura N, Oka H, Mabuchi A, En-Yo Y, Yoshida M, Saika A, Suzuka T, Yoshida H, Ishibashi H, Yamamoto S, Kawaguchi H, Nakamura K
    • Organizer
      34th annual meeting of the European Calcified Tissue Society (ECTS)
    • Place of Presentation
      Copenhagen, Denmark
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Osteoporosis and osteoarthritis: is osteoporosis a predictor of the incidence of osteoarthritis or vice versa?2007

    • Author(s)
      Yoshimura N, Muraki S, Oka H, Mabuchi A, Kawaguch H, Nakamura K
    • Organizer
      34th annual meeting of the European Calcified Tissue Society (ECTS)
    • Place of Presentation
      Copenhagen, Denmark
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Transcriptional regulation of cartilage degeneration from amouse OA model (invited lecture).2007

    • Author(s)
      Hiroshi Kawaguchi
    • Organizer
      2007 World Congress on Osteoarthritis (OARSI)
    • Place of Presentation
      Ft.Lauderdale,Florida,USA
    • Related Report
      2007 Annual Research Report
  • [Book] 変形性関節症の分子メカニズム-治療標的分子の同定を目指して-医学の歩み2011

    • Author(s)
      川口浩
    • Related Report
      2011 Final Research Report
  • [Book] 整形外科専門医テキスト2010

    • Author(s)
      川口浩
    • Total Pages
      985
    • Publisher
      南江堂
    • Related Report
      2010 Annual Research Report
  • [Book] 新国民病ロコモティブシンドローム 長寿社会は警告する2010

    • Author(s)
      中村耕三
    • Total Pages
      315
    • Publisher
      NHK出版生活人新書
    • Related Report
      2009 Self-evaluation Report
  • [Book] ロコモティブシンドローム (監修)「BS朝日テレビテキスト「医療の現場! 4」2010

    • Author(s)
      中村耕三
    • Related Report
      2009 Self-evaluation Report
  • [Book] ロコモティブシンドローム特集にあたって (巻頭言)「Modern Physician 30」2010

    • Author(s)
      中村耕三
    • Related Report
      2009 Self-evaluation Report
  • [Book] 特集 ロコモティブシンドローム-予防・治療のための運動支援- (巻頭言)「臨床スポーツ医学 27」2010

    • Author(s)
      中村耕三
    • Related Report
      2009 Self-evaluation Report
  • [Book] 関節・軟骨疾患の分子医学 : 変形性関節症の治療標的分子の探索. BIO CLINICA (特集 : 骨・軟骨疾患の分子医学)2010

    • Author(s)
      川口浩
    • Related Report
      2009 Self-evaluation Report
  • [Book] 変形性関節症の治療ガイドライン. Geriatric Medicine 老年医学 (特集 : 変形性関節症・脊椎症)-診断と治療の最前線-2010

    • Author(s)
      川口浩
    • Related Report
      2009 Self-evaluation Report
  • [Book] 高齢社会におけるロコモティブシンドローム「運動療法と物理療法 20」2009

    • Author(s)
      中村耕三
    • Related Report
      2009 Self-evaluation Report
  • [Book] 筋肉・バランス感覚「NHKここが聞きたい! 名医にQロコモティブシンドローム](共同監修)2009

    • Author(s)
      中村耕三, 遠藤直人, 宗田大
    • Publisher
      日本放送出版協会
    • Related Report
      2009 Self-evaluation Report
  • [Book] ひざ痛・骨粗しょう症の新常識! ロコモティブシンドローム (監修)「NHKテレビテキスト きょうの健康4」2009

    • Author(s)
      中村耕三
    • Related Report
      2009 Self-evaluation Report
  • [Book] Osteovisual「変形性関節症における軟骨破壊のメカニズム」. Arthritis2009

    • Author(s)
      川口浩
    • Related Report
      2009 Self-evaluation Report
  • [Book] 遺伝子変異マウスによる変形性関節症の病態解明へのアプローチ. The Bone (特集 : 変形性関節症の基礎と臨床)2009

    • Author(s)
      川口浩
    • Related Report
      2009 Self-evaluation Report
  • [Book] 変形性関節症 : 研究・診療の現状と問題点. 日本老年病学会雑誌 (骨粗鬆症と変形性関節症 : 研究と診療の最前線)2009

    • Author(s)
      川口浩
    • Related Report
      2009 Self-evaluation Report
  • [Book] 変形性関節症に対する分子標的治療の展望. CLINICAL CALCIUM (特集 : 変形性関節症 Up-to-date)2009

    • Author(s)
      川口浩
    • Related Report
      2009 Self-evaluation Report
  • [Book] 変形性関節症の疫学研究の現状と問題点 : ROAD (Research on Osteoarthritis Against Disability) 研究. 日本整形外科学会雑誌 (シンポジウム : 変形性膝関節症のマネージメント-最新の臨床エビデンスとエキスパートオピニオン-)2009

    • Author(s)
      川口浩, 阿久根徹, 村木重之, 岡敬之, 中村耕三, 吉村典子
    • Related Report
      2009 Self-evaluation Report
  • [Book] 筋肉・バランス感覚「NHKここが聞きたい!名医にQロコモラィブシンドローム」2009

    • Author(s)
      中村耕三
    • Total Pages
      338
    • Publisher
      日本放送出版協会
    • Related Report
      2009 Annual Research Report
  • [Book] 変形性関節症 : ROAD 研究が明らかにした実態. 日経メディカル (特集 : 骨粗鬆症と運動器不安定症)2008

    • Author(s)
      川口浩, 阿久根徹, 岡敬之, 村木重之, 中村耕三, 吉村典子
    • Related Report
      2009 Self-evaluation Report
  • [Book] 変形性関節症の治療標的分子の解明. 骨の remodeling における Dickkopf-1 の役割. リウマチ科 (特集 : 変形性関節症の病態と治療-最近の進歩)2008

    • Author(s)
      川口浩
    • Related Report
      2009 Self-evaluation Report
  • [Book] OARSIによる股・膝関節OAの治療ガイドライン. Osteoarthritis Update (特集 : 変形性関節症の最新知見)2008

    • Author(s)
      川口浩
    • Related Report
      2009 Self-evaluation Report
  • [Book] 世界におけるOAの疫学. Osteoarthritis Update (特集 : 変形性関節症の最新知見)2008

    • Author(s)
      村木重之, 川口浩
    • Related Report
      2009 Self-evaluation Report
  • [Book] OAの画像診断. Osteoarthritis Update (特集 : 変形性関節症の最新知見)2008

    • Author(s)
      岡敬之, 川口浩
    • Related Report
      2009 Self-evaluation Report
  • [Book] 「運動器リハビリテーションクルズス」第1章 運動を司る構造と機能 : 解剖・生理について. I. 筋骨格系骨. 1. 骨の構造と機能(編集 : 岩谷力、黒沢尚、江藤文夫、赤居正美、星野雄一、飛松好子)2008

    • Author(s)
      川口浩
    • Publisher
      南江堂
    • Related Report
      2009 Self-evaluation Report
  • [Book] 軟骨のメカニカルストレスと変形性関節症. CLINICAL CALCIUM (特集 : メカニカルストレスと骨)2008

    • Author(s)
      川口浩
    • Related Report
      2009 Self-evaluation Report
  • [Book] コンピュータを用いた大腿骨頸部骨形態自動計測法の開発. Osteoporos Jpn2008

    • Author(s)
      村木重之, 阿久根徹, 岡敬之, 吉村典子
    • Related Report
      2009 Self-evaluation Report
  • [Book] 運動器リハビリテーションクルズス2008

    • Author(s)
      川口浩
    • Total Pages
      443
    • Publisher
      南江堂
    • Related Report
      2008 Annual Research Report
  • [Book] Molecules&Cells2008

    • Author(s)
      Hiroshi Kawaguchi
    • Total Pages
      252
    • Publisher
      Springer
    • Related Report
      2007 Annual Research Report
  • [Book] 変形性関節症の疫学研究. 日本整形外科学会雑誌 (シンポジウム : 変形性関節症の病態解明・診断・治療の新世紀)2007

    • Author(s)
      吉村典子, 岡敬之, 村木重之, 馬淵昭彦, 延與良夫, 吉田宗人, 鈴木隆雄, 山本精三, 川口浩, 中村耕三
    • Related Report
      2009 Self-evaluation Report
  • [Remarks]

    • URL

      http://www.u-tokyo-ortho.jp/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.u-tokyo-ortho.jp/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.u-tokyo-ortho.jp/

    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 膝関節診断支援方法及び装置並びにプログラム2012

    • Inventor(s)
      岡敬之、吉村典子、川口浩、中村耕三
    • Industrial Property Rights Holder
      岡敬之、吉村典子、川口浩、中村耕三
    • Acquisition Date
      2012-03-02
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 脊椎疾患診断支援装置、及び脊椎疾患診断支援プログラム2010

    • Inventor(s)
      岡敬之、吉村典子、阿久根徹、川口浩、中村耕三
    • Industrial Property Rights Holder
      岡敬之、吉村典子、阿久根徹、川口浩、中村耕三
    • Filing Date
      2010-04-19
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 膝関節診断支援方法及び装置並びにプログラム2009

    • Inventor(s)
      岡敬之、川口浩、中村耕三
    • Industrial Property Rights Holder
      岡敬之、川口浩、中村耕三
    • Patent Publication Number
      2008-093229
    • Filing Date
      2009-06-10
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 膝関節診断支援方法及び装置並びにプログラム公開番号:2009

    • Inventor(s)
      岡敬之、川口浩、中村耕三
    • Industrial Property Rights Holder
      岡敬之、川口浩、中村耕三
    • Patent Publication Number
      2008-093229
    • Filing Date
      2009-06-10
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 膝関節診断支援方法及び装置並びにプログラム2008

    • Inventor(s)
      岡敬之、吉村典子、川口浩、中村耕三
    • Industrial Property Rights Holder
      岡敬之、吉村典子、川口浩、中村耕三
    • Filing Date
      2008-04-24
    • Acquisition Date
      2012-03-02
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 膝関節診断支援方法及び装置並びにプログラム

    • Inventor(s)
      中村耕三, 川口浩, 岡敬之
    • Industrial Property Rights Holder
      中村耕三, 川口浩, 岡敬之
    • Patent Publication Number
      2008-093229
    • Related Report
      2009 Self-evaluation Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi